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Orbital aspergillosis in an immunocompromised host [Letter]
Vitale AT; Spaide RF; Warren FA; Moussouris HF; D'Amico RA
PMID: 1598973
ISSN: 0002-9394
CID: 24779
Frosted branch angiitis associated with cytomegalovirus retinitis [Case Report]
Spaide, R F; Vitale, A T; Toth, I R; Oliver, J M
We examined three patients with acquired immunodeficiency syndrome who had frosted branch angiitis associated with small patches of cytomegalovirus retinitis. Each patient had a low CD4-helper T-lymphocyte count and a T-lymphocyte helper-suppressor ratio of less than 0.1. Treatment with intravenous anticytomegalovirus antibiotics caused the vascular sheathing to resolve within two weeks in all three patients, but each patient continued to have a smoldering retinitis. Retinal biopsy in one of the patients demonstrated virions whose morphologic characteristics were consistent with cytomegalovirus on electron microscopy and the identity of which was confirmed by immunohistochemistry. Although frosted branch angiitis in otherwise healthy patients responds to corticosteroids, similar treatment with corticosteroids for frosted branch angiitis associated with cytomegalovirus retinitis in patients with AIDS does not seem to be indicated. Before corticosteroid treatment is started for a patient with the clinical signs and symptoms of frosted branch angiitis, careful medical examination of the patient is necessary
PMID: 1349456
ISSN: 0002-9394
CID: 103536
Posterior scleritis in children [Case Report]
Wald KJ; Spaide R; Patalano VJ; Sugin S; Yannuzzi LA
Posterior scleritis was diagnosed in four adolescent boys. These patients represented a distinct subgroup of patients with posterior scleritis that differed from the adult variant by gender, lack of systemic disease, and absence of the associated ocular findings often seen in the adult variant of the disorder. The four patients had diminished visual acuity, ocular pain, and exudative retinal detachments at initial examination. Fluorescein angiography demonstrated multiple pinpoint leaks at the level of the retinal pigment epithelium in three patients with late-phase patchy staining of a mass-like lesion in one patient. B-scan ultrasonography demonstrated choroidal and scleral thickening with increased acoustic density of the choroid in all patients. Systemic evaluation of these patients disclosed no underlying disease. Clinical signs and symptoms resolved in three of the patients after treatment with low-dose, orally administered corticosteroid or noncorticosteroid anti-inflammatory medication. High systemic doses of corticosteroid in combination with noncorticosteroid anti-inflammatory medication and local corticosteroid therapy was required to induce remission in one patient. All patients recovered good visual acuity
PMID: 1543220
ISSN: 0002-9394
CID: 24623
CHOROIDAL VASCULITIS IN ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY [Meeting Abstract]
SPAIDE, RF; YANNUZZI, LA; SLAKTER, J
A 24-year-old Caucasian female presented with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and associated infiltration round some of the larger choroidal blood vessels. This infiltration dissipated as the patient's clinical condition improved and did not induce any permanent alteration of the overlying retinal pigment epithelium. We suggest that the infiltration round the choroidal vessels was due to a choroidal vasculitis. The finding of choroidal inflammation in this case lends support to the hypothesis that choroidal vasculitis is an underlying pathological process in APMPPE. $$:
ISI:A1992HA92200001
ISSN: 0007-1161
CID: 103677
CHOROIDAL VASCULITIS IN ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY [Meeting Abstract]
SPAIDE, RF; YANNUZZI, LA; SLAKTER, J
A 24-year-old Caucasian female presented with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and associated infiltration round some of the larger choroidal blood vessels. This infiltration dissipated as the patient's clinical condition improved and did not induce any permanent alteration of the overlying retinal pigment epithelium. We suggest that the infiltration round the choroidal vessels was due to a choroidal vasculitis. The finding of choroidal inflammation in this case lends support to the hypothesis that choroidal vasculitis is an underlying pathotogical process in APMPPE. $$:
