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In this article, we present clinical results of primary total shoulder arthroplasty for osteoarthritis using an implant that provides dual eccentricity and variable neck and version angles for reconstruction of proximal humeral anatomy. Two hundred one patients with symptomatic osteoarthritis underwent 218 total shoulder arthroplasties with a fourth-generation anatomical shoulder and a replicator plate at 4 centers between August 1, 2006, and December 31, 2010. Fourth-generation implants allow for varying humeral neck and version angles and have dual eccentricity so as to be consistently able to cover the humeral head cut. At a mean follow-up of 3 years (minimum, 2 years), there was an 81% follow-up rate. At final follow-up, 3 objective measures were significantly (P < .05) improved over preoperative levels: average active elevation (preoperative, 92°; postoperative, 137°), active external rotation (pre, 15°; post, 42°), and active internal rotation (pre, S3; post, L2). The functional outcome scores that were significantly (P < .05) improved at final follow-up were Constant normalized (pre, 39; post, 79), Shoulder Pain and Disability Index (pre, 86; post, 20), Simple Shoulder Test (pre, 3.3; post, 10), UCLA Shoulder Rating Scale (pre, 13; post, 31), and American Shoulder and Elbow Surgeons Shoulder Assessment (pre, 33; post, 85). Complications were noted in 11% of the shoulders. The most common complications were rotator cuff failure (13, 6%) and infection (5, 2%).

UNLABELLED:Many glenohumeral studies have demonstrated how anatomy varies across the population. Third and fourth generation shoulder prosthesis designs were developed to provide greater modularity and size ranges to better reproduce this anatomy and thus achieve better results in terms of shoulder function. This study quantifies the quality of anatomic reconstruction and compares that to long-term clinical outcomes using one fourth generation platform shoulder system. METHODOLOGY/METHODS:One hundred and forty primary total shoulder arthroplasties were performed by one experienced single surgeon between 2001 and 2009, using the same fourth generation modular prosthesis. Pre- and postoperative clinical assessments were quantified with the Constant, ASES, SPADI, SST, and UCLA scores, and active range of motion was measured. Five anatomic parameters were defined, measured, and compared pre- and postoperatively on the anterior-posterior (AP) radiographs: Humeral Head Height (HHH), Humeral Head Centering (HHC), Humeral Head Medial Offset (HHMO), Humeral Head Diameter (HHD), and Humeral Neck Angle (HNA). The differences between each of the parameters were then calculated and rated from 0 to 2 and then summed for each patient to obtain the Anatomic Reconstruction Index (ARI), which objectively quantifies and assesses the quality of the anatomic reconstruction. Patients were sorted based upon their ARI score into two groups (ARI 5 to 7 and ARI 8 to 10), and their latest follow-up outcomes were compared using the Mann-Whitney test to identify differences in preoperative and postoperative results, where p < 0.05 denoted a significant difference. RESULTS:Of the 140 primary prostheses performed, 78 patients were lost to follow-up, and 13 were excluded for complications that were not related to the anatomic reconstruction. Forty-nine patients (75.8 yrs., 31F/18M) were included with an average follow-up of 9.1 years. The average score for HHH was 1.9 ± 0.4, 1.8 ± 0.5 for HHC, 1.7 ± 0.5 for HHMO, 1.7 ± 0.5 for HHD, and 1.5 ± 0.7 for HNA. Thus, all reconstructions were rated good to excellent with 86% of very good/excellent reconstruction (ARI 8 to 10) and 14% good reconstruction (ARI 5 to 7). A comparison of radiographic anatomic parameters was performed for these two cohorts: HHC (< 0.0001), HNA (0.000), and ARI (<0.0001) were significantly greater for the ARI 8 to 10 cohort. Four of five postoperative clinical outcome metrics for the ARI 8 to 10 cohort were significantly greater than the mean values for the ARI 5 to 7 cohort. Additionally, mean postoperative pain on a daily basis and shoulder function for the ARI 8 to 10 cohort were significantly greater than that for the ARI 5 to 7 cohort. DISCUSSION/CONCLUSIONS:The relatively small number of good reconstructions (14%) compared to very good/excellent reconstructions (86%) and the absence of fair/poor reconstructions limited the ability for any strong linear correlations between anatomical reconstruction and clinical parameters. Despite this, patients with larger mean ARI scores were associated with significantly better outcomes for some measures. This study is limited by the use of 2D assessments from standard AP radiographs; this method can be further refined by the use of 3D quantitative assessment of each parameter. CONCLUSION/CONCLUSIONS:This study confirmed that an improved anatomic reconstruction results in better postoperative clinica outcomes. The fourth generation prosthesis used for this study allows continuous in-situ adjustment of the humeral head orientation through use of the spherical taper on the replicator plate and also a double adjustment of offset through the use of the offset humeral head and offset taper on the replicator plate.

