NYUHSL Faculty Bibliography

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758

Annals of thoracic surgery. 2020:110(1):236-240.DOI: 10.1016/j.athoracsur.2020.01.077

Robotic Sleeve Resection of the Airway: Outcomes and Technical Conduct using Video Vignettes

Geraci, Travis C; Ferrari-Light, Dana; Wang, Simeng; Mitzman, Brian; Chang, Stephanie; Kent, Amie; Pass, Harvey; Bizekis, Costas; Zervos, Michael; Cerfolio, Robert J

BACKGROUND:Our objective is to report our outcomes and demonstrate our evolving technique for robotic sleeve resection of the airway, with or without lobectomy, using video vignettes. METHODS:We retrospectively reviewed a single surgeon prospective database from October 2010 to October 2019. RESULTS:Over 9 years, there were 5,573 operations of which 1951 were planned for a robotic approach. There were 755 robotic lobectomies, 306 robotic segmentectomies, and 23 consecutive patients were scheduled for elective completely portal, robotic sleeve resection. Sleeve lobectomy was performed in 18 patients: 10 right upper lobe, 6 left upper lobe, and 2 right lower lobe. Two patients had mainstem bronchus resections and two underwent right bronchus intermedius resections that preserved all of the lung. One patient had a robotic pneumonectomy. There was one conversion to open thoracotomy due to concern for anastomotic tension in a patient who received neoadjuvant therapy. All patients had an R0 resection. In the last 10 operations, we modified our airway anastomosis, using a running self-locking absorbable suture. The median length of stay was 3 days (range 1-11). There were no 30- or 90-day mortalities. Within a median follow-up of 18 months, there were no anastomotic strictures and no recurrent cancers. CONCLUSIONS:Our early and midterm results show that a completely portal robotic sleeve resection is safe and oncologically effective. The technical aspects of a robotic sleeve resection of the airway are demonstrated using video vignettes.

PMID: 32151577

ISSN: 1552-6259

CID: 4348742

Journal of thoracic & cardiovascular surgery. 2020:159(5):2094-2095.DOI: 10.1016/j.jtcvs.2019.09.101

Commentary: Not only SMART clinically, but translationally! [Editorial]

Pass, Harvey I

PMID: 31677887

ISSN: 1097-685x

CID: 4179092

Journal of thoracic & cardiovascular surgery. 2020:159(5):2090-2091.DOI: 10.1016/j.jtcvs.2019.10.127

Discussion

Pass, Harvey I

PMID: 31866085

ISSN: 1097-685x

CID: 4718422

Journal of thoracic oncology. 2020:15(5):e75-e77.DOI: 10.1016/j.jtho.2020.02.017

Reply to Waller etÂ al. Standardizing Surgical Treatment for Mesothelioma [Letter]

Friedberg, Joseph S; Culligan, Melissa J; Tsao, Anne S; Rusch, Valerie; Adusumilli, Prasad S; Sepesi, Boris; Pass, Harvey I; Bueno, Raphael; Burt, Bryan; Sugarbaker, David J; de Perrot, Marc; Adjei, Alex A; Hirsch, Fred R; Malik, Shakuntala M; Harpole, David J

PMID: 32340682

ISSN: 1556-1380

CID: 4422282

Journal of thoracic & cardiovascular surgery. 2020:159(4):1609-1610.DOI: 10.1016/j.jtcvs.2019.10.128

Discussion [Comment]

Pass, Harvey I

PMID: 31879168

ISSN: 1097-685x

CID: 4718432

Journal of thoracic & cardiovascular surgery. 2020:159(4):1611-1612.DOI: 10.1016/j.jtcvs.2019.12.043

Commentary: "Hot" gene signatures for checkpoint response prediction: A very cool idea [Editorial]

Pass, Harvey I

PMID: 32037244

ISSN: 1097-685x

CID: 4304062

Clinical cancer research. 2020:26(6).DOI: 10.1158/1078-0432.CCR-20-0338

Expression of Concern: HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients

