Faculty Bibliography

With the development of open-configuration magnetic resonance imaging (MRI) systems, magnetic resonance-compatible navigational tools, and fast pulse sequences, MRI-guided biopsy of musculoskeletal lesions has evolved into an effective and safe, minimally invasive technique. Magnetic resonance-guided percutaneous biopsy of musculoskeletal lesions is especially suited for lesions that are detectable only with MRI, lesions that require double-angulated needle paths, and for patients in which radiation exposure needs to be avoided. In this article, we review pertinent principles, techniques, and clinical applications of low-field MRI for biopsy procedures in the musculoskeletal system.

Magnetic resonance (MR)-guided spine injections describe techniques for selective spine injection procedures, in which MR imaging is used to visualize spinal targets and needle placement, monitor the injected drugs, and detect spread to potentially confounding nearby structures. The introduction of clinical high-field wide-bore MR imaging systems has increased the practicability and availability of MR-guided spine injections. The use of 1.5-T field strength, modern coils, and parallel imaging technology increases the MR signal, which can be utilized for faster temporal image acquisition, higher image resolution, better image contrast, or combinations thereof. Magnetic resonance imaging guidance provides excellent osseous and soft-tissue detail of spinal structures and is well suited to avoid radiation exposure. In this article, we discuss the technical background of interventional MR imaging, review the literature, and illustrate interventional MR imaging techniques of commonly performed spinal injection procedures, including sacroiliac joint injections, lumbar facet joint injections, selective spinal nerve root infiltration, and percutaneous drug delivery to the lumbar sympathetic nerves.

Magnetic resonance imaging (MRI) is promising tool for image-guided therapy. In musculoskeletal setting, image-guided therapy is used to direct diagnostic and therapeutic procedures and to steer patient management. Studies have demonstrated that MRI-guided interventions involving bone, soft tissue, joints, and intervertebral disks are safe and in selected indications can be the preferred action to manage clinical situation. Often, these procedures are technically similar to those performed in other modalities (computed tomography, fluoroscopy) for bone and soft tissue lesions. However, the procedural perception to the operator can be very different to other modalities because of the vastly increased data.Magnetic resonance imaging guidance is particularly advantageous should the lesion not be visible by other modalities, for selective lesion targeting, intra-articular locations, cyst aspiration, and locations adjacent to surgical hardware. Palliative tumor-related pain management such as ablation therapy forms a subset of procedures that are frequently performed under MRI. Another suitable entity for MRI guidance are the therapeutic percutaneous osseous or joint-related benign or reactive conditions such as osteoid osteoma, epiphyseal bone bridging, osteochondritis dissecans, bone cysts, localized bone necrosis, and posttraumatic lesions. In this article, we will describe in detail the technical aspects of performing MRI-guided therapeutic musculoskeletal procedures as well as the clinical indications.

The posterior tibial tendon (PTT) is the most important dynamic stabilizer of the medial ankle and longitudinal arch of the foot. PTT dysfunction is a degenerative disorder of the tendon, which secondarily involves multiple ligaments, joint capsules, fascia, articulations, and bony structures of the ankle, hindfoot, midfoot, and forefoot. When the tendon progressively attenuates, the patient develops a painful, progressive collapsed flatfoot or pes planovalgus deformity. This comprehensive review illustrates the 3-Tesla magnetic resonance imaging (3T MRI) features of PTT dysfunction. In addition, the reader will gain knowledge of the expected pathologic findings on MRI, as they are related to clinical staging of PTT dysfunction.

PURPOSE/OBJECTIVE:To perform in vitro assessment of needle artifacts with an interactive three-dimensional (3D) near-real-time magnetic resonance (MR) fluoroscopy system for musculoskeletal interventions in a 1.5-T open-bore magnet. MATERIALS AND METHODS/METHODS:One MR-compatible titanium needle, one MR-compatible Inconel (nickel-chromium superalloy) needle, and one MR-compatible carbon fiber needle were imaged with an interactive 3D MR sequence. Slice orientations, measurement parameters (fast low-angle shot, repetition time/echo time of 1,358/5 msec, flip angle of 15 degrees , bandwidth of 250 Hz/pixel; and true fast imaging with steady-state precession, repetition time/echo time of 770/2.2 msec, flip angle of 50 degrees , bandwidth of 558 Hz/pixel), phase encoding directions, and orientations to the main magnetic field (B(0)) were systematically varied. Artifact sizes, normalized artifact contrasts, and tip location errors were assessed for all variations of acquisition parameters and needles and compared with t tests. RESULTS:Mean artifact sizes, normalized artifact contrast, and tip location errors were 22.9 mm, 96%, and 5.4 mm, respectively, for the Inconel needle; 6.1 mm, 70%, and 0.3 mm, respectively, for the titanium needle; and 2.8 mm, 38%, and -1.9 mm, respectively, for the carbon fiber needle. Artifact widths depended on needle materials and needle orientation to B(0), with significant differences on ttests. Artifact contrast did not depend on measurement parameters. No significant influence on artifact character was found for changes in phase encoding direction and slice orientation. CONCLUSIONS:Because of its robustness in depicting needle artifacts, the interactive 3D MR fluoroscopy system appears to be suitable for MR-guided interventions. The titanium needle showed optimal artifacts with all combinations of measurement parameters. Artifacts with the other needles were too large (Inconel) or too small (carbon fiber).

