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GENOMIC LANDSCAPE OF DIFFUSE INTRINSIC PONTINE GLIOMA: AN ANALYSIS OF THE DIPG-BATS COHORT [Meeting Abstract]
Bandopadhayay, Pratiti; Greenwald, Noah F; Wala, Jeremiah; Sharpira, Ofer; Tracy, Adam; Filbin, Mariella; O'Rourke, Ryan; Ho, Patricia; Sinai, Claire; Malkin, Hayley; Greenspan, Lianne; Lawler, Kristen; Pelton, Kristine; Banerjee, Anu; Becher, Oren; Ayyanar, Kaynalakshmi; Gump, William; Bendel, Anne; Bowers, Daniel C; Nagib, Mahmoud; Weprin, Bradley; Bredlau, Amy-Lee; Gururangan, Sridharan; Fuchs, Herbert; Cohen, Kenneth; Comito, Melanie; Dias, Mark; Fangusaro, Jason; Goldman, Stewart; Elster, Jennifer D; Fisher, Paul G; Tomita, Tadanori; Alden, Tord; DiPatri, Arthur; Gardner, Sharon; Karajannis, Matthias; Harter, David; Handler, Michael H; Gauvain, Karen; Limbrick, David; Leonard, Jeffrey; Geyer, Russ; Leary, Sarah ES; Khatib, Ziab; Browd, Samuel; Ragheb, John; Bhatia, Sanjiv; McDonald, Tobey; Aguilera, Dolly; Brahma, Barun; Manley, Peter; Wright, Karen D; Chi, Susan; Mueller, Sabine; Murray, Jeff; Nazemi, Kellie; Baird, Lissa; Monje, Michelle; Robison, Nathan; Kiehna, Erin; Krieger, Mark; Sandler, Eric; Aldana, Philipp; Rubin, Joshua; Snuderl, Matija; Wang, Zhihong Joanne; Sood, Sandeep; Neuberg, Donna; Suva, Mario; Segal, Rosalind; Jabado, Nada; Puligandla, Maneka; Prados, Michael D; Marcus, Karen; Haas-Kogan, Daphne A; Goumnerova, Liliana; Gupta, Nalin; Ligon, Keith; Beroukhim, Rameen; Kieran, Mark
ISI:000402766800046
ISSN: 1523-5866
CID: 2591432
HIGH FREQUENCY OF PROGRAMMED DEATH LIGAND 1 EXPRESSION IN PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS [Meeting Abstract]
Sherani, Farha; Liechty, Benjamin; Snuderl, Matija; Gardner, Sharon
ISI:000402766800117
ISSN: 1523-5866
CID: 2591442
TREATMENT OF OPTIC PATHWAY GLIOMA AND IMMUNE THROMBOCYTOPENIA (ITP) WITH EVEROLIMUS [Meeting Abstract]
Singh, Rohini; Gardner, Sharon; Allen, Jeffrey
ISI:000402766800233
ISSN: 1523-5866
CID: 2591482
SUBGROUP-SPECIFIC OUTCOMES OF CHILDREN WITH MALIGNANT CHILDHOOD BRAIN TUMORS TREATED WITH AN IRRADIATION-SPARING PROTOCOL [Meeting Abstract]
Hidalgo, Eveline Teresa; Gardner, Sharon L.; Kvint, Svetlana; Wang, Shiyang; Thomas, Cheddhi; Liechty, Benjamin; Phillips, Sophie; Serrano, Jonathan; Jones, David T. W.; Hovestadt, Volker; Pfister, Stefan M.; Allen, Jeffrey C.; Wisoff, Jeffrey H.; Snuderl, Matija; Karajannis, Matthias A.