Napolitano, Andrea; Antoine, Daniel J; Pellegrini, Laura; Baumann, Francine; Pagano, Ian; Pastorino, Sandra; Goparaju, Chandra M; Prokrym, Kirill; Canino, Claudia; Pass, Harvey I; Carbone, Michele; Yang, Haining

PMID: 32169964

ISSN: 1078-0432

CID: 4718452

Lung cancer. 2020:142:90-97.DOI: 10.1016/j.lungcan.2020.02.018

Stable and discriminating radiomic predictor of recurrence in early stage non-small cell lung cancer: Multi-site study

Khorrami, Mohammadhadi; Bera, Kaustav; Leo, Patrick; Vaidya, Pranjal; Patil, Pradnya; Thawani, Rajat; Velu, Priya; Rajiah, Prabhakar; Alilou, Mehdi; Choi, Humberto; Feldman, Michael D; Gilkeson, Robert C; Linden, Philip; Fu, Pingfu; Pass, Harvey; Velcheti, Vamsidhar; Madabhushi, Anant

OBJECTIVES/OBJECTIVE:To evaluate whether combining stability and discriminability criteria in building radiomic classifiers will improve the prognosis of cancer recurrence in early stage non-small cell lung cancer on non-contrast computer tomography (CT). MATERIALS AND METHODS/METHODS:) validation sets. A linear discriminant analysis (LDA) classifier was built based on the most stable and discriminate features. In addition, a radiomic risk score (RRS) was generated by using least absolute shrinkage and selection operator, Cox regression model to predict time to progression (TTP) following surgery. RESULTS:, 0.76 vs. 0.63). The RRS generated by most stable-discriminating features was significantly associated with TTP compared to discriminating alone criteria (HR = 1.66, C-index of 0.72 vs. HR = 1.04, C-index of 0.62). CONCLUSION/CONCLUSIONS:Accounting for both stability and discriminability yielded a more generalizable classifier for predicting cancer recurrence and TTP in early stage NSCLC.

