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MRI phenotype in renal cancer: is it clinically relevant?

Campbell, Naomi; Rosenkrantz, Andrew B; Pedrosa, Ivan
Renal cell carcinoma (RCC) is most commonly diagnosed as an incidental finding on cross-sectional imaging and represents a significant clinical challenge. Although most patients have a surgically curable lesion at the time of diagnosis, the variability in the biologic behavior of the different histologic subtypes and tumor grade of RCC, together with the increasing array of management options, creates uncertainty for the optimal clinical approach to individual patients. State-of-the-art magnetic resonance imaging (MRI) provides a comprehensive assessment of renal lesions that includes multiple forms of tissue contrast as well as functional parameters, which in turn provides information that helps to address this dilemma. In this article, we review this evolving and increasingly comprehensive role of MRI in the detection, characterization, perioperative evaluation, and assessment of the treatment response of renal neoplasms. We emphasize the ability of the imaging "phenotype" of renal masses on MRI to help predict the histologic subtype, grade, and clinical behavior of RCC.
PMCID:4484274
PMID: 24690616
ISSN: 0899-3459
CID: 931782

Complex cystic renal masses: Comparison of cyst complexity and Bosniak classification between 1.5T and 3T MRI

Rosenkrantz, Andrew B; Wehrli, Natasha E; Mussi, Thais C; Taneja, Samir S; Triolo, Michael J
PURPOSE: To retrospectively compare perceived complexity and Bosniak cyst classification of cystic renal lesions between 1.5T and 3T MRI. METHODS: 33 cystic renal lesions in 26 patients that underwent contrast-enhanced MRI at both 1.5T and 3T within a 12 month span were included. Two radiologists (R1, R2) independently assessed lesions, unaware of field strength, in terms of number of septations, septal thickening, mural thickening, presence of mural nodule, and Bosniak cyst category. Scores were compared between field strengths for each lesion. RESULTS: R1 observed increases in septal number, septal thickening, mural thickening, and presence of mural nodule at 3T in 8, 7, 4, and 2 lesions, and at 1.5T in 3, 3, 2, and 0 lesions, respectively; R2 observed increases in septal number, septal thickening, mural thickening, and presence of mural nodule at 3T in 3, 4, 3, and 0 lesions, and at 1.5T in 2, 0, 0, and 0 lesions, respectively. R1 provided higher Bosniak category at 3T in 9 cases and at 1.5T in 4 cases; R2 provided higher Bosniak category at 3T in 4 cases and at 1.5T in 0 cases. Higher scores at 3T than 1.5T were associated with differences in advised clinical management in 7/9 cases for R1 and 4/4 cases for R2. CONCLUSION: There was an overall tendency for both readers to upgrade cyst complexity and Bosniak cyst category at 3T than 1.5T, which impacted advised management. Thus, we suggest that serial MRI evaluation of cystic renal lesions be performed at constant field strength.
PMID: 24359883
ISSN: 0720-048x
CID: 763702

Combination of Increased Flip Angle, Radial k-Space Trajectory, and Free Breathing Acquisition for Improved Detection of a Biliary Variant at Living Donor Liver Transplant Evaluation Using Gadoxetic Acid-Enhanced MRCP

Rosenkrantz, Andrew B; Block, Tobias K; Hindman, Nicole; Vega, Emilio; Chandarana, Hersh
Gadoxetic acid-enhanced magnetic resonance cholangiopancreatography (MRCP) was performed for evaluation of living donor liver transplantation. T2-weighted MRCP and hepatobiliary-phase postcontrast MRCP showed an aberrant right posterior bile duct, although the precise variant was uncertain. Optimized hepatobiliary-phase MRCP was obtained using 3 sequence modifications: increased flip angle to improve contrast between the biliary tree and surrounding tissues; radial k-space sampling to minimize motion artifact; and free-breathing acquisition to improve signal-to-noise ratio and, in turn, spatial resolution (resolution of 1.28 x 1.28 x 1.5 mm). The optimized sequence demonstrated that the right posterior bile duct drained into the cystic duct, consistent with type 3C biliary variant, thus modifying surgical planning.
PMID: 24625601
ISSN: 0363-8715
CID: 851902