INTRODUCTION/BACKGROUND:The rate of clinical improvement has never been studied after anatomic (aTSA) and reverse (rTSA) total shoulder arthroplasty. This study quantifies the rate of improvement after aTSA and rTSA using five different scoring metrics for 1,641 patients. METHODS:We evaluated 1,641 (69 ± 9.3 years old) patients treated by 14 orthopaedic surgeons using either aTSA or rTSA with a single platform shoulder system. Seven hundred twenty-nine patients received aTSA, and 912 patients received rTSA. Each patient was scored preoperatively and at various follow-up intervals (2 weeks, 6 weeks, 3 months, 6 months, annually, etc.) with a maximum follow-up time of 139 months using the SST, UCLA, ASES, Constant, and SPADI metrics. In addition, range of motion was measured. The rate of improvement was analyzed using a 40-point moving filter treadline over the entire range of follow-up. RESULTS:All metrics improved in a majority of patients with less than 5% worsening after 6 months. While gains in motion were present in the majority of patients after aTSA, a higher incidence of patients failed to experience improvement in range of motion after rTSA. Clinical worsening was seen in up to 10% and 20% of the visits for active flexion and abduction and external rotation, respectively. The majority of clinical improvement after aTSA and rTSA was noted in the first 6 months with full improvement noted by 12 to 24 months. During the first 12 months, the rate of improvement associated with rTSA patients was generally 30% larger than that of aTSA patients. DISCUSSION/CONCLUSIONS:The results of this large-scale database analysis demonstrate the reliability of improvements in outcomes and motion achieved with both aTSA and rTSA for various indications. For both aTSA and rTSA, less than 5% of patients reported worsening in each of the five clinical metrics after 6 months postoperative follow-up time. This study is significant because it quantifies how patient outcomes improve with time following treatment with both aTSA and rTSA. These results can be used to establish realistic patient expectations regarding the typical follow-up time required for pain to be reduced and function restored following surgical treatment with a total shoulder prosthesis.

INTRODUCTION/BACKGROUND:ASTM F2028-14 was adopted to recom mend a cyclic eccentric glenoid edge loading test that simulates the rocking horse loading mechanism beleived to cause aTSA glenoid loosening. While this method accurately simulates that failure mechanism, the recommended 750 N load may not be sufficient to simulate worst-case loading magnitudes, and the recommended 100,000 cycles may not be sufficient to simulate device fatigue-related failure modes. Finally, if greater loading magnitude or a larger number of cycles is performed, the recommended substrate density may not be sufficiently strong to support the elevated loads and cycles. To this end, a new test method is proposed to supplement ASTM F2028-14. METHODS:A series of cyclic tests were performed to evaluate the long-term fixation strength of two different hybrid glenoid designs in both low (15 pcf) and high (30 pcf) density polyurethane blocks at elevated loads relative to ASTM F2028-14. To simulate a worst case clinical condition in which the humeral head is superiorly migrated, a cyclic load was applied to the superior glenoid rim to induce a maximum torque on the fixation pegs for three different cyclic loading tests: 1. 1,250 N load for 0.75 M cycles in a 15 pcf block, 2. 1,250 N load for 1.5 M cycles in a 30 pcf block, and 3. 2,000 N load for 0.65 M cycles in a 30 pcf block. RESULTS:All devices completed cyclic loading without failure, fracture, or loss of fixation regardless of glenoid design, polyurethane density, loading magnitude, or cycle length. No significant difference in post-cyclic displacement was noted between designs in any of the three tests. Post-cyclic radiographs demonstrated that each device maintained fixa - tion with the metal pegs within the bone-substitute blocks with no fatigue related failures. DISCUSSION/CONCLUSIONS:These results demonstrate that both cemented hybrid glenoids maintained fixation when tested according to each cyclic loading scenario, with no difference in post-cyclic displacement observed between designs. The lack of fatigue-related failures in these elevated load and high cycle test scenarios are promising, as are the relatively low displacements given the extreme nature of each test. This cyclic loading method is intended to supplement the ASTM F2028-14 standard that adequately simulates the rocking horse loading mechanism but may not adequately simulate the fatigue-related failure modes.

