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Isolation of mouse THP gene promoter and demonstration of its kidney-specific activity in transgenic mice

Zhu, Xinhua; Cheng, Jin; Gao, Jing; Lepor, Herbert; Zhang, Zhong-Ting; Pak, Joanne; Wu, Xue-Ru
Tamm-Horsfall protein (THP), the most abundant urinary protein synthesized by the kidney epithelial cells, is believed to play important and diverse roles in the urinary system, including renal water balance, immunosuppression, urinary stone formation, and inhibition of bacterial adhesion. In the present study, we describe the isolation of a 9.3-kb, 5'-region of the mouse THP gene and show the highly conserved nature of its proximal 589-bp, 5'-flanking sequence with that in rats, cattle, and humans. We also demonstrate using the transgenic mouse approach that a 3.0-kb, proximal 5'-flanking sequence is sufficient to drive the kidney-specific expression of a heterologous reporter gene. Within the kidney, transgene expression was confined to the renal tubules that endogenously expressed the THP protein, which suggests specific transgene activity in the thick ascending limb of the loop of Henle and early distal convoluted tubules. Our results establish the kidney- and nephron-segment-specific expression of the mouse THP gene. The availability of the mouse THP gene promoter that functions in vivo should facilitate additional studies of the molecular mechanisms of kidney-specific gene regulation and should provide new molecular tools for better understanding renal physiology and disease through nephron-specific gene targeting
PMID: 11880321
ISSN: 1931-857x
CID: 39700

Surgical, Pharmacological, and Technological Advances in Adult and Pediatric Urology - State of the Art: Highlights of the 7th Annual NYU Department of Urology Postgraduate Course December 7-9, 2000, New York, NY

Lepor, Herbert
PMCID:1475965
PMID: 16985649
ISSN: 1523-6161
CID: 115347

Selecting treatment for high-risk, localized prostate cancer: the case for radical prostatectomy

Lepor, Herbert
The most common treatment options for men with clinically localized prostate cancer include radical prostatectomy and radiation therapy. The choice between these options is often controversial, and selecting the optimal treatment poses a great challenge for patients and physicians. Factors important to the decision include age and life expectancy of the patient, the natural history of the prostate cancer, how curable the disease is, and the morbidity of treatment. Use of these criteria to select treatment for a healthy, 70-year-old man presenting with a nonpalpable tumor, stage T1c disease, serum prostate-specific antigen of 12 ng/mL, and an adenocarcinoma with a Gleason score of 8 that is present in 2 of 12 biopsy cores would lead to the choice of radical prostatectomy over radiation therapy. Data show that such a patient has a life expectancy of more than 12.3 years if the prostate cancer can be cured and a high probability of dying from the disease if it is not cured. Data further show that radical prostatectomy in such a patient would confer a survival advantage over radiation therapy without resulting in greater complications or reduction in quality of life
PMCID:1475986
PMID: 16985670
ISSN: 1523-6161
CID: 115346

Assessing quality of life following radiotherapy

Lepor, Herbert
PMCID:1475984
PMID: 16985674
ISSN: 1523-6161
CID: 115345

Complexed PSA for early detection of prostate cancer in men with serum PSA levels of 2-4 ng/mL [Meeting Abstract]

Bartsch, G; Cheli, CD; Horninger, W; Babaian, RJ; Fritsche, HA; Lepor, H; Taneja, S; Childs, S; Stamey, TA; Sokoll, L; Chan, D; Brawer, MK; Partin, AW
ISI:000184566700839
ISSN: 0022-5347
CID: 1871942

Complexed PSA as a surgical staging tool: Results of a multicenter prospective evaluation [Meeting Abstract]

Taneja, SS; Hsu, E; Lepor, H; Walden, P; Cheli, CD; Bartsch, G; Horninger, W; Babaian, R; Childs, S; Stamey, T; Sokoll, L; Chan, D; Brawer, MK; Partin, A
ISI:000184566700908
ISSN: 0022-5347
CID: 1871952

Decision tree algorithms for prostate cancer detection: Complexed PSA and other significant predictors using CHAID analysis [Meeting Abstract]

Childs, SJ; Lugg, J; Thiel, R; Cheli, C; Bartsch, G; Horninger, W; Babaian, R; Fritsche, H; Lepor, H; Taneja, S; Chan, D; Sokoll, L; Partin, A; Stamey, T; Brawer, M
ISI:000184566701312
ISSN: 0022-5347
CID: 1871962

Prospective application of PSA velocity as a sole selection criteria for radiation therapy in patients with biochemical relapse following radical prostatectomy [Meeting Abstract]

Patel, R; Lepor, H; Taneja, SS
ISI:000184566701385
ISSN: 0022-5347
CID: 1871972

The use of laterally directed prostate needle biopsies in the prediction of prostate cancer pathologic stage [Meeting Abstract]

Hsu, EI; Lefkowitz, G; Lepor, H; Taneja, SS
ISI:000184566700928
ISSN: 0022-5347
CID: 1872392

Accuracy of Prostascint and Prostascint-MRI fusion in the prediction of durable response to radiation therapy for biochemical relapse after radical prostatectomy [Meeting Abstract]

Padmanabhan, P; Schettino, CJ; Kramer, E; Patel, R; Lepor, H; Taneja, SS
ISI:000184566701408
ISSN: 0022-5347
CID: 1872402