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Differential Immunogenicity of mRNA-1273 Versus BNT162b2 as a Third Vaccine Dose for Solid Organ Transplant Recipients Seronegative After Two BNT162b2 Doses. [Meeting Abstract]
Chang, Amy; Chiang, Teresa P. Y.; Alejo, Jennifer L.; Mitchell, Jonathan; Kim, Jake D.; Abedon, Aura T.; Avery, Robin K.; Tobian, Aaron A. R.; Massie, Allan B.; Levan, Macey L.; Warren, Daniel S.; Levan, Macey L.; Warren, Daniel S.; Garonzik-Wang, Jacqueline M.; Segev, Dorry L.; Werbel, William A.
ISI:000889117000006
ISSN: 0041-1337
CID: 5480662
Domains for a Comprehensive Geriatric Assessment of Older Adults with Chronic Kidney Disease: Results from the CRIC Study
Chiu, Venus; Gross, Alden L; Chu, Nadia M; Segev, Dorry; Hall, Rasheeda K; McAdams-DeMarco, Mara
INTRODUCTION/BACKGROUND:A comprehensive geriatric assessment (CGA) tailored to the chronic kidney disease (CKD) population would yield a more targeted approach to assessment and care. We aimed to identify domains of a CKD-specific CGA (CKD-CGA), characterize patterns of these domains, and evaluate their predictive utility on adverse health outcomes. METHODS:We used data from 864 participants in the Chronic Renal Insufficiency Cohort aged ≥55 years and not on dialysis. Constituents of the CKD-CGA were selected a priori. Latent class analysis informed the selection of domains and identified classes of participants based on their domain patterns. The predictive utility of class membership on mortality, dialysis initiation, and hospitalization was examined. Model discrimination was assessed with C-statistics. RESULTS:The CKD-CGA included 16 domains: cardiovascular disease, diabetes, five frailty phenotype components, depressive symptoms, cognition, five kidney disease quality-of-life components, health literacy, and medication use. A two-class latent class model fit the data best, with 34.7% and 65.3% in the high- and low-burden of geriatric conditions classes, respectively. Relative to the low-burden class, participants in the high-burden class were at increased risk of mortality (aHR = 2.09; 95% CI: 1.56, 2.78), dialysis initiation (aHR = 1.63; 95% CI: 1.06, 2.52), and hospitalization (aOR = 2.00; 95% CI: 1.38, 2.88). Model discrimination was the strongest for dialysis initiation (C-statistics = 0.86) and moderate for mortality and hospitalization (C-statistics = 0.70 and 0.66, respectively). CONCLUSION/CONCLUSIONS:With further validation in an external cohort, the CKD-CGA has the potential to be used in nephrology practices for assessing and managing geriatric conditions in older adults with CKD.
PMID: 36502797
ISSN: 1421-9670
CID: 5431742
Designing Continuous Distribution for Liver Allocation. [Meeting Abstract]
Mankowski, M.; Wood, N.; Segev, D.; Gentry, S.
ISI:000842606302312
ISSN: 1600-6135
CID: 5486642
Designing Continuous Distribution for Liver Allocation [Meeting Abstract]
Mankowski, Michal; Wood, Nicholas; Segev, Dorry; Gentry, Sommer
ISI:000739470700008
ISSN: 1600-6135
CID: 5133502
Public Perceptions and Information Needs of VCA Transplantation and Donation: A Mixed Methods Study
Ferzola, Alexander; Uriarte, Jefferson; Sung, Hannah C; Anderson, Naomi; Sidoti, Carolyn; Van Pilsum Rasmussen, Sarah E; Downey, Max; Vanterpool, Karen B; Langlee, Whitney; Klitenic, Samantha; Young, Lisa; Cooney, Carisa M; Johnson, Ieesha; Coleman, Allison; Shores, Jaimie T; Segev, Dorry L; Brandacher, Gerald; Gordon, Elisa J; Levan, Macey L
Vascularized Composite Allotransplantation (VCA) involves transplantation of multiple tissues from a donor to a recipient (e.g., skin, muscle, bone). Little is known about the US public's perceptions of and attitudes toward VCA organ donation. This multi-site, cross-sectional, mixed methods study involved focus groups and surveys to assess members of the general public's attitudes about VCA, and willingness and barriers to donate VCA organs. Qualitative data were analyzed by thematic analysis; quantitative data were analyzed by descriptive statistics. In focus groups (n = 6, 42 participants), most participants were female (57%) and Black (62%) with mean age of 42.6 years. Three main themes emerged: 1) awareness and perceptions of VCA, 2) purpose of VCA donation, 3) and barriers to VCA donation. Participants had heard little about VCA and sought information about VCA donation. Participants perceived VCA as challenging their concepts of "normality" and voiced concerns that VCA would create "Frankenstein[s]." Barriers to VCA donation included disruptions to end-of-life arrangements and information gaps regarding the donation process. Participants reported moderate to high willingness to donate their hands (69%) and face (50%) Public education efforts should address the specific needs and concerns of the public to facilitate VCA donation and family authorization.
