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Amended Safety Assessment of Mentha piperita (Peppermint)-Derived Ingredients as Used in Cosmetics

Johnson, Wilbur; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of M piperita (peppermint)-derived ingredients. The Panel reviewed data relevant to the safety of these ingredients. Because final product formulations may contain multiple botanicals, each containing the same constituent(s) of concern, formulators are advised to be aware of these constituents and avoid reaching levels that may be hazardous to consumers. Industry should continue to use good manufacturing practices to limit impurities that could be present in botanical ingredients. The Panel concluded that M piperita (Peppermint) Oil, Extract, Leaf, and leaf-derived ingredients are safe in cosmetics in the present practices of use and concentration when formulated to be non-sensitizing, and that the available data are insufficient for determining that M piperita (Peppermint) Flower/Leaf/Stem Extract, M piperita (Peppermint) Flower/Leaf/Stem Water, and M piperita (Peppermint) Meristem Cell Culture are safe under the intended conditions of use in cosmetic formulations.
PMID: 37800357
ISSN: 1092-874x
CID: 5643352

Methacrylate Ester Monomers

Johnson, Wilbur; Bergfeld, Wilma F; Belsito, Donald V; Cohen, David E; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Peterson, Lisa A; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 2005, along with updated information regarding product types and concentrations of use, and confirmed that these 22 methacrylate ester monomers are safe as used in nail enhancement products in the practices of use and concentration as described in this report, when skin contact is avoided.
PMID: 37794531
ISSN: 1092-874x
CID: 5643342

Peanut Glycerides

Raj, Preethi S; Bergfeld, Wilma F; Belsito, Donald V; Cohen, David E; Klaassen, Curtis D; Rettie, Allan E; Ross, David; Slaga, Thomas J; Snyder, Paul W; Tilton, Susan; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed updated information that has become available since their original assessment from 2001, along with updated information regarding product types, and frequency and concentrations of use, and reaffirmed their original conclusion that Peanut Glycerides is safe as a cosmetic ingredient in the practices of use and concentration as described in this report.
PMID: 37784241
ISSN: 1092-874x
CID: 5643332

Imidazolidinyl Urea

Burnett, Christina; Bergfeld, Wilma F; Belsito, Donald V; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed updated information that has become available since their original assessment from 1980, along with updated information regarding product types, and frequency and concentrations of use, and reaffirmed their original conclusion that Imidazolidinyl Urea is safe as a cosmetic ingredient in the practices of use and concentration as described in this report.
PMID: 37776363
ISSN: 1092-874x
CID: 5643322

Acetyl Trialkyl Citrates

Johnson, Wilbur; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 2002, along with updated information regarding product types and concentrations of use, and confirmed that Acetyl Triethyl Citrate, Acetyl Tributyl Citrate, Acetyl Triethylhexyl Citrate, and Acetyl Trihexyl Citrate are safe as cosmetic ingredients in the practices of use and concentration as described in this report.
PMID: 37776193
ISSN: 1092-874x
CID: 5643312

Hexamidine and Hexamidine Diisethionate

Cherian, Priya; Bergfeld, Wilma F; Belsito, Donald V; Cohen, David E; Klaassen, Curtis D; Liebler, Daniel C; Rettie, Allan E; Ross, David; Slaga, Thomas J; Snyder, Paul W; Tilton, Susan; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 2007, along with updated information regarding product types and concentrations of use, and confirmed that Hexamidine and Hexamidine Diisethionate are safe as cosmetic ingredients in the practices of use and concentration as described in this report if used at concentrations less than or equal to .10%.
PMID: 37776172
ISSN: 1092-874x
CID: 5643302

Quaternium-18 and Quaternium-18 Bentonite

Cherian, Priya; Bergfeld, Wilma F; Belsito, Donald V; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Peterson, Lisa A; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1982, along with updated information regarding product types and concentrations of use, and confirmed that Quaternium-18 and Quaternium-18 Bentonite are safe as cosmetic ingredients in the practices of use and concentration as described in this report.
PMID: 37772402
ISSN: 1092-874x
CID: 5643232

EDTA and Salts

Cherian, Priya; Bergfeld, Wilma F; Belsito, Donald V; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1998, along with updated information regarding product types and concentrations of use and confirmed that EDTA and certain salts are safe as cosmetic ingredients in the practices of use and concentration as described in this report.
PMID: 37772606
ISSN: 1092-874x
CID: 5643242

Prunus Amygdalus Dulcis (Sweet Almond) Seed Meal

Burnett, Christina L; Bergfeld, Wilma F; Belsito, Donald V; Cohen, David E; Klaassen, Curtis D; Rettie, Allan E; Ross, David; Slaga, Thomas J; Snyder, Paul W; Tilton, Susan; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed updated information that has become available since their original assessment from 1983, along with updated information regarding product types, and frequency and concentrations of use, and reaffirmed their original conclusion that Prunus Amygdalus Dulcis (Sweet Almond) Seed Meal is safe for topical application to humans in the practices of use and concentration as described in this report.
PMID: 37773611
ISSN: 1092-874x
CID: 5643252

Sodium Naphthalenesulfonate and Sodium Polynaphthalenesulfonate

Burnett, Christina; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Gill, Lillian J; Fiume, Monice; Heldreth, Bart
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 2003, along with updated information regarding product types and concentrations of use, and confirmed that Sodium Naphthalenesulfonate and Sodium Polynaphthalenesulfonate are safe as cosmetic ingredients in the practices of use and concentration as described in this report in formulations intended to be applied to the skin.
PMID: 37770072
ISSN: 1092-874x
CID: 5643222