PMID: 32120229

ISSN: 1872-8332

CID: 4338772

Nature. 2020:578(7793):82-93.DOI: 10.1038/s41586-020-1969-6

Pan-cancer analysis of whole genomes

Campbell, Peter J; Getz, Gad; Korbel, Jan O; Stuart, Joshua M; Jennings, Jennifer L; Stein, Lincoln D; Perry, Marc D; Nahal-Bose, Hardeep K; Ouellette, B F Francis; Li, Constance H; Rheinbay, Esther; Nielsen, G Petur; Sgroi, Dennis C; Wu, Chin-Lee; Faquin, William C; Deshpande, Vikram; Boutros, Paul C; Lazar, Alexander J; Hoadley, Katherine A; Louis, David N; Dursi, L Jonathan; Yung, Christina K; Bailey, Matthew H; Saksena, Gordon; Raine, Keiran M; Buchhalter, Ivo; Kleinheinz, Kortine; Schlesner, Matthias; Zhang, Junjun; Wang, Wenyi; Wheeler, David A; Ding, Li; Simpson, Jared T; O'Connor, Brian D; Yakneen, Sergei; Ellrott, Kyle; Miyoshi, Naoki; Butler, Adam P; Royo, Romina; Shorser, Solomon I; Vazquez, Miguel; Rausch, Tobias; Tiao, Grace; Waszak, Sebastian M; Rodriguez-Martin, Bernardo; Shringarpure, Suyash; Wu, Dai-Ying; Demidov, German M; Delaneau, Olivier; Hayashi, Shuto; Imoto, Seiya; Habermann, Nina; Segre, Ayellet V; Garrison, Erik; Cafferkey, Andy; Alvarez, Eva G; Heredia-Genestar, José María; Muyas, Francesc; Drechsel, Oliver; Bruzos, Alicia L; Temes, Javier; Zamora, Jorge; Baez-Ortega, Adrian; Kim, Hyung-Lae; Mashl, R Jay; Ye, Kai; DiBiase, Anthony; Huang, Kuan-Lin; Letunic, Ivica; McLellan, Michael D; Newhouse, Steven J; Shmaya, Tal; Kumar, Sushant; Wedge, David C; Wright, Mark H; Yellapantula, Venkata D; Gerstein, Mark; Khurana, Ekta; Marques-Bonet, Tomas; Navarro, Arcadi; Bustamante, Carlos D; Siebert, Reiner; Nakagawa, Hidewaki; Easton, Douglas F; Ossowski, Stephan; Tubio, Jose M C; De La Vega, Francisco M; Estivill, Xavier; Yuen, Denis; Mihaiescu, George L; Omberg, Larsson; Ferretti, Vincent; Sabarinathan, Radhakrishnan; Pich, Oriol; Gonzalez-Perez, Abel; Taylor-Weiner, Amaro; Fittall, Matthew W; Demeulemeester, Jonas; Tarabichi, Maxime; Roberts, Nicola D; Van Loo, Peter; Cortés-Ciriano, Isidro; Urban, Lara; Park, Peter; Zhu, Bin; PitkÃ¤nen, Esa; Li, Yilong; Saini, Natalie; Klimczak, Leszek J; Weischenfeldt, Joachim; Sidiropoulos, Nikos; Alexandrov, Ludmil B; Rabionet, Raquel; Escaramis, Georgia; Bosio, Mattia; Holik, Aliaksei Z; Susak, Hana; Prasad, Aparna; Erkek, Serap; Calabrese, Claudia; Raeder, Benjamin; Harrington, Eoghan; Mayes, Simon; Turner, Daniel; Juul, Sissel; Roberts, Steven A; Song, Lei; Koster, Roelof; Mirabello, Lisa; Hua, Xing; Tanskanen, Tomas J; Tojo, Marta; Chen, Jieming; Aaltonen, Lauri A; RÃ¤tsch, Gunnar; Schwarz, Roland F; Butte, Atul J; Brazma, Alvis; Chanock, Stephen J; Chatterjee, Nilanjan; Stegle, Oliver; Harismendy, Olivier; Bova, G Steven; Gordenin, Dmitry