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Cytologic diagnosis of cystic brain tumors: A retrospective study of 88 cases [Meeting Abstract]
Hernandez, O; Golfinos, J; Zagzag, D; Levine, PH
ISI:000180720100313
ISSN: 0893-3952
CID: 38514
Tumors of the cerebellopontine angle
Chapter by: Golfinos JG; Russell S; Roland JT
in: Textbook of neurological surgery : principles and practice by Batjer HH; Loftus CM [Eds]
Philadelphia : Lippincott, 2003
pp. ?-?
ISBN: 0781712718
CID: 3146
Preoperative assessment of intracranial tumors with perfusion MR and a volumetric interpolated examination: a comparative study with DSA
Wetzel, Stephan G; Cha, Soonmee; Law, Meng; Johnson, Glyn; Golfinos, John; Lee, Peter; Nelson, Peter Kim
BACKGROUND AND PURPOSE: In evaluating intracranial tumors, a safe low-cost alternative that provides information similar to that of digital subtraction angiography (DSA) may be of interest. Our purpose was to determine the utility and limitations of a combined MR protocol in assessing (neo-) vascularity in intracranial tumors and their relation to adjacent vessels and to compare the results with those of DSA. METHODS: Twenty-two consecutive patients with an intracranial tumor who underwent preoperative stereoscopic DSA were examined with contrast-enhanced dynamic T2*-weighted perfusion MR imaging followed by a T1-weighted three-dimensional (3D) MR study (volumetric interpolated brain examination [VIBE]). The maximum relative cerebral blood volume (rCBV) of the tumor was compared with tumor vascularity at DSA. Critical vessel structures were defined in each patient, and VIBE images of these structures were compared with DSA findings. For full exploitation of the 3D data sets, maximum-intensity projection algorithms reconstructed in real time with any desired volume and orientation were used. RESULTS: Tumor blush scores at DSA were significantly correlated with the rCBV measurements (r = 0.75; P <.01, Spearman rank correlation coefficient). In 17 (77%) patients, VIBE provided all relevant information about the venous system, whereas information about critical arteries were partial in 50% of the cases and not relevant in the other 50%. CONCLUSION: A fast imaging protocol consisting of perfusion MR imaging and a volumetric MR acquisition provides some of the information about tumor (neo-) vascularity and adjacent vascular anatomy that can be obtained with conventional angiography. However, the MR protocol provides insufficient visualization of distal cerebral arteries
PMID: 12427637
ISSN: 0195-6108
CID: 43233
Use of the LandmarX (TM) surgical navigation system in lateral skull base and temporal bone surgery - Comments for publication [Editorial]
Golfinos, JG; Roland, JT
ISI:000172437900006
ISSN: 1531-5010
CID: 105551
Detection of additional brain metastases with triple dose gadolinium for stereotactic radiosurgery imaging [Meeting Abstract]
Donahue, BR; Golfinos, JG; Rush, SC; Han, K; Holland, B; Cooper, JS
ISI:000172773300044
ISSN: 1528-9117
CID: 27530
A stereotactic device for experimental rat and mouse irradiation using gamma knife model B--technical note
Kamiryo T; Han K; Golfinos J; Nelson PK
BACKGROUND: For radiobiological experiments using the Gamma Knife model B, we constructed a stereotactic device to irradiate rat and mouse brains and verify the absorbed dose at the target using thermoluminescence dosimetry and a head phantom. METHODS: Our stereotactic device is primarily designed for rats using the fixation principles of a stereotactic atlas. A head-fixation adapter for a mouse was constructed to enable targeted irradiation of mouse brains. We built simple phantoms to simulate rat and mouse heads. We placed thermoluminescent dosimeters at various positions on the phantom for dose measurements. Dose planning employed the Leksell Gamma Plan version 4.11 software, assuming a spherical skull geometry for all calculations. FINDINGS: The measurements demonstrated that the actual absorbed dose agreed with our calculations within the errors of thermoluminescence dosimetry and the accuracy of our irradiation technique and dose calculations. INTERPRETATION: This device provides an accurate method for irradiating rat and mouse brains using the Gamma Knife model B
PMID: 11345722
ISSN: 0001-6268
CID: 20676
Head injury
Cooper, Paul R; Golfinos, John
New York : McGraw-Hill, 2000
Extent: 598 p. ; 24 cm.
ISBN: 0838536875
CID: 675
Nutrition in the patient with severe head injury
Chapter by: Mogilner A; Golfinos JG
in: Head injury by Cooper PR [Eds]
New York : McGraw-Hill Health Professions, 2000
pp. 517-524
ISBN: 0838536875
CID: 3573
Skull fracture and post-traumatic cerebrospinal fluid fistula
Chapter by: Golfinos JG; Cooper PR
in: Head injury by Cooper PR [Eds]
New York : McGraw-Hill Health Professions, 2000
pp. 155-174
ISBN: 0838536875
CID: 3570
Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging
Knopp EA; Cha S; Johnson G; Mazumdar A; Golfinos JG; Zagzag D; Miller DC; Kelly PJ; Kricheff II
PURPOSE: To evaluate the role of T2*-weighted echo-planar perfusion imaging by using a first-pass gadopentetate dimeglumine technique to determine the association of magnetic resonance (MR) imaging-derived cerebral blood volume (CBV) maps with histopathologic grading of astrocytomas and to improve the accuracy of targeting of stereotactic biopsy. MATERIALS AND METHODS: MR imaging was performed in 29 patients by using a first-pass gadopentetate dimeglumine T2*-weighted echo-planar perfusion sequence followed by conventional imaging. The perfusion data were processed to obtain a color map of relative regional CBV. This information formed the basis for targeting the stereotactic biopsy. Relative CBV values were computed with a nondiffusible tracer model. The relative CBV of lesions was expressed as a percentage of the relative CBV of normal white matter. The maximum relative CBV of each lesion was correlated with the histopathologic grading of astrocytomas obtained from samples from stereotactic biopsy or volumetric resection. RESULTS: The maximum relative CBV in high-grade astrocytomas (n = 26) varied from 1.73 to 13.7, with a mean of 5.07 +/- 2.79 (+/- SD), and in the low-grade cohort (n = 3) varied from 0.92 to 2.19, with a mean of 1.44 +/- 0.68. This difference in relative CBV was statistically significant (P < .001; Student t test). CONCLUSION: Echo-planar perfusion imaging is useful in the preoperative assessment of tumor grade and in providing diagnostic information not available with conventional MR imaging. The areas of perfusion abnormality are invaluable in the precise targeting of the stereotactic biopsy
PMID: 10352608
ISSN: 0033-8419
CID: 6128