Faculty Bibliography

PURPOSE OF REVIEW: A variety of techniques have emerged for the optimization of prostate biopsy. In this review, we summarize and critically discuss the most recent developments regarding the optimal systematic biopsy and sampling labeling along with multiparametric MRI and magnetic resonance-targeted biopsies. RECENT FINDINGS: The use of 10-12-core-extended sampling protocols increases cancer detection rates compared with traditional sextant sampling and reduces the likelihood that patients will require a repeat biopsy, ultimately allowing more accurate risk stratification without increasing the likelihood of detecting insignificant cancers. As the number of cores increases above 12 cores, the increase in diagnostic yield becomes marginal. However, the limitations of this technique include undersampling, oversampling, and the need for repetitive biopsy. MRI and magnetic resonance-targeted biopsies have demonstrated superiority over systematic biopsies for the detection of clinically significant disease and representation of disease burden, while deploying fewer cores and may have applications in men undergoing initial or repeat biopsy and those with low-risk cancer on or considering active surveillance. SUMMARY: A 12-core systematic biopsy that incorporates apical and far-lateral cores in the template distribution allows maximal cancer detection, avoidance of a repeat biopsy while minimizing the detection of insignificant prostate cancers. MRI-guided prostate biopsy has an evolving role in both initial and repeat prostate biopsy strategies, as well as active surveillance, potentially improving sampling efficiency, increasing the detection of clinically significant cancers, and reducing the detection of insignificant cancers.

PURPOSE: To retrospectively compare perceived complexity and Bosniak cyst classification of cystic renal lesions between 1.5T and 3T MRI. METHODS: 33 cystic renal lesions in 26 patients that underwent contrast-enhanced MRI at both 1.5T and 3T within a 12 month span were included. Two radiologists (R1, R2) independently assessed lesions, unaware of field strength, in terms of number of septations, septal thickening, mural thickening, presence of mural nodule, and Bosniak cyst category. Scores were compared between field strengths for each lesion. RESULTS: R1 observed increases in septal number, septal thickening, mural thickening, and presence of mural nodule at 3T in 8, 7, 4, and 2 lesions, and at 1.5T in 3, 3, 2, and 0 lesions, respectively; R2 observed increases in septal number, septal thickening, mural thickening, and presence of mural nodule at 3T in 3, 4, 3, and 0 lesions, and at 1.5T in 2, 0, 0, and 0 lesions, respectively. R1 provided higher Bosniak category at 3T in 9 cases and at 1.5T in 4 cases; R2 provided higher Bosniak category at 3T in 4 cases and at 1.5T in 0 cases. Higher scores at 3T than 1.5T were associated with differences in advised clinical management in 7/9 cases for R1 and 4/4 cases for R2. CONCLUSION: There was an overall tendency for both readers to upgrade cyst complexity and Bosniak cyst category at 3T than 1.5T, which impacted advised management. Thus, we suggest that serial MRI evaluation of cystic renal lesions be performed at constant field strength.