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"Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes". Letter to the editor [Letter]
Murawski, Christopher D; Kennedy, John G
PMID: 21123838
ISSN: 1552-3365
CID: 3523862
Lateral ligament repair and reconstruction restore neither contact mechanics of the ankle joint nor motion patterns of the hindfoot
Prisk, Victor R; Imhauser, Carl W; O'Loughlin, Padhraig F; Kennedy, John G
BACKGROUND:Ankle sprains may damage both the lateral ligaments of the hindfoot and the osteochondral tissue of the ankle joint. When nonoperative treatment fails, operative approaches are indicated to restore both native motion patterns at the hindfoot and ankle joint contact mechanics. The goal of the present study was to determine the effect of lateral ligament injury, repair, and reconstruction on ankle joint contact mechanics and hindfoot motion patterns. METHODS:Eight cadaveric specimens were tested with use of robotic technology to apply combined compressive (200-N) and inversion (4.5-Nm) loads to the hindfoot at 0° and 20° of plantar flexion. Contact mechanics at the ankle joint were simultaneously measured. A repeated-measures experiment was designed with use of the intact condition as control, with the other conditions including sectioned anterior talofibular and calcaneofibular ligaments, the Broström and Broström-Gould repairs, and graft reconstruction. RESULTS:Ligament sectioning decreased contact area and caused a medial and anterior shift in the center of pressure with inversion loads relative to those with the intact condition. There were no significant differences in inversion or coupled axial rotation with inversion between the Broström repair and the intact condition; however, medial translation of the center of pressure remained elevated after the Broström repair relative to the intact condition. The Gould modification of the Broström procedure provided additional support to the hindfoot relative to the Broström repair, reducing inversion and axial rotation with inversion beyond that of intact ligaments. There were no significant differences in center-of-pressure excursion patterns between the Broström-Gould repair and the intact ligament condition, but this repair increased contact area beyond that with the ligaments intact. Graft reconstruction more closely restored inversion motion than did the Broström-Gould repair at 20° of plantar flexion but limited coupled axial rotation. Graft reconstruction also increased contact areas beyond the lateral ligament-deficient conditions but altered center-of-pressure excursion patterns relative to the intact condition. CONCLUSIONS:No lateral ankle ligament reconstruction completely restored native contact mechanics of the ankle joint and hindfoot motion patterns.
PMID: 20962188
ISSN: 1535-1386
CID: 3523842
Anteromedial impingement in the ankle joint: outcomes following arthroscopy
Murawski, Christopher D; Kennedy, John G
BACKGROUND:Arthroscopic debridement is a well-accepted method of removing osseous and/or soft tissue impingement from the ankle joint. To the best of the authors' knowledge, this is the first case series reporting the outcomes following arthroscopic resection of anteromedial impingement. PURPOSE/OBJECTIVE:The authors report the results at a minimum 2-year follow-up of 41 patients who underwent arthroscopic resection for anteromedial impingement. STUDY DESIGN/METHODS:Case series; Level of evidence, 4. METHODS:Arthroscopic surgery for anteromedial impingement was performed on 43 patients under the care of the senior surgeon between January 2005 and July 2007; 41 patients were included in the present study. All patients were assessed preoperatively and postoperatively using the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot and Short Form 36 (SF-36v2) outcome scores. The mean patient age at the time of surgery was 31.12 years (range, 13-57 years). The mean follow-up time was 34.41 months (range, 24-52 months). Thirty-four patients (83%) were competing at some level of athletic sport. RESULTS:Thirty-eight patients (93%) were satisfied with the procedure. The AOFAS scores improved from 62.83 points preoperatively to 91.17 points postoperatively (range, 61-100 points) (P < .001). The SF-36v2 scores improved from 61.54 points preoperatively to 92.21 points postoperatively (range, 58-100 points) (P = .002). All but 1 patient returned to their prior level of sporting activity. Three patients (7%) reported a complication. CONCLUSION/CONCLUSIONS:Arthroscopic resection for anteromedial impingement provides excellent functional outcomes, thereby allowing the athlete an expedited return to sport at previous levels of competition.