INTRODUCTION/BACKGROUND:Osteoarthritis of the shoulder often results in significant posterior glenoid wear. The options for treating this have been eccentric glenoid reaming and occasionally bone grafting. More recently reverse total shoulder arthroplasty (rTSA) with or without bone grafting and posterior augmented glenoids (PAGs) has been introduced. The PAG restores the native joint line while reaming a minimal amount of glenoid bone. The purpose of this study is to compare osteoarthritic shoulders with significant posterior glenoid wear treated with anatomic total shoulder arthroplasty (aTSA) using a PAG to shoulders without glenoid wear treated with aTSA using a standard all poly pegged glenoid. METHODS:The patients' data in this study were retrospectively queried from prospectively acquired data in a multi-institutional IRB approved database. The study population consisted of 24 patients with osteoarthritis and posterior glenoid wear who were treated with aTSA using a PAG with a minimum of two-year follow-up. This population was age, sex, and follow-up matched to patients treated with an all poly non-augmented pegged glenoid (NAG) for osteoarthritis. Seven females and 17 males with an average age of 65.8 ± 11.5 years received a posterior augmented glenoid. The control group consisted of 7 females and 17 males with an average age of 66.4 ± 9.1 years who underwent aTSA for osteoarthritis using an all poly standard glenoid. These age, gender, and follow-up matched patients were evaluated and scored preoperatively and at latest follow-up using the SST, UCLA, ASES, Constant, and SPADI scoring metrics; active abduction, elevation, and external rotation were also measured. A Grashey and axillary lateral radiograph was evaluated at two-year follow-up. The Shoulder Arthroplasty Subluxation Index was used to determine the degree of humeral component subluxation on the glenoid component. A Student's two-tailed, unpaired t-test was used to identify differences in preoperative and postoperative results, where p < 0.05 denoted a significant difference. RESULTS:All patients demonstrated significant improvements in pain and function with the primary aTSA. Sixty per-cent of PAG shoulders had a radiolucent line with an average radiographic line score of 1.10, and 33.3% of NAG had a radiolucent line with an average radiographic line score of 0.438. One glenoid in the PAG group is radiographically but not clinically loose. In the PAG group, the Grashey view showed that 18/20 humeral heads were centered with the two remaining joints demonstrating superior subluxation. On the axillary lateral in the PAG group, 17/20 humeral heads were centered, and three were anteriorly subluxated; none were posteriorly subluxated. There were no differences in any of the measured postoperative clinical outcomes or any difference in improvement between the two groups. DISCUSSION/CONCLUSIONS:At a minimum of two-year follow-up, there were no statistical clinical differences between the PAG and NAG groups despite the PAG group being disadvantaged with posterior worn glenoids. There were no revisions in either group. No humeral heads resubluxated posteriorly. The PAG group had a higher incidence of lucent lines. Based on this short-term follow-up, a posterior augmented glenoid is a viable option for the posterior worn osteoarthritic glenoid.

