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Surgical treatment improves clinical and functional outcomes for patients who sustain incomplete bisphosphonate-related femur fractures

Egol, Kenneth A; Park, Ji H; Prensky, Colin; Rosenberg, Zehava S; Peck, Valerie; Tejwani, Nirmal C
OBJECTIVE: : To describe the outcomes for patients treated at a single institution, who sustained incomplete bisphosphonate-induced femoral fractures. DESIGN: : Retrospective review. SETTING: : University-based academic medical center. PATIENTS: : Thirty-one patients with 43 incomplete fractures met the inclusion criteria. INTERVENTION: : Nonoperative management or surgical intervention for fractures with refractory symptoms or progression of fracture lucency on radiographs. MAIN OUTCOME MEASUREMENTS: : Radiographic assessments and the Short Musculoskeletal Functional Assessment to gauge functional status. RESULTS: : The cohort was all women with an average age of 69.2 (range: 46-92) years and had been treated with bisphosphonate therapy for an average of 9.1 (range: 5-20) years. The average healing time for all incomplete fractures was 9.4 (range: 1.5-36) months. Forty-nine percent of the fractures (21 of 43 fractures) were ultimately treated with surgery for impending complete fracture or failure of nonsurgical management. Of the incomplete fractures treated with surgery, 81% became pain free and 100% were radiographically healed at a mean of 7.1 (range: 1.5-12) months. In contrast, of the nonoperatively treated incomplete fractures, only 64% were pain free at latest follow-up, with only 18% of fractures demonstrating radiographic evidence of healing at an average of 11 (range: 6-24) months. Standardized dysfunction index from the Short Musculoskeletal Functional Assessment was better (19.7) in the surgical group than in the nonsurgical group (19.7 vs. 25.7, P = 0.0017). CONCLUSIONS: : A higher percentage of patients treated surgically became asymptomatic and demonstrated radiographic evidence of healing earlier than those treated nonsurgically. Surgical intervention is effective for relief of symptoms when treating incomplete bisphosphonate-related femur fractures, and patients should be counseled to the potential benefits of prophylactic surgery. LEVEL OF EVIDENCE: : Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
PMID: 22986315
ISSN: 0890-5339
CID: 361632

Cortical encroachment after cephalomedullary nailing of the proximal femur: evaluation of a more anatomic radius of curvature

Bazylewicz, Daniel B; Egol, Kenneth A; Koval, Kenneth J
OBJECTIVES: : A unique complication of using full-length intramedullary nails for pertrochanteric and subtrochanteric femur fractures is nail penetration of the anterior cortex at the distal end of the femur because of a mismatch of the anatomic femoral bow with that of currently available cephalomedullary nails (CMNs). This study was performed to determine the rate of distal femoral cortical penetration after stabilization of the proximal femur in a consecutive series of patients using a long CMN with a curvature of 180 cm and to examine the final location of the nails within the femoral canal. DESIGN: : Retrospective chart review. SETTING: : Level 1 trauma center with tertiary care. PATIENTS/PARTICIPANTS: : Between June 2005 and September 2008, 271 consecutive proximal femoral fractures or impending fractures were stabilized using a specially designed CMN [pertrochanteric nail (PTN) system; Biomet, Warsaw, IN]. Fifty-seven fractures were excluded because of inadequate lateral radiographs, leaving 214 nails in 212 patients available for analysis. INTERVENTION: : The proximal femur fractures or impending fractures were stabilized with a full-length CMN with a shaft diameter of 11 mm and a radius of curvature of 180 cm. MAIN OUTCOME MEASUREMENTS: : Nail position was determined from the lateral radiograph, which included the minimal distance from the nail to the anterior cortex of the distal femur and the relative position of the nail within the medullary canal, at a level within 2 cm proximal to the superior pole of the patella. Based on the nail position within the distal femoral canal, the following were calculated: (1) the overall rate of distal femoral anterior cortical penetration, (2) the distribution of nail distances to the anterior cortex, and (3) the proportion of nails lying in each quarter of the space available for the nail. RESULTS: : Four surgeries (1.9%) were performed for pathologic fracture and 22 (10.3%) for impending pathologic fracture. The remaining 188 CMNs were used to stabilize OTA Type 31A1 fractures (52 nails, 24.3%), Type 31A2 fractures (62 nails, 29%), Type 31A3 fractures (15 nails, 6.5%), and Type 32 fractures (59 nails, 27.6%). Of the 214 cases available for radiographic analysis, there was 1 case (0.47%) of distal femoral anterior cortical penetration. Of the remaining 213 CMNs, 40% of nails ended up far anterior, 48% anterior, 10% posterior, and 2% far posterior. Sixteen percent (1/6) were within 3 mm of the anterior cortex and half were within 7 mm. The average distance from nail to the anterior cortex was 8.5 mm. CONCLUSION: : Use of a CMN with a radius of curvature of 180 cm to stabilize the proximal femur resulted in a very low rate of distal femoral anterior cortical penetration. However, most of the intramedullary nails ended up in the anterior half of the space available for the nail with 16% within 3 mm of the anterior cortex. These results highlight the importance of being aware of the complication of anterior cortical impingement and perforation during CMN insertion. LEVEL OF EVIDENCE: : Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
PMID: 23287752
ISSN: 0890-5339
CID: 361652

