Faculty Bibliography

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642

Journal of the American College of Surgeons. 2019:229(4):S69-S70.DOI:

Prognostic Impact of KRAS Mutational Status in Patients with Colorectal Cancer Liver Metastases Differs According to the Location of the Primary Tumor [Meeting Abstract]

Amini, Neda; Margonis, Georgios Antonios; Kreis, Martin E.; Poultsides, George A.; Sasaki, Kazunari; Wagner, Doris; Pikoulis, Emmanouil; Weiss, Matthew J.; Wolfgang, Christopher L.; Safar, Bashar
ISI:000492740900114
ISSN: 1072-7515
CID: 4745062
Journal of the American College of Surgeons. 2019:228(4):424-426.DOI:

Enhancing Patient Outcomes while Containing Costs after Complex Abdominal Operation: A Randomized Controlled Trial of the Whipple Accelerated Recovery Pathway Discussion [Editorial]

Adams, David B.; Lillemoe, Keith D.; Wolfgang, Christopher; Vickers, Selwyn; Shoup, Margo; Hughes, Marybeth; Lavu, Harish
ISI:000461357100017
ISSN: 1072-7515
CID: 4744922
Gastrointestinal endoscopy. 2019:89(6):AB143-AB144.DOI:

A MULTI-MODALITY TEST TO GUIDE THE MANAGEMENT OF PATIENTS WITH PANCREATIC CYSTS [Meeting Abstract]

Dal Molin, Marco; Springer, Simeon; Masica, David; Li, Lu; Douville, Christopher; Thoburn, Christopher; Asfari, Bahman; Cohen, Joshua; Thompson, Elizabeth; Allen, Peter; Klimstra, David; Schattner, Mark A.; Schmidt, C. Max; Yip-Schneider, Michele; Simpson, Rachel E.; Fernandez-Del Castillo, Carlos; Mino-Kenudson, Mari; Brugge, William R.; Brand, Randall; Singhi, Aatur; Scarpa, Aldo; Lawlor, Rita Teresa; Salvia, Roberto; Zamboni, Giuseppe; Hong, Seung-Mo; Hwang, Dae Wook; Jang, Jin-Young; Kwon, Wooil; Swan, Niall; Geoghegan, Justin; Falconi, Massimo; Crippa, Stefano; Doglioni, Claudio; Paulino, Jorge; Schulick, Richard D.; Edil, Barish H.; Park, Walter G.; Yachida, Shinichi; Hijioka, Susuma; Van Hooft, Jeanin E.; He, Jin; Weiss, Matthew J.; Burkhart, Richard; Makary, Martin; Canto, Marcia I.; Goggins, Michael G.; Karchin, Rachel; Klein, Alison; Tomasetti, Cristian; Papadopoulos, Nickolas; Kinzler, Kenneth; Vogelstein, Bert; Wolfgang, Christopher L.; Hruban, Ralph; Lennon, Anne Marie
ISI:000470094900190
ISSN: 0016-5107
CID: 4744962
Journal of the American College of Surgeons. 2019:228(4):413-414.DOI:

Development of Diabetes after Pancreaticoduodenectomy: Results of a 10-Year Series Using Prospective Endocrine Evaluation Discussion [Editorial]

Wolfgang, Christopher; Adams, David; Yeo, Charles J.; Jones, R. Scott; Sarmiento, Juan
ISI:000461357100015
ISSN: 1072-7515
CID: 4744912
Nature communications. 2019:10.DOI:

