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115


A Practical Guide to Patch Testing

Fonacier, Luz
Contact dermatitis is a common disease seen by allergists, dermatologists, and primary care physicians. The gold standard for diagnosing allergic contact dermatitis (ACD) is patch testing and is indicated in any patient with a chronic, pruritic, eczematous, or lichenified dermatitis if underlying or secondary ACD is suspected. Patients with acute generalized dermatitis who have extensive eczema on the back, are on immunosuppressant medications, and have applied topical corticosteroids, topical calcineurin inhibitors, or ultraviolet radiation to the patch test (PT) site may have suppressed PT reactions. The procedure of patch testing is not a difficult one to perform, but the interpretation of the PT needs some critical components, including having an appropriate level of suspicion for the diagnosis of ACD, testing the relevant allergens in their proper vehicle and concentration, and the necessary experience to properly interpret the results. Careful history and physical examination must be correlated with the result of the PT to establish clinical relevance. Once the PT is completed, allergens are identified, and relevance has been established, educating the patient about the avoidance of exposure is critical. The Joint Task Force of the American Academy of Allergy, Asthma and Immunology and American College of Allergy, Asthma and Immunology has developed updated practice parameters for contact dermatitis and patch testing, and their recommendations will be discussed (Fonacier LF, Bernstein DI, Pacheco K, Holness DL. Contact dermatitis: a practice parameter update 2015. J Allergy Clin Immunol Pract 2015; 3(3S):S1-S40.).
PMID: 26054552
ISSN: 2213-2201
CID: 3431772

Flexural eczema versus atopic dermatitis

Jacob, Sharon E; Goldenberg, Alina; Nedorost, Susan; Thyssen, Jacob P; Fonacier, Luz; Spiewak, Radoslaw
Flexural eczema and atopic dermatitis are frequently synonymized. As respiratory atopy is rarely tested for and found in these patients, systematically equating a flexural distribution of dermatitis with atopic dermatitis may too frequently result in misclassified diagnoses and potentially missed opportunity for intervention toward improving patients' symptoms and quality of life. We present a critical review of the available evidence for the atopic dermatitis diagnosis and discuss the similarities between atopic dermatitis and allergic contact dermatitis. Because neither flexural predilection nor atopy is specific for atopic dermatitis, we conclude that the term atopic dermatitis is a misnomer and propose an etymologic reclassification of atopic dermatitis to "atopy-related" dermatitis. Allergic contact dermatitis can induce an atopic dermatitis-like phenotype, and thus, flexural dermatitis cannot be assumed as atopic without further testing. Patch testing should at least be considered in cases of chronic or recurrent eczema regardless of the working diagnosis.
PMID: 25984686
ISSN: 2162-5220
CID: 3431762

Contact dermatitis: a practice parameter-update 2015

Fonacier, Luz; Bernstein, David I; Pacheco, Karin; Holness, D Linn; Blessing-Moore, Joann; Khan, David; Lang, David; Nicklas, Richard; Oppenheimer, John; Portnoy, Jay; Randolph, Christopher; Schuller, Diane; Spector, Sheldon; Tilles, Stephen; Wallace, Dana
This parameter was developed by the Joint Task Force on Practice Parameters, which represents the American Academy of Allergy, Asthma & Immunology (AAAAI); the American College of Allergy, Asthma & Immunology (ACAAI); and the Joint Council of Allergy, Asthma & Immunology. The AAAAI and the ACAAI have jointly accepted responsibility for establishing "Contact Dermatitis: A Practice Parameter-Update 2015." This is a complete and comprehensive document at the current time. The medical environment is changing and not all recommendations will be appropriate or applicable to all patients. Because this document incorporated the efforts of many participants, no single individual, including members serving on the Joint Task Force, are authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters. Any request for information or interpretation of this practice parameter by the AAAAI or ACAAI should be directed to the Executive Offices of the AAAAI, the ACAAI, and the Joint Council of Allergy, Asthma & Immunology. These parameters are not designed for use by the pharmaceutical industry in drug development or promotion. Previously published practice parameters of the Joint Task Force on Practice Parameters for Allergy & Immunology are available at http://www.JCAAI.org or http://www.allergyparameters.org.
PMID: 25965350
ISSN: 2213-2201
CID: 3431752