INTRODUCTION/BACKGROUND:The aim of this study was to evaluate the preliminary outcomes of a hybrid cage glenoid design in comparison to pegged all-polyethylene glenoid components in anatomic total shoulder arthroplasty (aTSA). MATERIALS AND METHODS/METHODS:Ninety-two patients undergoing primary anatomic total shoulder arthroplasty with minimum two-year follow-up were reviewed. Forty-six patients had an ultra-high molecular weight polyethylene (UHMWPE) cemented pegged glenoid component, and 46 had a hybrid cage glenoid component. Patient data was retrospectively reviewed from prospectively acquired data in a multi-institutional IRB approved database. These age, gender, and follow-up matched patients were evaluated and scored preoperatively and a latest follow-up using the SST, UCLA, ASES, Constant, and SPADI scoring metrics. Additional measures included active abduction, elevation, and external rotation. Radiolucent line assessment of the glenoid was performed by use of a Grashey and axillary radiograph at latest follow-up. A Student's two tailed, unpaired t-test was used to identify differences in preoperative and postoperative results, where p < 0.05 denoted a significant difference. RESULTS:All patients demonstrated significant improvements in pain and function following treatment with the primary aTSA. The database contained three complications for the aTSA patients with a cage glenoid, and three complications for patients with a UHMWPE pegged glenoid. Radiographic data was available for 37 of 46 cage glenoid patients and 29 of 46 UHMWPE pegged glenoid patients. Five of 37 cage glenoid patients had a radiolucent line (13.5%) with an average radiographic line score of 0.22. Eight of 29 UHMWPE peg glenoid patients had a radiolucent line (27.6%) with an average radiographic line score of 0.57. Cage aTSA patients were associated with significantly less blood loss than aTSA UHMWPE pegged glenoid patients (avg. blood loss = 242 vs. 337; p = 0.022). CONCLUSION/CONCLUSIONS:At minimum two-year follow-up, hybrid cage aTSA components show equal clinical outcomes to UHMWPE pegged glenoids. However, the hybrid cage components had significantly fewer radiolucent lines and less intra-operative blood loss. Additional and longer-term clinical and radiographic follow-up is necessary to confirm these promising early results.

INTRODUCTION/BACKGROUND:Indications for anatomic (aTSA) and reverse (rTSA) total shoulder arthroplasty are well defined and dependent on the function of the rotator cuff; however, indications for rTSA have gradually extended to complex fractures, revisions, and primary arthritis in very elderly patients. The risk of secondary rupture of a weakened or degenerative rotator cuff is difficult to assess and can lead the orthopaedic surgeon to hesitate between aTSA or rTSA. It, therefore, seems appropriate to compare these two types of prostheses in terms of pain, functional, clinical outcome metric scores, and complications, despite suspected differences between populations and the respective diseases. METHODOLOGY/METHODS:1,145 patients (69.2 ± 8.9 years) were treated by 12 orthopaedic surgeons in France and in the USA, using either aTSA or rTSA with one platform shoulder system. Five hundred twenty-eight patients received aTSA (66.2 ± 9.0 years; 283 female, 245 male) for treatment of degenerative arthritis, and 617 patients received rTSA (71.8 ± 8.0 years; 392 female, 225 male) for treatment of cuff tear arthroplasty, rotator cuff tear, and osteoarthritis. Each patient was scored preoperatively and at latest follow-up using the SST, UCLA, ASES, Constant, and SPADI metrics; active range of motion was also measured. The average follow-up for all patients was 39.7 ± 18.7 months (aTSA: 42.7 ± 21.9 months; rTSA: 37.1 ± 15.1 months). Improvements in outcome using each metric score were normalized on a 100 point scale, correlated, and compared. A Student's two-tailed, unpaired t-test was used to identify differences in preoperative, postoperative, and pre-to-postoperative improvements, where p < 0.05 denoted a significant difference. RESULTS:Preoperatively, rTSA patients had significantly lower mean outcome scores and significantly lower mean active range of motion as compared to aTSA patients. Post-operatively, rTSA and aTSA patients showed no significant difference in active forward flexion or in mean outcome scores as measured by four of the five metrics. rTSA patients had significantly lower active abduction, internal rotation, and active and passive external rotation than aTSA patients. However, they had significantly better strength (9.7 vs. 7.3 lbs, p < 0.0001). Preoperative to postoperative mean improvements were compared between both cohorts. rTSA patients were associated with significantly larger improvements in outcomes and also had significantly better improvements in active forward flexion and strength. Conversely, aTSA patients had significantly better improvement in active and passive external rotation and active internal rotation. Analysis of complications demonstrated a very similar rate between cohorts, with aTSA patients associated with a slightly lower rate (6.6 vs. 7.3%). CONCLUSION/CONCLUSIONS:This retrospective analysis of prospectively acquired data from 1,145 patients who received either a primary aTSA or rTSA prosthesis demonstrates that each device provides significant improvements with very similar mean results. In fact, the mean clinical outcomes associated with the reverse shoulder prostheses approach that of the "gold standard" anatomic device for their respective indications. Furthermore, the complication rates in this series are very similar and also favorable relative to the clinical literature. Findings, such as these, may at some point extend the indications of the reverse prosthesis to patients for whom an anatomical prosthesis could lead to a premature deterioration of the result.

