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Are accelerated 3-year md pathway students prepared for day one of internship? [Meeting Abstract]

Kalet, A; Eliasz, K L; Ng, G; Szyld, D; Zabar, S; Pusic, M V; Gillespie, C C; Buckvar-Keltz, L; Cangiarella, J; Abramson, S B; Riles, T S
NEEDS AND OBJECTIVES: To address rising education costs, physician shortages, and the need for educational reform, several medical schools have developed accelerated 3-year MD programs. In 2013, NYU School of Medicine began its new 3-year MD program with guaranteed acceptance into residency upon graduation. Using the AAMC's 13 Core Entrustable Professional Activities for Entry into Residency (CEPAER) framework, we designed an immersive 4-hour simulated "Night on Call" (NOC) experience to compare performance of our first graduating cohort of fifteen 3-year MD students (3A), with third (3T) and fourth year (4T) students in the traditional 4-year MD program. SETTING AND PARTICIPANTS: 73 medical students (39 women, age 26.5 (+2.6) years; 36 '3T', 12 '3A', 25 '4T') completed an IRB-approvedNOC at our simulation center 4 weeks prior to the end of their third or final year of medical school. DESCRIPTION: We developed NOC to measure competence and entrustment across all 13 CEPAERs from the perspective of patients, nurses, and attendings. During the simulation, a medical student rotated through a series of 8 clinical coverage scenarios including: 4 standardized patient (SP) cases with varying degrees of complexity, each of which require answering a call from a standardized nurse (SN), evaluating an SP with the SN in the room, making immediate management decisions and writing a coverage note; a phone call to an experienced clinician to orally present (OP) the case; formulation of a clinical question and finding the most appropriate evidence-based medicine (EBM) answer using digital library resources; a clinical vignette (CV) to test ability to recognize a pre-entrustable peer; and a handoff (HO) of 4 cases to a peer (a senior medical student). CEPAERs assessments based on validated tools included communication, physical exam, patient education and interprofessional teamwork skills assessed by an SP and SN, and clinical reasoning based on notes, OP, EBM, CV, HO. Each rater also provided an entrustment judgment. EVALUATION: Although overall student performance improved across cases and some interesting individual performance patterns emerged, there were no significant differences across the three groups in the core competency and entrustment measures evaluated across various NOC activities. DISCUSSION/REFLECTION/LESSONS LEARNED: The 13 CEPAERs are meant to define what students should be expected to perform (without direct supervision) prior to entering residency. Our results, based on multiple rater perspectives, suggest that our cohort of 3A students is as prepared for residency as their 4T counterparts
EMBASE:615582076
ISSN: 0884-8734
CID: 2553762

Roadmap for creating an accelerated three-year medical education program

Leong, Shou Ling; Cangiarella, Joan; Fancher, Tonya; Dodson, Lisa; Grochowski, Colleen; Harnik, Vicky; Hustedde, Carol; Jones, Betsy; Kelly, Christina; Macerollo, Allison; Reboli, Annette C; Rosenfeld, Melvin; Rundell, Kristen; Thompson, Tina; Whyte, Robert; Pusic, Martin
Medical education is undergoing significant transformation. Many medical schools are moving away from the concept of seat time to competency-based education and introducing flexibility in the curriculum that allows individualization. In response to rising student debt and the anticipated physician shortage, 35% of US medical schools are considering the development of accelerated pathways. The roadmap described in this paper is grounded in the experiences of the Consortium of Accelerated Medical Pathway Programs (CAMPP) members in the development, implementation, and evaluation of one type of accelerated pathway: the three-year MD program. Strategies include developing a mission that guides curricular development - meeting regulatory requirements, attaining institutional buy-in and resources necessary to support the programs, including student assessment and mentoring - and program evaluation. Accelerated programs offer opportunities to innovate and integrate a mission benefitting students and the public. ABBREVIATIONS: CAMPP: Consortium of accelerated medical pathway programs; GME: Graduate medical education; LCME: Liaison committee on medical education; NRMP: National residency matching program; UME: Undergraduate medical education.
PMCID:5706474
PMID: 29117817
ISSN: 1087-2981
CID: 2771972

"Low-grade squamous intraepithelial lesion, cannot exclude high-grade:" TBS says "Don't Use It!" should I really stop it?

