Faculty Bibliography

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331

Blood. 2010:116(23):4874-84.DOI: 10.1182/blood-2009-08-239681

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

Harvey, Richard C; Mullighan, Charles G; Wang, Xuefei; Dobbin, Kevin K; Davidson, George S; Bedrick, Edward J; Chen, I-Ming; Atlas, Susan R; Kang, Huining; Ar, Kerem; Wilson, Carla S; Wharton, Walker; Murphy, Maurice; Devidas, Meenakshi; Carroll, Andrew J; Borowitz, Michael J; Bowman, W Paul; Downing, James R; Relling, Mary; Yang, Jun; Bhojwani, Deepa; Carroll, William L; Camitta, Bruce; Reaman, Gregory H; Smith, Malcolm; Hunger, Stephen P; Willman, Cheryl L
To resolve the genetic heterogeneity within pediatric high-risk B-precursor acute lymphoblastic leukemia (ALL), a clinically defined poor-risk group with few known recurring cytogenetic abnormalities, we performed gene expression profiling in a cohort of 207 uniformly treated children with high-risk ALL. Expression profiles were correlated with genome-wide DNA copy number abnormalities and clinical and outcome features. Unsupervised clustering of gene expression profiling data revealed 8 unique cluster groups within these high-risk ALL patients, 2 of which were associated with known chromosomal translocations (t(1;19)(TCF3-PBX1) or MLL), and 6 of which lacked any previously known cytogenetic lesion. One unique cluster was characterized by high expression of distinct outlier genes AGAP1, CCNJ, CHST2/7, CLEC12A/B, and PTPRM; ERG DNA deletions; and 4-year relapse-free survival of 94.7% +/- 5.1%, compared with 63.5% +/- 3.7% for the cohort (P = .01). A second cluster, characterized by high expression of BMPR1B, CRLF2, GPR110, and MUC4; frequent deletion of EBF1, IKZF1, RAG1-2, and IL3RA-CSF2RA; JAK mutations and CRLF2 rearrangements (P < .0001); and Hispanic ethnicity (P < .001) had a very poor 4-year relapse-free survival (21.0% +/- 9.5%; P < .001). These studies reveal striking clinical and genetic heterogeneity in high-risk ALL and point to novel genes that may serve as new targets for diagnosis, risk classification, and therapy.
PMCID:3321747
PMID: 20699438
ISSN: 0006-4971
CID: 453532
Blood. 2010:116(21):882-882.DOI:

Administration of Erwinia Asparaginase (Erwinase (R)) Following Allergy to PEG-Asparaginase In Children and Young Adults with Acute Lymphoblastic Leukemia Treated on AALL07P2 Achieves Therapeutic Nadir Serum Asparaginase Activity: A Report From the Children's Oncology Group (COG) [Meeting Abstract]

Salzer, Wanda; Asselin, Barbara; Supko, Jeffrey; Devidas, Meenakshi; Kaiser, Nicole; Plourde, Paul V.; Winick, Naomi; Reaman, Gregory; Raetz, Elizabeth; Carroll, William L.; Hunger, Stephen
ISI:000289662202357
ISSN: 0006-4971
CID: 134502
Blood. 2010:116(21):183-184.DOI:

Gene Expression Profiling Reveals Genes Predictive of Outcome In Infant Acute Lymphoblastic Leukemia (ALL) and Distinctive Age Related Gene Expression Profiles (< 90 Days vs > 90 Days) A Children's Oncology Group Study [Meeting Abstract]

Kang, Huining; Wilson, Carla S.; Harvey, Richard C.; Chen, I. Ming; Murphy, Maurice H.; Atlas, Susan R.; Bedrick, Edward J.; Devidas, Meenakshi; Carroll, Andrew J.; Robinson, Blaine W.; Heerema, Nyla A.; Hilden, Joanne M.; Dreyer, Zoann E.; Camitta, Bruce; Winick, Naomi; Carroll, William L.; Felix, Carolyn A.; Reaman, Gregory H.; Hunger, Stephen P.; William, Cheryl L.
ISI:000285025202410
ISSN: 0006-4971
CID: 130857
Blood. 2010:116(21):184-184.DOI:

Early Response Characteristics and Blast Cytogenetic FEatures In 5,377 Children with Standard Risk Acute Lymphoblastic Leukemia (SR-ALL) A Children's Oncology Group (COG) Study [Meeting Abstract]

Maloney, Kelly W.; Loh, Mignon L.; Raetz, Elizabeth; Borowitz, Michael J.; Devidas, Meenakshi; Friedmann, Alison M.; Mattano, Leonard A.; Wood, Brent; Winick, Naomi; Hunger, Stephen; Carroll, William L.
ISI:000285025202412
ISSN: 0006-4971
CID: 130858
Blood. 2010:116(21):221-221.DOI:

