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148


Patient Characteristics That Predict the Effect of Laparoscopic Adjustable Gastric Band Weight Loss Surgery on Knee Osteoarthritis Pain [Meeting Abstract]

Chen, Shannon; Bomfim, Fernando; Youn, Heekoung; Ren-Fielding, Christine; Samuels, Jonathan
ISI:000411824102109
ISSN: 2326-5205
CID: 2767142

Combinatorial Peripheral Blood Inflammatory and MRI-Based Biomarkers Predict Radiographic Joint Space Narrowing in Knee OA [Meeting Abstract]

Samuels, Svetlana Krasnokutsky; Zhou, Hua; Attur, Mukundan; Samuels, Jonathan; Chang, Gregory; Bencardino, Jenny; Ma, Sisi; Rybak, Leon; Abramson, Steven B
ISI:000411824105040
ISSN: 2326-5205
CID: 2766802

Comparison of dual-energy CT, ultrasound and surface measurement for assessing tophus dissolution during rapid urate debulking

Modjinou, Dodji V; Krasnokutsky, Svetlana; Gyftopoulos, Soterios; Pike, Virginia C; Karis, Elaine; Keenan, Robert T; Lee, Kristen; Crittenden, Daria B; Samuels, Jonathan; Pillinger, Michael H
Tophaceous gout is painful and impairs quality of life. The optimal modality for assessing tophus resolution in response to urate-lowering treatment remains poorly defined. Using pegloticase as a model system for resolving tophi, we compared multiple imaging and physical diagnostic strategies for assessing tophus resolution. A 32-year-old subject with chronic refractory tophaceous gout was enrolled and received 6 months of pegloticase treatment. Measurements of tophi using vernier calipers (monthly), photographs and musculoskeletal ultrasound (MSK-US; every 3 months), and dual-energy CT (DECT) were compared. Pegloticase persistently lowered the patient's sUA to <0.5 mg/dl. After 6 months, caliper measurements revealed 73, 60, and 61% reductions of three index tophi, while MSK-US revealed 47, 65, and 48% reductions. In contrast, DECT revealed 100% resolution of monosodium urate deposition in all three index tophi, and resolution or improvement of all other tophi identified. On caliper and MSK-US measurement, index tophus size fluctuated, with some lesions enlarging before ultimately contracting. Correlation between assessment modalities during tophus resolution may be poor. DECT identifies urate deposits invisible to physical exam and reveals that some urate deposits completely resolve even as their physically/sonographically measurable lesions persist. Recognition of urate resorption during the urate-lowering process may be confounded by fluctuating lesion volumes during initial tophus breakdown. While DECT was superior for identifying total (including occult) urate deposition, and assessing volume of deposits, other modalities may permit better assessment of non-urate tophus components.
PMID: 28623421
ISSN: 1434-9949
CID: 2595342

Serum Urate Levels Predict Joint Space Narrowing in Non-gout Patients with Medial Knee Osteoarthritis

Krasnokutsky, Svetlana; Oshinsky, Charles; Attur, Mukundan; Ma, Sisi; Zhou, Hua; Zheng, Fangfei; Chen, Meng; Patel, Jyoti; Samuels, Jonathan; Pike, Virginia C; Regatte, Ravinder; Bencardino, Jenny; Rybak, Leon; Abramson, Steven; Pillinger, Michael H
OBJECTIVE: OA pathogenesis includes both mechanical and inflammatory features. Studies have implicated synovial fluid urate (UA) as a potential OA biomarker, possibly reflecting chondrocyte damage. Whether serum urate (sUA) levels reflect/contribute to OA is unknown. We investigated whether sUA predicts OA progression in a non-gout knee OA population. METHODS: Eighty-eight subjects with medial knee OA (BMI <33) but without gout were included. Baseline sUA was measured in previously banked serum. At 0 and 24 months, subjects underwent standardized weight-bearing fixed-flexion posteroanterior knee radiographs to determine joint space width (JSW) and Kellgren-Lawrence (KL) grades. Joint space narrowing (JSN) was determined as JSW change from 0 to 24 months. Twenty-seven subjects underwent baseline contrast-enhanced 3T knee MRI for synovial volume (SV) assessment. RESULTS: sUA correlated with JSN in both univariate (r=0.40, p/=6.8; JSN of 0.31 mm for sUA<6.8, p<0.01). Baseline sUA distinguished progressors (JSN>0.2mm) and fast progressors (JSN>0.5mm) from nonprogressors (JSN
PMCID:5449226
PMID: 28217895
ISSN: 2326-5205
CID: 2460142

CLINIMETRICS OF ULTRASONOGRAPHY IN OSTEOARTHRITIS: A SYSTEMATIC LITERATURE REVIEW [Meeting Abstract]

Oo, W; Linklater, JM; Saarakkala, S; Samuels, J; Conaghan, PG; Daniel, M; Keen, H; Deveza, L; Hunter, DJ
ISI:000406888100412
ISSN: 1522-9653
CID: 2675512

KNEE OSTEOARTHRITIS PAIN IMPROVEMENT FOLLOWING LAP BAND SURGERY AT NEW YORK UNIVERSITY FROM 2002-2008 [Meeting Abstract]

Chen, SX; Ren-Fielding, C; Youn, H; Samuels, J
ISI:000406888100703
ISSN: 1522-9653
CID: 2675502