A; Haan, David; Sieverling, Lina; Feuerbach, Lars; Chalmers, Don; Joly, Yann; Knoppers, Bartha; MolnÃ¡r-GÃ¡bor, Fruzsina; Phillips, Mark; Thorogood, Adrian; Townend, David; Goldman, Mary; Fonseca, Nuno A; Xiang, Qian; Craft, Brian; Piñeiro-YÃ¡ñez, Elena; Muñoz, Alfonso; Petryszak, Robert; FÃ¼llgrabe, Anja; Al-Shahrour, Fatima; Keays, Maria; Haussler, David; Weinstein, John; Huber, Wolfgang; Valencia, Alfonso; Papatheodorou, Irene; Zhu, Jingchun; Fan, Yu; Torrents, David; Bieg, Matthias; Chen, Ken; Chong, Zechen; Cibulskis, Kristian; Eils, Roland; Fulton, Robert S; Gelpi, Josep L; Gonzalez, Santiago; Gut, Ivo G; Hach, Faraz; Heinold, Michael; Hu, Taobo; Huang, Vincent; Hutter, Barbara; JÃ¤ger, Natalie; Jung, Jongsun; Kumar, Yogesh; Lalansingh, Christopher; Leshchiner, Ignaty; Livitz, Dimitri; Ma, Eric Z; Maruvka, Yosef E; Milovanovic, Ana; Nielsen, Morten Muhlig; Paramasivam, Nagarajan; Pedersen, Jakob Skou; PuiggrÃ²s, Montserrat; Sahinalp, S Cenk; Sarrafi, Iman; Stewart, Chip; Stobbe, Miranda D; Wala, Jeremiah A; Wang, Jiayin; Wendl, Michael; Werner, Johannes; Wu, Zhenggang; Xue, Hong; Yamaguchi, Takafumi N; Yellapantula, Venkata; Davis-Dusenbery, Brandi N; Grossman, Robert L; Kim, Youngwook; Heinold, Michael C; Hinton, Jonathan; Jones, David R; Menzies, Andrew; Stebbings, Lucy; Hess, Julian M; Rosenberg, Mara; Dunford, Andrew J; Gupta, Manaswi; Imielinski, Marcin; Meyerson, Matthew; Beroukhim, Rameen; Reimand, JÃ¼ri; Dhingra, Priyanka; Favero, Francesco; Dentro, Stefan; Wintersinger, Jeff; Rudneva, Vasilisa; Park, Ji Wan; Hong, Eun Pyo; Heo, Seong Gu; Kahles, André; Lehmann, Kjong-Van; Soulette, Cameron M; Shiraishi, Yuichi; Liu, Fenglin; He, Yao; DemircioÄŸlu, Deniz; Davidson, Natalie R; Greger, Liliana; Li, Siliang; Liu, Dongbing; Stark, Stefan G; Zhang, Fan; Amin, Samirkumar B; Bailey, Peter; Chateigner, Aurélien; Frenkel-Morgenstern, Milana; Hou, Yong; Huska, Matthew R; Kilpinen, Helena; Lamaze, Fabien C; Li, Chang; Li, Xiaobo; Li, Xinyue; Liu, Xingmin; Marin, Maximillian G; Markowski, Julia; Nandi, Tannistha; Ojesina, Akinyemi I; Pan-Hammarström, Qiang; Park, Peter J; Pedamallu, Chandra Sekhar; Su, Hong; Tan, Patrick; Teh, Bin Tean; Wang, Jian; Xiong, Heng; Ye, Chen; Yung, Christina; Zhang, Xiuqing; Zheng, Liangtao; Zhu, Shida; Awadalla, Philip; Creighton, Chad J; Wu, Kui; Yang, Huanming; Göke, Jonathan; Zhang, Zemin; Brooks, Angela N; Fittall, Matthew W; Martincorena, Iñigo; Rubio-Perez, Carlota; Juul, Malene; Schumacher, Steven; Shapira, Ofer; Tamborero, David; Mularoni, Loris; HornshÃ¸j, Henrik; Deu-Pons, Jordi; Muiños, Ferran; Bertl, Johanna; Guo, Qianyun; Gonzalez-Perez, Abel; Xiang, Qian; Bazant, Wojciech; Barrera, Elisabet; Al-Sedairy, Sultan