Faculty Bibliography

Objectives. We have described and evaluated the impact of a unique fellowship program designed to train postdoctoral, physician fellows in research at the interface of medicine and public health. Methods. We developed a rigorous curriculum in public health content and research methods and fostered linkages with research mentors and local public health agencies. Didactic training provided the foundation for fellows' mentored research initiatives, which addressed real-world challenges in advancing the health status of vulnerable urban populations. Results. Two multidisciplinary cohorts (6 per cohort) completed this 2-year degree-granting program and engaged in diverse public health research initiatives on topics such as improving pediatric care outcomes through health literacy interventions, reducing hospital readmission rates among urban poor with multiple comorbidities, increasing cancer screening uptake, and broadening the reach of addiction screening and intervention. The majority of fellows (10/12) published their fellowship work and currently have a career focused in public health-related research or practice (9/12). Conclusions. A fellowship training program can prepare physician investigators for research careers that bridge the divide between medicine and public health. (Am J Public Health. Published online ahead of print May 17, 2012: e1-e7. doi:10.2105/AJPH.2011.300486).

Background: Having a usual source of primary care is known to improve health. Currently only two-thirds of ED patients have a usual source of care outside the ED, far short of Healthy People 2020's target of 84%. Prior attempts to link ED patients with primary care have had mixed results. Objectives: To determine if an intervention directly linking low-acuity patients with a primary care clinic at the time of an ED visit could lead to future primary care linkage. Methods: DESIGN: Pseudo-randomized controlled trial. SETTING: Urban safety-net hospital. SUBJECTS: Adults presenting to the ED 1/07-1/08 for select problems a layperson would identify as low-acuity. Patients were excluded if they arrived by EMS, had a PCP outside our hospital, were febrile, or the triage nurse felt they needed ED care. Consecutive patients were enrolled weekday business hours when the primary care clinic was open. Patients were assigned to usual care in the ED if a provider was ready to see them before they had completed the baseline study survey. Otherwise they were offered the intervention if a clinic slot was available. INTERVENTION: Patients agreeing to the intervention were escorted to a primary care clinic in the same hospital building. They were assigned a personal physician and given an overview of clinic services. A patient navigator ensured patients received timely same-day care. Intervention group patients could refuse the intervention and instead remain in the ED for care. Both clinic and ED patients were given follow-up clinic appointments, or a phone number to call for one, as per usual provider practice. ANALYSIS: The main outcome measure was primary care linkage, defined as having one or more primary care clinic visits within a year of the index ED visit for patients with no prior PCP. Results: 1,292 patients were potentially eligible and 853 were enrolled (662 intervention and 191 controls). Groups had similar baseline characteristics. Nearly 75% in both groups had no prior PCP. Using an intention to treat analysis, 50.3% of intervention group patients with no prior PCP achieved successful linkage (95%CI 45.7-54.9%) vs. 36.9% of the control group (95%CI 28.9-45.4%). Conclusion: A point-of-care program offering low-acuity ED patients the opportunity to instead be seen at the hospital's primary care clinic resulted in increased future primary care linkage compared to standard ED referral practices

Background: The ED is a point of frequent contact for medically vulnerable, chronically homeless patients with alcohol use disorders, or chronic public inebriates (CPI). Despite this population's exposure to health and social agencies, its outcomes suffer due, in part, to lack of stable housing and fragmented, 'treat and street' medical care. Objectives: NYU School of Medicine and the Bellevue Hospital Center ED partnered with the Department of Homeless Services (DHS) to implement a multifaceted pilot initiative. This integration of services is hypothesized to improve access to housing and comprehensive medical care resulting in reduced costly ED and inpatient admissions, and homelessness. Engaging the ED as a point of intervention, a cohort of CPIs received needs assessments, enhanced care management, and coordination with DHS outreach. Methods: CPIs were identified primarily through an administrative database search and chart reviews. At the time of this 10-month analysis, 20 of the 56 patients who met inclusion criteria were enrolled. Enrolled (Figure presented) patients had a minimum of 20 ED visits in a 24-month period with at least one visit within 5 months of the pilot commencement in January 2011 and met the DHS standard for chronic homelessness. Preference was given to those with greater visit frequency, co-morbidities, or staff referral. The intervention for enrolled patients included the ongoing implementation of individualized multidisciplinary action plans, case management, and coordination with the housing outreach team upon discharge. Results: Eighteen of the 20 enrolled patients were placed in housing. After first housing placement (mean length, 4.7 months), monthly ED and inpatient use declined 48% and 40%, respectively. ED and inpatient use by the nonenrolled remained stable throughout the study period. Prior to intervention, hospital use had increased over time for the enrolled patients (Figures 1,2). Conclusion: ED-based collaboration amongst medical and social services for a small cohort of CPIs resulted in housing placements and reduced ED and inpatient visits. While promising, the results of this interim pilot data are limited by the non-random sampling method, power, duration, and singular location. Further study is needed to determine the intervention's effect on public health expenditures and patient outcomes

