Faculty Bibliography

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60

Journals of gerontology. Series A. Biological sciences & medical sciences. 2010:65(8):800-8.DOI: 10.1093/gerona/glq078

Aging per se increases the susceptibility to free fatty acid-induced insulin resistance

Einstein, Francine H; Huffman, Derek M; Fishman, Sigal; Jerschow, Elina; Heo, Hye J; Atzmon, Gil; Schechter, Clyde; Barzilai, Nir; Muzumdar, Radhika H
Elevations in systemic free fatty acids (FFA) contribute to insulin resistance. To determine the effects of an acute elevation in FFA on insulin action with aging, we infused saline or intralipid (IL) during a hyperinsulinemic-euglycemic clamp in three groups of rats: young ad libitum-fed (YAL), old ad libitum-fed (OAL), and old on lifelong calorie restriction (OCR). The OCR group was included to distinguish between aging per se and age-related changes in body fat distribution. IL induced marked insulin resistance in both YAL and OCR, but the onset of insulin resistance was approximately two to three times more rapid in OCR as compared with YAL. In response to IL infusion, plasminogen-activating inhibitor-1 (PAI-1) expression was increased in subcutaneous fat from OAL animals. In visceral fat, a marked increase in PAI-1 and interleukin-6 expression was observed in OAL and OCR rats, but not YAL, in response to IL treatment. Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging.
PMCID:2903785
PMID: 20504893
ISSN: 1758-535x
CID: 2624892
American journal of obstetrics & gynecology. 2009:201(6):S131-S131.DOI:

Sonographic suspicion of macrosomia effecting mode of delivery [Meeting Abstract]

Heo, Hye J; Goffman, Dena; Lipkind, Heather; Alkalay, Avishai; Dar, Peer; Bernstein, Peter S; Dayal, Ashlesha K; Einstein, Francine H
ISI:000279559500329
ISSN: 0002-9378
CID: 2635242
American journal of obstetrics & gynecology. 2009:201(6):S97-S97.DOI:

Hexosamine biosynthetic pathway: does it contribute to insulin resistance of pregnancy? [Meeting Abstract]

Heo, Hye; Donepudi, Roopali; Madankumar, Reshmi; Huffman, Derek M; Muzumdar, Radhika; Barzilai, Nir; Einstein, Francine H
ISI:000279559500232
ISSN: 0002-9378
CID: 2635232
Reproductive sciences (Thousand Oaks, Calif.). 2009:16(3):327A-327A.DOI:

Telomere Length in Hematopoietic Stem Cells and Differentiated Lymphocytes of Infants with Intrauterine Growth Restriction [Meeting Abstract]

Heo, Hye J; Atzmon, Gil; Budagov, Temuri; Lo, Lewis W; Muzundar, Radhika H; Barzilai, Nir; Einstein, Francine H
ISI:000263609801353
ISSN: 1933-7191
CID: 2635222
Reproductive sciences (Thousand Oaks, Calif.). 2009:16(3):259A-259A.DOI:

Parity Leads to Metabolic Alterations and Telomere Length Attrition in Rats [Meeting Abstract]

Heo, Hye J; Atzmon, Gil; Budagov, Temuri; Lo, Lewis W; Muzumdar, Radhika H; Barzilai, Nir; Einstein, Francine H
ISI:000263609801124
ISSN: 1933-7191
CID: 2635212
Reproductive sciences (Thousand Oaks, Calif.). 2009:16(3):99A-99A.DOI:

Intrauterine Growth Restriction (IUGR) Induces Regional Changes in DNA Methylation in Human Hematopoietic Stem Cells [Meeting Abstract]

Einstein, Francine H; Thompson, Reid; Heo, Hye J; Montagna, Cristina; Barzilai, Nir; Greally, John M
ISI:000263609800106
ISSN: 1933-7191
CID: 2635202
American journal of obstetrics & gynecology. 2008:199(6):S129-S129.DOI: 10.1016/j.ajog.2008.09.458

PRENATAL SUSPICION OF INTRAUTERINE GROWTH RESTRICTION EFFECTING MODE OF DELIVERY AND NEWBORN OUTCOME [Meeting Abstract]

Heo, Hye; Goffman, Dena; Alkalay, Avishai; Mehta, Shilpi; Bernstein, Peter S; Einstein, Francine; Dayal, Ashlesha K
ISI:000262205700427
ISSN: 0002-9378
CID: 2635152
American journal of obstetrics & gynecology. 2008:199(6):S158-S158.DOI: 10.1016/j.ajog.2008.09.569

HEPATIC AND PERIPHERAL INSULIN RESISTANCE OF PREGNANCY ARE NOT REVERSED IN EARLY POSTPARTUM RATS [Meeting Abstract]

Heo, Hye; Cui, Lingguang; Muzumdar, Radhika H; Huffman, Derek M; Barzilai, Nir; Einstein, Francine
ISI:000262205700535
ISSN: 0002-9378
CID: 2635162
American journal of obstetrics & gynecology. 2008:199(6):S205-S205.DOI: 10.1016/j.ajog.2008.09.748

PHYSIOLOGICAL INSULIN RESISTANCE OF PREGNANCY LEADS TO INCREASED GLUCOSE UPTAKE RAT PUPS [Meeting Abstract]

Einstein, Francine; Heo, Hye; Cui, Lingguang; Huffman, Derek M; Muzumdar, Radhika H; Barzilai, Nir
ISI:000262205700711
ISSN: 0002-9378
CID: 2635182
American journal of obstetrics & gynecology. 2008:199(6):S173-S173.DOI: 10.1016/j.ajog.2008.09.630

ABNORMAL INTRAUTERINE GROWTH INDUCES GLOBAL EPIGENETIC CHANGES IN HUMAN STEM CELLS [Meeting Abstract]

Einstein, Francine; Thompson, Reid F; Heo, Hye; Budagov, Temuri; Atzmon, Gil; Goffman, Dena; Barzilai, Nir; Montagna, Cristina; Greally, John M
ISI:000262205700595
ISSN: 0002-9378
CID: 2635172