T; Aretz, Axel; Bell, Cindy; Betancourt, Miguel; Buchholz, Christiane; Calvo, Fabien; Chomienne, Christine; Dunn, Michael; Edmonds, Stuart; Green, Eric; Gupta, Shailja; Hutter, Carolyn M; Jegalian, Karine; Jones, Nic; Lu, Youyong; Nakagama, Hitoshi; Nettekoven, Gerd; Planko, Laura; Scott, David; Shibata, Tatsuhiro; Shimizu, Kiyo; Stratton, Michael R; Yugawa, Takashi; Tortora, Giampaolo; VijayRaghavan, K; Zenklusen, Jean C; Townend, David; Knoppers, Bartha M; Aminou, Brice; Bartolome, Javier; Boroevich, Keith A; Boyce, Rich; Buchanan, Alex; Byrne, Niall J; Chen, Zhaohong; Cho, Sunghoon; Choi, Wan; Clapham, Peter; Dow, Michelle T; Dursi, Lewis Jonathan; Eils, Juergen; Farcas, Claudiu; Fayzullaev, Nodirjon; Flicek, Paul; Heath, Allison P; Hofmann, Oliver; Hong, Jongwhi H; Hudson, Thomas J; HÃ¼bschmann, Daniel; Ivkovic, Sinisa; Jeon, Seung-Hyup; Jiao, Wei; Kabbe, Rolf; Kahles, Andre; Kerssemakers, Jules N A; Kim, Hyunghwan; Kim, Jihoon; Koscher, Michael; Koures, Antonios; Kovacevic, Milena; Lawerenz, Chris; Liu, Jia; Mijalkovic, Sanja; Mijalkovic-Lazic, Ana Mijalkovic; Miyano, Satoru; Nastic, Mia; Nicholson, Jonathan; Ocana, David; Ohi, Kazuhiro; Ohno-Machado, Lucila; Pihl, Todd D; Prinz, Manuel; Radovic, Petar; Short, Charles; Sofia, Heidi J; Spring, Jonathan; Struck, Adam J; Tijanic, Nebojsa; Vicente, David; Wang, Zhining; Williams, Ashley; Woo, Youngchoon; Wright, Adam J; Yang, Liming; Hamilton, Mark P; Johnson, Todd A; Kahraman, Abdullah; Kellis, Manolis; Polak, Paz; Sallari, Richard; Sinnott-Armstrong, Nasa; von Mering, Christian; Beltran, Sergi; Gerhard, Daniela S; Gut, Marta; Trotta, Jean-Rémi; Whalley, Justin P; Niu, Beifang; Espiritu, Shadrielle M G; Gao, Shengjie; Huang, Yi; Lalansingh, Christopher M; Teague, Jon W; Wendl, Michael C; Abascal, Federico; Bader, Gary D; Bandopadhayay, Pratiti; Barenboim, Jonathan; Brunak, SÃ¸ren; Carlevaro-Fita, Joana; Chakravarty, Dimple; Chan, Calvin Wing Yiu; Choi, Jung Kyoon; Diamanti, Klev; Fink, J Lynn; Frigola, Joan; Gambacorti-Passerini, Carlo; Garsed, Dale W; Haradhvala, Nicholas J; Harmanci, Arif O; Helmy, Mohamed; Herrmann, Carl; Hobolth, Asger; Hodzic, Ermin; Hong, Chen; Isaev, Keren; Izarzugaza, Jose M G; Johnson, Rory; Juul, Randi Istrup; Kim, Jaegil; Kim, Jong K; Jan Komorowski; Lanzós, Andrés; Larsson, Erik; Lee, Donghoon; Li, Shantao; Li, Xiaotong; Lin, Ziao; Liu, Eric Minwei; Lochovsky, Lucas; Lou, Shaoke; Madsen, Tobias; Marchal, Kathleen; Martinez-Fundichely, Alexander; McGillivray, Patrick D; Meyerson, William; Paczkowska, Marta; Park, Keunchil; Park, Kiejung; Pons, Tirso; Pulido-Tamayo, Sergio; Reyes-Salazar, Iker; Reyna, Matthew A; Rubin, Mark A; Salichos, Leonidas; Sander, Chris; Schumacher, Steven