Faculty Bibliography

Concomitant mesh repair of large umbilical hernias and abdominoplasty pose a serious risk of devascularizing the umbilical stalk. A technique of placing mesh in a sublay manner, deep to the fascial defect, for an umbilical herniorrhaphy to avoid damage to the deep umbilical perforators during an abdominoplasty is described.

Hand-assisted laparoscopic surgery (HALS) bridges traditional open surgery and pure laparoscopy. The HALS technique provides the necessary site for organ retrieval, reduces operative time, and realizes the postoperative benefits of laparoscopic techniques. Although the reported rates of incisional hernia should be theoretically low, we sought to determine our incidence of hernia after HALS procedures. A retrospective review of all HALS procedures was performed from July 2006 to June 2011. All patients who developed postoperative incisional hernias at the hand port site were confirmed by imaging or examination findings. Patient factors were reviewed to determine any predictors of hernia formation. Over the 5 years, 405 patients undergoing HALS procedures were evaluated: colectomy (264), nephrectomy (107), splenectomy/pancreatectomy (18), and ostomy reversal (10). The overall incidence of incisional hernia was 10.6 per cent. There were three perioperative wound dehiscences. The mean body mass index was significantly higher in the hernia group versus the no hernia cohort (32.1 vs 29.2 kg/m(2); P = 0.001). The hernia group also had a higher incidence of renal disease (18.6 vs 7.2%; P = 0.018). Mean time to hernia formation was 11.4 months (range, 1 to 57 months). Follow-up was greater than 12 months in 188 (46%) of patients, in which the rate of incisional hernia was 17 per cent. The rate of incisional hernia formation after hand-assisted laparoscopic procedures is higher than the reported literature. Because the mean time to hernia development is approximately 1 year, it is important to follow these patients to this end point to determine the true incidence of incisional hernia after hand-assisted laparoscopy.

Although the safety of bariatric surgery in patients with established cardiovascular disease has been demonstrated, little is known about the mid- to long-term survival of these patients after surgery. We conducted a retrospective cohort study of bariatric surgical patients (n = 349) compared with morbidly obese surgical controls (n = 903). Data were obtained on all patients 40 to 79 years of age, from 1996 to 2008, with a diagnosis code of morbid obesity, a primary surgical procedure of interest, and a cardiovascular event history. Data sources were the statewide South Carolina UB92 inpatient hospitalization database and death records. The primary outcome was all-cause mortality. A total of 349 bariatric and 903 control patients with cardiovascular event histories were identified. Among bariatric patients, 19 deaths occurred in 986 person-years of follow-up versus 150 deaths among controls in 3138 person-years of follow-up. Unadjusted all-cause mortality was estimated at 7 ± 2 per cent at 5 years in bariatric patients compared with 19 ± 2 per cent (P < 0.001) in controls. Adjusting for age, comorbidities, and event history, the relative risk of mortality was reduced by 40 per cent in bariatric patients compared with controls [hazard ratios (95% confidence interval): 0.60 (0.36, 0.99)]. In patients with a history of cardiovascular events, bariatric surgery is associated with a significantly decreased risk of all-cause mortality.

BACKGROUND:Computed tomographic angiography (CTA) has recently emerged as a non-invasive alternative to digital subtraction angiography (DSA) for the detection of residual cerebral aneurysms (RA). OBJECTIVE:To compare the diagnostic accuracy of CTA with the current 'gold standard', DSA, in the postoperative detection of RA. METHODS:Patient data from this single institution were prospectively gathered, and imaging results retrospectively blinded and analyzed. Between 2001 and 2005 eligible patients received microsurgical repair of cerebral aneurysms and were evaluated postoperatively by DSA and CTA. These single-institutional data were compiled with qualified studies published from 1997 to 2009, and a meta-analysis was performed. RESULTS:This institutional series reports sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of 100%. Eleven studies met the inclusion criteria for the meta-analysis. A total of 427 patients with 513 aneurysms were included, with 61 RA detected by DSA and 40 detected by CTA. Unweighted analysis resulted in pooled sensitivity of 73.8%, specificity of 96.3%, PPV of 91.0% and NPV of 86.1%. Stratified analysis of studies using 16-slice CTA versus 2D DSA reported pooled sensitivity of 92.6%, specificity of 99.3%, PPV of 95.8%, and NPV of 97.8%. CONCLUSIONS:This meta-analysis supports CTA as an acceptable modality for postoperative detection of RA, although DSA remains the gold standard. By implementing multidetector CTA technology in experienced centers, the sensitivity and specificity of CTA may approach that of traditional DSA for detecting RA. As a cost-effective, non-invasive modality, CTA is a promising alternative to DSA for initial and long-term evaluation of RA.

The reliability of Nissen fundoplication for the successful treatment of laryngopharyngeal reflux (LPR) symptoms remains in question. The purpose of this study was to assess the effect that antireflux surgery has on a variety of LPR symptoms as well as the patient's perceived success of surgical intervention. A retrospective review of all antireflux surgeries between 1998 and 2008 provided a patient base for a survey in which patients ranked pre- and postoperative LPR symptoms in addition to patient satisfaction with the outcome. Of the 611 patients identified and sent the evaluation forms, 244 responses (40%) were obtained. The percentage of patients with symptom improvement after surgery were: heartburn (90.1%), regurgitation (92.6%), voice fatigue (75.2%), chronic cough (76.3%), choking episodes (83.1%), sore throat (82.9%), lump in throat (77.4%), repetitive throat clearing (72.8%), and adult-onset asthma (59.6%). Twenty per cent with repetitive throat clearing and 30 per cent with adult-onset asthma had no improvement in symptoms. Eighty-one per cent considered surgery to be a success. Comparison of those who claimed the operation was successful with those who claimed it was not revealed no difference in demographics, primary diagnosis, procedure type, or reflux symptom index score. There was a statistically significant difference in patient-perceived outcome according to the length of time since surgery. More than 88 per cent in the "not successful" group had an operation greater than 4 years prior as compared with only 70 per cent in the "successful" group (P = 0.020). Nissen fundoplication is an effective treatment for most LPR symptoms, although patients with adult-onset asthma and repetitive throat clearing appear to benefit least from surgical intervention.

