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78


ABERRANT LONG INTERSPERSED ELEMENT-1PROTEIN EXPRESSION IS A FEATURE OF SOMEMALIGNANT MELANOMAS [Meeting Abstract]

Rodic, Nemanja; Zampella, John; Taube, Janis; Burns, Kathleen
ORIGINAL:0012279
ISSN: 1471-1753
CID: 2726642

Translocation junctions in TCF3-PBX1 acute lymphoblastic leukemia/lymphoma cluster near transposable elements

Rodic, Nemanja; Zampella, John G; Cornish, Toby C; Wheelan, Sarah J; Burns, Kathleen H
BACKGROUND: Hematolymphoid neoplasms frequently harbor recurrent genetic abnormalities. Some of the most well recognized lesions are chromosomal translocations, and many of these are known to play pivotal roles in pathogenesis. In lymphoid malignancies, some translocations result from erroneous V(D)J-type events. However, other translocation junctions appear randomly positioned and their underlying mechanisms are not understood. RESULTS: We tested the hypothesis that genomic repeats, including both simple tandem and interspersed repeats, are involved in chromosomal translocations arising in hematopoietic malignancies. Using a database of translocation junctions and RepeatMasker annotations of the reference genome assembly, we measured the proximity of translocation sites to their nearest repeat. We examined 1,174 translocation breakpoints from 10 classifications of hematolymphoid neoplasms. We measured significance using Student's t-test, and we determined a false discovery rate using a random permutation statistics technique. CONCLUSIONS: Most translocations showed no propensity to involve genomic repeats. However, translocation junctions at the transcription factor 3 (TCF3)/E2A immunoglobulin enhancer binding factors E12/E47 (E2A) locus clustered within, or in proximity to, transposable element sequences. Nearly half of reported TCF3 translocations involve a MER20 DNA transposon. Based on this observation, we propose this sequence is important for the oncogenesis of TCF3-PBX1 acute lymphoblastic leukemia.
PMCID:4015642
PMID: 24135088
ISSN: 1759-8753
CID: 2673822

Racial differences in mycosis fungoides: a retrospective study with a focus on eosinophilia

Zampella, John G; Hinds, Ginette A
BACKGROUND: Mycosis fungoides (MF) is often associated with eosinophilia and portends a poorer prognosis. MF is more common in blacks and follows a more aggressive course compared with whites. OBJECTIVE: We further elucidate racial differences between blacks and whites with MF, focusing on blood eosinophilia. METHODS: The records of 345 patients with MF were reviewed for demographic, clinical, and pathologic data and evaluated by analysis of variance. RESULTS: The average age at diagnosis for blacks was 45 years and was 55 years for white patients (P < .001). In the cohorts of patients with and without blood eosinophilia, the average maximum blood eosinophil count had a greater range in blacks. Independent of race, blood eosinophilia was predictive of more advanced disease (P < .0001), increased number of treatment types (P < .002), and less responsiveness to treatment (P < .0006). LIMITATIONS: This was a retrospective study at a single institution. CONCLUSIONS: These differences observed in eosinophil values may highlight disparities in MF diagnosis or a difference in pathophysiology between races.
PMID: 23374234
ISSN: 1097-6787
CID: 2673832

INTEGRATED ANALYSIS OF HOMOZYGOUSDELETIONS IN MERKEL CELL CARCINOMAS [Meeting Abstract]

Rodic, Nemanja; Zampella, John; Taube, Janis
ORIGINAL:0012281
ISSN: 1471-1753
CID: 2726662

Mapping mobile DNAs in human cancer cell lines [Meeting Abstract]

Zampella, John G; Yang, Wan Rho; Rodic, Nemanja; Huang, Cheng Ran Lisa; Welch, Jane; Gnanakkan, Veena P; Cornish, Toby C; Boeke, Jef D; Burns, Kathleen H
ORIGINAL:0012282
ISSN: 1538-7445
CID: 2726672

Race and eosinophilia in mycosis fungoides: Retrospective study of eosinophilia and race [Meeting Abstract]

Zampella, J; Hinds, GA
ISI:000302866900284
ISSN: 0022-202x
CID: 2726622

Novel L1 and Alu retrotransposon insertions in melanoma related gene loci in NCI-60 melanoma cell lines [Meeting Abstract]

Zampella, J; Burns, KH
ISI:000302866900169
ISSN: 0022-202x
CID: 2726632

Emerging themes from post-discharge, non-medical home visits: Knowing the patient as a person in the Johns Hopkins Bayview Aliki Initiative. [Meeting Abstract]

Zampella, JG; Federowicz, M; Rand, C; Ziegelstein, RC
ISI:000289524600231
ISSN: 0002-8614
CID: 2673872