E; Shackleton, Mark; Shen, Ciyue; Shrestha, Raunak; Shuai, Shimin; Tsunoda, Tatsuhiko; Umer, Husen M; UuskÃ¼la-Reimand, Liis; Verbeke, Lieven P C; Wadelius, Claes; Wadi, Lina; Warrell, Jonathan; Wu, Guanming; Yu, Jun; Zhang, Jing; Zhang, Xuanping; Zhang, Yan; Zhao, Zhongming; Zou, Lihua; Lawrence, Michael S; Raphael, Benjamin J; Bailey, Peter J; Craft, David; Goldman, Mary J; Aburatani, Hiroyuki; Binder, Hans; Dinh, Huy Q; Heath, Simon C; Hoffmann, Steve; Imbusch, Charles David; Kretzmer, Helene; Laird, Peter W; Martin-Subero, Jose I; Nagae, Genta; Shen, Hui; Wang, Qi; Weichenhan, Dieter; Zhou, Wanding; Berman, Benjamin P; Brors, Benedikt; Plass, Christoph; Akdemir, Kadir C; Bowtell, David D L; Burns, Kathleen H; Busanovich, John; Chan, Kin; Dueso-Barroso, Ana; Edwards, Paul A; Etemadmoghadam, Dariush; Haber, James E; Jones, David T W; Ju, Young Seok; Kazanov, Marat D; Koh, Youngil; Kumar, Kiran; Lee, Eunjung Alice; Lee, Jake June-Koo; Lynch, Andy G; Macintyre, Geoff; Markowetz, Florian; Navarro, Fabio C P; Pearson, John V; Rippe, Karsten; Scully, Ralph; Villasante, Izar; Waddell, Nicola; Yang, Lixing; Yao, Xiaotong; Yoon, Sung-Soo; Zhang, Cheng-Zhong; Bergstrom, Erik N; Boot, Arnoud; Covington, Kyle; Fujimoto, Akihiro; Huang, Mi Ni; Islam, S M Ashiqul; McPherson, John R; Morganella, Sandro; Mustonen, Ville; Ng, Alvin Wei Tian; Prokopec, Stephenie D; VÃ¡zquez-García, Ignacio; Wu, Yang; Yousif, Fouad; Yu, Willie; Rozen, Steven G; Rudneva, Vasilisa A; Shringarpure, Suyash S; Turner, Daniel J; Xia, Tian; Atwal, Gurnit; Chang, David K; Cooke, Susanna L; Faltas, Bishoy M; Haider, Syed; Kaiser, Vera B; KarliÄ‡, Rosa; Kato, Mamoru; KÃ¼bler, Kirsten; Margolin, Adam; Martin, Sancha; Nik-Zainal, Serena; P'ng, Christine; Semple, Colin A; Smith, Jaclyn; Sun, Ren X; Thai, Kevin; Wright, Derek W; Yuan, Ke; Biankin, Andrew V; Garraway, Levi; Grimmond, Sean M; Adams, David J; Anur, Pavana; Cao, Shaolong; Christie, Elizabeth L; Cmero, Marek; Cun, Yupeng; Dawson, Kevin J; Dentro, Stefan C; Deshwar, Amit G; Donmez, Nilgun; Drews, Ruben M; Gerstung, Moritz; Ha, Gavin; Haase, Kerstin; Jerman, Lara; Ji, Yuan; Jolly, Clemency; Lee, Juhee; Lee-Six, Henry; Malikic, Salem; Mitchell, Thomas J; Morris, Quaid D; Oesper, Layla; Peifer, Martin; Peto, Myron; Rosebrock, Daniel; Rubanova, Yulia; Salcedo, Adriana; Sengupta, Subhajit; Shi, Ruian; Shin, Seung Jun; Spiro, Oliver; Vembu, Shankar; Wintersinger, Jeffrey A; Yang, Tsun-Po; Yu, Kaixian; Zhu, Hongtu; Spellman, Paul T; Weinstein, John N; Chen, Yiwen; Fujita, Masashi; Han, Leng; Hasegawa, Takanori; Komura, Mitsuhiro; Li, Jun; Mizuno, Shinichi; Shimizu, Eigo; Wang, Yumeng; Xu, Yanxun; Yamaguchi, Rui; Yang, Fan; Yang, Yang; Yoon, Christopher