Results following operative treatment of tibial plateau fractures

Urruela, Adriana M; Davidovitch, Roy; Karia, Raj; Khurana, Sonya; Egol, Kenneth A
A total of 96 displaced tibial plateau fractures in 94 patients (average age, 48 years) were treated with open reduction and internal fixation. At 12 months postoperatively, mean range of knee motion was 126 degrees and 10 (10%) of the patients had required a secondary surgery. Using a binary regression model, no demographic variable such as age, gender, smoking history, diabetes, BMI; or fracture characteristic such as mechanism of injury, initial plateau depression, Schatzker classification was identified that correlated with short-term functional outcome such as a complication, range of motion, healing time, or residual depression. We determined that radiographic fracture reduction was not superior following fractures with less initial displacement, and increased plateau collapse at 12 months postoperatively was not indicative of decreased function. However, an increased postoperative articular step-off was found to be associated with an increased risk of plateau collapse (p < 0.01). Furthermore, at 12 months, 76% of the patients had returned to their preinjury employment and the overall complication rate was 13%.
PMID: 23288754
ISSN: 1538-8506
CID: 438742

Stability of the posteromedial fragment in a tibial plateau fracture

Immerman, Igor; Bechtel, Christopher; Yildirim, Gokce; Heller, Yonah; Walker, Peter S; Egol, Kenneth A
The posteromedial fragment in tibial plateau fractures is considered unstable and requires specific fixation. However, if not loaded by the femur, it may remain stable and not require additional fixation. Our purpose was to determine the size of the posteromedial fragment that would remain unloaded by the femoral-tibial contact area, as a function of fracture line orientation and knee flexion angle. Seven human cadaveric knees with intact capsule and ligaments were mounted in a mechanical rig and flexed from 0 to 30, 90, 105, and 120 degrees of flexion. The fiducial points and articular surfaces were digitized, and 3-dimensional software models of the knees at each flexion angle were created. The femoral-tibial contact areas were determined using the software under high- and low-load conditions. Posteromedial fragments of various sizes and fracture line orientations relative to the posterior femoral condylar axis (PFCA) were modeled, and their locations relative to contact areas were determined. The size of unloaded fragments decreased with increased flexion angle. Fragments occupying 60% of the medial plateau were loaded at all angles, but fragments with 30% of the plateau became loaded at 90 degrees under high load and 120 degrees under low load. Fracture line orientations of 0 to 20 degrees external rotation relative to PFCA allowed for the largest fragments to remain unloaded. The size of posteromedial tibial plateau fracture fragment that remains unloaded by the femur varies with knee flexion angle and fracture line orientation. This may have implications for the management of posteromedial tibial plateau fractures.
PMID: 23288766
ISSN: 1538-8506
CID: 301102

