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Prostate Cancer: Diffusion-weighted MR Imaging for Detection and Assessment of Aggressiveness-Comparison between Conventional and Kurtosis Models

Tamada, Tsutomu; Prabhu, Vinay; Li, Jianhong; Babb, James S; Taneja, Samir S; Rosenkrantz, Andrew B
Purpose To compare standard diffusion-weighted (DW) imaging and diffusion kurtosis (DK) imaging for prostate cancer (PC) detection and characterization in a large patient cohort, with attention to the potential added value of DK imaging. Materials and Methods This retrospective institutional review board-approved study received a waiver of informed consent. Two hundred eighty-five patients with PC underwent 3.0-T phased-array coil prostate magnetic resonance (MR) imaging, including a DK imaging sequence (b values 0, 500, 1000, 1500, and 2000 sec/mm2) before prostatectomy. Maps of apparent diffusion coefficient (ADC) and diffusional kurtosis (K) were derived by using maximal b values of 1000 and 2000 sec/mm2, respectively. Mean ADC and K were obtained from volumes of interest (VOIs) placed on each patient's dominant tumor and benign prostate tissue. Metrics were compared between benign and malignant tissue, between Gleason score (GS) /= 3 + 4 tumors, and between GS /= 4 + 3 tumors by using paired t tests, analysis of variance, receiver operating characteristic (ROC) analysis, and exact tests. Results ADC and K showed significant differences for benign versus tumor tissues, GS /= 3 + 4 tumors, and GS /= 4 + 3 tumors (P < .001 for all). ADC and K were highly correlated (r = -0.82; P < .001). Area under the ROC curve was significantly higher (P = .002) for ADC (0.921) than for K (0.902) for benign versus malignant tissue but was similar for GS /= 3 + 4 tumors (0.715-0.744) and GS /= 4 + 3 tumors (0.694-0.720) (P > .15). ADC and K were concordant for these various outcomes in 80.0%-88.6% of patients; among patients with discordant results, ADC showed better performance than K for GS /= 4 + 3 tumors (P = .016) and was similar to K for other outcomes (P > .136). Conclusion ADC and K were highly correlated, had similar diagnostic performance, and were concordant for the various outcomes in the large majority of cases. These observations did not show a clear added value of DK imaging compared with standard DW imaging for clinical PC evaluation. (c) RSNA, 2017 Online supplemental material is available for this article.
PMID: 28394755
ISSN: 1527-1315
CID: 2528142

The role of whole-lesion apparent diffusion coefficient analysis for predicting outcomes of prostate cancer patients on active surveillance

Tamada, Tsutomu; Dani, Hasan; Taneja, Samir S; Rosenkrantz, Andrew B
PURPOSE: To explore the role of whole-lesion apparent diffusion coefficient (ADC) analysis for predicting outcomes in prostate cancer patients on active surveillance. METHODS: This study included 72 prostate cancer patients who underwent MRI-ultrasound fusion-targeted biopsy at the initiation of active surveillance, had a visible MRI lesion in the region of tumor on biopsy, and underwent 3T baseline and follow-up MRI examinations separated by at least one year. Thirty of the patients also underwent an additional MRI-ultrasound fusion-targeted biopsy after the follow-up MRI. Whole-lesion ADC metrics and lesion volumes were computed from 3D whole-lesion volumes-of-interest placed on lesions on the baseline and follow-up ADC maps. The percent change in lesion volume on the ADC map between the serial examinations was computed. Statistical analysis included unpaired t tests, ROC analysis, and Fisher's exact test. RESULTS: Baseline mean ADC, ADC0-10th-percentile, ADC10-25th-percentile, and ADC25-50th-percentile were all significantly lower in lesions exhibiting >/=50% growth on the ADC map compared with remaining lesions (all P /=50% growth observed for ADC0-10th-percentile (585 +/- 308 vs. 911 +/- 336; P = 0.001). ADC0-10th-percentile achieved highest performance for predicting >/=50% growth (AUC = 0.754). Mean percent change in tumor volume on the ADC map was 62.3% +/- 26.9% in patients with GS >/= 3 + 4 on follow-up biopsy compared with 3.6% +/- 64.6% in remaining patients (P = 0.050). CONCLUSION: Our preliminary results suggest a role for 3D whole-lesion ADC analysis in prostate cancer active surveillance.
PMID: 28396920
ISSN: 2366-0058
CID: 2528182