PMCID:9701711
PMID: 36451683
ISSN: 1432-2277
CID: 5382812
Antibody Response to a Third Dose of SARS-CoV-2 Vaccine in Heart and Lung Transplant Recipients [Meeting Abstract]
Alejo, Jennifer; Ruck, Jessica M.; Chiang, Teresa P. Y.; Massie, Allan B.; Abedon, Aura T.; Tobian, Aaron A. R.; Levan, Macey L.; Warren, Daniel S.; Garonzik-Wang, Jacqueline M.; Segev, Dorry L.; Werbel, William A.
ISI:000889117000105
ISSN: 0041-1337
CID: 5480672
Diabetes-free survival among living kidney donors and non-donors with obesity: A longitudinal cohort study
Killian, A Cozette; Reed, Rhiannon D; McLeod, M Chandler; MacLennan, Paul A; Kumar, Vineeta; Pittman, Sydney E; Maynor, Andrew G; Stanford, Luke A; Baker, Gavin A; Schinstock, Carrie A; Silkensen, John R; Roll, Garrett R; Segev, Dorry L; Orandi, Babak J; Lewis, Cora E; Locke, Jayme E
BACKGROUND:Approval of living kidney donors (LKD) with end-stage kidney disease (ESKD) risk factors, such as obesity, has increased. While lifetime ESKD development data are lacking, the study of intermediate outcomes such as diabetes is critical for LKD safety. Donation-attributable diabetes risk among persons with obesity remains unknown. The purpose of this study was to evaluate 10-year diabetes-free survival among LKDs and non-donors with obesity. METHODS:This longitudinal cohort study identified adult, LKDs (1976-2020) from 42 US transplant centers and non-donors from the Coronary Artery Risk Development in Young Adults (1985-1986) and the Atherosclerosis Risk in Communities (1987-1989) studies with body mass index ≥30 kg/m2. LKDs were matched to non-donors on baseline characteristics (age, sex, race, body mass index, systolic and diastolic blood pressure) plus diabetes-specific risk factors (family history of diabetes, impaired fasting glucose, smoking history). Accelerated failure time models were utilized to evaluate 10-year diabetes-free survival. FINDINGS:Among 3464 participants, 1119 (32%) were LKDs and 2345 (68%) were non-donors. After matching on baseline characteristics plus diabetes-specific risk factors, 4% (7/165) LKDs and 9% (15/165) non-donors developed diabetes (median follow-up time 8.5 (IQR: 5.6-10.0) and 9.1 (IQR: 5.9-10.0) years, respectively). While not significant, LKDs were estimated to live diabetes-free 2 times longer than non-donors (estimate 1.91; 95% CI: 0.79-4.64, p = 0.15). CONCLUSIONS:LKDs with obesity trended toward living longer diabetes-free than non-donors with obesity, suggesting within the decade following donation there was no increased diabetes risk among LKDs. Further work is needed to evaluate donation-attributable diabetes risk long-term.
PMCID:9674148
PMID: 36399462
ISSN: 1932-6203
CID: 5371742
Evaluation of Diabetes-Free Life Expectancy Among Living Kidney Donors and Non-Donors with Obesity: A Longitudinal Cohort Study. [Meeting Abstract]
Killian, C.; Reed, R.; McLeod, M.; MacLennan, P.; Kumar, V.; Brooks, S.; Maynor, A.; Stanford, L.; Baker, G.; Schinstock, C.; Silkensen, J.; Roll, G.; Segev, D.; Orandi, B.; Lewis, C.; Locke, J.
ISI:000842606302099
ISSN: 1600-6135
CID: 5521262
BMI Trajectory and Attributable Risk of New Onset Hypertension Among Obese Living Kidney Donors. [Meeting Abstract]
Reed, R. D.; McLeod, M. C.; MacLennan, P. A.; Kumar, V.; Brooks, S. E.; Maynor, A. G.; Stanford, L. A.; Baker, G. A.; Schinstock, C. A.; Silkensen, J. R.; Roll, G. R.; Segev, D. L.; Orandi, B. J.; Lewis, C. E.; Locke, J. E.
ISI:000842606302100
ISSN: 1600-6135
CID: 5521272
Prediction of ESRD Risk in Living Kidney Donors Through Thirty Years Postdonation [Meeting Abstract]
Massie, Allan; Bendersky, Victoria A.; Snyder, Jon J.; Levan, Macey L.; Al-Ammary, Fawaz; Brennan, Daniel C.; Segev, Dorry L.
ISI:000889117000219
ISSN: 0041-1337
CID: 5480702