Moral reasoning strategies of orthopaedic surgery residents

Mercuri, John J; Karia, Raj J; Egol, Kenneth A; Zuckerman, Joseph D
BACKGROUND: Little is known about the moral reasoning utilized by orthopaedic surgery residents when resolving moral dilemmas. METHODS: Sixty-three residents in an accredited program took the Defining Issues Test-2, an online examination designed to measure and analyze moral reasoning. Scores approximate how often residents utilize three schemas in their moral reasoning: personal interest, maintaining social norms, and postconventional. Scores were analyzed for differences among years of training, previous literature, and established norms. RESULTS: Approximately 9.5% of residents utilized personal interest heavily in their moral reasoning, 27% utilized maintaining norms, and 63.5% utilized postconventional reasoning. There were no significant differences between years of training. The fourth-year (R4) class recorded the highest utilization of principled reasoning, while the fifth-year (R5) class recorded the lowest. The range of principled reasoning scores narrowed from the first year (R1) to R5. The principled reasoning scores of residents were significantly lower than previously reported scores of professional degree-holders and medical students, and empirically lower than previously reported scores of orthopaedic attendings and medical students. CONCLUSIONS: Residents utilized principled reasoning less frequently than expected for physicians. It remains unclear as to what factors contributed to high utilization of principled reasoning in the R4 class but low utilization in the R5 class. Our cross-sectional data suggest that each year of training homogenizes toward a class-specific utilization of principled reasoning. It remains unclear why residents utilized principled reasoning less than orthopaedic attendings, medical students, and other professional degree-holders.
PMID: 23515996
ISSN: 1535-1386
CID: 248332

The effects of pronator quadratus repair on outcomes after volar plating of distal radius fractures

Hershman, Stuart H; Immerman, Igor; Bechtel, Christopher; Lekic, Nikola; Paksima, Nader; Egol, Kenneth A
OBJECTIVES: : The purpose of this study was to evaluate forearm rotation after volar plating of the distal radius fractures with and without pronator quadratus repair. DESIGN: : This was an institutional review board-approved retrospective review of prospectively collected data. SETTING: : The study was conducted at an Academic Medical Center. PATIENTS: : Over a 5-year period, 606 patients with distal radius fractures (OTA classifications 23-A through 23-C) were enrolled in an institutional review board-approved, prospectively collected, distal radius database. One hundred and seventy-five patients underwent open reduction and internal fixation with volar plating. Of these, 112 patients had complete 1-year follow-up (6 weeks, 3, 6, and 12 months) and were included in this study. INTERVENTION: : Volar plating of the distal radius was performed with pronator quadratus repair (group A), versus volar plating without pronator quadratus repair (group B). Surgeries in group A were performed by a fellowship trained hand surgeon utilizing volar plates from Depuy Orthopedics (Warsaw, IN), whereas the surgeries in group B were performed by a fellowship trained orthopedic trauma surgeon utilizing volar plates from Stryker (Mahwah, NJ). MAIN OUTCOME MEASUREMENTS: : Primary outcomes include forearm range of motion. Secondary outcomes include grip strength, pain levels, functional outcomes (DASH scores), radiographs, and complications. RESULTS: : Baseline and demographic characteristics of the patients were similar between the 2 groups. There was no difference in mean pronation (P = 0.08) at 1 year. Among secondary analyses, radial deviation was significantly different (P = 0.03); however, pain (P = 0.13) and DASH scores (P = 0.14) were not. The only patient that requested plate removal had the pronator repaired (group A). CONCLUSIONS: : We conclude that there is no advantage in repairing the pronator quadratus during volar plating of distal radius fractures. LEVEL OF EVIDENCE: : Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
PMID: 22664580
ISSN: 0890-5339
CID: 250642

Operative treatment of nonunion following distal fibula and medial malleolar ankle fractures

Khurana, Sonya; Karia, Raj; Egol, Kenneth A
BACKGROUND: The purpose of this study was to evaluate the outcomes following operative treatment of nonunited rotational distal fibula and medial malleolar ankle fractures. METHODS: Seventeen patients were identified as having a nonunion of a rotational ankle fracture. All patients were evaluated clinically, radiographically, and functionally with the Short Musculoskeletal Functional Assessment (SMFA) questionnaire. They were divided into lateral and medial malleolus groups and compared with 44 patients following a nonoperative (SE2/3) ankle fracture and 25 patients who underwent operative fixation of their SE4 ankle fracture for functional comparison. RESULTS: Two of the 17 patients were excluded. The patients in the medial malleolar group were notably older than those in the other groups. Nonunions included 12 distal fibulas and 3 medial malleoli. All patients were treated with open reduction with plate and screw fixation or screw fixation alone. Adjunctive grafting was performed in all but 2 cases. The average time to healing was 5.2 months post surgery. At latest follow-up, mean 33.9 months, all nonunions had resolved. Standardized SMFA scores differed notably among the groups in the Bothersome, Emotional, and Mobility categories. There was no difference between lateral malleolar nonunion patients and surgically treated SE4 patients. CONCLUSIONS: Reports of nonunions of fractures of lateral and medial malleoli have been rarely reported. Operative treatment of these nonunions in this study led to reliable bony healing. Patients who underwent surgery for these nonunions ultimately had similar outcomes and range of motion compared with patients who underwent operative treatment for acute ankle fractures. Level of Evidence: Level III, retrospective comparative series.
PMID: 23520294
ISSN: 1071-1007
CID: 255322

