Faculty Bibliography

About 65 million Americans, one fourth of the adult population in the United States, and over 1 billion people worldwide have hypertension (HTN). HTN therefore is present in 1 of every 4 patients admitted to any US hospital. Surprisingly, no guidelines are available for the management of inpatient HTN. Based on a comprehensive search of the literature we are proposing a pathway for the management of HTN in nonpregnant hospitalized patients. The pathway provides a definition and clinical assessment of HTN for patients admitted to the hospital. The assessment is followed by an organ/system based therapeutic approach specifying timing, blood pressure goals, recommended antihypertensive drug therapy and the sequence of add-on drugs. The pathway specifically discusses assessment and management of HTN in patients with (1) acute aortic syndrome, (2) acute neurologic syndrome, (3) acute coronary syndrome, (4) congestive heart failure, (5) renal failure, and (6) secondary forms. Finally, the pathway provides a step by step recommendation for the management of in hospital HTN and of hypertensive emergencies

OBJECTIVES: The purpose of this study was to evaluate cross-sectional imaging to longitudinal plane imaging for measurement of flow-mediated dilatation (FMD). BACKGROUND: Accurate and reproducible assessment of FMD as a measure of endothelial function has important implications. Conventional imaging of the brachial artery is in a longitudinal plane. However, the changes in vasodilatation seen are subtle and minimal (10%-20%) in healthy states with an even smaller change in diseased states, thus, affecting interobserver and intraobserver variability and reproducibility. METHODS: Nine healthy volunteers (5 men, 4 women) between the ages of 25 and 65 years had baseline FMD measurements done using both longitudinal and cross-sectional imaging. Brachial artery was occluded by inflating the sphygmomanometer cuff on the arm at a pressure of 150 mm Hg for 5 minutes. The artery was imaged continuously for 5 minutes postdeflation. The images were recorded digitally on a computer and analyzed for area and diameter changes by user-guided semiautomated boundary detection method described by our group earlier. RESULTS: The baseline measurements were normalized to 1.00 for both longitudinal and cross-sectional images. After cuff deflation, the mean longitudinal diameter increased to 1.10 +/- 0.04 versus 1.30 +/- 0.17 (P = .007) for the cross-sectional method. The mean longitudinal measurements were 85.7 +/- 13.9 pixels at baseline that increased to 94.3 +/- 13.1 pixels for a mean change of 8.6 +/- 3.1 pixels after cuff deflation, compared with a mean of 8577.4 +/- 2950.8 pixels that increased to 11120.5 +/- 3989.4 pixels for a mean change of 2543 +/- 1552 pixels by the cross-sectional method (P < .001). CONCLUSIONS: Cross-sectional imaging produced a much larger change in area and pixels compared with longitudinal imaging. This translates into greater sensitivity in detecting small changes produced by FMD

OBJECTIVES: The purpose of this study was to evaluate the prognostic value of assessing right ventricular (RV) wall motion abnormalities during stress echocardiography (SE). BACKGROUND: The results of SE are usually interpreted based on wall motion abnormalities of the left ventricle (LV). There is increasing recognition of the prognostic importance of RV. However, RV is still a 'forgotten' chamber during routine SE. METHODS: We evaluated 2,703 patients referred for SE. The LV was evaluated on a 16-segment model 5-point scale and the RV was evaluated on a 3-segment model 5-point scale for wall motion abnormalities. An abnormal RV or LV was defined as one with new (ischemic) or fixed (infarction) wall motion abnormalities. Follow-up (2.7 +/- 1.0 years) for confirmed myocardial infarction and cardiac death (n = 122) were obtained. RESULTS: An abnormal RV was seen in 112 patients (4%). In the presence of an abnormal LV, patients with abnormal RV had a worse prognosis than those with normal RV. Abnormal RV was a significant predictor of events (adjusted hazard ratio 2.69, 95% confidence interval 1.22 to 5.92; p = 0.014) independent of LV ischemia and ejection fraction. A forward conditional Cox model showed that peak RV wall motion score index provided incremental prognostic value over rest and conventional SE variables (global chi-square increased from 141.4 to 161.8 to 197.0; p < 0.0001 and p = 0.006, respectively). CONCLUSIONS: In patients referred for SE, RV wall motion analysis provides prognostic value independent of LV ischemia and ejection fraction and provides incremental value over rest and conventional SE variables. Right ventricular wall motion analysis should be routinely performed in patients referred for SE for effective risk stratification

Traditionally, beta-blockers, used as first-line agents to treat uncomplicated hypertension, were recommended by national and international guidelines despite a paucity of evidence regarding their cardiovascular benefit. However, evidence from recent trials and meta-analyses has questioned the use of beta-blockers as preferred agents. This article reviews the data available from clinical trials and argues that beta-blockers are less efficacious than other currently available antihypertensive agents for patients with uncomplicated hypertension