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Prophylactic carotid endarterectomy in patients with high-grade carotid stenosis undergoing coronary bypass: does it decrease the incidence of perioperative stroke?

Hines, G L; Scott, W C; Schubach, S L; Kofsky, E; Wehbe, U; Cabasino, E
The etiology of perioperative stroke in patients undergoing isolated coronary artery bypass grafting (CABG) is multifactorial. One significant cause is thought to be high-grade internal carotid artery stenosis. Between April 1992 and June 1995, 1686 patients undergoing isolated CABG underwent preoperative carotid duplex scanning. This represented 77% of patients who underwent CABG during that time period (2188 patients). Sixty-eight patients (4.0%) had 80%-99% stenosis of at least one carotid artery. Fifteen patients underwent CABG without carotid intervention (Group I) and 53 patients underwent either carotid endarterectomy prior to CABG or simultaneous with CABG (Group II). Age, sex, history of prior neurologic events, ejection fraction, number of distal bypasses performed, total pump time, and aortic cross clamp times were similar between the two groups. Three patients in Group I developed a permanent postoperative neurologic deficit (20%) and one patient developed a transient deficit. The defect was focal and ipsilateral to high-grade stenosis in three patients and global in one. No patient in Group II developed either a transient or permanent neurologic deficit. There was one death in Group I in the patient who developed a global neurologic deficit and one death in Group II 2 weeks after CABG in a patient who had undergone prophylactic preCABG-carotid endarterectomy. Statistical analysis (Fisher's exact test, 2-tail) demonstrated a significant decrease both in total neurologic events (p = 0.001) and permanent neurologic defects (p = 0.005) in those patient undergoing prophylactic CE (Group II). Patients with 80%-99% carotid stenosis undergoing CEA prior to or in conjunction with isolated CABG have a decreased incidence of neurologic events postoperatively.
PMID: 9451992
ISSN: 0890-5096
CID: 3497762

Hemodynamically significant carotid disease and prophylactic carotid endarterectomy in CABG patients - Impact on perioperative neurologic events

Hines, GL; Scott, WC; Schubach, SL; Tyd, D; Wehbe, U
Perioperative neurologic deficits occur in 2-5% of patients undergoing isolated coronary artery bypass grafting (CABG). The effect of preexisting high-grade carotid artery stenosis, as determined by (1) the presence of a cervical bruit, (2) ocular plethysmography (OPG), and (3) duplex scan, and the value of prophylactic carotid endarterectomy in preventing stroke, are uncertain. The hospital courses of 427 patients who underwent pre-CABG carotid duplex scan and coronary artery bypass (CAB) as the only cardiac procedure between April 1992 and June 1994 were reviewed (1) to evaluate the relationship between carotid stenosis and perioperative neurologic events and (2) to determine whether endarterectomy for high-grade lesions (80-99%) decreases the risk of perioperative cerebrovascular accident (CVA). There were 11 strokes (2.58%) in 427 patients, 4 CVAs occurred in 389 patients without significant carotid disease; 12 patients had total occlusion of one carotid artery and 4 of them developed a CVA (33.3%); 26 patients had a high-grade stenosis (80-99%) of one carotid artery. Twelve of these patients underwent either a pre-CABG carotid endarterectomy (CE) (5 patients) or simultaneous CE + CABG (7 patients). There were no neurologic events in this group. The 14 other patients with 80-99% stenosis did not undergo a CE. There were 3 CVAs and 1 transient ischemic attack (TIA) in this group. Seven of 11 CVAs (64%) occurred in 34 patients with either total or high-grade carotid disease (P <.0001 by Fisher Exact Test and Wilcoxin Rank Sum).
ISI:A1997WP65100007
ISSN: 0042-2835
CID: 3496202

EARLY DIAGNOSIS AND REPAIR OF POPLITEAL ARTERY AND VEIN INJURIES OCCURRING DURING ARTHROSCOPY OF THE KNEE - CASE-REPORTS [Note]

FOGERTY, MD; HINES, GL; SUTARIA, M
Injuries to the popliteal vessels during arthroscopic procedures of the knee are rare but may lead to amputation of the extremity. Early recognition and repair of such injuries is essential to avoid this complication.
ISI:A1995TE46300009
ISSN: 0042-2835
CID: 3496192

Thoraco-abdominal aneurysm resection. Determinants of survival in a community hospital

