Faculty Bibliography

It has been over 30 years since Dr. Mohs first realized the potential for the surgery that now bears his name, and since then hundreds of articles have been published in dozens of Journals regarding his research and clinical experience, and the work of those who followed him. Collated in his memory by Drs. David Goldberg and C. William Hanke, and Ronald Moy, these 25 articles are meant to represent a cross-section of the most important articles ever published on the subject of Mohs surgery, and provide an excellent resource for those interested in learning about its development and refinement over the years

BACKGROUND: The presence of lesions of pemphigus vulgaris in the larynx and nasal cavity has been reported in individual case reports. However, the frequency with which these sites are involved is not known. OBJECTIVE: Our purpose was to investigate the incidence of laryngeal and nasal disease involvement in patients with pemphigus vulgaris. METHODS: This was a retrospective analysis conducted in a referral private practice in an academic department of dermatology. A total of 53 sequential patients with pemphigus vulgaris diagnosed by clinical, histologic, and immunofluorescence criteria were selected on the basis of having been treated by one of us (J. C. B.) during most of their illness. Patients' charts were reviewed for documentation of laryngeal and nasal symptoms, ear/nose/throat evaluation, and response to treatment. RESULTS: Twenty-six (49%) of the patients complained of laryngeal or nasal symptoms at some time during the course of their disease. Twenty-one patients had laryngeal symptoms and 12 had nasal symptoms. More than 80% of patients with laryngeal or nasal symptoms had evidence of pemphigus involvement based on ear/nose/throat examination or rapid response to increased doses of corticosteroids, and 2 patients had candidiasis confirmed by fungal culture. CONCLUSION: These observations indicate that laryngeal and nasal symptoms are common in pemphigus vulgaris. In the majority of cases, this appears to be a result of involvement with the disease or with candidiasis

We present a 69-year-old white woman with pemphigus vulgaris limited to the oral mucosa who presented with oral pain and difficulty swallowing of 2 days duration, followed by multiple irregular ulcers arising from normal mucosa with no grouping of individual lesions--herpes simplex should be considered in the differential diagnosis of lesions that appear suddenly in patients with PV, particularly if the lesions fail to respond to an increased dose of corticosteroids