Children with Down Syndrome (DS) and NCI Standard Risk (SR) Acute Lymphoblastic Leukemia (ALL) Have a Superior Five Year Event Free Survival (EFS) When Treated with Escalating Intravenous Methotrexate on the Children's Cancer Group (CCG) Study 1991 [Meeting Abstract]

Matloub, Yousif; Bostrom, Bruce C.; Hunger, Stephen; Angiolillo, Anne; Devidas, Meenakshi; La, Mei; Heerema, Nyla A.; Winick, Naomi; Nachman, James; Sather, Harland; Carroll, William L.; Gaynon, Paul S.
ISI:000285025202495
ISSN: 0006-4971
CID: 130860
Blood. 2010:116(21):378-378.DOI:

Nelarabine May Be Safely Incorporated Into a Phase III Study for Newly Diagnosed T Lineage Acute Lymphoblastic Leukemia A Report From the Children's Oncology Group [Meeting Abstract]

Winter, Stuart S.; Devidas, Meenakshi; Wood, Brent; Borowitz, Michael J.; Loh, Mignon L.; Asselin, Barbara; Murphy, John; Raetz, Elizabeth; Winick, Naomi; Hunger, Stephen; Carroll, William; Dunsmore, Kimberly
ISI:000285025202863
ISSN: 0006-4971
CID: 130863
Blood. 2010:116(21):378-379.DOI:

Phase 2 Results of Clofarabine In Combination with Etoposide and Cyclophosphamide In Pediatric Patients with Refractory or Relapsed Acute Lymphoblastic Leukemia [Meeting Abstract]

Huiya, Nobuko; Paul, Jo Anne; Borowitz, Michael J.; Thomson, Blythe; Isakoff, Michael; Silverman, Lewis B.; Steinherz, Peter G.; Kadota, Richard; Pressey, Joseph G.; Shen, Violet; Chu, Roland; Cooper, Todd; Jeha, Sima; Razzouk, Bassem I.; Rytting, Michael E.; Barry, Elly; Carroll, William L.; Gaynon, Paul
ISI:000285025202864
ISSN: 0006-4971
CID: 130864
Blood. 2010:116(21):1135-1135.DOI:

Lack of Somatic Sequence Mutations In Protein Tyrosine Kinase Genes Other Than the JAK Kinase Family In High Risk B Precursor Childhood Acute Lymphoblastic Leukemia (ALL) A Report From the Children's Oncology Group (COG) High Risk (HR) ALL TARGET Project [Meeting Abstract]

Zhang, Jinghui; Mullighan, Charles; Harvey, Richard; Carroll, William L.; Chen, I. Ming L.; Devidas, Meenakshi; Larsen, Eric; Edmonson, Michael; Buetow, Ken; Gerhard, Daniela S.; Loh, Mignon L.; Reaman, Gregory H.; Relling, Mary V.; Smith, Malcolm A.; Downing, James R.; Willman, Cheryl L.; Hunger, Stephen
ISI:000285025203084
ISSN: 0006-4971
CID: 130865
Blood. 2010:116(21):1137-1137.DOI:

Infant Acute Lymphoblastic Leukemias Are Pan Sensitive to Obatoclax Across molecular/Cytogenetic Subtypes, Especially MLL ENL, and gene Expression Profiles Determine Obatoclax IC50 A Report on the Children's Oncology Group (COG) P9407 Trial [Meeting Abstract]

Urtishak, Karen A.; Wang, Li San; Harvey, Richard; Atlas, Susan R.; Chen, I. Ming L.; Robinson, Blaine W.; Moukarzel, Lea; Cao, Kajia; Devidas, Meenakshi; Carroll, Andrew J.; Heerema, Nyla A.; Hunger, Stephen; Reaman, Gregory H.; Hilden, Joanne M.; Camitta, Bruce; Winick, Naomi; Carroll, William L.; Zhang, Alena Y.; Cory, Lori; McVeigh, Steven; Barrett, Jeffery S.; Dreyer, Zoann E.; Willman, Cheryl L.; Felix, Carolyn A.
ISI:000285025203089
ISSN: 0006-4971
CID: 130866
Blood. 2010:116(21):1326-1326.DOI:

High Throughput Transcriptome Sequencing of Pediatric Relapsed Acute Lymphoblastic Leukemia (ALL) Identifies Relapse Specific Mutations and Expression [Meeting Abstract]

Meyer, Julia A.; Hogan, Laura E.; Wang, Jinhua; Yang, Jun J.; Patel, Jay; Levine, Ross L.; Hunger, Stephen P.; Raetz, Elizabeth; Mason, Christopher; Carroll, William L.
ISI:000285025203564
ISSN: 0006-4971
CID: 130868