The Director of Prostate Imaging: advancing care for prostate cancer patients

Westphalen, Antonio C; Margolis, Daniel J A; Rosenkrantz, Andrew B
The radiologist's role extends far beyond interpretation and reporting of medical imaging. In this manuscript, we describe the role of the Director of Prostate Imaging. We believe that this model can and should be implemented at other institutions, ultimately serving to improve the care for prostate cancer patients. Moreover, this model can be translated to support the development of an array of patient-centered service lines not only in abdominal imaging, but throughout radiology practices at large.
PMID: 28396916
ISSN: 2366-0058
CID: 2528172

Abdominal imaging ordering patterns by referring provider specialty

Rosenkrantz, Andrew B; Ayoola, Abimbola; Duszak, Richard Jr
PURPOSE: Prior work has demonstrated marked growth in the volume of abdominal imaging performed by radiologists. However, decisions to pursue imaging are largely driven by referring providers. In this study, we take the novel approach of investigating abdominal imaging utilization patterns by referring provider specialty. METHODS: Data on imaging services were obtained from the 2014 DocGraph Medicare Referring Provider Utilization for Procedures (MrPUP) public use file. MrPUP contains aggregated transaction data for combinations of unique referring provider and service code. Imaging services were classified by modality and body region using the Neiman Institute Types of Service (NITOS). Each referring provider's specialty was determined using Medicare Physician Compare. Abdominal imaging ordering patterns were summarized by referring specialty. RESULTS: The final dataset included 5,824,754 abdominal imaging transactions. The most common ordering specialties of abdominal imaging were as follows: (1) internal medicine; (2) urology; (3) emergency medicine; (4) family practice; and (5) gastroenterology. The most common ordering specialties by abdominal imaging modality were emergency medicine for CT; gastroenterology for MRI and nuclear medicine; and internal medicine for ultrasound and radiography. While numerous specialties commonly ordered abdominal radiography and CT, urologists also commonly ordered retroperitoneal ultrasound and retrograde urography, and gastroenterologists also commonly ordered abdominal ultrasound, abdominal MRI, and esophagrams. Internal medicine, family practice, and emergency medicine providers ordered a much broader mix of imaging, including many non-abdominal imaging examinations. CONCLUSION: Referring specialty abdominal imaging ordering patterns are varied but distinct. Awareness of these patterns may facilitate focused educational and policy initiatives to improve abdominal imaging appropriateness and utilization.
PMID: 28361225
ISSN: 2366-0058
CID: 2509022

Variation in Patients' Travel Times among Imaging Examination Types at a Large Academic Health System

Rosenkrantz, Andrew B; Liang, Yu; Duszak, Richard Jr; Recht, Michael P
RATIONALE AND OBJECTIVES: Patients' willingness to travel farther distances for certain imaging services may reflect their perceptions of the degree of differentiation of such services. We compare patients' travel times for a range of imaging examinations performed across a large academic health system. MATERIALS AND METHODS: We searched the NYU Langone Medical Center Enterprise Data Warehouse to identify 442,990 adult outpatient imaging examinations performed over a recent 3.5-year period. Geocoding software was used to estimate typical driving times from patients' residences to imaging facilities. Variation in travel times was assessed among examination types. RESULTS: The mean expected travel time was 29.2 +/- 20.6 minutes, but this varied significantly (p < 0.001) among examination types. By modality, travel times were shortest for ultrasound (26.8 +/- 18.9) and longest for positron emission tomography-computed tomography (31.9 +/- 21.5). For magnetic resonance imaging, travel times were shortest for musculoskeletal extremity (26.4 +/- 19.2) and spine (28.6 +/- 21.0) examinations and longest for prostate (35.9 +/- 25.6) and breast (32.4 +/- 22.3) examinations. For computed tomography, travel times were shortest for a range of screening examinations [colonography (25.5 +/- 20.8), coronary artery calcium scoring (26.1 +/- 19.2), and lung cancer screening (26.4 +/- 14.9)] and longest for angiography (32.0 +/- 22.6). For ultrasound, travel times were shortest for aortic aneurysm screening (22.3 +/- 18.4) and longest for breast (30.1 +/- 19.2) examinations. Overall, men (29.9 +/- 21.6) had longer (p < 0.001) travel times than women (27.8 +/- 20.3); this difference persisted for each modality individually (p
PMID: 28356203
ISSN: 1878-4046
CID: 2508942

