Faculty Bibliography

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492

Seminars in liver disease. 2011:31(4):410-9.DOI: 10.1055/s-0031-1297929

The conundrum of relapse in STAT-C therapy: does HCV play the Red Queen or Rip Van Winkle?

Ralston, Robert; Jacobson, Ira; Scull, Margaret
New treatments for chronic hepatitis C combining direct-acting antivirals (DAAs) with pegylated interferon and ribavirin (PEG-IFN/RBV) have dramatically increased the number of patients whose viral load declines to undetectable levels early in treatment. Most go on to achieve a sustained virologic response, but some patients who maintain undetectable levels of virus throughout treatment later relapse during follow-up. These data suggest that hepatitis C virus (HCV) genomes may persist in form(s) that are refractory to eradication by DAAs and PEG-IFN/RBV. Here we examine the molecular biology of HCV replication and review the clinical virology of relapse for clues as to how the virus might survive months of antiviral therapy to later reappear when treatment is withdrawn.
PMID: 22189980
ISSN: 1098-8971
CID: 2568742
Hepatology. 2011:54:812A-812A.DOI:

EFFECT OF BASELINE VIRAL LOAD (VL) ON RESPONSE TO BOCEPREVIR (BOC) PLUS PEGINTERFERON ALFA-2B/RIBAVIRIN (PR) IN PATIENTS INFECTED WITH HCV GENOTYPE 1 [Meeting Abstract]

Gordon, Stuart C; Reddy, KRajender; McCone, Jonathan; Jacobson, Ira M; Esteban, Rafael; Pedicone, Lisa; Shen, Junwu; Burroughs, Margaret; Brass, Clifford A; Albrecht, Janice K; Lawitz, Eric
ISI:000295578003187
ISSN: 0270-9139
CID: 2570512
Hepatology. 2011:54:1437A-1438A.DOI:

ONCE DAILY NARLAPREVIR (NVR; SCH 900518) AND RITONAVIR (RTV) IN COMBINATION WITH PEGINTERFERON ALFA-2B/RIBAVIRIN (PR) FOR 12 WEEKS PLUS 12 WEEKS PR IN TREATMENT-NAIVE PATIENTS WITH HCV GENOTYPE 1 (G1): SVR RESULTS FROM NEXT-1, A PHASE 2 STUDY [Meeting Abstract]

Vierling, John M; Poordad, FFred; Lawitz, Eric; Ghalib, Reem H; Lee, William M; Ravendhran, Natarajan; Galati, Joseph S; Bacon, Bruce R; Flamm, Steven L; Balart, Luis A; Freilich, Bradley; Schiff, Eugene R; Jacobson, Ira M; Kwo, Paul Y; Gordon, Stuart C; Sulkowski, Mark S; Jiang, Ruiyun; Boparai, Navdeep; Chaudhri, Eirum I; Treitel, Michelle A; Hughes, Eric A; Brass, Clifford A; Albrecht, Janice K
ISI:000295578004749
ISSN: 0270-9139
CID: 2570632
Hepatology. 2011:54:838A-838A.DOI:

OVERALL SAFETY PROFILE OF BOCEPREVIR (BOC) PLUS PEGINTERFERON ALFA-2A/RIBAVIRIN IN GENOTYPE 1 PREVIOUS NON-RESPONDERS AND RELAPSERS TO PEGINTERFERON/RIBAVIRIN [Meeting Abstract]

Flamm, Steven L; Lawitz, Eric; Jacobson, Ira M; Bourliere, Marc; Hezode, Christophe; Vierling, John M; Niederau, Claus; Sherman, Morris; Bacon, Bruce R; Pedicone, Lisa; Goteti, Venkata S; Burroughs, Margaret; Brass, Clifford A; Albrecht, Janice K; Poordad, FFred
ISI:000295578003236
ISSN: 0270-9139
CID: 2570532
Hepatology. 2011:54:848A-849A.DOI:

REASONS FOR SCREEN FAILURE IN 2 PHASE III STUDIES OF BOCEPREVIR WITH PEGINTERFERON/RIBAVIRIN IN PATIENTS WITH CHRONIC HCV GENOTYPE 1 INFECTION (SPRINT-2 AND RESPOND-2) [Meeting Abstract]

