A PROSPECTIVE COMPARATIVE STUDY OF TARGETED PROSTATE BIOPSY DIRECTED TO MRI-SUSPICIOUS REGIONS VERSUS ARTEMIS (TM) COMPUTERIZED 12 CORE TEMPLATE BIOPSY [Meeting Abstract]
Wysock, James S; Rosenkrantz, Andrew B; Huang, William C; Stifelman, Michael; Lepor, Herbert; Taneja, Samir S
ISI:000320281603061
ISSN: 0022-5347
CID: 1871422
Management of high-grade prostatic intraepithelial neoplasia (HGPIN)
Chapter by: Ramaswamy, K; Lepor, H; Taneja, SS
in: Prostate Cancer Diagnosis: PSA, Biopsy and Beyond by
pp. 241-254
ISBN: 9781627031882
CID: 2733722
Impact of delay after biopsy and post-biopsy haemorrhage on prostate cancer tumour detection using multi-parametric MRI: A multi-reader study
Rosenkrantz, A B; Mussi, T C; Hindman, N; Lim, R P; Kong, M X; Babb, J S; Melamed, J; Taneja, S S
AIM: To assess impact of haemorrhage and delay after biopsy on prostate tumour detection using multi-parametric (MP) magnetic resonance imaging (MRI) assessment. MATERIALS AND METHODS: Forty-four patients underwent prostate MRI at 1.5 T using a pelvic phased-array coil, including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging, before prostatectomy. Three radiologists independently reviewed images during four sessions [T2WI, DWI, DCE, and all parameters combined (MP-MRI)] to assess for tumour in each sextant. In a separate session, readers reviewed T1WI to score the extent of haemorrhage per sextant. Accuracy was assessed using logistic regression for correlated data. RESULTS: There was no significant difference in accuracy between readers for any session (p >/= 0.166), and results were averaged across the three readers for remaining comparisons. Accuracy was significantly greater for MP-MRI than for any parameter alone (p = 0.020). For T2WI alone, there was a trend toward decreased sensitivity in sextants with extensive haemorrhage (p = 0.072). However, accuracy, sensitivity, and specificity were otherwise similar for sextants with and without extensive haemorrhage for all sessions (p = 0.192-0.934). No session showed a significant improvement in accuracy, sensitivity, or specificity in cases with delay after biopsy of over 4 weeks compared with shorter delay. CONCLUSION: Extensive haemorrhage and short delay after biopsy did not negatively impact accuracy for tumour detection using MP-MRI. Further studies using MP-MRI protocols and interpretation schemes from other institutions are required to confirm these observations.
PMID: 22981729
ISSN: 0009-9260
CID: 182452