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From microdroplets to microfluidics: selective emulsion separation in microfluidic devices
Fidalgo, Luis M; Whyte, Graeme; Bratton, Daniel; Kaminski, Clemens F; Abell, Chris; Huck, Wilhelm T S
PMID: 18264960
ISSN: 1521-3773
CID: 3850992
Are there limits to swimming world records?
Nevill, A M; Whyte, G P; Holder, R L; Peyrebrune, M
The purpose of this article was to investigate whether swimming world records are beginning to plateau and whether the inequality between men and women's swimming performances is narrowing, similar to that observed in running world records. A flattened "S-shaped curve" logistic curve is fitted to 100-m, 200-m, and 400-m front-crawl world-record swimming speeds for men and women from 1 May 1957 to the present time, using the non-linear least-squares regression. The inequality between men and women's world records is also assessed using the ratio, Women's/Men's world record speeds. The results confirm that men and women's front-crawl swimming world-record speeds are plateauing and the ratio between women's and men's world records has remained stable at approximately 0.9. In conclusion, the logistic curves provide evidence that swimming world-record speeds experienced a period of "accelerated" growth/improvements during the 1960 - 1970s, but are now beginning to plateau. The period of acceleration corresponded with numerous advances in science and technology but also coincided with the anecdotal evidence for institutionalised doping. Also noteworthy, however, is the remarkably consistency in the women's/men's world record ratio, circa 0.9, similar to those observed in middle and long distance running performances. These finding supports the notion that a 10 % gender inequality exists for both swimming and running.
PMID: 17534781
ISSN: 0172-4622
CID: 3850482
Treat the patient not the blood test: the implications of an increase in cardiac troponin after prolonged endurance exercise [Case Report]
Whyte, G; Stephens, N; Senior, R; George, K; Shave, R; Wilson, M; Sharma, S
Collapse after prolonged endurance exercise is common and usually benign. This case study reports a triathlete who suffered a vaso-vagal associated collapsed after exercise. Misdiagnosis of myocardial injury in the presence of elevated cardiac troponins and ECG anomalies led to inappropriate management and highlights the difficulty in treating the collapsed athlete following arduous exercise.
PMCID:2465398
PMID: 17261549
ISSN: 1473-0480
CID: 3851632
Preload maintenance and the left ventricular response to prolonged exercise in men
Dawson, E A; Shave, R; Whyte, G; Ball, D; Selmer, C; Jans, Ø; Secher, N H; George, K P
This study examined whether left ventricular function was reduced during 3 h of semi-recumbent ergometer cycling at 70% of maximal oxygen uptake while preload to the heart was maintained via saline infusion. Indices of left ventricular systolic function (end-systolic blood pressure-volume relationship, SBP/ESV) and diastolic filling (ratio of early to late peak filling velocities into the left ventricle, E:A) were calculated during recovery and compared with baseline resting data. During exercise in seven healthy, trained male subjects, an arterial catheter allowed continuous assessment of arterial pressure, stroke volume (SV), cardiac output ( ) and an index of contractility (dP/dt(max)). A venous catheter assessed that central venous pressure (CVP) was maintained throughout rest, exercise and 10 min into recovery. Both systolic blood pressure and heart rate (HR) increased with the onset of exercise (from 132 +/- 5 to 185 +/- 19 mmHg and from 66 +/- 9 to 135 +/- 23 beats min(-1); increases from rest to the end of the first 5 min of exercise in SBP and HR, respectively) but systolic blood pressure did not change from 30 to 180 min of exercise ( approximately 150 mmHg), while heart rate only increased by 8 +/- 9 beats min(-1) (means +/- s.d.; P > 0.05). The attenuated increase in HR compared with other studies suggests that the maintained CVP ( approximately 5 mmHg) helped to prevent cardiovascular drift in this protocol. Stroke volume, and dP/dt(max) were all increased with the onset of exercise (from 85 +/- 8 to 120 +/- 18 ml, from 5.4 +/- 1.3 to 16.5 +/- 3.3 l min(-1) and from 14.4 +/- 4 to 28 +/- 8 mmHg s(-1); values from rest to the end of the first 5 min of exercise for SV, and dP/dt(max), respectively) and were maintained during exercise. There was no difference in the SBP/ESV ratio from pre- to postexercise. Conversely, E:A was reduced from 2.0 +/- 0.4 to 1.6 +/- 0.5 postexercise (P < 0.05), returning to normal values at 24 h postexercise. This change in diastolic filling could not be fully explained (r(2) = 0.39) by an increased heart rate and, with CVP unchanged, it is likely to represent some depression of intrinsic relaxation properties of left ventricular myocytes. Three hours of semi-supine cycling resulted in no evidence of a depression in left ventricular systolic function, while left ventricular diastolic function declined postexercise.