Gordon, Stuart C; Sulkowski, Mark S; Jacobson, Ira M; Vierling, John M; Davis, Gary L; Afdhal, Nezam H; Kowdley, Kris V; Pedicone, Lisa; Jiang, Ruiyun; Burroughs, Margaret; Brass, Clifford A; Albrecht, Janice K; Esteban, Rafael
ISI:000295578003257
ISSN: 0270-9139
CID: 2570542
Hepatology. 2011:54:984A-985A.DOI:

SUMMARY OF CLINICAL VIROLOGY FINDINGS FROM CLINICAL TRIALS OF TELAPREVIR [Meeting Abstract]

Bartels, Doug J; De Meyer, Sandra; Sullivan, James; Dierynck, Inge; Adda, Nathalie; Kauffman, Robert S; Jacobson, Ira M; Sherman, Kenneth E; Zeuzem, Stefan; Kwong, Ann D; Picchio, Gaston; Kieffer, Tara L
ISI:000295578003551
ISSN: 0270-9139
CID: 2570552
Hepatology. 2011:54:796A-797A.DOI:

EFFICACY OF BOCEPREVIR IN PRIOR NULL RESPONDERS TO PEGINTERFERON/RIBAVIRIN: THE PROVIDE STUDY [Meeting Abstract]

Vierling, John M; Flamm, Steven L; Gordon, Stuart C; Lawitz, Eric; Bronowicki, Jean-Pierre; Davis, Mitchell; Yoshida, Eric M; Pedicone, Lisa; Deng, Weiping; Treitel, Michelle A; Brass, Clifford A; Albrecht, Janice K; Jacobson, Ira M
ISI:000295578003158
ISSN: 0270-9139
CID: 2570492
Hepatology. 2011:54:808A-809A.DOI:

TREATMENT WEEK 12/24 STOPPING RULES FOR BOCEPREVIR (BOC) COMBINATION THERAPY WITH PEGINTERFERON plus RIBAVIRIN (PR): EXPLORATORY ANALYSES OF SPRINT-2 AND RESPOND-2 [Meeting Abstract]

Jacobson, Ira M; Marcellin, Patrick; Zeuzem, Stefan; Sulkowski, Mark S; Esteban, Rafael; Pedicone, Lisa; Boparai, Navdeep; Burroughs, Margaret; Brass, Clifford A; Albrecht, Janice K; Bronowicki, Jean-Pierre
ISI:000295578003180
ISSN: 0270-9139
CID: 2570502
Hepatology. 2011:54:472A-473A.DOI:

ONCE-DAILY PSI-7977 PLUS PEG/RBV IN TREATMENT-NAiVE PATIENTS WITH HCV GT1: ROBUST END OF TREATMENT RESPONSE RATES ARE SUSTAINED POST-TREATMENT [Meeting Abstract]

Lawitz, Eric; Lalezari, Jacob P; Hassanein, Tarek; Kowdley, Kris V; Poordad, FFred; Sheikh, Aasim M; Afdhal, Nezam H; Bernstein, David Eric; DeJesus, Edwin; Freilich, Bradley; Nelson, David R; Dieterich, Douglas T; Jacobson, Ira M; Jensen, Donald M; Abrams, Gary A; Darling, Jama M; Rodriguez-Torres, Maribel; Reddy, KRajender; Sulkowski, Mark S; Bzowej, Natalie H; DeMicco, Michael P; Strohecker, James S; Hyland, Robert H; Mader, Michael; Albanis, Efsevia; Symonds, William T; Berrey, MMichelle
ISI:000295578002225
ISSN: 0270-9139
CID: 2570482
Hepatology. 2011:54:822A-823A.DOI:

TREATMENT-NAIVE BLACK PATIENTS TREATED WITH BOCEPREVIR COMBINED WITH PEGINTERFERON ALFA-2B+RIBAVIRIN: RESULTS FROM HCV SPRINT-2 [Meeting Abstract]

McCone, Jonathan; Jacobson, Ira M; Bacon, Bruce R; Pedicone, Lisa; Goteti, Venkata S; Burroughs, Margaret; Brass, Clifford A; Albrecht, Janice K; Reddy, KRajender
ISI:000295578003207
ISSN: 0270-9139
CID: 2570522