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The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary [Guideline]
Feldman, David; Pamboukian, Salpy V; Teuteberg, Jeffrey J; Birks, Emma; Lietz, Katherine; Moore, Stephanie A; Morgan, Jeffrey A; Arabia, Francisco; Bauman, Mary E; Buchholz, Hoger W; Deng, Mario; Dickstein, Marc L; El-Banayosy, Aly; Elliot, Tonya; Goldstein, Daniel J; Grady, Kathleen L; Jones, Kylie; Hryniewicz, Katarzyna; John, Ranjit; Kaan, Annemarie; Kusne, Shimon; Loebe, Matthias; Massicotte, M Patricia; Moazami, Nader; Mohacsi, Paul; Mooney, Martha; Nelson, Thomas; Pagani, Francis; Perry, William; Potapov, Evgenij V; Eduardo Rame, J; Russell, Stuart D; Sorensen, Erik N; Sun, Benjamin; Strueber, Martin; Mangi, Abeel A; Petty, Michael G; Rogers, Joseph
PMID: 23352391
ISSN: 1557-3117
CID: 2465682
Algorithm for the diagnosis and management of suspected pump thrombus
Goldstein, Daniel J; John, Ranjit; Salerno, Christopher; Silvestry, Scott; Moazami, Nader; Horstmanshof, Douglas; Adamson, Robert; Boyle, Andrew; Zucker, Mark; Rogers, Joseph; Russell, Stuart; Long, James; Pagani, Francis; Jorde, Ulrich
Pump thrombosis is a dreaded complication of long-term implantable ventricular assist devices. No guidance exists regarding the diagnosis and management of this entity despite its significant morbidity. After considerable thought and deliberation, a group of leading investigators in the field of mechanical support propose an algorithm for the diagnosis and management of this vexing entity based on clinical symptoms and serologic and imaging studies.
PMID: 23796150
ISSN: 1557-3117
CID: 2465672
HLA and MICA allosensitization patterns among patients supported by ventricular assist devices
Askar, Medhat; Hsich, Eileen; Reville, Patrick; Nowacki, Amy S; Baldwin, William; Bakdash, Suzanne; Daghstani, Jenna; Zhang, Aiwen; Klingman, Lynne; Smedira, Nicholas; Moazami, Nader; Taylor, David O; Starling, Randall C; Gonzalez-Stawinski, Gonzalo
BACKGROUND: Ventricular assist devices (VADs) are increasingly being used as a bridge to transplantation and have been implicated as a risk factor for allosensitization to human leukocyte antigens (HLA). We investigate the association between VAD and allosensitization to human leukocyte antigens (HLA) and major-histocompatibility-complex (MHC) class I-related Chain A (MICA) antigens. METHODS: We considered all patients who received a VAD at our institution between 2000 and 2009; 89 of them had pre-VAD and post-VAD (=6 months after implant) HLA antibody screening. A control group of non-VAD heart transplant candidates was constructed with at least 2 pre-transplant panel-reactive antibody (PRA) tests within 8 months. Two controls were randomly selected/VAD patient matched for year (n = 178). Patients and controls with available sera from these time-points were tested by Luminex/flow PRA single-antigen beads and by MICA antibody Luminex single-antigen beads. Medical records were reviewed for comparison of pre-transplant immunologic risk factors and post-transplant outcomes between the 2 groups. RESULTS: Compared with controls, VAD patients had greater Class I differences between peak and initial PRA (18% vs. 0%, p < 0.0001) and higher peak PRA (24% vs. 6%, p < 0.0001). The differences between the 2 groups in Class II were less pronounced than in Class I. Of patients who had single-antigen testing, VAD implantation was significantly associated with development of new HLA antibody specificities (Class I and/or Class II) post-VAD with an increase in calculated PRA (cPRA) post-VAD compared with controls (16% vs. 0%, p < 0.0001). This risk was still present after adjusting for age, gender, pre-VAD PRA, transfusion and duration of follow-up in a multivariate analysis (p < 0.0001 and 0.02, respectively). There were no differences in development of MICA antibodies between the 2 groups (14% in both). There was no significant difference in the incidence of pre-transplant positive T-cell crossmatch, pre-transplant donor-specific HLA antibodies, rejection episodes or graft survival between the 2 groups. CONCLUSION: Our results suggest that VAD is associated with significant HLA allosensitization independent of common risk factors.
PMID: 24075503
ISSN: 1557-3117
CID: 2465662
Bivalirudin Bridging to Oral Anticoagulation After Left Ventricular Assist Device Implantation [Meeting Abstract]
Kantorovich, Alexander; Fink, Jodie M; Moazami, Nader; Militello, Michael A
ISI:000332162905337
ISSN: 1524-4539
CID: 2467192
Aggressive Preoperative Optimization Is a Better Determinant of Survival Than Current Risk Models for Acute Cardiogenic Shock [Meeting Abstract]
Moazami, N; Feldman, D; Hryniewicz, K; Lillyblad, M; Cabuay, B; Shao, E; Sun, B
ISI:000302207900782
ISSN: 1053-2498
CID: 2467032
Bivalirudin Is a Safe and Effective Anticoagulant for Post-Operative Bridging to Warfarin in LVAD Patients [Meeting Abstract]
Moazami, N; Richardson, LB; Sun, B; Cabuay, B; Shao, E; Hryniewicz, KM; Feldman, D
ISI:000302207900115
ISSN: 1053-2498
CID: 2467002
Avoiding RVADs: Pre-Operative Optimization Is the Best Predictor of Need for RVADs [Meeting Abstract]
Hryniewicz, K; Lillyblad, M; Shao, ES; Feldman, DS; Cabuay, B; Sun, B; Moazami, N
ISI:000302207900791
ISSN: 1053-2498
CID: 2467042
Impact of Malnutrition on Early Outcomes Following Implantation of Continuous Flow Left Ventricular Assist Devices [Meeting Abstract]
Goldstein, DJ; Holman, W; Moazami, N; John, R; Naftel, D; Pagani, F
ISI:000302207900241
ISSN: 1053-2498
CID: 2467022
Increased LVAD Utilization Has Increased Waiting Time for Medically Bridged Patients [Meeting Abstract]
Shao, ES; Garberich, R; Hryniewicz, K; Sun, B; Moazami, N; Cabuay, B; Feldman, D
ISI:000302207900163
ISSN: 1053-2498
CID: 2467012
Optimal Medical Management and Lowering LVAD Speed Prevents Progression of Aortic Insufficiency [Meeting Abstract]
Hryniewicz, K; Moazami, N; Lillyblad, M; Shao, ES; Feldman, D; Maxfield, C; Cabuay, B; Carter, E; Sun, B
ISI:000302207900037
ISSN: 1053-2498
CID: 2466992