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44


Grade 2+Bladder Toxicity in Patients Receiving SBRT for Prostate Cancer: Incidence and Dosimetric Characterization in a Large Patient Cohort [Meeting Abstract]

Blacksburg, S. R.; Sheu, R.; Demircioglu, G.; Mirza, A.; Carpenter, T. J.; Morgenstern, J.; Witten, M. R.; Mendez, C.; Katz, A. E.; Endres, P.; Oshinsky, G.; Lumerman, J.; Shepard, B.; D'Esposito, R.; Edelman, R.; Gershbaum, M. D.; Nejat, R.; Haas, J. A.
ISI:000447811600228
ISSN: 0360-3016
CID: 3493572

A Reference Architecture for Secure Medical Devices

Harp, Steven; Carpenter, Todd; Hatcliff, John
We propose a reference architecture aimed at supporting the safety and security of medical devices. The ISOSCELES (Intrinsically Secure, Open, and Safe Cyber-Physically Enabled, Life-Critical Essential Services) architecture is justified by a collection of design principles that leverage recent advances in software component isolation based on hypervisor and other separation technologies. The instantiation of the architecture for particular medical devices is supported by a development process based on Architecture Analysis and Design Language. The architecture models support safety and security analysis as part of a broader risk management framework. The models also can be used to derive skeletons of the device software and to configure the platform's separation policies and an extensive set of services. We are developing prototypes of the architecture and example medical device instantiations on low-cost boards that can be used in product solutions. The prototype and supporting development and assurance artifacts are being released under an open-source license.
PMID: 30260670
ISSN: 0899-8205
CID: 3498562

Promoting High-Value Care During Hospitalist and Intensivist Comanagement in the Care of the Deteriorating Child With Bronchiolitis

Lockwood, Justin; Robison, Justin; Carpenter, Todd; Reese, Jennifer
PMID: 29748427
ISSN: 2154-1663
CID: 3498522

Simulation order for patients undergoing SBRT: Identifying predictors of lengthier insurance authorization. [Meeting Abstract]

Blacksburg, Seth; Mirza, Awais; Demircioglu, Gizem; Carpenter, Todd; Witten, Matthew; Morgenstern, Jason; Ebling, David; Catell, Donna; Castellano, Elaine; Accordino, Diane; Giambona, Maria
ISI:000442916005730
ISSN: 0732-183x
CID: 4610322

PROSTATE FIDUCIAL MARKER PLACEMENT IN PATIENTS WHILE ON ANTICOAGULATION: FEASIBILITY PRIOR TO PROSTATE SBRT [Meeting Abstract]

Haas, Jonathan; Katz, Aaron; Harris, Joshua; Carpenter, Todd; Carbone, Susan; Kole, Thomas; Pristupa, Steven; Witten, Matthew; Blacksburg, Seth
ISI:000398276600099
ISSN: 0022-5347
CID: 3502622

Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma

Kann, Benjamin H; Buckstein, Michael; Carpenter, Todd J; Bakst, Richard; Misiukiewicz, Krzysztof; Genden, Eric; Posner, Marshall; Kostakoglu, Lale; Som, Peter; Gupta, Vishal
BACKGROUND:Pathologic extracapsular extension (pECE) in metastatic lymph nodes is associated with poor prognosis for oropharyngeal carcinoma. The prognostic value of radiographic extracapsular extension (rECE) has not been studied. METHODS:A retrospective analysis was conducted of 111 patients with locally advanced oropharyngeal carcinoma treated in the Mount Sinai Radiation Oncology Department with accessible pretreatment CT reports. Univariate Kaplan-Meier and multivariate Cox regression analyses compared cohorts for locoregional control, distant control, progression-free (PFS), and overall survival (OS). RESULTS:Sixty-four patients had rECE-present and 47 had rECE-absent scans. The patients with rECE presence had significantly worse OS (3-year: 95% vs 77%; p = .006), PFS (3-year: 91% vs 71%; p = .002), and distant control (3-year: 98% vs 81%; p = .008), with no difference in locoregional control. On multivariate analysis, rECE-presence was a negative prognosticator for OS, PFS, and distant control. CONCLUSION/CONCLUSIONS:This study suggests that rECE is an independent prognosticator of poor distant control and survival with little impact on locoregional control for oropharyngeal carcinoma.
PMID: 24123603
ISSN: 1097-0347
CID: 3498442

Vocal cord paralysis after stereotactic body radiation therapy to the left lung apex [Case Report]

Carpenter, Todd J; Rosenzweig, Kenneth E
PMID: 25436809
ISSN: 1556-1380
CID: 3498472

Tolerability, toxicity, and temporal implications of transoral robotic surgery (TORS) on adjuvant radiation therapy in carcinoma of the head and neck

Carpenter, Todd J; Kann, Benjamin; Buckstein, Michael H; Ko, Eric C; Bakst, Richard L; Misiukiewicz, Krzysztof J; Posner, Marshall R; Genden, Eric M; Gupta, Vishal
OBJECTIVES/OBJECTIVE:Overall treatment package time (from surgery to radiotherapy [RT] completion) > 100 days can portend poor outcomes in head and neck cancer. Faster postoperative recovery seen with transoral robotic surgery may decrease treatment duration and toxicity for adjuvant RT and chemoradiation. METHODS:We retrospectively reviewed all patients treated with transoral robotic surgery (n = 124) and adjuvant RT and chemoradiation (n = 33) at our institution for head and neck cancer from April 2007 to December 2011 to determine treatment duration, acute toxicity, and long-term percutaneous gastric tube rates. RESULTS:The median overall treatment time was 86 days and from surgery to RT start was 41 days; median RT duration was 44 days. No wound breakdown or infection occurred during or after RT. Two-year actuarial locoregional control, distant metastasis-free survival, and overall survival rates were 93%, 96%, and 97%, respectively. CONCLUSIONS:Adjuvant RT after transoral robotic surgery for head and neck cancer can be completed safely and in a timely fashion. Longer follow-up and a larger cohort will be needed to determine if this regimen is more effective than traditional surgery followed by adjuvant RT.
PMID: 24847162
ISSN: 0003-4894
CID: 3498452

Does response to induction chemotherapy (IC) predict locoregional control after concurrent chemoradiotherapy (CCRT) in locally advanced head and neck cancer (LAHNC)? [Letter]

Cotter, Ryan; Blacksburg, Seth; Carpenter, Todd; Kann, Benjamin; Bakst, Richard; Misiukiewicz, Krzysztof; Posner, Marshall; Som, Peter; Gupta, Vishal
PMID: 24680084
ISSN: 1879-0593
CID: 3498002

Radiographic extracapsular extension (ECE) and treatment outcomes in locally advanced oropharyngeal carcinoma (OPC) [Meeting Abstract]

Kann, Benjamin H.; Buckstein, Michael; Carpenter, Todd J.; Golchin, Ava; Bakst, Richard Lorne; Misiukiewicz, Krzysztof; Genden, Eric Michael; Posner, Marshall R.; Kostakoglu, Lale; Som, Peter M.; Gupta, Vishal
ISI:000335419602143
ISSN: 0732-183x
CID: 3495622