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Initial Outcomes of Symmetrically Flared Covered Nitinol Stents for Esophageal Pathologies

Yaffee, David W; Solomon, Brian; Xia, Yu; Grossi, Eugene A; Zervos, Michael D; Bizekis, Costas S
BACKGROUND:: A recently available, low profile, fully covered metal stent with symmetrical flares (FCMSF) may offer improved resistance to migration in esophageal disease. MATERIALS AND METHODS:: A retrospective review of 58 esophageal FCMSF placed in 46 consecutive patients was performed. Pathologies included stricture and leak of benign and malignant etiology. RESULTS:: Sixteen of 58 stents (28%) were placed urgently/emergently. All patients had successful stent deployment with 0% stent-related hospital mortality. Postoperative morbidity occurred in 15 of the 58 (26%) stents and included stent migration, atrial fibrillation, pneumonia, pneumothorax, urinary retention, hemodynamic instability, and chronic obstructive pulmonary disease exacerbation. In patients with stricture (n=29), mean dysphagia scores were reduced from 3.1+/-0.6 preoperatively to 1.1+/-0.8 postoperatively (P<0.001). For leak, stent therapy (+/-drainage) avoided formal esophageal operation in 95% (21/22). Four stents (6.9%) were removed for stent migration, 2 of which migrated after adjuvant chemoradiation. Adjuvant chemoradiation therapy was an independent risk factor for stent migration (odds ratio=1.6; P=0.02) by multivariable regression analysis. The mean duration of stent therapy was 65+/-62 days for stricture (27/34 remain in situ) and 57+/-57 days for leak (10/22 remain in situ). The median hospital length of stay was 2 days. CONCLUSIONS:: FCMSF provide a safe and effective therapy for both benign and malignant esophageal dysphagia and leaks. The symmetrical property may contribute to the overall low observed migration rate while still allowing for simple and safe stent retrieval.
PMID: 25654183
ISSN: 1530-4515
CID: 1456712

A Novel Case Of EBUS Diagnosis Of Bronchogenic Cyst Causing A Correctible Restrictive Ventilatory Defect [Meeting Abstract]

Adams, Alexandra McGann; Rajmane, Ravindra C; Zervos, Micahel; Suh, James; Rajmane, Oojwala
ORIGINAL:0008996
ISSN: 1073-449x
CID: 1019122

CUMALATIVE BIOMARKER MODEL PREDICTS 3-YEAR RECURRENCE IN RESECTED STAGE I ADENOCARCINOMA OF THE LUNG [Meeting Abstract]

Donington, Jessica; Hirsch, Nathalie; Levine, Joseph; Harrington, Ryan; Crawford, Bernard; Zervos, Micheal; Bizekis, Costas; Pass, Harvey
ISI:000339624902138
ISSN: 1556-1380
CID: 1317582

SEX-BASED DIFFERERNCES IN MORBIDITY AND MORTALITY ASSOCIATED WITH NON-SMALL CELL LUNG CANCER RESECTIONS [Meeting Abstract]

Pendleton, Audrey; Pass, Harvey; Gonzalez, Gerardo; Goldberg, Judith; Harrington, Ryan; Crawford, Bernard; Zervos, Micheal; Bizekis, Costas; Donington, Jessica
ISI:000339624905200
ISSN: 1556-1380
CID: 1317622

Initial outcomes of symmetrically flared covered nitinol stents for esophageal pathologies [Meeting Abstract]

Bizekis, C; Yaffee, D W; Solomon, B; Xia, Y; Pass, H I; Grossi, E A; Zervos, M
Background: Covered stents have become part of the armamentarium for treating various esophageal pathologies. A recently available, low profile, fully covered metal stent with symmetrical flares (FCMSF) may offer improved deployment and resistance to migration. Methods: A retrospective review of 58 esophageal FCMSF placed in 47 consecutive patients by a single thoracic surgeon between March 2010 and February 2012 was performed. Pathologies included benign and malignant stricture and leak. Stents were placed endoscopically under general anesthesia using a 6 mm deployment system; bidirectional maneuverability was possible. Dysphagia score (0-4) was prospectively recorded. Leak treatment was assessed with postoperative esophagrams. Results: Mean age was 62.0 years. Sixteen of 58 stents (28%) were placed urgently/emergently. All patients had successful stent deployment with 0% stent-related hospital morbidity/mortality. Overall post-operative morbidity occurred following 12/58 stents, including arrhythmia, pneumonia, pneumothorax, urinary retention, hemodynamic instability, and COPD exacerbation. In patients with stricture (n = 29), mean dysphagia scores were reduced from 3.0 preoperatively to 1.2 post-operatively (p < 0.001). for leak, stent therapy (+/- drainage) avoided formal esophageal operation in 94% (17/18). Fifteen stents were removed during follow-up, 4 after migration. Mean overall survival was 2.3 +/- 2.6 months for stricture (21/35 remain alive) and 8.7 +/- 9.6 months for leak (16/18 remain alive). Mean duration of stent therapy was 4.9 +/- 4.8 months for stricture (29/35 remain in situ) and 3.5 +/- 3.2 months for leak (10/20 remain in situ). Mean hospital stay was 3.9 +/- 7.0 days. Discussion: FCMSF are an effective therapy for both esophageal strictures and leaks. The symmetrical covered flares likely contribute to the low observed migration rate
EMBASE:70949717
ISSN: 1120-8694
CID: 209742

