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A Phase II clinical trial of GVAX pancreas vaccine (with Cyclophosphamide) in combination with Nivolumab and Stereotactic Body Radiation Therapy (SBRT) followed by definitive resection for patients with borderline resectable pancreatic adenocarcinoma (BR-PDAC) [Meeting Abstract]
Osipov, Arsen; Sugar, Elizabeth; Ferguson, Anna; Durham, Jennifer; Rodriguez, Christina; Parkinson, Rose; Sena, Laura; Zheng, Lei; Wolfgang, Christopher; Burkhart, Richard; He, Jin; Weiss, Matthew; Narang, Amol; Laheru, Daniel; Azad, Nilofer; Jaffee, Elizabeth; Weekes, Colin; Yarchoan, Mark
ISI:000488129900146
ISSN: 0008-5472
CID: 4745042
Analysis of spatial relationships between infiltrating immune cells within the tumor microenvironment following combinatorial immunotherapy [Meeting Abstract]
Thomas, Dwayne L., II; Murphy, Adrian G.; Weiss, Matthew J.; He, Jin; Makary, Martin A.; Burkhart, Richard A.; Wolfgang, Christopher L.; Jaffee, Elizabeth M.; Zheng, Lei; Thompson, Elizabeth D.
ISI:000488279402050
ISSN: 0008-5472
CID: 4745052
Prognostic Impact of KRAS Mutational Status in Patients with Colorectal Cancer Liver Metastases Differs According to the Location of the Primary Tumor [Meeting Abstract]
Amini, Neda; Margonis, Georgios Antonios; Kreis, Martin E.; Poultsides, George A.; Sasaki, Kazunari; Wagner, Doris; Pikoulis, Emmanouil; Weiss, Matthew J.; Wolfgang, Christopher L.; Safar, Bashar
ISI:000492740900114
ISSN: 1072-7515
CID: 4745062
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin, Claire; Melenec, Pauline; Rouet, Romain; Nobis, Max; Cazet, Aurelie S.; Murphy, Kendelle J.; Herrmann, David; Reed, Daniel A.; Lucas, Morghan C.; Warren, Sean C.; Elgundi, Zehra; Pinese, Mark; Kalna, Gabriella; Roden, Daniel; Samuel, Monisha; Zaratzian, Anaiis; Grey, Shane T.; Da Silva, Andrew; Leung, Wilfred; Mathivanan, Suresh; Wang, Yingxiao; Braithwaite, Anthony W.; Christ, Daniel; Benda, Ales; Parkin, Ashleigh; Phillips, Phoebe A.; Whitelock, John M.; Gill, Anthony J.; Sansom, Owen J.; Croucher, David R.; Parker, Benjamin L.; Pajic, Marina; Morton, Jennifer P.; Cox, Thomas R.; Timpson, Paul; Johns, Amber L.; Chantrill, Lorraine A.; Chou, Angela; Steinmann, Angela; Arshi, Mehreen; Dwarte, Tanya; Froio, Danielle; Pereira, Brooke; Ritchie, Shona; Chambers, Cecilia R.; Metcalf, Xanthe; Waddell, Nicola; Pearson, John, V; Patch, Ann-Marie; Nones, Katia; Newell, Felicity; Mukhopadhyay, Pamela; Addala, Venkateswar; Kazakoff, Stephen; Holmes, Oliver; Leonard, Conrad; Wood, Scott; Grimmond, Sean M.; Hofmann, Oliver; Christ, Angelika; Bruxner, Tim; Samra, Jaswinder S.; Pavlakis, Nick; High, Hilda A.; Asghari, Ray; Merrett, Neil D.; Pavey, Darren; Das, Amitabha; Cosman, Peter H.; Ismail, Kasim; O\Connnor, Chelsie; Stoita, Alina; Williams, David; Spigellman, Allan; Lam, Vincent W.; McLeod, Duncan; Kirk, Judy; Kench, James G.; Grimison, Peter; Cooper, Caroline L.; Sandroussi, Charbel; Goodwin, Annabel; Mead, R. Scott; Tucker, Katherine; Andrews, Lesley; Texler, Michael; Forest, Cindy; Epari, Krishna P.; Ballal, Mo; Fletcher, David R.; Mukhedkar, Sanjay; Zeps, Nikolajs; Beilin, Maria; Feeney, Kynan; Nguyen, Nan Q.; Ruszkiewicz, Andrew R.; Worthley, Chris; Chen, John; Brooke-Smith, Mark E.; Papangelis, Virginia; Clouston, Andrew D.; Barbour, Andrew P.; O\Rourke, Thomas J.; Fawcett, Jonathan W.; Slater, Kellee; Hatzifotis, Michael; Hodgkinson, Peter; Nikfarjam, Mehrdad; Eshleman, James R.; Hruban, Ralph H.; Wolfgang, Christopher L.; Lawlor, Rita T.; Beghelli, Stefania; Corbo, Vincenzo; Scardoni, Maria; Bassi, Claudio; Biankin, Andrew, V; Dixon, Judith; Jamieson, Nigel B.; Chang, David K.