Identifying Radiology's Place in the Expanding Landscape of Episode Payment Models

Rosenkrantz, Andrew B; Hirsch, Joshua A; Allen, Bibb Jr; Harvey, H Benjamin; Nicola, Gregory N
The current fee-for-service system for health care reimbursement in the United Stated is argued to encourage fragmented care delivery and a lack of accountability that predisposes to insufficient focus on quality as well as unnecessary or duplicative resource utilization. Episode payment models (EPMs) seek to improve coordination by linking payments for all services related to a patient's condition or procedure, thereby improving quality and efficiency of care. The CMS Innovation Center has implemented a broadening array of EPMs. Early models with relevance to radiologists include Bundled Payment for Care Improvement (involving 48 possible clinical conditions), Comprehensive Care for Joint Replacement (involving knee and hip replacement), and the Oncology Care Model (involving chemotherapy). In July 2016, CMS expanded the range of EPMs through three new models with mandatory hospital participation addressing inpatient and 90-day postdischarge care for acute myocardial infarction, coronary artery bypass graft, and surgical hip and femur fracture treatment. Moreover, some of the EPMs include tracks that allow participating entities to qualify as an Advanced Alternative Payment Model under the Medicare Access and CHIP Reauthorization Act (MACRA), reaping the associated reporting and payment benefits. Even though none of the available EPMs are radiology specific, the models will nevertheless likely influence reimbursements for some radiologists. Thus, radiologists should partner with hospitals and other specialties in care coordination through these episode-based initiatives, thereby having opportunities to apply their imaging expertise to help lower spending while improving quality and overall levels of health.
PMID: 28291598
ISSN: 1558-349x
CID: 2489882

County-Level Population Economic Status and Medicare Imaging Resource Consumption

Rosenkrantz, Andrew B; Hughes, Danny R; Prabhakar, Anand M; Duszak, Richard Jr
PURPOSE: The aim of this study was to assess relationships between county-level variation in Medicare beneficiary imaging resource consumption and measures of population economic status. METHODS: The 2013 CMS Geographic Variation Public Use File was used to identify county-level per capita Medicare fee-for-service imaging utilization and nationally standardized costs to the Medicare program. The County Health Rankings public data set was used to identify county-level measures of population economic status. Regional variation was assessed, and multivariate regressions were performed. RESULTS: Imaging events per 1,000 Medicare beneficiaries varied 1.8-fold (range, 2,723-4,843) at the state level and 5.3-fold (range, 1,228-6,455) at the county level. Per capita nationally standardized imaging costs to Medicare varied 4.2-fold (range, $84-$353) at the state level and 14.1-fold (range, $33-$471) at the county level. Within individual states, county-level utilization varied on average 2.0-fold (range, 1.1- to 3.1-fold), and costs varied 2.8-fold (range, 1.1- to 6.4-fold). For both large urban populations and small rural states, Medicare imaging resource consumption was heterogeneously variable at the county level. Adjusting for county-level gender, ethnicity, rural status, and population density, countywide unemployment rates showed strong independent positive associations with Medicare imaging events (beta = 26.96) and costs (beta = 4.37), whereas uninsured rates showed strong independent positive associations with Medicare imaging costs (beta = 2.68). CONCLUSIONS: Medicare imaging utilization and costs both vary far more at the county than at the state level. Unfavorable measures of county-level population economic status in the non-Medicare population are independently associated with greater Medicare imaging resource consumption. Future efforts to optimize Medicare imaging use should consider the influence of local indigenous socioeconomic factors outside the scope of traditional beneficiary-focused policy initiatives.
PMID: 28291599
ISSN: 1558-349x
CID: 2489892

Academic Radiologist Subspecialty Identification Using a Novel Claims-Based Classification System