Chiaffarano, Jeanine M; Alexander, Melissa; Rogers, Robert; Zhou, Fang; Cangiarella, Joan; Yee-Chang, Melissa; Elgert, Paul; Simsir, Aylin
BACKGROUND: The Bethesda System uses a two-tiered approach in the diagnosis of cervical squamous intraepithelial lesions (SILs). Occasionally, Papanicolaou (Pap) tests with evident low-grade SIL (LSIL) also have some features suggestive but not diagnostic of high-grade SIL (HSIL). This study reviews our experience with "Low-grade Squamous Intraepithelial Lesion, Cannot Exclude High-grade" (LSIL-H) and discusses the best approach to report such Paps if the LSIL-H interpretation is abandoned. METHODS: Abnormal Paps were identified between January and December 2014 that had surgical follow-up within 6 months. Their biopsy outcomes were compared. Statistical analysis was performed using Pearson's Chi-square and McNemar tests in SPSS software version 23. Statistical significance was defined as P
PMCID:5458421
PMID: 28603542
ISSN: 1742-6413
CID: 2593522

Accelerating medical education: a survey of deans and program directors

Cangiarella, Joan; Gillespie, Colleen; Shea, Judy A; Morrison, Gail; Abramson, Steven B
BACKGROUND:A handful of medical schools in the U.S. are awarding medical degrees after three years. While the number of three-year pathway programs is slowly increasing there is little data on the opinions of medical education leaders on the need for shortening training. PURPOSE/OBJECTIVE:To survey deans and program directors (PDs) to understand the current status of 3-year medical degree programs and to elicit perceptions of the need for shortening medical school and the benefits and liabilities of 3-year pathway programs (3YPP). METHODS:Online surveys were emailed to the academic deans of all U.S. medical schools and to a convenience sample of residency and fellowship PDs. Frequency distributions are reported for key survey items and content analysis was used to describe open-ended responses. RESULTS:Of the respondents, 7% have a 3YPP, 4% were developing one, and 35% were considering development. In 2014, 47% of educational deans and 32% of PDs agreed that there may be a need to shorten medical school. From a list of benefits, both deans and PDs agreed that the greatest benefit to a 3YPP was debt reduction (68%). PDs and deans felt reduced readiness for independence, reduced exposure to complementary curricula regarding safety and quality improvement, premature commitment to a specialty, and burnout were all potential liabilities. From a list of concerns, PDs were concerned about depth of clinical exposure, direct patient care experience, ability to assume increased responsibility, level of maturity, and certainty regarding career choice. CONCLUSIONS:Over one-third of medical schools are considering the development of a 3YPP. While there may be benefits for a select group of students, concerns regarding maturity, depth of clinical exposure, and competency must be addressed for these programs to be well received.
PMID: 27301381
ISSN: 1087-2981
CID: 3484162

Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) diagnosis of metastatic neoplasms to the pancreas: An institutional experience [Meeting Abstract]

Zhou, F; Grunes, D; Yee-Chang, M; Acosta-Gonzalez, G; Zamuco, R; Cangiarella, J; Wei, X -J; Simsir, A; Shi, Y
Introduction: Metastatic neoplasms (MN) are rare in the pancreas. An accurate diagnosis is challenging because MNs mimic primary pancreatic neoplasms, both clinically and on cytology. However, the distinction is critical for patient management. In this study, we reviewed our experience in diagnosing MNs by EUS-FNA of the pancreas. Material and Methods: We searched our database for pancreatic EUS-FNA specimens with a diagnosis of MN from 1994 to 2014. The clinical history, radiologic findings and follow-up of these cases, if available, were reviewed. Results: There were 17 cases of MNs to the pancreas in 7 males and 10 females, ranging in age from 37 to 85 years (mean = 62). The primary malignancies included carcinomas of the lung (4), colon (3), breast (2), ovary (1), kidney (1), liver (1), melanoma (3) and sarcoma (2). The pancreatic head and neck were the most common locations (73%).16 cases (94%) had a known prior history of malignancy; the clinical history was not provided in one case. All cases presented as a single mass in the pancreas. The average tumor size was 1.9 cm (range: 0.5 - 4 cm). 12 cases (71%) were poorly-differentiated carcinomas, indistinguishable from a pancreatic adenocarcinoma without immunohistochemical (IHC) studies and/or clinical history. 12 (71%) cases were correctly diagnosed as MN, 3 (18%) cases had indeterminate tumor origin, and 2 (12%) were misdiagnosed as primary pancreatic adenocarcinoma. A correct diagnosis was reached by cytomorphology alone in 3 cases (18%); morphology and immunohistochemical stains in 7 cases (41%); and morphologic comparison to the prior tumors in 2 cases (12%). Conclusions: EUS-FNA is an effective approach to diagnose pancreatic tumors. MNs can be difficult to differentiate from primary pancreatic carcinomas based on cytology alone. Clinical history and adequate cell block for IHC studies are essential to reach an accurate diagnosis
EMBASE:72235906
ISSN: 2213-2945
CID: 2093802

Sensitivity of high-risk HPV Hybrid Capture II (hrHPV HC2) test using SurePath specimens in the prediction of cervical high-grade squamous lesions