ISI:000480385800007
ISSN: 2041-1723
CID: 4744992
A MULTI-MODALITY TEST TO GUIDE THE MANAGEMENT OF PATIENTS WITH PANCREATIC CYSTS [Meeting Abstract]
Dal Molin, Marco; Springer, Simeon; Masica, David; Li, Lu; Douville, Christopher; Thoburn, Christopher; Asfari, Bahman; Cohen, Joshua; Thompson, Elizabeth; Allen, Peter; Klimstra, David; Schattner, Mark A.; Schmidt, C. Max; Yip-Schneider, Michele; Simpson, Rachel E.; Fernandez-Del Castillo, Carlos; Mino-Kenudson, Mari; Brugge, William R.; Brand, Randall; Singhi, Aatur; Scarpa, Aldo; Lawlor, Rita Teresa; Salvia, Roberto; Zamboni, Giuseppe; Hong, Seung-Mo; Hwang, Dae Wook; Jang, Jin-Young; Kwon, Wooil; Swan, Niall; Geoghegan, Justin; Falconi, Massimo; Crippa, Stefano; Doglioni, Claudio; Paulino, Jorge; Schulick, Richard D.; Edil, Barish H.; Park, Walter G.; Yachida, Shinichi; Hijioka, Susuma; Van Hooft, Jeanin E.; He, Jin; Weiss, Matthew J.; Burkhart, Richard; Makary, Martin; Canto, Marcia I.; Goggins, Michael G.; Karchin, Rachel; Klein, Alison; Tomasetti, Cristian; Papadopoulos, Nickolas; Kinzler, Kenneth; Vogelstein, Bert; Wolfgang, Christopher L.; Hruban, Ralph; Lennon, Anne Marie
ISI:000470094900190
ISSN: 0016-5107
CID: 4744962
Enhancing Patient Outcomes while Containing Costs after Complex Abdominal Operation: A Randomized Controlled Trial of the Whipple Accelerated Recovery Pathway Discussion [Editorial]
Adams, David B.; Lillemoe, Keith D.; Wolfgang, Christopher; Vickers, Selwyn; Shoup, Margo; Hughes, Marybeth; Lavu, Harish
ISI:000461357100017
ISSN: 1072-7515
CID: 4744922
Development of Diabetes after Pancreaticoduodenectomy: Results of a 10-Year Series Using Prospective Endocrine Evaluation Discussion [Editorial]
Wolfgang, Christopher; Adams, David; Yeo, Charles J.; Jones, R. Scott; Sarmiento, Juan
ISI:000461357100015
ISSN: 1072-7515
CID: 4744912
Post-Pancreaticoduodenectomy Outcomes and Epidural Analgesia: A 5-year Single-Institution Experience Discussion [Editorial]
Sarmiento, Juan; Adams, David B.; Hayes-Jordan, Andrea; Hughes, Marybeth; Page, Andrew; Wolfgang, Christopher; Lillemoe, Keith D.; Schmidt, C. Max
ISI:000461357100023
ISSN: 1072-7515
CID: 4744932
NON-SELECTIVE beta-ADRENERGIC BLOCKADE IMPACTS PANCREATIC CANCER TUMOR BIOLOGY, DECREASES PERINEURAL INVASION AND IMPROVES PATIENT SURVIVAL [Meeting Abstract]
Blair, Alex; Jurcak, Noelle; Javed, Ammar A.; Teinor, Jonathan; Rozich, Noah; Groot, Vincent P.; Cameron, John; Weiss, Matthew J.; He, Jin; Wolfgang, Christopher L.; Zheng, Lei; Burkhart, Richard
ISI:000467106005414
ISSN: 0016-5085
CID: 5373032
Incidence and risk factors for abdominal occult metastatic disease in patients with pancreatic adenocarcinoma
Gemenetzis, Georgios; Groot, Vincent P; Blair, Alex B; Ding, Ding; Thakker, Sameer S; Fishman, Elliot K; Cameron, John L; Makary, Martin A; Weiss, Matthew J; Wolfgang, Christopher L; He, Jin
BACKGROUND:The incidence of occult metastatic disease (OMD) in pancreatic ductal adenocarcinoma (PDAC) and associated risk factors are largely unknown. METHODS:We identified all patients with PDAC, who had an aborted oncologic operation due to OMD within a 10-year period. The cases were matched to a cohort of resected PDAC patients on a 1:3 ratio, based on age and sex, for comparison of preoperative clinical characteristics and potential risk factors for OMD. RESULTS:In the studied period, 117 patients with OMD were identified in 1423 pancreatectomies performed for PDAC (8%). Liver metastases were the most common finding (79%) followed by peritoneal implants (16%). When compared with non-OMD cases, patients with OMD presented more often with abdominal pain (P < 0.001), and higher preoperative carbohydrate antigen 19-9 (CA 19-9) values ( P = 0.007). Additionally, indeterminate liver lesions on preoperative computed tomography (CT) were identified in 40% of OMD versus 17% of non-OMD patients ( P < 0.001). Multivariable analysis distinguished four independent predictors for OMD: indeterminate lesions on preoperative CT, tumor size > 30 mm, abdominal pain, and preoperative CA 19-9 > 192 U/mL. CONCLUSIONS:Occurrence of OMD in PDAC accounts for 8% of cases. Preoperative CA 19-9 > 192 U/mL, primary tumor size > 30 mm, and identification of indeterminate lesions in preoperative CT may indicate the need for diagnostic laparoscopy.
PMID: 30380143
ISSN: 1096-9098
CID: 4740912