KNEE OSTEOARTHRITIS IMPROVEMENT AND RELATED BIOMARKER PROFILES ARE SUSTAINED AT 24 MONTHS FOLLOWING BARIATRIC SURGERY [Meeting Abstract]

Chen, SX; Bomfim, F; Mukherjee, T; Wilder, E; Aharon, S; Toth, K; Browne, L; Vieira, RLa Rocca; Patel, J; Ren-Fielding, C; Parikh, M; Abramson, SB; Attur, M; Samuels, J
ISI:000406888100099
ISSN: 1522-9653
CID: 2675532

VISCOSUPPLEMENTATION EFFICACY IS SIMILAR IN SINGLE VS MULTI-WEEK FORMULATIONS BUT HIGHER IN YOUNGER PATIENTS AND MILDER RADIOGRAPHIC DISEASE [Meeting Abstract]

Chen, SX; Bomfim, F; Mukherjee, T; Wilder, E; Leyton-Mange, A; Aharon, S; Browne, L; Toth, K; Strauss, E; Samuels, J
ISI:000406888100754
ISSN: 1522-9653
CID: 2675492

Effects of Chest Physical Therapy in Patients with Non-Tuberculous Mycobacteria

Basavaraj, Ashwin; Segal, Leopoldo; Samuels, Jonathan; Feintuch, Jeremy; Feintuch, Joshua; Alter, Kevin; Moffson, Daniella; Scott, Adrienne; Addrizzo-Harris, Doreen; Liu, Mengling; Kamelhar, David
Antibiotic therapy against non-tuberculous mycobacteria (NTM) is prolonged and can be associated with toxicity. We sought to evaluate whether chest physical therapy (PT) was associated with clinical improvement in patients with NTM not receiving anti-mycobacterial pharmacotherapy. A retrospective review of 77 subjects that were followed from June 2006 to September 2014 was performed. Baseline time point was defined as the first positive sputum culture for NTM; symptoms, pulmonary function, and radiology reports were studied. Subjects were followed for up to 24 months and results analyzed at specified time points. Half of the subjects received chest PT at baseline. Cough improved at 12 (p = 0.001) and 24 months (p = 0.003) in the overall cohort when compared with baseline, despite lack of NTM antibiotic treatment. Cough decreased at 6 (p = 0.01), 9 (p = 0.02), 12 (p = 0.02) and 24 months (p = 0.002) in subjects that received chest PT. Sputum production also improved at 24 months in the overall cohort (p = 0.01). There was an increase in the percent change of total lung capacity in subjects that received chest PT (p = 0.005). Select patients with NTM may have clinical improvement with chest PT, without being subjected to prolonged antibiotic therapy. Future studies are warranted to prospectively evaluate outcomes in the setting of non-pharmacologic treatment and aid with the decision of antibiotic initiation.
PMCID:5552049
PMID: 28804763
ISSN: 2378-3516
CID: 2669242

Implementation of a musculoskeletal ultrasound teaching program is not determined by fellowship program size [Meeting Abstract]

Torralba, K M D; Cannella, A C; Kissin, E Y; Kaeley, G S; Evangelisto, A M; Nishio, M J; De, Marco P J; Higgs, J B; Wang, C -B; Samuels, J; Kohler, M J
Background/Purpose: In 2008, 18% of rheumatology fellowship program (RFP) program directors (PDs) included musculoskeletal ultrasound (MSUS) in their training programs. Overall goal of this study was to assess the current state and ascertain the needs for MSUS education among RFPs. The objective of this study was to determine if fellowship program size impacts inclusion of MSUS in training. Methods: Out of two surveys sent via QualtricsTM in 2015, a 13-item needs assessment survey was sent to all RFP PDs determining implementation of MSUS teaching including machine accessibility, faculty training, and institutional support. The second survey assessed teaching and evaluation methods used. For the first survey, Fischer's Exact Test was used to test differences between fellowship programs based on size. Small programs were defined as programs with 1-2 fellows yearly, while big programs were those with at least 3 fellows yearly. Results: Out of 113 RFPs, 103 (91%) PDs responded to the needs assessment survey. In total, 94% of RFPs are currently offering some form of MSUS training. Of 73 small programs, 91.8% offered MSUS training; 97.1% of big programs offered MSUS training. By large, there was no statistically significant difference between small and big programs (p=0.429). Majority of both small and big programs (81.8 vs. 93.9%) cited at least one faculty who was competent in performing MSUS (p=0.212). Majority of the teaching was done by a key clinical faculty member other than the PD (39.7% vs. 54.5%). Majority owned an US machine (72.1 vs. 87.9%; p=0.037). When asked if they wanted MSUS to be part of the Rheumatology fellowship training curriculum, majority wanted its inclusion however most wanted it they wanted MSUS to be part of the Rheumatology fellowship training curriculum, majority wanted its inclusion however most wanted it only to be optional (66.2% vs. 66.7%), as compared to those wanted it to be a standard requirement (29.4% vs. 30.3%). Conclusion: MSUS has become prevalent among RFPs. The size of a fellowship program is not a factor in determining inclusion of a MSUS teaching program. Small programs have comparable capacity to include MSUS in teaching programs when compared to big programs. There is openness to including MSUS in Rheumatology fellowship training, whether as an optional or standard part of the curriculum
EMBASE:613889052
ISSN: 2326-5205
CID: 2397842