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Subgroup Analyses Of Baseline Demographics And Efficacy In Patients With Refractory Nontuberculous Mycobacteria (ntm) Lung Infection Treated With Liposomal Amikacin For Inhalation (lai) [Meeting Abstract]
Winthrop, KL; Eagle, G; McGinnis, JP; Micioni, L; Daley, CL; Ruoss, SJ; Addrizzo-Harris, DJ; Flume, PA; Dorgan, DJ; Salathe, M; Brown-Elliott, BA; Wallace, RJ; Griffith, DE; Olivier, KN
ISI:000377582808529
ISSN: 1535-4970
CID: 2161912
Efficacy Of Liposomal Amikacin For Inhalation (lai) In Achieving Nontuberculous Mycobacteria (ntm) Culture Negativity In Patients Whose Lung Infection Is Refractory To Guideline-Based Therapy [Meeting Abstract]
Biller, JA; Eagle, G; McGinnis, JP; Micioni, L; Daley, CL; Winthrop, KL; Ruoss, SJ; Addrizzo-Harris, DJ; Flume, PA; Dorgan, DJ; Salathe, M; Brown-Elliott, BA; Wallace, RJ; Griffith, DE; Olivier, KN
ISI:000377582808530
ISSN: 1535-4970
CID: 2161922
Mycobacterium Abscessus Infection After Surgical Resection Of A Pulmonary Cavity [Meeting Abstract]
Basavaraj, A; Mukherjee, V; Aksamit, TR; Addrizzo-Harris, DJ
ISI:000377582808537
ISSN: 1535-4970
CID: 2161942
Analysis Of Functional Exercise Capacity (via The Six-Minute Walk Test [6mwt]) And Culture Negativity In Patients With Nontuberculous Mycobacteria (ntm) Lung Infection Refractory To Guideline-Based Therapy Treated With Liposomal Amikacin For Inhalation (lai) [Meeting Abstract]
Ruoss, SJ; Eagle, G; McGinnis, JP; Micioni, L; Daley, CL; Winthrop, KL; Addrizzo-Harris, DJ; Flume, PA; Dorgan, DJ; Salathe, M; Griffith, DE; Olivier, KN
ISI:000377582808531
ISSN: 1535-4970
CID: 2161932
Scedosporium - A Master Of Disguise [Meeting Abstract]
Mahmoudi, M; Sternschein, RM; Addrizzo-Harris, DJ
ISI:000377582801259
ISSN: 1535-4970
CID: 2162042
Case Report of a Patient With Treatment-Refractory Nontuberculous Mycobacteria (NTM) Lung Infection Treated With Once Daily (QD) Liposomal Amikacin for Inhalation (LAI) [Meeting Abstract]
Daglian, Dena; Lau, Stephanie; Eagle, Gina; McGinnis, John; Micioni, Liza; Addrizzo-Harris, Doreen
ISI:000366134400158
ISSN: 0012-3692
CID: 1909272
Randomized, double-blind ( [Meeting Abstract]
Olivier, K N; Eagle, G; McGinnis, J P; Micioni, L; Daley, C L; Winthrop, K L; Ruoss, S; Addrizzo-Harris, D J; Flume, P; Dorgan, D; Salathe, M; Brown-, Elliott B A; Wallace, R; Griffith, D E
Objective: NTM-LD management often requires lengthy multidrug antibiotic regimens (MDARs) and can be complicated by drug toxicity and poor prognosis. Efficacy, safety, and tolerability of LAI, a novel amikacin formulation, were evaluated in refractory NTM-LD. Methods: In the 84-day
EMBASE:71951483
ISSN: 1569-1993
CID: 1702782
Successful treatment of ulcerative bronchiolitis in a woman with refractory Mycobacterium intracellulare infection
Egan, John Patrick 3rd; Seides, Benjamin J; Olivier, Kenneth N; Addrizzo-Harris, Doreen
We present a case of a woman with medically refractory ulcerative colitis (UC) who developed severe bronchiectasis, bronchitis, bronchiolitis and Mycobacterium intracellulare (MAC) infection 2 years after total colectomy. Despite being on optimal therapy for her MAC and sterilising multiple consecutive sputum cultures, she remained highly symptomatic, and this led to further investigations that revealed the presence of UC-related airways disease. Addition of immunosuppressive therapy to her antimycobacterial treatment resulted in sustained and complete clinical remission of her disease. To our knowledge, this is the only case published in the literature that describes a case of successful treatment of concomitant UC-related pulmonary disease and symptomatic MAC.