There is no consensus on surgical fixation and treatment of proximal humerus fractures, even though they are common fractures with several fixation techniques. This retrospective study quantifies the outcomes of patients who sustained a proximal humerus fracture and were treated with open reduction and internal fixation by at a single academic center between December 2010 and December 2014 using the Equinoxe® proximal humerus locking plate. Following enrollment, injury and surgical data was recorded. Forty-nine patients (31 female, 18 male) with 50 fractures were identified who met the inclusion criteria. Mean follow-up period was 16.8 months (range: 6 to 44 months). Mean age was 60.7 years with no significant difference in mean age by gender. Mean age-adjusted Charlson Comorbidity Index (CCI) was 2.9 (range: 0 to 6). The overall complication rate was 10% (N = 5) with the most common complication being osteonecrosis (N = 3). Four patients required reoperation. At final follow-up, mean active forward flexion for the cohort was 140.8º ± 30.1º, mean passive forward flexion was 155.7º ± 25.2º, and mean active external rotation was 50.1º ± 17.9º. For patients with postoperative complications, mean active forward flexion was 106.0º ± 23.0º, mean passive forward flexion was 136.7º ± 23.1º, and mean active external rotation was 34.2º ± 24.4. Active forward flexion and external rotation were significantly different in the presence of a complication (p = 0.005 and p = 0.038, respectively). Mean DASH score for the cohort was 19.1 ± 20.9. Mean DASH score for patients who developed complications or underwent reoperations was 34.2 ± 24.3. This study demonstrates that the Equinoxe® proximal humerus locking plate provides stable fracture treatment with excellent clinical results and a low complication rate when performed by experienced orthopaedic traumatologists.

INTRODUCTION: Achieving glenoid fixation with posterior bone loss can be challenging. The purpose of this study was to quantify the impact of two different sizes of posterior glenoid defects (10 degrees and 20 degrees ) on reverse shoulder arthroplasty (rTSA) glenoid baseplate fixation and determine if utilizing different sizes of posterior augmented baseplates (8 degrees and 16 degrees ) with off-axis reaming provides comparable fixation to using a standard baseplate with different amounts of eccentric reaming. METHODS: We quantified the impact of 10 degrees and 20 degrees posterior glenoid defects on rTSA baseplate fixation in composite scapulae using the ASTM F2028-14 rTSA glenoid loosening test method. Forty-two total implants (N = 7 for each size defect and for each type of baseplate) were tested at 750 N for 10,000 cycles. Baseplate displacement was measured before and after cyclic loading in the superior-inferior and anterior-posterior directions. Statistical analysis was performed with a two-tailed unpaired Student's t-test (significance defined as p < 0.05) to compare prosthesis displacements relative to each scapula (10 degrees and 20 degrees posterior defects for each type of baseplate versus the non-defect control) before and after cyclic loading. RESULTS: All glenoid baseplates remained well-fixed after cyclic loading in composite scapulae without a defect and in scapulae with posterior defects. Increased pre- and post-cyclic displacement was observed with increased posterior defect size and differences in displacement were observed between standard and augmented baseplates. Augmented baseplates were observed to remove significantly less bone than standard baseplates when correcting posterior defects, regardless of size. DISCUSSION: Both standard baseplates with eccentric reaming and two different sizes of augmented baseplates with off-axis reaming successfully maintained fixation following cyclic loading in composite scapula with corrected 10 degrees and 20 degrees posterior glenoid defects. Augmented glenoids may be more advantageous long-term from a fixation perspective as they preserve more subchondral glenoid bone due to the minimal reaming occurring by the off-axis method. Mid and long-term clinical follow-up comparisons of outcomes are necessary between these two techniques.

Multiple different reverse total shoulder arthroplasty (rTSA) prosthesis designs are available in the global marketplace for surgeons to perform this growing procedure. Subtle differences in rTSA prosthesis design parameters have been shown to have significant biomechanical impact and clinical consequences. We propose an rTSA prosthesis design classification system to objectively identify and categorize different designs based upon their specific glenoid and humeral prosthetic characteristics for the purpose of standardizing nomenclature that will help the orthopaedic surgeon determine which combination of design configurations best suit a given clinical scenario. The impact of each prosthesis classification type on shoulder muscle length and deltoid wrapping are also described to illustrate how each prosthesis classification type impacts these biomechanical parameters.