AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
Shefner, Jeremy M.; Cudkowicz, Merit E.; Hardiman, Orla; Cockroft, Bettina M.; Lee, Jacqueline H.; Malik, Fady, I; Meng, Lisa; Rudnicki, Stacy A.; Wolff, Andrew A.; Andrews, Jinsy A.; Van Damme, Philip; Korngut, Lawrence; Johnston, Wendy; O\Connell, Colleen; Grant, Ian; Turnbull, John; Shoesmith, Christen; Zinman, Lorne; Botez, Stephan; Genge, Angela; Dionne, Annie; Couratier, Philippe; Attarian, Shahram; Pouget, Jean; Camu, William; Desnuelle, Claude; Salachas, Francois; Corcia, Philippe; Meyer, Thomas; Petri, Susanne; Ludolph, Albert; Calvo, Andrea; Lunetta, Christian; Silani, Vincenzo; van den Berg, Leonard; de Carvalho, Mamede; Mora Pardina, Jesus; Young, Carolyn; Al-Chalabi, Ammar; Radunovic, Aleksander; Hanemann, Clemens; Ladha, Shafeeq; Goyal, Namita; Ravits, John; Lewis, Richard; Joyce, Nanette; Oskarsson, Bjorn; Katz, Jonathan S.; So, Yuen; Quan, Dianna; Felice, Kevin; Bayat, Elham; Boylan, Kevin; Benatar, Michael G.; Tuan Vu; Glass, Jonathan; Sufit, Robert; Bodkin, Cynthia; Swenson, Andrea; Statland, Jeffrey; Maragakis, Nicholas; Berry, James; Brown, Robert; Salameh, Johnny; Goutman, Stephen; Newman, Daniel S.; Guliani, Gaurav; Maiser, Samuel; Pestronk, Alan; Hayat, Ghazala; Pattee, Gary; Cohen, Jeffrey; Brooks, Benjamin; Bedlack, Richard; Caress, James; Mitsumoto, Hiroshi; Lange, Dale; Bradshaw, Deborah; Kolb, Stephen J.; Karam, Chafic; Khoury, Julie; Goslin, Kimberly; Simmons, Zachary; Mc Cluskey, Leo; Heiman-Patterson, Terry; Donofrio, Peter; Heitzman, Daragh; Harati, Yadollah; Jackson, Carlayne; Phillips, Lawrence; Weiss, Michael; Nance, Christopher; Sultan, Shumaila; Barkhaus, Paul
ISI:000488128900016
ISSN: 2167-8421
CID: 5874392
Value of gated-SPECT MPI for ischemia-guided PCI of non-culprit vessels in STEMI patients with multivessel disease after primary PCI
Phillips, Lawrence M; Vitola, João V; Shaw, Leslee J; Giubbini, Raffaele; Karthikeyan, Ganesan; Alexanderson, Erick; Dondi, Maurizio; Paez, Diana; Peix, Amalia
There remains a clinical question of which patients benefit from revascularization of non-culprit coronary artery stenosis in the setting of acute ST-segment elevation myocardial infraction (STEMI). This is a large population of patients with prior studies showing 40 to 70% of patients with STEMI having non-culprit stenosis. This article reviews the current state of the literature evaluating outcomes of those previously randomized to revascularization of non-culprit stenosis around the time of the STEMI. We propose a new study design to utilize gated-SPECT in the decision process by using an ischemic burden of > 5% as a cut-off for revascularization vs. complete revascularization without ischemia assessment.
PMID: 30069820
ISSN: 1532-6551
CID: 3217522
Evolving, innovating, and revolutionary changes in cardiovascular imaging: We've only just begun!
Shaw, Leslee J; Hachamovitch, Rory; Min, James K; Di Carli, Marcelo; Mieres, Jennifer H; Phillips, Lawrence; Blankstein, Ron; Einstein, Andrew; Taqueti, Viviany R; Hendel, Robert; Berman, Daniel S
In this review, we highlight the need for innovation and creativity to reinvent the field of nuclear cardiology. Revolutionary ideas brought forth today are needed to create greater value in patient care and highlight the need for more contemporary evidence supporting the use of nuclear cardiology practices. We put forth discussions on the need for disruptive innovation in imaging-guided care that places the imager as a central force in care coordination. Value-based nuclear cardiology is defined as care that is both efficient and effective. Novel testing strategies that defer testing in lower risk patients are examples of the kind of innovation needed in today's healthcare environment. A major focus of current research is the evolution of the importance of ischemia and the prognostic significance of non-obstructive atherosclerotic plaque and coronary microvascular dysfunction. Embracing novel paradigms, such as this, can aid in the development of optimal strategies for coronary disease management. We hope that our article will spurn the field toward greater innovation and focus on transformative imaging leading the way for new generations of novel cardiovascular care.
PMID: 29468466
ISSN: 1532-6551
CID: 2963812