Impact of size of region-of-interest on differentiation of renal cell carcinoma and renal cysts on multi-phase CT: Preliminary findings

Rosenkrantz, Andrew B; Matza, Brent W; Portnoy, Elie; Melamed, Jonathan; Taneja, Samir S; Wehrli, Natasha E
INTRODUCTION: To assess impact of size of regions-of-interest (ROI) on differentiation of RCC and renal cysts using multi-phase CT, with focus on differentiating papillary RCC (pRCC) and cysts given known hypovascularity of pRCC. METHODS: 99 renal lesions (23 pRCC, 47 clear-cell RCC, 7 chromophobe RCC, 22 cysts) underwent multi-phase CT. Subjective presence of visual enhancement was recorded for each lesion. Whole-lesion (WL) ROIs, and small (
PMID: 24239241
ISSN: 0720-048x
CID: 666882

Is there an association between radiologist turnaround time of emergency department abdominal CT studies and radiologic report quality?

Rosenkrantz, Andrew B; Bonavita, John A; Foran, Mark P; Matza, Brent W; McMenamy, John M
The aim of this study was to assess for an association between radiologists' turnaround time (TAT) and report quality for emergency department (ED) abdominopelvic CT examinations. Reports of 60 consecutive ED abdominopelvic CT studies from five abdominal radiologists (300 total reports) were included. An ED radiologist, abdominal radiologist, and ED physician independently evaluated satisfaction with report content (1-10 scale), satisfaction with report clarity (1-10 scale), and extent to which the report advanced the patient on a previously published clinical spectrum scale (1-5 scale). TAT (time between completion of imaging and completion of the final report) and report quality were compared between radiologists using unpaired t tests; associations between TAT and report quality scores for individual radiologists were assessed using Pearson's correlation coefficients. The five radiologists' mean TAT varied from 35 to 53 min. There were significant differences in report content in half of comparisons between radiologists by observer 1 (p
PMID: 24197655
ISSN: 1070-3004
CID: 666892

Prevalence of pelvic organ prolapse detected at dynamic MRI in women without history of pelvic floor dysfunction: Comparison of two reference lines

Rosenkrantz, A B; Lewis, M T; Yalamanchili, S; Lim, R P; Wong, S; Bennett, G L
AIM: To retrospectively evaluate the prevalence of pelvic organ prolapse as an incidental finding on dynamic magnetic resonance imaging (MRI) using two different references lines. MATERIALS AND METHODS: Sixty women with symptoms unrelated to pelvic floor dysfunction who underwent MRI including a dynamic sagittal true fast imaging with steady-state free precession (TrueFISP) sequence during straining were identified. Two radiologists in consensus used the pubococcygeal line (PCL) and mid-pubic line (MPL) to diagnose and grade prolapse in all three pelvic compartments. RESULTS: Cystocele was absent, mild, moderate, and severe in 88% (53/60), 7% (4/60), 5% (3/60), and 0% (0/60) of patients, respectively, using PCL, versus 78% (47/60), 13% (8/60), 5% (3/60), and 3% (2/60) of patients, respectively, using MPL. Vaginal prolapse was absent, mild, moderate, and severe in 95% (57/60), 5% (3/60), 0% (0/60), and 0% (0/60) of patients, respectively, using PCL, versus 80% (48/60), 17% (10/60), 3% (2/60), and 0% (0/60) of patients, respectively, using MPL. Rectal descent was absent, mild, moderate, and severe in 63% (38/60), 10% (6/60), 23% (14/60), and 3% (2/60) of patients, respectively, using PCL, versus 43% (26/60), 27% (16/60), 27% (16/60), and 3% (2/60) of patients, respectively, using MPL. No enterocele, peritoneocele, or muscular defect was identified. Two percent (1/60) of patients had mild rectocele, 8% (5/60) had abnormal vesico-urethral angle, and 25% (15/60) had abnormal levator plate angle. CONCLUSION: In asymptomatic women, dynamic MRI identified the greatest degrees of prolapse in the posterior compartment. The MPL consistently yielded greater frequency of prolapse than the PCL. Findings of pelvic organ prolapse may be observed in asymptomatic patients and are of uncertain significance, requiring correlation with clinical and physical examination findings.
PMID: 24290773
ISSN: 0009-9260
CID: 740932

