Faculty Bibliography

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Otolaryngology, head & neck surgery. 2020.DOI: 10.1177/0194599820935853

Socioeconomic and Racial Disparities and Survival of Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma

Rotsides, Janine M; Oliver, Jamie R; Moses, Lindsey E; Tam, Moses; Li, Zujun; Schreiber, David; Jacobson, Adam S; Hu, Kenneth S; Givi, Babak
OBJECTIVE:To investigate differences in epidemiology of oropharyngeal squamous cell carcinoma (OPSCC) with regards to human papillomavirus (HPV), race, and socioeconomic status (SES) using the National Cancer Database (NCDB). STUDY DESIGN/METHODS:Population-based cohort study. SETTING/METHODS:Racial and socioeconomic disparities in survival of OPSCC have been previously acknowledged. However, the distribution of HPV-related cancers and its influence on survival in conjunction with race and SES remain unclear. SUBJECTS AND METHODS/METHODS:All patients with OPSCC in the NCDB with known HPV status from 2010 to 2016 were included. Differences in presentation, HPV status, treatment, and outcomes were compared along racial and socioeconomic lines. Univariable and multivariable Cox regression survival analyses were performed. RESULTS:< .001) were associated with worse survival. CONCLUSION/CONCLUSIONS:Significant differences in HPV status exist between socioeconomic and racial groups, with HPV-negative disease more common among blacks and lower SES. When controlling for HPV status, race and SES still influence outcomes in oropharyngeal cancers.
PMID: 32660368
ISSN: 1097-6817
CID: 4527952
Photobiomodulation, photomedicine, & laser surgery. 2020:38(6):355-363.DOI: 10.1089/photob.2019.4766

Photobiomodulation Therapy to Mitigate Radiation Fibrosis Syndrome

Tam, Moses; Arany, Praveen R; Robijns, Jolien; Vasconcelos, Rebeca; Corby, Patricia; Hu, Kenneth
PMID: 32460618
ISSN: 2578-5478
CID: 4474262
Journal of laryngology, rhinology, & otology. 2020:134(6):533-540.DOI: 10.1017/S0022215120001176

Radiotherapy dose and survival outcomes in human papillomavirus positive oropharyngeal cancer

Tam, M; Wu, S P; Gerber, N K; Lee, A; Schreiber, D; Givi, B; Hu, K
OBJECTIVE:To evaluate the effect of definitive radiotherapy dose on survival in patients with human papillomavirus positive oropharyngeal carcinoma. METHODS:Human papillomavirus positive oropharyngeal carcinoma patients staged T1-3 and N0-2c, who received definitive radiotherapy (fraction sizes of 180 cGy to less than 220 cGy), were identified from the National Cancer Database 2010-2014 and stratified by radiation dose (50 Gy to less than 66 Gy, or 66 Gy or more). RESULTS:A total of 2173 patients were included, of whom 124 (6 per cent) received a radiation dose of 50 Gy to less than 66 Gy. With a median follow up of 33.8 months, patients had a 3-year overall survival rate of 88.6 per cent (95 per cent confidence interval = 87.1-90.1 per cent). On multivariate Cox analysis, a radiotherapy dose of 50 Gy to less than 66 Gy (hazard ratio = 0.95, 95 per cent confidence interval = 0.52-1.74, p = 0.86) was not a predictor of increased mortality risk. CONCLUSION/CONCLUSIONS:Human papillomavirus positive oropharyngeal carcinoma patients had excellent outcomes with definitive radiotherapy doses of 50 Gy to less than 66 Gy. These results further support patients enrolling into clinical trials for radiation dose de-escalation.
PMID: 32616096
ISSN: 1748-5460
CID: 4537442
Cancer. 2020:126(7):1413-1423.DOI: 10.1002/cncr.32679

Human papillomavirus and survival of patients with sinonasal squamous cell carcinoma

