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Mood Disorders in Systemic Lupus Erythematousus (SLE): Results from an International, Inception Cohort Study. [Meeting Abstract]
Hanly, John G; Su, Li; Urowitz, Murray; Romero-Diaz, Juanita; Gordon, Caroline; Bae, Sang-Cheol; Bernatsky, Sasha R; Clarke, Ann E; Wallace, Daniel J; Merrill, Joan T; Isenberg, David A; Rahman, Anisur; Ginzler, Ellen M; Fortin, Paul; Gladman, Dafna D; Sanchez-Guerrero, Jorge; Petri, Michelle A; Bruce, Ian; Dooley, Mary Anne; Ramsey-Goldman, Rosalind; Aranow, Cynthia; Alarcon, Graciela S; Fessler, Barri J; Steinsson, Kristjan; Nived, Ola; Sturfelt, Gunnar K; Manzi, Susan; Khamashta, Munther A; van Vollenhoven, Ronald F; Zoma, Asad; Ramos-Casals, Manuel; Ruiz-Irastorza, Guillermo; Lim, SSam; Stoll, Thomas; Inanc, Murat; Kalunian, Kenneth C; Kamen, Diane L; Maddison, Peter; Peschken, Christine A; Jacobsen, Soren; Askanase, Anca; Buyon, Jill P; Theriault, Chris; Thompson, Kara; Farewell, Vernon; Systemic Lupus
ISI:000344384905323
ISSN: 2326-5205
CID: 1443382
Antimalarials Regulate TLR7/8 Mediated Macrophage Activation Via Epigenetic Modification at the TNF alpha Promoter. [Meeting Abstract]
Markham, Androo J; Halushka, Mark; Guiducci, Cristiana; Clancy, Robert M; Buyon, Jill P
ISI:000344384901415
ISSN: 2326-5205
CID: 1443972
Modulation of Natural IgM-Autoantibodies to Oxidative Stress-Related Neo-Epitopes on Apoptotic Cells in Newborns of Mothers with Anti-Ro Autoimmunity [Meeting Abstract]
Groenwall, Caroline; Clancy, Robert M; Getu, Lelise; Siegel, Don L; Reed, Joanne; Buyon, Jill P; Silverman, Gregg J
ISI:000344384902432
ISSN: 2326-5205
CID: 1444002
Elevated Regulatory Mediators and Interferon Gamma Associated Responses, but Not Interferon Alpha, BLyS or IP-10, Accompany High-Titer Anti-Ro Autoantibodies in Asymptomatic Mothers of Children with Neonatal Lupus. [Meeting Abstract]
Izmirly, Peter M; Clancy, Robert M; Munroe, Melissa; Rasmussen, Sara; Saxena, Amit; Scher, Jose U; Thanou, Aikaterini; Kamp, Stan; Merrill, Joan T; Buyon, Jill P; James, Judith
ISI:000344384903229
ISSN: 2326-5205
CID: 1444042
Cell Bound Complement Activation Products Have Higher Sensitivity Than Serum C3 and C4 Levels in Systemic Lupus Erythematosus. [Meeting Abstract]
Ramsey-Goldman, Rosalind; Furie, Richard; Putterman, Chaim; Askanase, Anka; Buyon, Jill P; Kalunian, Kenneth; Chatham, WWinn; Massarotti, E; Kirou, Kyriakos A; Weinstein, A; Chitkara, Puja; Manzi, Susan; Ahearn, Joe; Wolover, Leilani; Conklin, John; O'Malley, Tyler; Ibarra, Claudia; Barken, Derren; Dervieux, Thierry
ISI:000344384904074
ISSN: 2326-5205
CID: 1444092
Cell Bound Complement Activation Products and Their Relationship to Disease Activity and Quality of Life Measures in Systemic Lupus Erythematosus [Meeting Abstract]
Furie, Richard; Buyon, Jill P; Ramsey-Goldman, R; Putterman, Chaim; Kalunian, Kenneth; O'Malley, Tyler; Conklin, John; Barken, Derren; Dervieux, Thierry
ISI:000344384903255
ISSN: 2326-5205
CID: 1444052
Association Between Carrying at Least One Apolipoprotein1 Variant Allele and Hypertension in Lupus Patients with Normal Renal Function [Meeting Abstract]
Blazer, Ashira; Belmont, HMichael; Clancy, Robert; Izmirly, Peter M; Buyon, Jill P
ISI:000344384903259
ISSN: 2326-5205
CID: 1747252
Relation of carotid plaque with natural IgM antibodies in patients with systemic lupus erythematosus
Gronwall, Caroline; Reynolds, Harmony; Kim, June K; Buyon, Jill; Goldberg, Judith D; Clancy, Robert M; Silverman, Gregg J
Noninvasive carotid measurements have proven value in the estimation of future cardiovascular (CV) outcomes in systemic lupus erythematosus (SLE). Natural IgM-antibodies to phosphorylcholine (PC) epitopes can enhance apoptotic-cell clearance and induce anti-inflammatory pathways. Herein, we show that subclinical CV disease, as detected by carotid ultrasound, in a cross-sectional SLE cohort was associated with lower levels of IgM anti-PC, as well as lower levels of the ratio of IgM anti-PC/total IgM, compared to patients without plaque (p=0.004 and p=0.02, respectively). The IgM anti-PC/total IgM association remained significant after adjusting for age, cholesterol and hypertension. Adiponectin and sE-selectin were significantly elevated in patients with plaque, and statistical models showed that combining adiponectin, sE-selectin and IgM anti-PC/total IgM was better for predicting plaque than either test alone. These results support the hypothesis that IgM-natural autoantibodies may inhibit atherogenesis, and confirm the utility of IgM anti-PC levels as a biomarker for subclinical CV disease.
PMCID:4068957
PMID: 24704464
ISSN: 1521-6616
CID: 960172
CORRELATION OF CAROTID INTIMAL PLAQUE IN SLE WITH NON-TRADITIONAL SERUM BIOMARKERS [Meeting Abstract]
Groenwall, C; Reynolds, HR; Buyon, J; Kim, J; Goldberg, JD; Silverman, GJ; Clancy, RM
ISI:000346919803214
ISSN: 1468-2060
CID: 1599012
Reply [Letter]
Petri, Michelle A; van Vollenhoven, Ronald F; Buyon, Jill; Levy, Roger A; Navarra, Sandra V; Cervera, Ricard; Zhong, Z John; Freimuth, William W
PMID: 24504823
ISSN: 2326-5205
CID: 845742