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Vennin, Claire; Melenec, Pauline; Rouet, Romain; Nobis, Max; Cazet, Aurelie S.; Murphy, Kendelle J.; Herrmann, David; Reed, Daniel A.; Lucas, Morghan C.; Warren, Sean C.; Elgundi, Zehra; Pinese, Mark; Kalna, Gabriella; Roden, Daniel; Samuel, Monisha; Zaratzian, Anaiis; Grey, Shane T.; Da Silva, Andrew; Leung, Wilfred; Mathivanan, Suresh; Wang, Yingxiao; Braithwaite, Anthony W.; Christ, Daniel; Benda, Ales; Parkin, Ashleigh; Phillips, Phoebe A.; Whitelock, John M.; Gill, Anthony J.; Sansom, Owen J.; Croucher, David R.; Parker, Benjamin L.; Pajic, Marina; Morton, Jennifer P.; Cox, Thomas R.; Timpson, Paul; Johns, Amber L.; Chantrill, Lorraine A.; Chou, Angela; Steinmann, Angela; Arshi, Mehreen; Dwarte, Tanya; Froio, Danielle; Pereira, Brooke; Ritchie, Shona; Chambers, Cecilia R.; Metcalf, Xanthe; Waddell, Nicola; Pearson, John, V; Patch, Ann-Marie; Nones, Katia; Newell, Felicity; Mukhopadhyay, Pamela; Addala, Venkateswar; Kazakoff, Stephen; Holmes, Oliver; Leonard, Conrad; Wood, Scott; Grimmond, Sean M.; Hofmann, Oliver; Christ, Angelika; Bruxner, Tim; Samra, Jaswinder S.; Pavlakis, Nick; High, Hilda A.; Asghari, Ray; Merrett, Neil D.; Pavey, Darren; Das, Amitabha; Cosman, Peter H.; Ismail, Kasim; O\Connnor, Chelsie; Stoita, Alina; Williams, David; Spigellman, Allan; Lam, Vincent W.; McLeod, Duncan; Kirk, Judy; Kench, James G.; Grimison, Peter; Cooper, Caroline L.; Sandroussi, Charbel; Goodwin, Annabel; Mead, R. Scott; Tucker, Katherine; Andrews, Lesley; Texler, Michael; Forest, Cindy; Epari, Krishna P.; Ballal, Mo; Fletcher, David R.; Mukhedkar, Sanjay; Zeps, Nikolajs; Beilin, Maria; Feeney, Kynan; Nguyen, Nan Q.; Ruszkiewicz, Andrew R.; Worthley, Chris; Chen, John; Brooke-Smith, Mark E.; Papangelis, Virginia; Clouston, Andrew D.; Barbour, Andrew P.; O\Rourke, Thomas J.; Fawcett, Jonathan W.; Slater, Kellee; Hatzifotis, Michael; Hodgkinson, Peter; Nikfarjam, Mehrdad; Eshleman, James R.; Hruban, Ralph H.; Wolfgang, Christopher L.; Lawlor, Rita T.; Beghelli, Stefania; Corbo, Vincenzo; Scardoni, Maria; Bassi, Claudio; Biankin, Andrew, V; Dixon, Judith; Jamieson, Nigel B.; Chang, David K.
ISI:000480385800007
ISSN: 2041-1723
CID: 4744992
Cancer research. 2019:79(13).DOI:

A Phase II clinical trial of GVAX pancreas vaccine (with Cyclophosphamide) in combination with Nivolumab and Stereotactic Body Radiation Therapy (SBRT) followed by definitive resection for patients with borderline resectable pancreatic adenocarcinoma (BR-PDAC) [Meeting Abstract]

Osipov, Arsen; Sugar, Elizabeth; Ferguson, Anna; Durham, Jennifer; Rodriguez, Christina; Parkinson, Rose; Sena, Laura; Zheng, Lei; Wolfgang, Christopher; Burkhart, Richard; He, Jin; Weiss, Matthew; Narang, Amol; Laheru, Daniel; Azad, Nilofer; Jaffee, Elizabeth; Weekes, Colin; Yarchoan, Mark
ISI:000488129900146
ISSN: 0008-5472
CID: 4745042
Cancer research. 2019:79(13).DOI:

Analysis of spatial relationships between infiltrating immune cells within the tumor microenvironment following combinatorial immunotherapy [Meeting Abstract]

Thomas, Dwayne L., II; Murphy, Adrian G.; Weiss, Matthew J.; He, Jin; Makary, Martin A.; Burkhart, Richard A.; Wolfgang, Christopher L.; Jaffee, Elizabeth M.; Zheng, Lei; Thompson, Elizabeth D.
ISI:000488279402050
ISSN: 0008-5472
CID: 4745052
Journal of clinical oncology. 2019:37(15).DOI: 10.1200/JCO.2019.37.15_suppl.4122

Variation in the surgical management of locally advanced pancreatic cancer. [Meeting Abstract]

Reames, Bradley Norman; Blair, Alex; Krell, Robert Wallace; Padussis, James; Thayer, Sarah P.; Falconi, Massimo; Wolfgang, Christopher Lee; Weiss, Matthew J.; Are, Chandrakanth; He, Jin
ISI:000487345805309
ISSN: 0732-183x
CID: 4745032
Journal of surgical oncology. 2018:118(8):1277-1284.DOI: 10.1002/jso.25288

