Faculty Bibliography

We present clinical data obtained with the aid of a novel instrumentation using, high speed, ultrahigh resolution Spectral/Fourier domain Optical Coherence Tomography (SOCT). This method allows performing video rate. ultrahigh resolution cross-sectional images with 98 dB of sensitivity, 100 times faster that previously reported UHR OCT system with comparable axial resolution of 3 um. Ultrahigh resolution imaging enables improved visualization of retinal architectural morphology compared to standard resolution OCT. High speed, ultrahigh resolution OCT using Spectral/Fourier domain detection promises to significantly enhance the utility of OCT for clinical applications. High speed imaging enables high density data sets to be acquired which can increase the quality of reconstructed cross-sectional images and can help to visualize small focal pathologic changes. This technique helps reconstructing true retinal topography without motion artifacts. Submitted manuscript describes the technology, its clinical performance and present preliminary data obtained for various retinal pathologies.

A retinal tracker was integrated into a third-generation commercial clinical optical coherence tomography system (Stratus OCT) manufactured by Carl Zeiss Meditec Inc. (CZMI). The instrument, called tracking optical coherence tomography (TOCT), uses a secondary sensing beam in a confocal reflectometer and steering mirrors to compensate eye motion with a closed loop bandwidth of 1 kHz and a lateral accuracy of less than 15 mu m. Imaging and tracking control systems have been integrated into a single platform and user interface in order to admit new imaging capabilities and considerable simplification in acquisition of clinical data. The system was configured to acquire three-dimensional retinal OCT maps through all subject eye movements and blinks.