Hines, G L; Busutil, S
Twenty-five patients who underwent resection of a thoraco-abdominal aneurysm between 1985-1993 were reviewed to study determinants of survival in patients undergoing the procedure in a community hospital. Twelve procedures were performed electively, six urgently and seven emergently. Type I aneurysm was present in one patient (n = 1), Type II n = 7; Type III n = 5 and Type IV = 12. Hypertension (n = 17), cardiac disease (n = 10) and renal insufficiency (n = 4) were most common risk factors. Aneurysms were repaired using inclusion method without special techniques for renal or spinal cord preservation. Eighteen patients survived and were discharged; four patients died 30 days and three patients died 30 days. Causes of death were multisystem failure (n = 3), acute myocardial infarction (n = 2) coagulopathy (n = 1) and bowel infarction (n = 1). Major complications included renal failure (n = 2) myocardial infarction (n = 3), bleeding (n = 3), paraplegia (n = 1). Statistical significance was determined using Fisher's exact test-2 tail. Risk factors for death and complication included emergency or urgent surgery (4 deaths-emergent, 2 deaths-urgent) and preoperative renal insufficiency (2 deaths; 1 dialysis) 52% of patients in a community hospital setting underwent emergent or urgent operation and this accounted for 87% of deaths and most morbidity. Mortality in elective procedures was 8%. Based on this data, we believe that thoracoabdominal aneurysm resection can be reasonably undertaken in a community-type hospital.
PMID: 7775550
ISSN: 0021-9509
CID: 3497732

Paravertebral extramedullary hematopoiesis (as a posterior mediastinal tumor) associated with congenital dyserythropoietic anemia [Letter]

Hines, G L
PMID: 8412278
ISSN: 0022-5223
CID: 3497752

Spontaneous dissection of the abdominal aorta: experience with five patients [Case Report]

Busuttil, S; Hall, L; Hines, G L
Spontaneous dissection of the infradiaphragmatic abdominal aorta is a rare form of aortic dissection. Its natural history and management are not well defined. We have recently treated five patients with spontaneous aortic dissection. Two patients had acute dissections and three had chronic dissections. Three patients developed saccular aneurysms and underwent resection. Two patients had stable dissections and were treated medically. All patients are alive and well at 6 months to 5 years. We think that spontaneous aortic dissection can be treated as a variant of type III dissection with initial medical management, reserving surgery for those patients in whom a saccular aneurysm or a complication of the dissection develops.
PMID: 8268086
ISSN: 0890-5096
CID: 3497742

Descending thoracic aortomyoplasty: effect of chronically conditioned muscle on heart failure

Constance, C G; Sabini, G; Turi, G K; Hines, G L
The effect of descending thoracic aortomyoplasty using conditioned latissimus dorsi muscle on cardiac output in five mongrel dogs with pharmacologically induced congestive heart failure was evaluated. A neurovascular left latissimus dorsi flap was lifted and through a left thoracotomy placed around the proximal descending thoracic aorta. The flap was conditioned for 4-6 weeks with a neurostimulator using the following parameters: amplitude 0.5 V, pulse width 210 microseconds and frequency 2 Hz. The neurostimulator was then removed and a cardiomyostimulator inserted and programmed to burst-stimulate the muscle during diastole. Baseline measurements of central venous pressure, heart rate, mean arterial blood pressure, pulmonary capillary wedge pressure, and cardiac output were obtained with the cardiomyostimulator off and on (study 1). Heart failure was induced with a combination of propranolol and verapamil, and measurements again taken with the stimulator off and on. The neurostimulator was reimplanted to continue stimulation of the latissimus dorsi muscle, and another set of measurements taken at 6 weeks with the cardiomyostimulator off and on (study 2). Counterpulsation in control conditions (before cardiac failure) in both studies demonstrated no significant increase in cardiac output. However, mean(s.d.) cardiac output was significantly (P < 0.1) increased by muscle stimulation in dogs with heart failure (study 1: from 2.39(1.10) to 3.14(1.41)l/min; study 2: from 1.89(0.64) to 2.38(0.57)l/min). There was no significant difference in the increase in cardiac output associated with muscle stimulation between studies 1 and 2. The results indicate that the model can increase cardiac output in heart failure and that this improvement is constant over a 4-6 week period, suggesting that muscle fatigue may not occur.
PMID: 8076047
ISSN: 0967-2109
CID: 3276492

Physiologic and pathologic evaluation of chronic extra-aortic counterpulsation with latissimus dorsi flap. Preliminary results