Rosenkrantz, Andrew B; Wang, Wenyi; Hughes, Danny R; Ginocchio, Luke A; Rosman, David A; Duszak, Richard Jr
OBJECTIVE: The objective of the present study is to assess the feasibility of a novel claims-based classification system for payer identification of academic radiologist subspecialties. MATERIALS AND METHODS: Using a categorization scheme based on the Neiman Imaging Types of Service (NITOS) system, we mapped the Medicare Part B services billed by all radiologists from 2012 to 2014, assigning them to the following subspecialty categories: abdominal imaging, breast imaging, cardiothoracic imaging, musculoskeletal imaging, nuclear medicine, interventional radiology, and neuroradiology. The percentage of subspecialty work relative value units (RVUs) to total billed work RVUs was calculated for each radiologist nationwide. For radiologists at the top 20 academic departments funded by the National Institutes of Health, those percentages were compared with subspecialties designated on faculty websites. NITOS-based subspecialty assignments were also compared with the only radiologist subspecialty classifications currently recognized by Medicare (i.e., nuclear medicine and interventional radiology). RESULTS: Of 1012 academic radiologists studied, the median percentage of Medicare-billed NITOS-based subspecialty work RVUs matching the subspecialty designated on radiologists' own websites ranged from 71.3% (for nuclear medicine) to 98.9% (for neuroradiology). A NITOS-based work RVU threshold of 50% correctly classified 89.8% of radiologists (5.9% were not mapped to any subspecialty; subspecialty error rate, 4.2%). In contrast, existing Medicare provider codes identified only 46.7% of nuclear medicine physicians and 39.4% of interventional radiologists. CONCLUSION: Using a framework based on a recently established imaging health services research tool that maps service codes based on imaging modality and body region, Medicare claims data can be used to consistently identify academic radiologists by subspecialty in a manner not possible with the use of existing Medicare physician specialty identifiers. This method may facilitate more appropriate performance metrics for subspecialty academic physicians under emerging value-based payment models.
PMID: 28301213
ISSN: 1546-3141
CID: 2490072

Contrast reaction training in US radiology residencies: a (BLINDED) study

LeBedis, Christina A; Rosenkrantz, Andrew B; Otero, Hansel J; Decker, Summer J; Ward, Robert J
OBJECTIVE: To perform a survey-based assessment of current contrast reaction training in US diagnostic radiology residency programs. METHODS: An electronic survey was distributed to radiology residency program directors from 9/2015-11/2015. RESULTS: 25.7% of programs responded. 95.7% of those who responded provide contrast reaction management training. 89.4% provide didactic lectures (occurring yearly in 71.4%). 37.8% provide hands-on simulation training (occurring yearly in 82.3%; attended by both faculty and trainees in 52.9%). CONCLUSION: Wide variability in contrast reaction education in US diagnostic radiology residency programs reveals an opportunity to develop and implement a national curriculum.
PMID: 28314200
ISSN: 1873-4499
CID: 2490262

Alternative Metrics ("Altmetrics") for Assessing Article Impact in Popular General Radiology Journals

Rosenkrantz, Andrew B; Ayoola, Abimbola; Singh, Kush; Duszak, Richard Jr
RATIONALE AND OBJECTIVES: Emerging alternative metrics leverage social media and other online platforms to provide immediate measures of biomedical articles' reach among diverse public audiences. We aimed to compare traditional citation and alternative impact metrics for articles in popular general radiology journals. MATERIALS AND METHODS: All 892 original investigations published in 2013 issues of Academic Radiology, American Journal of Roentgenology, Journal of the American College of Radiology, and Radiology were included. Each article's content was classified as imaging vs nonimaging. Traditional journal citations to articles were obtained from Web of Science. Each article's Altmetric Attention Score (Altmetric), representing weighted mentions across a variety of online platforms, was obtained from Altmetric.com. Statistical assessment included the McNemar test, the Mann-Whitney test, and the Pearson correlation. RESULTS: Mean and median traditional citation counts were 10.7 +/- 15.4 and 5 vs 3.3 +/- 13.3 and 0 for Altmetric. Among all articles, 96.4% had >/=1 traditional citation vs 41.8% for Altmetric (P < 0.001). Online platforms for which at least 5% of the articles were represented included Mendeley (42.8%), Twitter (34.2%), Facebook (10.7%), and news outlets (8.4%). Citations and Altmetric were weakly correlated (r = 0.20), with only a 25.0% overlap in terms of articles within their top 10th percentiles. Traditional citations were higher for articles with imaging vs nonimaging content (11.5 +/- 16.2 vs 6.9 +/- 9.8, P < 0.001), but Altmetric scores were higher in articles with nonimaging content (5.1 +/- 11.1 vs 2.8 +/- 13.7, P = 0.006). CONCLUSIONS: Although overall online attention to radiology journal content was low, alternative metrics exhibited unique trends, particularly for nonclinical articles, and may provide a complementary measure of radiology research impact compared to traditional citation counts.
PMID: 28256440
ISSN: 1878-4046
CID: 2471672