J; Yuan, Yuan; Liang, Han; Alawi, Malik; Borozan, Ivan; Brewer, Daniel S; Cooper, Colin S; Desai, Nikita; Grundhoff, Adam; Iskar, Murat; Su, Xiaoping; Zapatka, Marc; Lichter, Peter; Alsop, Kathryn; Bruxner, Timothy J C; Christ, Angelika N; Cordner, Stephen M; Cowin, Prue A; Drapkin, Ronny; Fereday, Sian; George, Joshy; Hamilton, Anne; Holmes, Oliver; Hung, Jillian A; Kassahn, Karin S; Kazakoff, Stephen H; Kennedy, Catherine J; Leonard, Conrad R; Mileshkin, Linda; Miller, David K; Arnau, Gisela Mir; Mitchell, Chris; Newell, Felicity; Nones, Katia; Patch, Ann-Marie; Quinn, Michael C; Taylor, Darrin F; Thorne, Heather; Traficante, Nadia; Vedururu, Ravikiran; Waddell, Nick M; Waring, Paul M; Wood, Scott; Xu, Qinying; deFazio, Anna; Anderson, Matthew J; Antonello, Davide; Barbour, Andrew P; Bassi, Claudio; Bersani, Samantha; Cataldo, Ivana; Chantrill, Lorraine A; Chiew, Yoke-Eng; Chou, Angela; Cingarlini, Sara; Cloonan, Nicole; Corbo, Vincenzo; Davi, Maria Vittoria; Duthie, Fraser R; Gill, Anthony J; Graham, Janet S; Harliwong, Ivon; Jamieson, Nigel B; Johns, Amber L; Kench, James G; Landoni, Luca; Lawlor, Rita T; Mafficini, Andrea; Merrett, Neil D; Miotto, Marco; Musgrove, Elizabeth A; Nagrial, Adnan M; Oien, Karin A; Pajic, Marina; Pinese, Mark; Robertson, Alan J; Rooman, Ilse; Rusev, Borislav C; Samra, Jaswinder S; Scardoni, Maria; Scarlett, Christopher J; Scarpa, Aldo; Sereni, Elisabetta; Sikora, Katarzyna O; Simbolo, Michele; Taschuk, Morgan L; Toon, Christopher W; Vicentini, Caterina; Wu, Jianmin; Zeps, Nikolajs; Behren, Andreas; Burke, Hazel; Cebon, Jonathan; Dagg, Rebecca A; De Paoli-Iseppi, Ricardo; Dutton-Regester, Ken; Field, Matthew A; Fitzgerald, Anna; Hersey, Peter; Jakrot, Valerie; Johansson, Peter A; Kakavand, Hojabr; Kefford, Richard F; Lau, Loretta M S; Long, Georgina V; Pickett, Hilda A; Pritchard, Antonia L; Pupo, Gulietta M; Saw, Robyn P M; Schramm, Sarah-Jane; Shang, Catherine A; Shang, Ping; Spillane, Andrew J; Stretch, Jonathan R; Tembe, Varsha; Thompson, John F; Vilain, Ricardo E; Wilmott, James S; Yang, Jean Y; Hayward, Nicholas K; Mann, Graham J; Scolyer, Richard A; Bartlett, John; Bavi, Prashant; Chadwick, Dianne E; Chan-Seng-Yue, Michelle; Cleary, Sean; Connor, Ashton A; Czajka, Karolina; Denroche, Robert E; Dhani, Neesha C; Eagles, Jenna; Gallinger, Steven; Grant, Robert C; Hedley, David; Hollingsworth, Michael A; Jang, Gun Ho; Johns, Jeremy; Kalimuthu, Sangeetha; Liang, Sheng-Ben; Lungu, Ilinca; Luo, Xuemei; Mbabaali, Faridah; McPherson, Treasa A; Miller, Jessica K; Moore, Malcolm J; Notta, Faiyaz; Pasternack, Danielle; Petersen, Gloria M; Roehrl, Michael H A; Sam, Michelle; Selander, Iris; Serra, Stefano; Shahabi, Sagedeh; Thayer, Sarah P; Timms, Lee E; Wilson, Gavin