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Outcomes of patients with borderline resectable and resectable pancreatic adenocarcinoma treated with neoadjuvant three-week course chemoradiotherapy using capecitabine-based versus gemcitabine-based concurrent chemotherapy
Neibart, Shane S.; Mamidanna, Swati; Chundury, Anupama; Sayan, Mutlay; Alexander, H. Richard; August, David A.; Berim, Lyudmyla D.; Boland, Patrick M.; Grandhi, Miral S.; Gulhati, Prateek; Hochster, Howard S.; Langan, Russell C.; Spencer, Kristen R.; Kennedy, Timothy J.; Deek, Matthew P.; Jabbour, Salma K.
ISI:000719385100001
ISSN: 2078-6891
CID: 5754752
A PHASE 1B MULTI-TUMOR COHORT STUDY OF CABOZANTINIB PLUS ATEZOLIZUMAB IN ADVANCED SOLID TUMORS: RESULTS OF THE TRIPLE-NEGATIVE BREAST CANCER, OVARIAN CANCER, AND ENDOMETRIAL CANCER COHORTS [Meeting Abstract]
Winer, Ira; Wimalasingham, Akhila; Baranda, Joaquina; Santoro, Armando; Spencer, Kristen; Baldini, Capucine; Duska, Linda; Subbiah, Vivek; Patel, Sandip; Khrizman, Polina; Van Lancker, Griet; Andrianova, Lana; Atwal, Sumandeep; Sharma, Keerti; Manso, Luis
ISI:000774877500510
CID: 5754742
Immuno-oncologic care during COVID-19: Challenges and opportunities for improving clinical care and investigation
Spencer, Kristen; Singer, Eric A; Girda, Eugenia
Cancer care has been greatly impacted during the COVID-19 pandemic. The number of cases and deaths caused by the COVID-19 pandemic continues to escalate throughout the United States and the world. Worldwide, over 150 million people have been diagnosed with the coronavirus and more than 3 million have died. Now that we have gained additional experience with COVID-19, we are starting to learn its full impact on oncology care and its effects on the practice of medicine and clinical research.
PMCID:8870506
PMID: 35224563
ISSN: n/a
CID: 5180662
Fast Facts for Patients and Supporters: Cholangiocarcinoma: A cancer of the bile duct and liver. Information + Taking Control = Best Outcome
Denlinger, Crystal, Spencer, Kristen
ISBN:
CID: 5751472
A phase II/III study of perioperative nivolumab and ipilimumab in patients (pts) with locoregional esophageal (E) and gastroesophageal junction (GEJ) adenocarcinoma: Results of a safety run-in-A trial of the ECOG-ACRIN Cancer Research Group (EA2174). [Meeting Abstract]
Eads, Jennifer Rachel; Weitz, Michelle; Catalano, Paul J.; Gibson, Michael K.; Rajdev, Lakshmi; Khullar, Onkar; Lin, Steven H.; Gatsonis, Constantine; Wistuba, Ignacio Ivan; Sanjeevaiah, Aravind; Benson, Al Bowen; Bahary, Nathan; Spencer, Kristen Renee; Saba, Nabil F.; Hamilton, Stanley R.; Staley, Charles A.; Chakravarthy, Bapsi; Fisher, George A.; Wong, Terence Z.; O\Dwyer, Peter J.
ISI:000708120602164
ISSN: 0732-183x
CID: 5180762
PHASE 1 STUDY OF INCB086550, AN ORAL PD-L1 INHIBITOR, IN IMMUNE-CHECKPOINT NAIVE PATIENTS WITH ADVANCED SOLID TUMORS [Meeting Abstract]
Van Cutsem, Eric; Prenen, Hans; Delafontaine, Brant; Spencer, Kristen; Mitchell, Tara; Burris, Howard; Kotecki, Nuria; Kristeleit, Rebecca; Pinato, David; Sahebjam, Solmaz; Graham, Donna; Karasic, Thomas; Daniel, Jeannie; O\Hayer, Kevin; Geschwindt, Ryan; Piha-Paul, Sarina
ISI:000774877500508
ISSN: 2051-1426
CID: 5381472
Mamidanna, S., Neibart, S.S., Chundury, A., Sayan, M., Alexander, H.R., August, D., Berim, L.D., Boland, P.M., Grandhi, M.S., Gulhati, P., Gupta, K., Hochster, H.S., Kennedy, T.J., Langan, R.C., Minacapelli, C.C., Spencer, K., Nosher, J., Jabbour, S.K.