ISI:000379749000695
ISSN: 1522-8517
CID: 2964192
EFFICACY OF EVEROLIMUS IN PEDIATRIC BRAIN TUMORS: A SINGLE-INSTITUTION PATIENT SERIES [Meeting Abstract]
Segal, Devorah; Gardner, Sharon; Allen, Jeffrey; Karajannis, Matthias
ISI:000379749000110
ISSN: 1522-8517
CID: 2964222
SAFETY AND FEASIBILITY OF A MULTI-INSTITUTIONAL PHASE II TRIAL INCOPORATING BIOPSY AND MOLECULARLY DETERMINED TREATMENT OF CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPG) [Meeting Abstract]
Wright, Karen D.; Bandopadhayay, Pratiti; Gourmnerova, Liliana; Chi, Susan N.; Manley, Peter; Marcus, Karen; Kannan, Geoffrey; Banerjee, Anu; Becher, Oren; Bendel, Anne; Bowers, Daniel; Bredlau, Amy-Lee; Cohen, Kenneth; Comito, Melani; Elster, Jennifer D.; Etzl, Michael; Fisher, Paul G.; Gardner, Sharon; Goldman, Stewart; Gururangan, Sridharan; Handler, Michael H.; Jabado, Nada; Karajannis, Matthias; Khatib, Ziad; Leary, Sarah E.; MacDonald, Tobey J.; Monje, Michelle; Nazemi, Kellie; Robison, Nathan J.; Rubin, Joshua; Sandler, Eric S.; Snuderl, Matija; Wang, Zhihong Joanne; Sinai, Claire E.; Greenspan, Lianne; Lawler, Kristen; Neuberg, Donna; Filbin, Mariella; Segal, Rosalind; Suva, Mario L.; Beroukhim, Rameen; Ligon, Keith; Gupta, Nalin; Prados, Michael; Kieran, Markw.
ISI:000379749000248
ISSN: 1522-8517
CID: 2964252
Clinical, Pathological and Molecular Characteristics of Infiltrating Astrocytomas of the Spinal cord [Meeting Abstract]
Thomas, Cheddhi; Hidalgo, Eveline; Dastagirzada, Yosef; Serrano, Jonathan; Wang, Shiyang; Kannan, Kasthuri; Capper, David; Hovestadt, Volker; Pfister, Stefan; Jones, David; Sill, Martin; von Deimling, Andreas; Heguy, Adriana; Gardner, Sharon; Allen, Jeffrey; Zagzag, David; Karajannis, Matthias; Snuderl, Matija
ISI:000377665000019
ISSN: 0022-3069
CID: 2687522
Advancing methylation profiling in neuropathology: Diagnosis and clinical management [Meeting Abstract]
Kannan, Kasthuri S; Tsirigos, Aristotelis; Serrano, Jonathan; Forrester, Lynn Ann; Faustin, Arline; Thomas, Cheddhi; Capper, David; Hovestadt, Volker; Pfister, Stefan M; Jones, David TW; Sill, Martin; Schrimpf, Daniel; von Deimling, Andreas; Heguy, Adriana; Gardner, Sharon L; Allen, Jeffrey; Hedvat, Cyrus; Zagzag, David; Snuderl, Matija; Karajannis, Matthias A
ISI:000369082700032
ISSN: 1557-3265
CID: 2687512
Neuropsychological Outcomes on "Head Start" III: A Prospective, Non-Randomized Multi-Institutional Clinical Trial, 2003-2009 [Meeting Abstract]
O'Neil, SH; Kayser, K; Jin, Z; Finlay, JL; Dhall, G; Nelson, MBaron; Gardner, SL; Saigal, P; Haley, K; Sands, S
ISI:000384818800411
ISSN: 1545-5017
CID: 2385922
Utility of MRI versus tumor markers for post-treatment surveillance of marker-positive CNS germ cell tumors
Cheung, Victoria; Segal, Devorah; Gardner, Sharon L; Zagzag, David; Wisoff, Jeffrey H; Allen, Jeffrey C; Karajannis, Matthias A
Patients with marker-positive central nervous system (CNS) germ cell tumors are typically monitored for tumor recurrence with both tumor markers (AFP and b-hCG) and MRI. We hypothesize that the recurrence of these tumors will always be accompanied by an elevation in tumor markers, and that surveillance MRI may not be necessary. We retrospectively identified 28 patients with CNS germ cell tumors treated at our institution that presented with an elevated serum or cerebrospinal fluid (CSF) tumor marker at the time of diagnosis. We then identified those who had a tumor recurrence after having been in remission and whether each recurrence was detected via MRI changes, elevated tumor markers, or both. Four patients suffered a tumor recurrence. Only one patient had simultaneously elevated tumor markers and MRI evidence of recurrence. Two patients had evidence of recurrence on MRI without corresponding elevations in serum or CSF tumor markers. One patient had abnormal tumor markers with no evidence of recurrence on MRI until 6 months later. We conclude that in patients with marker-positive CNS germ cell tumors who achieve complete remission, continued surveillance imaging in addition to measurement of tumor markers is indicated to detect recurrences.
PMID: 27406584
ISSN: 1573-7373
CID: 2180172