Incidence and risk factors for abdominal occult metastatic disease in patients with pancreatic adenocarcinoma

Gemenetzis, Georgios; Groot, Vincent P; Blair, Alex B; Ding, Ding; Thakker, Sameer S; Fishman, Elliot K; Cameron, John L; Makary, Martin A; Weiss, Matthew J; Wolfgang, Christopher L; He, Jin
BACKGROUND:The incidence of occult metastatic disease (OMD) in pancreatic ductal adenocarcinoma (PDAC) and associated risk factors are largely unknown. METHODS:We identified all patients with PDAC, who had an aborted oncologic operation due to OMD within a 10-year period. The cases were matched to a cohort of resected PDAC patients on a 1:3 ratio, based on age and sex, for comparison of preoperative clinical characteristics and potential risk factors for OMD. RESULTS:In the studied period, 117 patients with OMD were identified in 1423 pancreatectomies performed for PDAC (8%). Liver metastases were the most common finding (79%) followed by peritoneal implants (16%). When compared with non-OMD cases, patients with OMD presented more often with abdominal pain (P < 0.001), and higher preoperative carbohydrate antigen 19-9 (CA 19-9) values ( P = 0.007). Additionally, indeterminate liver lesions on preoperative computed tomography (CT) were identified in 40% of OMD versus 17% of non-OMD patients ( P < 0.001). Multivariable analysis distinguished four independent predictors for OMD: indeterminate lesions on preoperative CT, tumor size > 30 mm, abdominal pain, and preoperative CA 19-9 > 192 U/mL. CONCLUSIONS:Occurrence of OMD in PDAC accounts for 8% of cases. Preoperative CA 19-9 > 192 U/mL, primary tumor size > 30 mm, and identification of indeterminate lesions in preoperative CT may indicate the need for diagnostic laparoscopy.
PMID: 30380143
ISSN: 1096-9098
CID: 4740912
Journal of surgical oncology. 2018:118(7):1074-1080.DOI: 10.1002/jso.25251

The prognosis of colorectal cancer liver metastases associated with inflammatory bowel disease: An exploratory analysis

Margonis, Georgios Antonios; Buettner, Stefan; Andreatos, Nikolaos; Wagner, Doris; Sasaki, Kazunari; Galjart, Boris; Kamphues, Carsten; Pawlik, Timothy M; Poultsides, George; Kaczirek, Klaus; Lønning, Per Eystein; Verhoef, Cornelis; Kreis, Martin E; Wolfgang, Christopher L; Weiss, Matthew J
BACKGROUND AND OBJECTIVES/OBJECTIVE:In contrast with sporadic colorectal cancer liver metastases (CRLM), inflammatory bowel disease (IBD)-related CRLM have not been studied to date. METHODS:Patients who underwent resection for IBD-related and sporadic CRLM from 2000 to 2015 were identified from an international registry and matched for pertinent prognostic variables. Overall survival (OS) and recurrence-free survival (RFS) were subsequently assessed. RESULTS:Twenty-eight patients had IBD-related CRLM. Synchronous extrahepatic disease was more common in IBD-related CRLM patients than patients with sporadic CRLM (28.6% vs 8.3%; P < 0.001), most commonly located in the lungs. In multivariable analysis, IBD did not have a significant influence on OS ( P = 0.835), and had a hazard ratio (HR) close to 1 (HR, 0.95; 95% confidence interval [CI], 0.57-1.57). IBD was also not associated with inferior RFS (HR, 1.07; 95%CI, 0.68-1.68; P = 0.780). Among patients with IBD-related CRLM, 9(50%) had isolated intrahepatic recurrence and 8(44.4%) isolated extrahepatic recurrence, while only 1(5.6%) developed combined recurrence. Of those who experienced recurrence after resection of IBD-related CRLM, 10 had their recurrence treated with curative intent. CONCLUSIONS:Patients with IBD-related CRLM had similar survival compared with patients with sporadic CRLM, even though they more often present with extrahepatic disease. In addition, patients with IBD-related CRLM may experience patterns of recurrence different from patients with sporadic CRLM.
PMID: 30261094
ISSN: 1096-9098
CID: 4740862