Purpose/Objective(s)Radiation therapy (RT) is a critical modality for the treatment of unresectable hepatocellular carcinoma (HCC). Little is known about how the etiology of HCC impacts overall and progression free survival (OS and PFS) in patients treated with definitive RT. We hypothesize that patients treated with definitive RT for HCC secondary to hepatitis B and hepatitis C viruses (viral group) would have favorable OS and PFS when compared to patients with HCC secondary to other etiologies (non-viral group).
ORIGINAL:0017472
ISSN: 0360-3016
CID: 5755102
A multicenter randomized phase 2 trial of atezolizumab as monotherapy or in combination with cobimetinib in biliary tract cancers (BTCs): A NCI Experimental Therapeutics Clinical Trials Network (ETCTN) study [Meeting Abstract]
Yarchoan, Mark; Cope, Leslie; Anders, Robert A.; Noonan, Anne; Goff, Laura W.; Goyal, Lipika; Lacy, Jill; Li, Daneng; Patel, Anuj; He, Aiwu R.; Abou-Alfa, Ghassan; Spencer, Kristen; Kim, Edward; Xavier, Stephanie; Ruggieri, Amanda; Davis, S. Lindsey; McRee, Autumn; Kunk, Paul; Zhu, Qingfeng; Wang-Gillam, Andrea; Poklepovic, Andrew; Chen, Helen; Sharon, Elad; Lesinski, Gregory B.; Azad, Nilo
ISI:000590059302169
ISSN: 0008-5472
CID: 5180742
The Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management
Khullar, Karishma; Patel, Nell Maloney; Anderson, Cristan; Chundury, Anupama; Carpizo, Darren; Feingold, Daniel; Grandhi, Miral; Hochster, Howard; Jani, Krupa; Kennedy, Timothy; Langan, Russell; Spencer, Kristen; August, David; Jabbour, Salma K
Locally advanced rectal cancer has broadly been defined as T3, T4, or lymph node-positive disease. In the 1990s, adjuvant chemoradiation was considered the optimal management for locally advanced rectal cancer. However, the paradigm shifted when the German CAO/ARO/AIO-94 Rectal Cancer trial established neoadjuvant chemoradiation as the standard of care, based on reduced rates of toxicity and local recurrence, as well as higher rates of sphincter preservation compared with postoperative chemoradiation. Both short-course radiation and long-course chemoradiation are currently accepted methods for neoadjuvant treatment, with recent trials showing equivalence in outcomes. While surgery remains the cornerstone of treatment, there are data supporting the use of magnetic resonance imaging for risk stratification in rectal cancer and encouraging prospective data regarding nonoperative management. This review summarizes data on the evolution of treatment for locally advanced rectal cancer and discusses emerging evidence for nonoperative management.
PMCID:7439775
PMID: 32832093
ISSN: 2052-3815
CID: 5180602
A phase Ib study of troriluzole (BHV-4157) in combination with nivolumab [Meeting Abstract]
Silk, Ann W.; Saraiya, Biren; Groisberg, Roman; Chan, Nancy; Spencer, Kristen Renee; Girda, Eugenia; Shih, Weichung; Manne, Veeraswamy; Palmeri, Marisa; Berman, Robert; Coric, Vlad; Vieth, Joshua; Chen, Suzie; Mehnert, Janice M.; Malhotra, Jyoti
ISI:000529994300077
ISSN: 0732-183x
CID: 5754812