ISI:A1992HX13100023
ISSN: 0007-1161
CID: 103678
Choroidal vasculitis in acute posterior multifocal placoid pigment epitheliopathy [Case Report]
Spaide, R F; Yannuzzi, L A; Slakter, J
A 24-year-old Caucasian female presented with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and associated infiltration round some of the larger choroidal blood vessels. This infiltration dissipated as the patient's clinical condition improved and did not induce any permanent alteration of the overlying retinal pigment epithelium. We suggest that the infiltration round the choroidal vessels was due to a choroidal vasculitis. The finding of choroidal inflammation in this case lends support to the hypothesis that choroidal vasculitis is an underlying pathological process in APMPPE
PMCID:1042529
PMID: 1793461
ISSN: 0007-1161
CID: 103401
Epstein-Barr virus antibodies in multifocal choroiditis and panuveitis
Spaide, R F; Sugin, S; Yannuzzi, L A; DeRosa, J T
Although it has been reported that patients with multifocal choroiditis and panuveitis have serologic evidence of a chronic or persistent Epstein-Barr virus infection, our patients did not seem to have other stigmata of Epstein-Barr virus infection. To reappraise the serologic evidence of chronic Epstein-Barr virus infection, the Epstein-Barr antibody levels in 11 patients with multifocal choroiditis and panuveitis and 11 sex- and age-matched control patients were measured. Neither the antiviral capsid antigen IgG (P = .15) nor the antinuclear antigen (P = .2) antibody titers of the patients with multifocal choroiditis and panuveitis were significantly different than those of the control patients. Neither the patients with multifocal choroiditis and panuveitis nor the control patients had increased antiviral capsid antigen IgM titers. One patient with multifocal choroiditis and panuveitis and three control patients had positive anti-early antigen antibody titers (P = .59). The results of this study do not support the hypothesis that patients with multifocal choroiditis and panuveitis have serologic evidence of chronic or persistent Epstein-Barr virus infection as a characteristic finding
PMID: 1656755
ISSN: 0002-9394
CID: 103479
Varicella-zoster virus retinitis in patients with the acquired immunodeficiency syndrome [Case Report]
Margolis, T P; Lowder, C Y; Holland, G N; Spaide, R F; Logan, A G; Weissman, S S; Irvine, A R; Josephberg, R; Meisler, D M; O'Donnell, J J
We examined five patients infected with the human immunodeficiency virus who developed a rapidly progressive necrotizing retinitis characterized by early patchy choroidal and deep retinal lesions and late diffuse thickening of the retina. In all but one case, the retinitis began in the posterior pole with little or no clinical evidence of vasculitis. All five patients had relentless progression of disease and were left with atrophic and necrotic retinae, pale optic-nerve heads, and narrowed vasculature. None of the patients developed aqueous or vitreal inflammation or retinal detachment. Clinical and laboratory evidence suggested that varicella-zoster virus was the causal agent in all five cases. First, the onset of retinitis in four cases either succeeded or was coincident with an eruption of dermatomal zoster. Second, varicella-zoster virus was cultured from the two chorioretinal specimens and varicella-zoster virus antigen was detected in the vitreal aspirate from one case. Third, by means of immunocytochemistry, varicella-zoster virus antigen was found in the outer retinae of both enucleation specimens. Fourth, viral capsids with the size and shape of herpesviridae were found in the outer retinae of both enucleation specimens. The clinical features observed in this study are distinct from those described for the acute retinal necrosis syndrome and appear to constitute a new and highly characteristic pattern of varicella-zoster virus-induced disease
PMID: 1651054
ISSN: 0002-9394
CID: 103568
POST-CATARACT SURGERY CYSTOID MACULAR EDEMA [Meeting Abstract]
SPAIDE, RF; YANNUZZI, LA; SISCO, L
ISI:A1991FC76200090
ISSN: 0146-0404
CID: 103679
EPSTEIN-BARR-VIRUS AND MULTIFOCAL CHOROIDITIS [Meeting Abstract]
SUGIN, SL; SPAIDE, RF; YANNUZZI, LA; DEROSA, JT
ISI:A1991FC76200076
ISSN: 0146-0404
CID: 103680