BACKGROUND:Anastomotic stricture remains the most common complication after laparoscopic gastric bypass with a circular-stapled gastrojejunostomy. The present study examined the effect of the use of bioabsorbable circular staple line reinforcement on the incidence of gastrojejunostomy anastomotic strictures as a complication of laparoscopic Roux-en-Y gastric bypass. METHODS:A retrospective review was performed of 851 consecutive patients who underwent laparoscopic Roux-en-Y gastric bypass with circular-stapled gastrojejunostomy. Gore SeamGuard bioabsorbable circular staple line reinforcement was used in 596 consecutive patients subsequent to 255 consecutive patients without anastomotic reinforcement. The incidence of anastomotic stricture was compared after mean follow-up periods of 19 and 22 months for the two groups. RESULTS:Anastomotic stricture requiring intervention was identified in 28 patients (2.94%). Only four patients (.67%) in the SeamGuard group developed anastomotic stricture compared with 24 patients (9.41%) in the no SeamGuard group. The use of staple line reinforcement is consistent with a 94% risk reduction in stricture formation. CONCLUSION/CONCLUSIONS:The results have shown that the use of bioabsorbable circular staple line reinforcement on gastrojejunal anastomoses in laparoscopic Roux-en-Y gastric bypass significantly reduces the incidence of anastomotic stricture. The standard use of the bioabsorbable reinforcement on circular staple line anastomoses could be a part of the solution to the most common complication of laparoscopic gastric bypass.

BACKGROUND:Despite the proven advantages of laparoscopic nephrectomy, the absence of local expertise and paucity of formal laparoscopic training in urology residencies has delayed the introduction of this technique into many institutions. We analyzed the impact of an initiative driven by the minimally-invasive division of the Department of Surgery on reducing the learning curve for hand-assisted laparoscopic nephrectomy (HALN) and maintaining good patient outcomes. METHODS:A retrospective chart review was performed on all laparoscopic renal procedures performed at Greenville Memorial Hospital University Medical Center. A collaborative effort between an fellowship-trained laparoscopic surgeon and an urologist began in August 2005. The data from the first 25 procedures performed in collaboration with general surgery were compared to the first 25 cases by urology alone. RESULTS:The breakdown of cases was similar in the collaborative group (22 radical/3 partial) and the urology alone group (21 radical/4 partial). The indication for nephrectomy was cancer in the majority of cases. The operative times were longer in the collaborative group (236 v. 163 min; p < 0.001). With general surgery collaboration, estimated blood loss (107 v. 757 ml; p = 0.005), need for transfusion (2 v. 9 pts; p = 0.037), and conversion to open (1 pt v. 9 pts; p = 0.011) were all significantly reduced when compared to urologists alone. CONCLUSION/CONCLUSIONS:An initiative by general surgery to facilitate the introduction of laparoscopic renal surgery can result in substantial improvement in perioperative patient outcomes. Collaboration with urologists and laparoscopic surgeons allows for the introduction of advanced minimally invasive techniques with a reduced learning curve compared to urologists alone.

BACKGROUND AND IMPORTANCE/BACKGROUND:Enterogenous cysts are rare tumors found most commonly in the spine, but they have also been reported intracranially. Cases of enterogenous cysts located within the posterior fossa have traditionally been resected via difficult craniotomies that require prolonged retraction and risk injury to cranial nerves. We describe a method for resection of an enterogenous cyst located anterior to the brainstem via the endoscopic transsphenoidal approach. CLINICAL PRESENTATION/METHODS:A 37-year-old man was found to have a 2-cm mass anterior to the brainstem during routine screening after a trauma. The mass was located within the prepontine cistern, enhanced with gadolinium contrast, and showed no restrictive diffusion. This lesion was most consistent with an enterogenous cyst. A minimally invasive endoscopic endonasal transsphenoidal transclival approach was performed for gross total resection of the tumor. CONCLUSION/CONCLUSIONS:We discuss the endoscopic transsphenoidal approach used for the resection of an enterogenous cyst in the posterior fossa anterior to the brainstem. The transsphenoidal approach provides direct access to lesions in this location using a minimally invasive technique while avoiding excessive brain retraction or injury to cranial nerves. In addition, we provide an updated review of the literature for enterogenous cysts located within the posterior fossa.

The cellular and molecular events that initiate and promote malignant glioma development are not completely understood. The treatment modalities designed to promote its demise are all ultimately ineffective, leading to disease progression. In this issue of the JCI, Kioi et al. demonstrate that vasculogenesis and angiogenesis potentially play distinct roles in the etiology of primary and recurrent malignant gliomas, suggesting that patient therapy should perhaps be tailored specifically against the predominant vasculature pathway at a given specific stage of gliomagenesis.