Zhou, Fang; Pulinthanathu, Rajiv; Elgert, Paul; Cangiarella, Joan; Simsir, Aylin
INTRODUCTION: High-risk HPV (hrHPV) testing is now considered standard of care in the detection and management of cervical high-grade squamous intraepithelial lesions (HSIL/CIN 2-3) and their precursors. Recently, there has been concern in the scientific literature and lay media about the lack of data regarding the false-negative rate (FNR) of HPV testing on SurePathTM cytology specimens. This is a critical issue, since guidelines on the management of Pap test abnormalities rely heavily on HPV status. We undertook this study to determine whether HPV testing on SurePathTM specimens is less sensitive compared to reports in the literature for ThinPrep(R). METHODS: We identified women with new diagnoses of CIN 2, CIN 3, and squamous cell carcinoma (SCC) on biopsy or excision in 2009-2013. For each patient, we recorded all SurePathTM cytology and hrHPV HC2 (high-risk HPV Hybrid Capture 2) test results from within 5 years prior to histologic diagnosis. Using the histologic diagnosis as the gold standard, we calculated the sensitivities of cytology and hrHPV HC2 tests for the detection of CIN 2, 3, and SCC. Our findings are based only on women who underwent biopsy or excision after having an abnormal cytology and/or positive HPV result. RESULTS: In our cohort, the sensitivity of testing in the 5 years prior to histologic diagnosis of CIN 2, 3, and SCC (combined as a single group) is 98.4% for SurePathTM cytology, 95.3% for hrHPV HC2, and 100% if both tests are used together. No conclusion can be drawn regarding testing for SCC alone, because there was only one case of SCC. CONCLUSION: Our results show that the false-negative rate of hrHPV HC2 testing on SurePathTM specimens for the detection of CIN 2 and CIN 3 is low and comparable to that of ThinPrep(R) specimens. Diagn. Cytopathol. 2014. (c) 2014 Wiley Periodicals, Inc.
PMID: 25546355
ISSN: 1097-0339
CID: 1419872

Primary large cell neuroendocrine carcinoma of the breast, a case report with an unusual clinical course

Janosky, Maxwell; Bian, Jessica; Dhage, Shubhada; Levine, Jamie; Silverman, Joshua; Jors, Kathryn; Moy, Linda; Cangiarella, Joan; Muggia, Franco; Adams, Sylvia
Large cell neuroendocrine carcinoma of the breast (NECB) is an extremely rare type of breast cancer; little is known about effective chemotherapies, and data on pathologic response to treatment are unavailable. We report the case of a 34-years-old woman with large cell NECB with initial clinical and pathologic evidence of treatment response to anthracycline-containing neo-adjuvant therapy. Histologic reassessment early during anthracycline chemotherapy revealed cell death with necrosis of 50% of the tumor cells seen in the biopsy specimen. After completing neo-adjuvant chemotherapy, the patient underwent breast-conserving surgery. Pathologic evaluation of the surgical specimen showed a partial response but margins were positive for residual carcinoma. Despite repeated neo-adjuvant chemotherapy, radiotherapy, and surgical resection, the tumor grew rapidly between surgeries and recurred systemically. Therefore, we review the literature on large cell NECB and its treatment options.
PMID: 25823996
ISSN: 1524-4741
CID: 1544112

Breast carcinoma with tubulopapillary features: a variant of papillary carcinoma with a stronger correlation with predictors of adverse prognosis

Darvishian, Farbod; Konno, Fumiko; Qian, Meng; Cangiarella, Joan
Papillary carcinoma of the breast consists of 3 morphologically distinct established subtypes: encapsulated papillary carcinoma, solid papillary carcinoma, and invasive papillary carcinoma. Papillary carcinoma is one of the special types of breast cancer and, as such, carries a more favorable prognosis. We sought to identify primary breast tumors with tubulopapillary morphology and correlate this finding with predictors of adverse prognosis. We investigated our pathology files for breast tumors exhibiting tubulopapillary features. The dominant morphology consisted of infiltrating gaping tubules with intratubular papillary projections. The study group consisted of 12 cases of papillary carcinoma with tubulopapillary features. A control group of 17 cases of papillary carcinoma were selected consisting of 4 encapsulated papillary carcinomas, 3 solid papillary carcinomas, and 10 invasive papillary carcinomas. The study group showed significantly higher mitotic rate, ki67 proliferation index, nuclear grade 3, lymphovascular invasion, p53 overexpression, unfavorable biomarker signature, and axillary nodal involvement compared to the control group (P = .01, .01, .04, .01, .007, .0001, .03, respectively). Invasive breast carcinomas with tubulopapillary features demonstrate significant correlation with predictors of adverse prognosis compared to ordinary papillary carcinomas. Larger studies with survival analysis are required to confirm aggressiveness in this group of breast cancers.
PMID: 24008438
ISSN: 1066-8969
CID: 818892

The Occurrence of Papillary Thyroid Carcinoma in Patients Undergoing Thyroidectomy for Hurthle Cell Adenoma: A Comparative Study [Meeting Abstract]

Kong, M. X.; Ren, Q.; Wang, B.; Cangiarella, J.; Sun, W.
ISI:000308126900401
ISSN: 0309-0167
CID: 178295

Atypical vascular lesion after radiation therapy for breast cancer. [Meeting Abstract]

Refinetti, Ana Paula; Shapiro, Richard; Cangiarella, Joan; Guth, Amber Azniv
ISI:000208892500181
ISSN: 0732-183x
CID: 3589832