Case report: separation from cardiopulmonary bypass with a rigid bronchoscope airway after hemoptysis and bronchial impaction with clot

Neuburger, Peter J; Galloway, Aubrey C; Zervos, Michael D; Kanchuger, Marc S
Hemoptysis after cardiopulmonary bypass (CPB) occasionally occurs, and has varying clinical significance based upon amount of bleeding. Hemoptysis resulting in a clot and airway obstruction is an extremely rare event found almost exclusively in the intensive care unit. We describe a unique case of hemoptysis resulting in bronchial impaction from a clot requiring an emergent return to CPB during valve replacement surgery. We used a rigid bronchoscope, without an endotracheal tube, to facilitate airway patency in a patient with diffuse airway bleeding after bronchial disimpaction to separate from CPB
PMID: 22034489
ISSN: 1526-7598
CID: 147685

Bronchoscopy in the diagnosis and evaluation of lung cancer

Chapter by: Sutedja, TG; Santo, TJ; Zervos, M; Herth, FJF
in: Principles and Practice of Lung Cancer: The Official Reference Text of the International Association for the Study of Lung Cancer (IASLC) by
pp. 417-424
ISBN: 9781451152968
CID: 2171122

Endoscopic ablational therapies and stenting

Chapter by: Zervos, M; Bizekis, C
in: Principles and Practice of Lung Cancer: The Official Reference Text of the International Association for the Study of Lung Cancer (IASLC) by
pp. 891-900
ISBN: 9781451152968
CID: 2171132

Bronchoscopic techniques including endobronchial ultrasound

Chapter by: Levin, J; Bizekis, C; Zervos, M
in: Cardiothoracic Surgery Review by
pp. 929-932
ISBN: 9781451154153
CID: 2229012

Simulating video-assisted thoracoscopic lobectomy: A virtual reality cognitive task simulation

Solomon, Brian; Bizekis, Costas; Dellis, Sophia L; Donington, Jessica S; Oliker, Aaron; Balsam, Leora B; Zervos, Michael; Galloway, Aubrey C; Pass, Harvey; Grossi, Eugene A
OBJECTIVE: Current video-assisted thoracoscopic surgery training models rely on animals or mannequins to teach procedural skills. These approaches lack inherent teaching/testing capability and are limited by cost, anatomic variations, and single use. In response, we hypothesized that video-assisted thoracoscopic surgery right upper lobe resection could be simulated in a virtual reality environment with commercial software. METHODS: An anatomy explorer (Maya [Autodesk Inc, San Rafael, Calif] models of the chest and hilar structures) and simulation engine were adapted. Design goals included freedom of port placement, incorporation of well-known anatomic variants, teaching and testing modes, haptic feedback for the dissection, ability to perform the anatomic divisions, and a portable platform. RESULTS: Preexisting commercial models did not provide sufficient surgical detail, and extensive modeling modifications were required. Video-assisted thoracoscopic surgery right upper lobe resection simulation is initiated with a random vein and artery variation. The trainee proceeds in a teaching or testing mode. A knowledge database currently includes 13 anatomic identifications and 20 high-yield lung cancer learning points. The 'patient' is presented in the left lateral decubitus position. After initial camera port placement, the endoscopic view is displayed and the thoracoscope is manipulated via the haptic device. The thoracoscope port can be relocated; additional ports are placed using an external 'operating room' view. Unrestricted endoscopic exploration of the thorax is allowed. An endo-dissector tool allows for hilar dissection, and a virtual stapling device divides structures. The trainee's performance is reported. CONCLUSIONS: A virtual reality cognitive task simulation can overcome the deficiencies of existing training models. Performance scoring is being validated as we assess this simulator for cognitive and technical surgical education
PMID: 21168026
ISSN: 1097-685x
CID: 116215