PMID: 20479141
ISSN: 1552-3365
CID: 3523832
A Review of Arthroscopic Bone Marrow Stimulation Techniques of the Talus: The Good, the Bad, and the Causes for Concern
Murawski, Christopher D; Foo, Li Foong; Kennedy, John G
Osteochondral lesions of the talus are common injuries following acute and chronic ankle sprains. Numerous surgical treatment strategies have been employed for treating these lesions; arthroscopic bone marrow stimulation is recognized as the first-line technique to provide fibrocartilage infill of the defect site. While the short- and medium-term outcomes of this technique are good, the long-term outcomes are not yet known. An increasing number of studies, however, show a cause for concern in employing this technique, including declining outcome scores over time. The current authors have therefore developed a treatment strategy based on previously established guidelines in addition to morphological cartilage-sensitive fast spin echo techniques and quantitative T2 mapping magnetic resonance imaging (MRI). Accordingly, the authors advocate arthroscopic bone marrow stimulation in lesion sizes up to 8 mm in diameter and osteochondral autograft transplant (OATS) in lesion sizes greater than 8 mm in diameter. In the absence of long-term studies, confining the use of arthroscopic bone marrow stimulation to smaller lesions may support prolonged joint life by decreasing the rate at which the fibrocartilage ultimately degenerates over time. Employing the OATS procedure in larger lesions has the advantage of replacing "like with like." The current review examines the role of arthroscopic bone marrow stimulation techniques of the talus.
PMID: 26069545
ISSN: 1947-6035
CID: 3524202
Osteochondral lesion of the fifth metatarsal head in a triathlete [Case Report]
O'Loughlin, P F; Carter, T I; Hodgkins, C W; Kennedy, J G
Osteochondral lesions (OCLs) are rare joint disorders, typically found in the larger joints of the body and less so in smaller joints (J Bone Joint Surg Am 41-A:988-1020, 1959; Arthroscopy 6(3):190-197, 1990; Clin Orthop Relat Res 148:245-253, 1980). Although their specific cause is subject to frequent debate, they are often caused by trauma with subsequent compromise of the articular cartilage (Arthroscopy 6(3):190-197, 1990; J Bone Joint Surg Am 78(3):439-456, 1996). Symptoms are typically attributable to a mechanical defect, either of the bony defect or a flap of cartilage. The current case report describes an osteochondral lesion of the head of the fifth metatarsal which is a heretofore unreported location. Magnetic resonance imaging (MRI) of the lesion revealed a notable subchondral bone signal change, indicating a possible synovial fluid pressure phenomenon rather than a mechanical defect.
PMID: 18704547
ISSN: 1863-4362
CID: 3702292
Current concepts in the diagnosis and treatment of osteochondral lesions of the ankle
O'Loughlin, Padhraig F; Heyworth, Benton E; Kennedy, John G
Osteochondral lesions of the ankle are a more common source of ankle pain than previously recognized. Although the exact pathophysiology of the condition has not been clearly established, it is likely that a variety of etiological factors play a role, with trauma, typically from ankle sprains, being the most common. Technological advancements in ankle arthroscopy and radiologic imaging, most importantly magnetic resonance imaging, have improved diagnostic capabilities for detecting osteochondral lesions of the ankle. Moreover, these technologies have allowed for the development of more sophisticated classification systems that may, in due course, direct specific future treatment strategies. Nonoperative treatment yields best results when employed in select pediatric and adolescent patients with osteochondritis dissecans. However, operative treatment, which is dependent on the size and site of the lesion, as well as the presence or absence of cartilage damage, is frequently warranted in both children and adults with osteochondral lesions. Arthroscopic microdrilling, micropicking, and open procedures, such as osteochondral autograft transfer system and matrix-induced autologous chondrocyte implantation, are frequently employed. The purpose of this article is to review the history, etiology, and classification systems for osteochondral lesions of the ankle, as well as to describe current approaches to diagnosis and management.