Hines, G L; Mishriki, Y; Williams, L; Monroe, K; Metwally, N
This study attempted to evaluate the efficacy of chronic extra-aortic counterpulsation with a latissimus dorsi neuro vascular flap. Five dogs had a preliminary procedure consisting of the creation of a latissimus dorsi flap and a thoracotomy in which the flap was wrapped around the descending aorta just distal to the left subclavian artery. An epicardial lead was placed on the left ventricle and a nerve stimulating lead placed around the thoraco-dorsal nerve. Three weeks later, both leads were connected to a cardiomyostimulator programmed to function in a counterpulsation mode with a 1:2 assist frequency. Hemodynamic measurements were made at 6 and 8 and 10 and 12 weeks and the dogs were sacrificed. Three dogs had all sets of hemodynamic measurements made. Two of the three dogs demonstrated diastolic augmentation at 6 and 8 and 10 and 12 weeks average 20 to 25 mmHg. The third dog failed to demonstrate any change. All dogs were sacrificed at 12 weeks and specimens were submitted for histologic evaluation. The muscle flap was preserved in all animals. The aorta subjacent to the flap showed, (1) normal intima with no evidence of disruption or thrombus in all animals, (2) in the animals in whom counterpulsation was observed, there appeared to be thinning of the media in the aorta subjacent to the muscle flap, and (3) no evidence of distal emboli. This study demonstrated that chronic counterpulsation can be obtained with a latissimus dorsi flap. The actual hemodynamic benefits are not determined from this study. The medial thinning in the aortic wall may limit the long-term benefit of this procedure.
PMID: 1864878
ISSN: 0021-9509
CID: 3497512

Extraaortic counterpulsation with a latissimus dorsi flap: hemodynamic effects in a heart failure model

Hymes, W; Hines, G L; Lemonick, D; Sabini, G; Wehbe, U
The aim of this study was to evaluate the hemodynamic effects of extraaortic counterpulsation with a latissimus dorsi (LD) neurovascular flap in a canine heart failure model. Five dogs (8-18 kg) had a left LD neurovascular muscle flap raised. The muscle was brought into the chest through the second interspace and wrapped around the aorta. Parameters studied were heart rate (HR), systolic pressure (SP), diastolic pressure (DP) pulmonary artery pressure (PAP), mixed venous oxygen saturation (MVO2), and cardiac output (CO). Baseline measurements were obtained with the muscle nonstimulated and stimulated by a prototype burst stimulation. The only parameter that changed significantly with muscle stimulation was DP (55.8 +/- 3.8 mmHg to 72.4 +/- 4.8 mmHg, p less than 0.05). Propranolol (3-4 mg/kg) and verapamil (2-3 mg) were given intravenously to induce heart failure. Mean blood pressure decreased from 64.12 +/- 5.03 mmHg to 43.3 +/- 9.28 mmHg (p less than 0.05). Repeat measurements were obtained. With stimulation of the muscle flap there was an increase in DP from 36.8 +/- 9.2 mmHg to 55.4 +/- 19.3 mmHg (p less than 0.05). Although CO increased from 8% to 18% in all animals (1.42 +/- 0.33 L/mm to 1.58 +/- 0.34 L/mm) this did not reach statistical significance. This data indicates that both DP and CO can be improved by this method of cardiac assist in a heart failure model.
PMID: 1807502
ISSN: 0886-0440
CID: 3497502

The effect of asanguinous cardioplegic arrest on atrial preservation using atrial ATP as a marker

Hines, G L; Scheaffer, P; Williams, L; Mantell, P; Cheifitz, P
Changes in atrial adenosine triphosphate (ATP) and the presence of postoperative arrhythmias were studied in 14 patients during routine coronary artery bypass grafting to 1) attempt to evaluate atrial preservation, and 2) determine if a relationship exists between changes in ATP and the development of postoperative arrhythmias. Atrial biopsies were obtained at the time of cannulation (preischemic sample) and after the removal of the aortic crossclamp (postischemic sample). Methods of myocardial protection included systemic hypothermia (28 degrees C), periodic reinfusion of crystalloid cardioplegia into the aortic root and completed vein grafts, and iced slush in the pericardial well. Atrial temperature was monitored. Preischemic ATP was 0.412 +/- 0.32 mu mol/gm, and the postischemic value was 0.220 +/- 0.13 mu mol/gm (p less than .02). Atrial temperature routinely decreased to 13-18 degrees C after cardioplegic infusion but rose to 24 degrees C between infusions. There was no correlation between postoperative supraventricular arrhythmias (4 patients) and changes in ATP. In conclusion, routine coronary artery bypass grafting with standard methods of cardiac preservation does not appear to satisfactorily preserve atrial tissue. The clinical correlation and significance of this remains to be elucidated.
PMID: 2370258
ISSN: 0021-9509
CID: 3497532