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Impact of laparoscopic adjustable gastric banding on pregnancy, maternal weight, and neonatal health
Carelli, Allison M; Ren, Christine J; Youn, Heekoung Allison; Friedman, Erica B; Finger, Anne E; Lok, Benjamin H; Kurian, Marina S; Fielding, George A
BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) is a proven method for weight reduction. Less is known about pregnancies in patients after LAGB. METHODS: Information was gathered, through database and survey, on women who underwent LAGB at NYU Medical Center between 2001 and 2008 then became pregnant. RESULTS: Pregnancy occurred in 133 women, resulting in 112 babies, including six sets of twins. The average pre-pregnancy body mass index (BMI) was 32.7. Average weight gain was 11.5 kg, but was higher for those with pre-pregnancy BMI <30.0 compared to BMI >30.0 (16.4 vs 8.6 kg). Of singleton pregnancies, 89% were carried to full term, with cesarean section in 45%. Those with pre-pregnancy BMI <30.0 had a lower rate of cesarean section (35.71%), but it was not statistically significant (p = 0.55). Average birth weight was 3,268.6 g. Eight percent of babies from singleton pregnancies were low birth weight (<2,500 g), and seven percent were high birth weight (>4,000 g). Average Apgar scores at 1 and 5 min were 8.89 and 9.17. Four percent of patients developed gestational diabetes, and 5% developed pre-eclampsia. Band adjustments were performed in 71% of patients. Weight gain was higher in those who had their bands loosened in the first trimester (p = 0.063). Three patients had intrapartum band slips; one required surgery during pregnancy. CONCLUSIONS: LAGB is tolerable in pregnancy with rare intrapartum band slips. Weight gain is less in those with higher pre-pregnancy BMI and those who had their bands filled or not adjusted. Babies born to these mothers are as healthy as the general population
PMID: 20835780
ISSN: 1708-0428
CID: 138309
An analysis of altered melanoma matrix metalloproteinase-23 (MMP-23) expression and response to immune biologic therapy. [Meeting Abstract]
Krogsgaard, M.; Ma, M. W.; Friedman, E. B.; de Miera, E. Vega-Saenz; Darvishian, F.; Perez-Garcia, A.; Berman, R. S.; Shapiro, R. L.; Christos, P. J.; Osman, I.; Pavlick, A. C.
ISI:000208880302400
ISSN: 0732-183x
CID: 3159202
An analysis of sera-based microRNAs as biomarkers of recurrence in melanoma [Meeting Abstract]
Friedman, E. B.; Shang, S.; de Miera, E. Vega-Saenz; Ma, M. W.; Berman, R. S.; Shapiro, R. L.; Pavlick, A. C.; Hernando, E.; Shao, Y.; Osman, I.
ISI:000208880302374
ISSN: 0732-183x
CID: 3159172
Laparoscopically assisted components separation technique for ventral incisional hernia repair
Milburn, Meghan L; Shah, Paulesh K; Friedman, Erica B; Roth, J Scott; Bochicchio, Grant V; Gorbaty, Benjamin; Silverman, Ronald P
Reconstruction of the abdominal wall to repair ventral hernias continues to pose a challenge to surgeons due to relatively high rates of recurrence and morbidity. In 1990, Ramirez pioneered a technique of components separation of the abdominal wall for ventral hernia repair. Although an effective hernia repair, the mobilization of skin and subcutaneous tissue endangers the blood supply and predisposes midline skin to necrosis. The goal of this study is to determine whether releasing incisions in the transversus abdominis fascia and posterior rectus sheath provide adequate mobilization of the abdominal wall necessary for ventral hernia repair, thus paving the way for a laparoscopic component separation technique. Ten fresh cadavers were used and one side of the abdomen underwent the conventional Ramirez components separation: midline incision, dissection of skin and subcutaneous tissue off the anterior abdominal wall, and incisions in the external oblique aponeurosis and posterior rectus sheath, while the other side received incisions in the transversus abdominis fascia and the posterior rectus sheath with no undermining of the skin. The amount of fascial translation was measured after each incision. Incising only the external oblique aponeurosis produced greater mobilization of the abdominal wall at the level of the umbilicus (P = 0.02) and anterior superior iliac spine (ASIS, P = 0.029) than releasing only transversus abdominis fascia. More importantly, there was no statistically significant difference in the amount of release produced by the complete internal-release components separation versus the conventional technique. In order to test the feasibility of performing the procedure laparoscopically, one additional cadaver underwent a laparoscopic transversus abdominis fascia release. The procedure was successful and resulted in comparable amounts of fascial release as the other 10 cadavers. From this study, it appears technically feasible to perform a laparoscopic components separation to repair a ventral hernia and the procedure produces the same amount of release as the conventional open component separation technique.
PMID: 17216395
ISSN: 1248-9204
CID: 159141