PMID: 19561175
ISSN: 1552-3365
CID: 3523812
Fracture of the medial tubercle of the posterior process of the talus: magnetic resonance imaging appearance with clinical follow-up
O'Loughlin, Padhraig; Sofka, Carolyn M; Kennedy, John G
Fractures of the medial tubercle of the posterior process of the talus are rare injuries. They are often misdiagnosed, resulting in increased morbidity and symptoms of chronic ankle pain and instability. When undetected, these fractures may become displaced, with potential additional injuries such as to the flexor hallucis longus tendon which may become interposed between the fracture fragments. We report a case of a clinically unsuspected fracture of the medial tubercle of the posterior process of the talus seen on magnetic resonance imaging, treated conservatively, with interval satisfactory healing of the fracture at 6 weeks follow-up.
PMID: 19347408
ISSN: 1556-3316
CID: 3523802
Ankle instability in sports
O'Loughlin, Padhraig F; Murawski, Christopher D; Egan, Christopher; Kennedy, John G
Ankle stability is integral to normal motion and to minimizing the risk of ankle sprain during participation in sport activities. The ability of the dynamic and static stabilizers of the ankle joint to maintain their structural integrity is a major component of the normal gait cycle. In sports, this quality assumes even greater importance given the range of movement and stresses imposed on the ankle during various sporting disciplines. In the general population, the incidence of ankle sprain is very high. In several studies, injuries to the lateral ankle ligaments have been shown to be the most common sports-related injuries, accounting for approximately 25% of all sports-related injuries. Furthermore, up to 80% of all ankle sprains involve the lateral ligament complex. Other studies have estimated their incidence as approximately 5000 injuries per day in the United Kingdom and 23 000 in the United States. Aggressive treatment of the sprained ankle is essential to maintain foot and ankle mobility and prevent prolonged disability and subsequent overuse injuries among athletes, both professional and "weekend warriors" alike.
PMID: 20048515
ISSN: 0091-3847
CID: 3523822
Arthroscopic-assisted fluoroscopic navigation for retrograde drilling of a talar osteochondral lesion [Case Report]
O'Loughlin, Padhraig F; Kendoff, Daniel; Pearle, Andrew D; Kennedy, John G
PMID: 19176191
ISSN: 1071-1007
CID: 3523782
Functional outcome after surgical reconstruction of posterior tibial tendon insufficiency in patients under 50 years
Tellisi, Nazzar; Lobo, M; O'Malley, Martin; Kennedy, John G; Elliott, Andrew J; Deland, Jonathan T
BACKGROUND:Procedures utilized to address the flatfoot in this study included medializing calcaneal osteotomy, posterior tibial tendon reconstruction with flexor digitorum longus tendon transfer, and in patients with more severe deformity, lateral column lengthening. We evaluated patients age 50 and less at the time of surgery, who underwent surgical reconstruction for Stage 2 posterior tibial tendon dysfunction. Pre- and postoperative activity levels were evaluated to assess the effect of surgical reconstruction in the younger patient. MATERIALS AND METHOD/METHODS:Thirty-four feet in 30 patients (11 male, 19 female) with an average age of 41.2 (range, 17 to 50) years had surgery between 1997 and 2004. All feet were examined at an average followup of 44.5 (range, 24 to 65) months and were evaluated with the American-Orthopaedic-Foot and Ankle Society (AOFAS) Hindfoot-Score and SF-36 score. RESULTS:The average preoperative AOFAS-Score was 53.1 +/- 14.5 points and 83.2 +/- 12.2 points at final postoperative followup. The mean improvement was 29.5. The difference between the preoperative and postoperative AOFAS score was significant (p < 0.0001) using a two-tailed t-test. The difference in the AOFAS pain and alignment subscales was also significant (p < 0.0001). The function subscale improvement was also significant (p = 0.018). The mean physical function component of the postoperative SF-36 score was 79.2. A correlation was found between the SF-36 physical component score and the post operative AOFAS score (r(2) = 0.754). CONCLUSION/CONCLUSIONS:While some lateral discomfort or pain occurred in patients with or without a lateral column lengthening, the posterior tibial tendon reconstruction utilizing medial calcaneal displacement osteotomy with flexor digitorum longus transfer and a lateral column lengthening with more deformity was successful in the higher-functioning, younger patients.
PMID: 19138480
ISSN: 1071-1007
CID: 3523772