PMCID:4422916
PMID: 25926588
ISSN: 1757-790x
CID: 1568672
Adult Bronchoscopy Training: Current State and Suggestions for the Future: CHEST Expert Panel Report
Ernst, Armin; Wahidi, Momen M; Read, Charles A; Buckley, John D; Addrizzo-Harris, Doreen J; Shah, Pallav L; Herth, Felix J F; de Hoyos Parra, Alberto; Ornelas, Joseph; Yarmus, Lonny; Silvestri, Gerard A
Background / Introduction: The determination of competency of trainees in programs performing bronchoscopy is quite variable. Some programs provide didactic lectures with hands-on supervision; other programs incorporate advanced simulation centers; while others have a checklist approach. Although no single method has been proven best, the variability alone suggests that outcomes are variable. Program directors and certifying bodies need guidance to create standards for training programs. Little well-developed literature on the topic exists. Methodology: To provide credible and trustworthy guidance, rigorous methodology has been applied to create this bronchoscopy consensus training statement. All panelists were vetted and approved by the CHEST Guidelines Oversight Committee. Each topic group drafted questions in a PICO (Population, Intervention, Comparator, Outcome) format. MEDLINE via PubMed and the Cochrane Library were systematically searched. Manual searches also supplemented the searches. All gathered references were screened for consideration based on inclusion criteria and all statements were designated as an "Ungraded Consensus-Based Statement". Results: We suggest that professional societies move from a volume-based certification system to skill acquisition and knowledge-based competency assessment for trainees. Bronchoscopy training programs should incorporate multiple tools including simulation. We suggest that ongoing quality and process improvement systems be introduced and that certifying agencies move from a volume-based certification system to skill acquisition and knowledge-based competency assessment for trainees. We also suggest that assessment of skill maintenance and improvement in practice be evaluated on a regular basis with ongoing quality and process improvement systems after initial skill acquisitions are introduced. Conclusions: The current methods used for bronchoscopy competency with training programs are variable. We suggest that professional societies and certifying agencies move from a volume- based certification system to a standardized skill acquisition and knowledge-based competency assessment for pulmonary and thoracic surgery trainees.
PMCID:4524325
PMID: 25674901
ISSN: 0012-3692
CID: 1461972
Entrustable professional activities and curricular milestones for fellowship training in pulmonary and critical care medicine: executive summary from the Multi-Society Working Group
Fessler, Henry E; Addrizzo-Harris, Doreen; Beck, James M; Buckley, John D; Pastores, Stephen M; Piquette, Craig A; Rowley, James A; Spevetz, Antoinette
Assessment of graduate medical trainee progress via the accomplishment of competency milestones is an important element of the Next Accreditation System of the Accreditation Council for Graduate Medical Education. This article summarizes the findings of a multisociety working group that was tasked with creating the entrustable professional activities and curricular milestones for fellowship training in pulmonary medicine, critical care medicine, and combined programs. Using the Delphi process, experienced medical educators from the American College of Chest Physicians, American Thoracic Society, Society of Critical Care Medicine, and Association of Pulmonary and Critical Care Medicine Program Directors reached consensus on the detailed curricular content and expected skill set of graduates of these programs. These are now available to trainees and program directors for the purposes of curriculum design, review, and trainee assessment.
PMID: 25226119
ISSN: 0090-3493
CID: 1423392