Outcomes After Fixation of Proximal Humerus (OTA Type 11) Fractures in the Elderly Patients Using Modern Techniques

Shulman, Brandon S; Ong, Crispin C; Lee, James H; Karia, Raj; Zuckerman, Joseph D; Egol, Kenneth A
PURPOSE: To investigate the effects of age on the clinical, functional, and radiographic outcomes of patients with proximal humerus fractures treated operatively with locking plates. METHODS: Between February 2003 and July 2012, all patients who sustained a proximal humerus fracture who presented to our institution were enrolled into a database. Patients were followed up at 1, 6, 12, 26, and 52 weeks postoperatively with physical examination and radiographs. Validated functional outcomes scores were collected at 6 and 12 months. Complications were recorded as they occurred. Statistical analysis was conducted to assess for functional, physical, or radiographic differences between patients age younger than 65 and patients age 65 or older. RESULTS: Of the 147 consecutive patients treated operatively for a proximal humerus fracture, 115 (78%) patients with an average follow-up of 16 months met the inclusion criteria for this study. The young cohort (patients < 65) included 70 patients with an average age of 53, whereas the elderly cohort (patients >/= 65) included 45 patients with an average age of 73. The older cohort had significantly more women (P = .04), but there was no statistical difference in fracture type between the age groups. There were no differences in the radiographic measures of screw penetration, humeral head height, and neck-shaft angle between the age groups. There were no differences in physical examination scores between the age groups. There were no significant differences in functional outcomes or complication rates between the age groups. CONCLUSION: Treating proximal humerus fractures operatively with locked plates can overcome the challenges of poor bone quality that often occur with increasing age. Age should not play a significant role in the decision-making process for treating proximal humerus fractures that would otherwise be indicated for surgical fixation.
PMCID:3739412
PMID: 23936736
ISSN: 2151-4585
CID: 495062

Comparison of Atypical Femoral Fracture Patients on Long term Bisphosphonates with Controls matched for age and duration of bisphosphonate therapy [Meeting Abstract]

Mehta, Deeksha; Shamsuddin, Nazia; Rosenberg, Zehava S; Vieira, Renata L; Tejwani, Nirmal C; Egol, Kenneth A; Babb, James S; Peck, Valerie
ISI:000332035800229
ISSN: 1523-4681
CID: 2476382

Bilateral disruption of soft tissue extensor mechanism of knee: functional outcome and comparison to unilateral injuries

Monroy, Alexa; Urruela, Adriana; Egol, Kenneth A; Tejwani, Nirmal C
BACKGROUND: Bilateral ruptures of the extensor mechanism are rare. QUESTIONS/PURPOSE: The purpose of this study was to compare the clinical outcomes of operatively treated unilateral and bilateral knee soft tissue extensor mechanism injuries and to identify risk factors for bilateral disruption. METHODS: All patients operatively treated for a knee extensor mechanism injury were entered into a database and prospectively followed. Postoperative protocol was standardized for all patients. Demographic data, baseline characteristics, range of motion, complications, pain, and functional status were assessed. The main patient-reported outcome measures used in this study were the SF-36 Health Survey and the Lysholm Scale. RESULTS: Patients who sustained bilateral injuries were more likely to have one or more systemic medical conditions. There was no statistical difference between the groups with regard to mechanism of injury or body mass index. The average follow-up was 29 months (range 6-60 months). Patient-reported outcomes, in the form of the SF-36 Health Survey and Lysholm scores, were not significantly different between the two groups at final follow-up. Range of motion and quadriceps strength was also similar between the two cohorts. At latest follow-up, 88% of patients with unilateral injuries and 83% of patients with bilateral disruption were able to return to their pre-injury employment. CONCLUSION: Operatively treated bilateral knee extensor mechanism disruptions fare similar to unilateral injuries with regard to ultimate functional outcome. The presence of one of more preexisting medical conditions was identified as a risk factor for bilateral tendinous disruption.
PMCID:3640716
PMID: 24426838
ISSN: 1556-3316
CID: 741272