Regional Variation in Medicare Imaging Utilization and Expenditures: 2007-2011 Trends and Comparison with Other Health Services

Rosenkrantz, Andrew B
PURPOSE: A 2008 federal report expressed concern regarding substantial regional variation in imaging expenditures. The aims of this study were to evaluate trends in regional variation in Medicare imaging utilization and expenditures from 2007 to 2011 and to compare these trends with regional variation in other health service categories. METHODS: Data were based on CMS's Chronic Condition Data Warehouse and organized on the basis of 306 US health referral regions (HRRs). Imaging costs per beneficiary, standardized for regional differences in reimbursement rates, and imaging utilization per beneficiary were recorded per HRR from 2007 through 2011. Costs and utilization were also recorded for other service categories in 2011. Regional variation was assessed via relative risk (RR; the ratio between the highest and lowest HRRs) and coefficient of variation (CV; the standard deviation divided by the mean among all HRRs). Correlations between imaging and other service categories were assessed using Pearson's correlation coefficient. RESULTS: There was minimal change in regional variation in imaging costs or utilization between 2007 and 2011. Regional variation in imaging costs (RR, 5.70-5.88; CV, 33.0%-33.3%) was considerably greater than variation in imaging utilization (RR, 2.11%-2.25%; CV, 14.2%-14.6%). Imaging costs and utilization showed moderate to strong correlations with those of other service categories (r = 0.572-0.869). In 2011, regional variation in imaging utilization (RR, 2.25; CV, 14.2%) was considerably lower than variation in utilization of other service categories (RR, 2.80-10.78; CV, 20.9%-33.3%). CONCLUSIONS: Regional variation in imaging utilization is considerably lower than both variation in imaging costs and variation in utilization of other major service categories. It is unclear whether variation in imaging utilization provides an optimal individual target for major policy decisions.
PMID: 24075216
ISSN: 1546-1440
CID: 666902

Radiologist, be aware: ten pitfalls that confound the interpretation of multiparametric prostate MRI

Rosenkrantz, Andrew B; Taneja, Samir S
OBJECTIVE. In this article, we describe 10 diagnostic challenges that may confound the interpretation of multiparametric prostate MRI for tumor, grouped into three categories on the basis of our experience: normal anatomic structures that may be misinterpreted as suspicious lesions if their normal appearance is not recognized, benign processes that may mimic tumor, and technical issues relating to acquisition and interpretation of diffusion-weighted imaging that may decrease sensitivity for tumor. Strategies for addressing these challenges are suggested. CONCLUSION. It is important that the radiologist involved in the interpretation of prostate MRI be aware of these pitfalls that will be encountered during routine clinical practice. This awareness can contribute to improved diagnostic performance in MRI interpretation.
PMID: 24370135
ISSN: 0361-803x
CID: 746052

Prostate Imaging Reporting and Data System (PI-RADS): Reflections on Early Experience With a Standardized Interpretation Scheme for Multiparametric Prostate MRI

Westphalen, Antonio C; Rosenkrantz, Andrew B
OBJECTIVE. In this article, we provide our perspective on current multiinstitutional efforts to improve standardization of interpretation and reporting of multiparametric prostate MRI, emphasizing their strengths and limitations based on our experiences, and provide several suggestions for guiding continued initiatives for standardizing multiparametric prostate MRI reporting. CONCLUSION. Significant steps are being taken to facilitate the adoption of prostate MRI by urologists and other physicians in the community. Ultimately, however, prospective multicenter validation studies assessing the various aspects of a diagnostic test will be required.
PMID: 24370136
ISSN: 0361-803x
CID: 746062

RISK OF CANCER ON MRI-TARGETED AND SYSTEMATIC PROSTATE BIOPSY [Meeting Abstract]

Bjurlin, Marc; Wysock, James; Sakar, Saradwata; Venkataraman, Rajesh; Rosenkrantz, Andrew; Taneja, Samir
ISI:000350277901449
ISSN: 1527-3792
CID: 1871552