OBJECTIVE:The purpose of this study was to investigate the role of dynamic contrast-enhanced MRI in the differential diagnosis of psoriatic and rheumatoid arthritis in the hand and wrist. SUBJECTS AND METHODS/METHODS:Forty-five consecutive patients (31 patients with rheumatoid arthritis and 14 patients with psoriatic arthritis) were examined in a 3-T whole-body MR unit. After contrast injection, a 3D encoded spoiled gradient-echo sequence was used for measurement of the time course of contrast-medium uptake in the synovial tissue. On the basis of the gained uptake curves, the rate of early enhancement was calculated after 35 and 52 seconds, and the relative enhancement rate was calculated after 35 seconds, 52 seconds, 3 minutes, and 15 minutes (late enhancement). Dynamic contrast-enhanced MRI rates of patients with rheumatoid arthritis and psoriatic arthritis were compared and correlated with laboratory and clinical data. RESULTS:A statistically significant difference between the two groups was found regarding the relative enhancement rate after 15 minutes (p < 0.01). In contrast, no difference in relative enhancement rate was found 35 seconds, 52 seconds, or 3 minutes after contrast injection (p = 0.695, p = 0.573, and p = 0.278, respectively). Regarding the rate of early enhancement at 35 and 52 seconds, no significant difference between patients with rheumatoid arthritis and those with psoriatic arthritis was found. Significant correlations were found between inflammatory parameters and dynamic contrast-enhanced parameters in patients with rheumatoid arthritis but not in those with psoriatic arthritis. CONCLUSION/CONCLUSIONS:Fifteen minutes after contrast injection, a statistically significant difference between rheumatoid arthritis and psoriatic arthritis was found in synovial enhancement that might play an important role in differentiating the two diseases.

OBJECTIVE:The purpose of this study was to test the hypothesis that freehand real-time MRI-guided lumbar spinal injection procedures are feasible, accurate, and safe when performed with a clinical open-bore 1.5-T MRI system. MATERIALS AND METHODS/METHODS:A retrospective analysis was made of spinal injection procedures performed over an 18-month period. Forty-nine procedures were performed on 37 patients (23 women, 14 men; mean age, 36 years; range, 18-48 years). A rapid FLASH 2D MRI sequence (TR/TE, 9.3/3.5; slice thickness, 5 mm; acquisition time, 1 second) was used for real-time needle placement with freehand technique. Data assessed were type of procedure, qualitative and quantitative image quality, dimensions of needle artifact, rate of successful drug delivery, rate of vascular uptake, time requirements, and occurrence of complications. RESULTS:Among the 49 procedures, 22 (45%) were nerve root injections, 18 (37%) were facet joint injections, and nine (18%) were epidural injections. The quality of real-time FLASH 2D MR images was sufficient in all cases. Contrast-to-noise ratios were sufficiently high for good delineation of relevant structures. The needle artifact made was remarkably constant with an average overestimation of length of 1.0 +/- 0.2 [SD] mm. Drug delivery was successful in all selective nerve root injections and epidural injections. The rate of successful drug delivery was 89% (16 of 18) for facet joint injections. No complete intravascular injections occurred. The mean table time was 36 minutes (range, 23-75 minutes). The mean real-time MRI time was 38 seconds (range, 12-185 seconds). No major complications occurred. CONCLUSION/CONCLUSIONS:We accept the hypothesis that freehand real-time MRI-guided lumbar spinal injection procedures are feasible, accurate, and safe when performed with a clinical open-bore 1.5-T MRI system. We note that real-time MRI guidance has the additional advantage of a complete absence of patient and operator exposure to ionizing radiation.

We retrospectively assessed the longitudinal changes of rheumatoid arthritis under rituximab therapy by use of quantitative and dynamic contrast-enhanced 3-T magnetic resonance (MR) imaging of the metacarpophalangeal joints of 10 patients at baseline and 26 weeks (n = 10). Additional studies were available at 12 weeks (n = 9) and at 52 weeks (n = 5). Clinical activity was assessed by use of the 28-joint disease activity score (DAS28). MR imaging was used to assess volumes of synovial enhancement, osseous enhancement, and erosions and early rapid enhancement. DAS28 and serum C-reactive protein trended down over time and were significantly lower at 26 weeks. Volume of synovial enhancement and early rapid enhancement showed a significant minimum at 26 weeks and increased thereafter. The erythrocyte sedimentation rate paralleled these two trends. Osseous enhancement did not significantly change over time. Erosions showed a significant progression. Trends of DAS28 and erosions were significantly different (P = 0.0075). In conclusion, our preliminary results suggest that rituximab is associated with a decrease of the inflammatory activity of synovitis with a minimum at 26 weeks and increasing activity thereafter suggesting recurrence. Our results further suggest subclinical progression of erosions with an inverse relationship to decreasing disease activity scores. Further studies are needed to confirm these results.