Fc gamma-Fragment and IgG Monoclonal Antibody Polarization of Human Macrophages; A Novel Immunomodulatory Mechanism [Meeting Abstract]

Steele, Ryan A; Littlefield, Michael J; Voloshyna, Iryna; Davis-Lorton, Mark A; Aquino, Marcella R; Fonacier, Luz S; Reiss, Allison B
ISI:000361129600499
ISSN: 1097-6825
CID: 2677962

Allergic contact dermatitis [Case Report]

Fonacier, Luz S; Sher, Janelle M
PMID: 24950843
ISSN: 1534-4436
CID: 3431722

Systemic contact dermatitis possibly related to metal implants [Editorial]

Lieberman, Phillip; Fonacier, Luz
PMID: 25017546
ISSN: 2213-2201
CID: 3431732

The role of contact dermatitis in patients with atopic dermatitis

Aquino, Marcella; Fonacier, Luz
Because both atopic dermatitis (AD) and contact dermatitis (CD) are characterized by a similar morphologic appearance and similar distribution of skin involvement, the diagnosis of CD in AD has been difficult. Historically, it was thought that patients with AD were unable or less likely to develop CD due to various studies in which patients with AD stimulated with strong allergens failed to develop sensitization at rates similar to patients without AD. However, more recent evidence from the United States and Europe has shown that patients with AD have similar if not higher rates of positive patch test results to common contact allergens, including metals and fragrance, than those patients without AD. In this review, we highlight evidence for and against the role of contact allergy in patients with AD and seek to give clinically relevant management recommendations for the evaluation of CD in the patient with AD.
PMID: 25017524
ISSN: 2213-2201
CID: 3428192

ASSOCIATION OF SERUM SOLUBLE ST2 AND INTERLEUKIN-33 WITH PRO-INFLAMMATORY CYTOKINES: A LINK BETWEEN ALLERGIC DISEASE AND INFLAMMATION [Meeting Abstract]

Sher, Janelle M; Littlefield, Michael; Reiss, Allison B; Carsons, Steven; Fonacier, Luz F; Voloshyna, Iryna
ISI:000333695300166
ISSN: 1708-8267
CID: 2677852

Association Of IL-33 With Atherogenic Cytokines: A Link Between Allergic Disease and Atherosclerosis [Meeting Abstract]

Paul, Misu; Reiss, Allison B; Carsons, Steven; Fonacier, Luz S; Voloshyna, Iryna
ISI:000330241300192
ISSN: 1097-6825
CID: 2677842

Mobile Phones: Potential Sources of Nickel and Cobalt Exposure for Metal Allergic Patients

Aquino, Marcella; Mucci, Tania; Chong, Melanie; Lorton, Mark Davis; Fonacier, Luz
The use of cellular phones has risen exponentially with over 300 million subscribers. Nickel has been detected in cell phones and reports of contact dermatitis attributable to metals are present in the literature. We determined nickel and cobalt content in popular cell phones in the United States. Adults (>18 years) who owned a flip phone, Blackberry®, or iPhone® were eligible. Seventy-two cell phones were tested using SmartPractice's® commercially available nickel and cobalt spot tests. Test areas included buttons, keypad, speakers, camera, and metal panels. Of the 72 cell phones tested, no iPhones or Droids® tested positive for nickel or cobalt. About 29.4% of Blackberrys [95% confidence interval (CI), 13%-53%] tested positive for nickel; none were positive for cobalt. About 90.5% of flip phones (95% CI, 70%-99%) tested positive for nickel and 52.4% of flip phones (95% CI, 32%-72%) tested positive for cobalt. Our study indicates that nickel and cobalt are present in popular cell phones. Patients with known nickel or cobalt allergy may consider their cellular phones as a potential source of exposure. Further studies are needed to examine whether there is a direct association with metal content in cell phones and the manifestation of metal allergy.
PMID: 24380018
ISSN: 2151-321x
CID: 3428182