PMID: 17158180
ISSN: 0958-0670
CID: 3851602
An optical trapped microhand for manipulating micron-sized objects
Whyte, Graeme; Gibson, Graham; Leach, Jonathan; Padgett, Miles; Robert, Daniel; Miles, Mervyn
We have developed a real time interface for holographic optical tweezers where the operator's fingertips are mapped to the positions of silica beads captured in optical traps. The beads act as the fingertips of a microhand which can be used to manipulate objects that otherwise do not lend themselves to tweezers control, e.g. objects that are strongly scattering or highly light sensitive. We illustrate the use of the microhand for the real time manipulation of micron sized chrome particles.
PMID: 19529684
ISSN: 1094-4087
CID: 3851052
Physiological left ventricular hypertrophy or hypertrophic cardiomyopathy in an elite adolescent athlete: role of detraining in resolving the clinical dilemma [Case Report]
Basavarajaiah, S; Wilson, M; Junagde, S; Jackson, G; Whyte, G; Sharma, S; Roberts, W O
The differentiation of physiological left ventricular hypertrophy (LVH) from hypertrophic cardiomyopathy (HCM) can prove challenging for even the most experienced cardiologists. The case is presented of a 17 year old elite swimmer who had electrocardiographic and echocardiographic features that were highly suggestive of HCM. However, indices of diastolic function were normal and cardiopulmonary exercise testing revealed high peak oxygen consumption in keeping with physiological LVH. To resolve the diagnostic dilemma, the patient underwent detraining for eight weeks, after which, there was complete resolution of the changes seen on electrocardiogram and echocardiogram, indicating physiological LVH rather than HCM.
PMCID:2579475
PMID: 16864569
ISSN: 1473-0480
CID: 3851562
Polarization and image rotation induced by a rotating dielectric rod: an optical angular momentum interpretation
Padgett, Miles; Whyte, Graeme; Girkin, John; Wright, Amanda; Allen, Les; Ohberg, Patrik; Barnett, Stephen M
When light is transmitted along the axis of a rotating glass rod, the polarization of the light is rotated through a small angle [Proc. R. Soc. London, Ser. A349, 423 (1976)]. Under the same conditions, we predict a rotation of the transmitted image by exactly the same angle. The treatment of the two effects in terms of light's spin and orbital angular momentum suggests that they share a common origin.
PMID: 16794727
ISSN: 0146-9592
CID: 3850972
Projection of world running records - Response [Letter]
Nevill, A; Whyte, G
ISI:000238205200025
ISSN: 0195-9131
CID: 3852632
Breathless in the bath [Case Report]
Whyte, G P; Harries, M; Dickinson, J; Polkey, M I
The case is reported of a male track and field athlete with breathing difficulties at rest and during exercise, which were exacerbated in the supine position and during water immersion. Right hemidiaphragmatic paralysis was diagnosed. The cause of this relatively benign disorder is not known and there are no serious clinical implications. There is no treatment, but a continuation of exercise together with interventions to strengthen the subsidiary inspiratory muscles is recommended.
PMCID:2465106
PMID: 16720891
ISSN: 1473-0480
CID: 3850432
Iterative algorithms for holographic shaping of non-diffracting and self-imaging light beams
Courtial, Johannes; Whyte, Graeme; Bouchal, Zdeniek; Wagner, Jaroslav
We have developed iterative algorithms for the calculation of holograms for non-diffracting or self-imaging light beams. Our methods make use of the special Fourier-space properties of the target beams. We demonstrate experimentally the holographic generation of perhaps the most challenging type of beam: a self-imaging beam shaped in more than one plane. Potential applications include the generation of light "crystals" for optical trapping and atomic diffraction studies.
PMID: 19503543
ISSN: 1094-4087
CID: 3851042