OBJECTIVES: Oximes such as pralidoxime (2-PAM) are essential antidotes for life-threatening organophosphate poisoning. Unfortunately, oximes are expensive, have limited use, and have short shelf lives. As such, maintaining large stockpiles in preparation for terrorist activity is not always possible. We have demonstrated that atropine is stable well beyond its labeled shelf life and that recently expired 2-PAM was clinically efficacious in a series of poisoned patients. Because 2-PAM is often dosed empirically, clinical improvement does not guarantee pharmacological stability. We therefore chose to analyze the chemical stability of expired 2-PAM. METHODS: Samples of lyophylized 2-PAM were maintained according to the manufacturer's recommendations for 20 years beyond the published shelf life. We studied 2-PAM contained in a MARK I autoinjector that was stored properly for 3 years beyond its expiration date. An Agilent LC/MSD 1100 with diode-array detector and an Agilent Sorbax SB-C-18, 4.6 x 150-mm, 5-mum column were used with the following solvent systems: water with 0.01% trifluoroacetic acid and methanol with 0.01% trifluoroacetic acid. Fresh reagent grade 2-PAM was used as a standard. Results were repeated for consistency. RESULTS: Lyophylized 2-PAM was a white powder that was clear and colorless in solution. Liquid chromatography was identical to the standard and resulted in 2 isolated peaks with identical mass spectra, suggesting that they are stereoisomers. The autoinjector discharged a clear, yellowish solution. In addition to the 2 peaks identified for lyophylized 2-PAM, a small third peak was identified with a mass spectra corresponding to the reported N -methyl pyridinium carboxaldehyde degradation product. CONCLUSIONS: When properly stored, lyophylized 2-PAM appears to be chemically stable well beyond its expiration date. Although the relative amount of degradation product found in solubilized (autoinjector) 2-PAM was small, it is unclear whether this may be toxic and therefore is of concern. Further studies performed with lots of drug stored under varied conditions would be required to fully determine the stability of expired 2-PAM.

BACKGROUND: The recent H1N1 influenza A pandemic was marked by multiple reports of illness and hospitalization in children, suggesting that children may have played a major role in the propagation of the virus. A comprehensive detailed analysis of the attack rates among children as compared with their contacts in various settings is of great importance for understanding their unique role in influenza pandemics. METHODOLOGY/PRINCIPAL FINDINGS: We searched MEDLINE (PubMed) and Embase for published studies reporting outbreak investigations with direct measurements of attack rates of the 2009 pandemic H1N1 influenza A among children, and quantified how these compare with those of their contacts. We identified 50 articles suitable for review, which reported school, household, travel and social events. The selected reports and our meta-analysis indicated that children had significantly higher attack rates as compared to adults, and that this phenomenon was observed for both virologically confirmed and clinical cases, in various settings and locations around the world. The review also provided insight into some characteristics of transmission between children and their contacts in the various settings. CONCLUSION/SIGNIFICANCE: The consistently higher attack rates of the 2009 pandemic H1N1 influenza A among children, as compared to adults, as well as the magnitude of the difference is important for understanding the contribution of children to disease burden, for implementation of mitigation strategies directed towards children, as well as more precise mathematical modeling and simulation of future influenza pandemics.

Evidence from Europe suggests establishing out-of-hospital, uncontrolled donation after circulatory determination of death (UDCDD) protocols has potential to substantially increase organ availability. The study objective was to derive an out-of-hospital UDCDD protocol that would be acceptable to New York City (NYC) residents. Participatory action research and the SEED-SCALE process for social change guided protocol development in NYC from July 2007 to September 2010. A coalition of government officials, subject experts and communities necessary to achieve support was formed. Authorized NY State and NYC government officials and their legal representatives collaboratively investigated how the program could be implemented under current law and regulations. Community stakeholders (secular and religious organizations) were engaged in town hall style meetings. Ethnographic data (meeting minutes, field notes, quantitative surveys) were collected and posted in a collaborative internet environment. Data were analyzed using an iterative coding scheme to discern themes, theoretical constructs and a summary narrative to guide protocol development. A clinically appropriate, ethically sound UDCDD protocol for out-of-hospital settings has been derived. This program is likely to be accepted by NYC residents since the protocol was derived through partnership with government officials, subject experts and community participants

Agents of opportunity (AO) in academic medical centers (AMC) are defined as unregulated or lightly regulated substances used for medical research or patient care that can be used as 'dual purpose' substances by terrorists to inflict damage upon populations. Most of these agents are used routinely throughout AMC either during research or for general clinical practice. To date, the lack of careful regulations for AOs creates uncertain security conditions and increased malicious potential. Using a consensus-based approach, we collected information and opinions from staff working in an AMC and 4 AMC-affiliated hospitals concerning identification of AO, AO attributes, and AMC risk and preparedness, focusing on AO security and dissemination mechanisms and likely hospital response. The goal was to develop a risk profile and framework for AO in the institution. Agents of opportunity in 4 classes were identified and an AO profile was developed, comprising 16 attributes denoting information critical to preparedness for AO misuse. Agents of opportunity found in AMC present a unique and vital gap in public health preparedness. Findings of this project may provide a foundation for a discussion and consensus efforts to determine a nationally accepted risk profile framework for AO. This foundation may further lead to the implementation of appropriate regulatory policies to improve public health preparedness. Agents of opportunity modeling of dissemination properties should be developed to better predict AO risk