Oliver, Jamie R; Lieberman, Seth M; Tam, Moses M; Liu, Cheng Z; Li, Zujun; Hu, Kenneth S; Morris, Luc G T; Givi, Babak
BACKGROUND:To the authors' knowledge, the question of whether human papillomavirus (HPV) infection is associated with outcomes in patients with sinonasal squamous cell carcinoma (SNSCC) is not well studied at this time. In the current study, the authors investigated patterns of HPV testing and its association with survival in patients with SNSCC using the National Cancer Data Base. METHODS:The authors selected all SNSCC cases diagnosed between 2010 and 2016. HPV testing practices, clinicodemographic factors, treatments, and survival were analyzed. Multivariable Cox regression and propensity score-matched survival analyses were performed. RESULTS:A total of 6458 SNSCC cases were identified. Of these, only 1523 cases (23.6%) were tested for HPV and included in the current study. The median patient age was 64 years and the majority had advanced stage tumors (overall AJCC stage III-IV, 721 patients; 62.1%). HPV-positive SNSCC comprised 31.5% (447 of 1418 cases) of the final study cohort. Among 15 hospitals that routinely tested nonoropharyngeal SCCs for HPV, the percentage of HPV-positive SNSCCs was smaller (24.6%; P = .04). Patients with HPV-positive SNSCC were younger (aged 60 years vs 65 years; P < .001), with tumors that were more likely to be high grade (55.3% vs 41.7%; P < .001), and attributed to the nasal cavity (62.2% vs 44.0%; P < .001). HPV-positive SNSCC was associated with significantly improved overall survival in multivariable regression analysis (hazard ratio, 0.45; 95% CI, 0.28-0.72 [P = .001]) and propensity score-matched (hazard ratio, 0.61; 95% CI, 0.38-0.96 [P = .03]) analyses controlling for clinicodemographic and treatment factors. CONCLUSIONS:Currently, only a minority of patients with SNSCC are tested for HPV. However, a sizable percentage of SNSCC cases may be HPV related; furthermore, HPV-positive SNSCC is associated with improved overall survival. Routine HPV testing may be warranted in patients with SNSCC.
PMID: 31886908
ISSN: 1097-0142
CID: 4251152
International journal of radiation oncology biology physics. 2020:106(5):1214-1214.DOI:

Treatment Related Risk Factors for Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement in Locally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC) [Meeting Abstract]

No, H. J.; Tam, M. M.; Wu, P.
ISI:000580656800260
ISSN: 0360-3016
CID: 4688632
International journal of radiation oncology biology physics. 2020:106(5):1179-1179.DOI:

Radiotherapy in Metastatic Oropharyngeal Cancer [Meeting Abstract]

Nguy, S.; Oh, C.; Wu, P.; Li, Z.; Persky, M.; Hu, K. S.; Givi, B.; Tam, M. M.
ISI:000580656800182
ISSN: 0360-3016
CID: 4688612
International journal of radiation oncology biology physics. 2020:106(5):1127-1127.DOI:

De-escalation with Definitive Unilateral Neck Radiation for T3 or N2b/N3 p16+Tonsil Squamous Cell Carcinoma Using Prospectively Defined Criteria [Meeting Abstract]

Yan, S. X.; Mojica, J.; Barbee, D.; Harrison, L. B.; Gamez, M. E.; Tam, M.; Concert, C. M.; Li, Z.; Culliney, B.; Jacobson, A.; Persky, M.; DeLacure, M.; Persky, M.; Tran, T.; Givi, B.; Hu, K. S.
ISI:000580656800061
ISSN: 0360-3016
CID: 4688592
International journal of radiation oncology biology physics. 2020:106(5):1142-1142.DOI:

Human Papillomavirus in Sinonasal Squamous Cell Carcinoma [Meeting Abstract]

Oliver, J. R.; Lieberman, S. M.; Tam, M. M.; Liu, C. Z.; Li, Z.; Hu, K. S.; Morris, L. G.; Givi, B.
ISI:000580656800095
ISSN: 0360-3016
CID: 4688602
Journal of radiation oncology. 2020:9(3-4):147-154.DOI:

Whole breast irradiation with high tangents in the prone position

Shaikh, Fauzia; Tam, Moses; Taneja, Sameer; Huppert, Nelly; McCarthy, Allison; Hitchen, Christine; Maisonet, Olivier; Perez, Carmen; Barbee, David; Gerber, Naamit Kurshan
ISI:000562705500001
ISSN: 1948-7894
CID: 4898682
International journal of radiation oncology biology physics. 2020:108(3):E810-E810.DOI:

Trimodality Treatment of Very Locally Advanced Sinonasal Cancer: A National Cancer Database Analysis [Meeting Abstract]

Karp, J. M.; Hu, K. S.; Persky, M.; Jacobson, A.; Tran, T.; Li, Z.; Givi, B.; Tam, M.
ISI:000582521502614
ISSN: 0360-3016
CID: 4686342