W; Wilson, Julie M; Wouters, Bradly G; McPherson, John D; Beck, Timothy A; Bhandari, Vinayak; Collins, Colin C; Fleshner, Neil E; Fox, Natalie S; Fraser, Michael; Heisler, Lawrence E; Lalonde, Emilie; Livingstone, Julie; Meng, Alice; Sabelnykova, Veronica Y; Shiah, Yu-Jia; Van der Kwast, Theodorus; Bristow, Robert G; Ding, Shuai; Fan, Daiming; Li, Lin; Nie, Yongzhan; Xiao, Xiao; Xing, Rui; Yang, Shanlin; Yu, Yingyan; Zhou, Yong; Banks, Rosamonde E; Bourque, Guillaume; Brennan, Paul; Letourneau, Louis; Riazalhosseini, Yasser; Scelo, Ghislaine; Vasudev, Naveen; Viksna, Juris; Lathrop, Mark; Tost, Jörg; Ahn, Sung-Min; Aparicio, Samuel; Arnould, Laurent; Aure, M R; Bhosle, Shriram G; Birney, Ewan; Borg, Ake; Boyault, Sandrine; Brinkman, Arie B; Brock, Jane E; Broeks, Annegien; BÃ¸rresen-Dale, Anne-Lise; Caldas, Carlos; Chin, Suet-Feung; Davies, Helen; Desmedt, Christine; Dirix, Luc; Dronov, Serge; Ehinger, Anna; Eyfjord, Jorunn E; Fatima, Aquila; Foekens, John A; Futreal, P Andrew; Garred, Ã˜ystein; Giri, Dilip D; Glodzik, Dominik; Grabau, Dorthe; Hilmarsdottir, Holmfridur; Hooijer, Gerrit K; Jacquemier, Jocelyne; Jang, Se Jin; Jonasson, Jon G; Jonkers, Jos; Kim, Hyung-Yong; King, Tari A; Knappskog, Stian; Kong, Gu; Krishnamurthy, Savitri; Lakhani, Sunil R; LangerÃ¸d, Anita; Larsimont, Denis; Lee, Hee Jin; Lee, Jeong-Yeon; Lee, Ming Ta Michael; LingjÃ¦rde, Ole Christian; MacGrogan, Gaetan; Martens, John W M; O'Meara, Sarah; Pauporté, Iris; Pinder, Sarah; Pivot, Xavier; Provenzano, Elena; Purdie, Colin A; Ramakrishna, Manasa; Ramakrishnan, Kamna; Reis-Filho, Jorge; Richardson, Andrea L; Ringnér, Markus; Rodriguez, Javier Bartolomé; RodrÃguez-GonzÃ¡lez, F GermÃ¡n; Romieu, Gilles; Salgado, Roberto; Sauer, Torill; Shepherd, Rebecca; Sieuwerts, Anieta M; Simpson, Peter T; Smid, Marcel; Sotiriou, Christos; Span, Paul N; StefÃ¡nsson, Ã“lafur Andri; Stenhouse, Alasdair; Stunnenberg, Henk G; Sweep, Fred; Tan, Benita Kiat Tee; Thomas, Gilles; Thompson, Alastair M; Tommasi, Stefania; Treilleux, Isabelle; Tutt, Andrew; Ueno, Naoto T; Van Laere, Steven; Van den Eynden, Gert G; Vermeulen, Peter; Viari, Alain; Vincent-Salomon, Anne; Wong, Bernice H; Yates, Lucy; Zou, Xueqing; van Deurzen, Carolien H M; van de Vijver, Marc J; Van't Veer, Laura; Ammerpohl, Ole; Aukema, Sietse; Bergmann, Anke K; Bernhart, Stephan H; Borkhardt, Arndt; Borst, Christoph; Burkhardt, Birgit; Claviez, Alexander; Goebler, Maria Elisabeth; Haake, Andrea; Haas, Siegfried; Hansmann, Martin; Hoell, Jessica I; Hummel, Michael; Karsch, Dennis; Klapper, Wolfram; Kneba, Michael; Kreuz, Markus; Kube, Dieter; KÃ¼ppers, Ralf; Lenze, Dido; Loeffler, Markus; López, Cristina; Mantovani-Löffler, Luisa; Möller, Peter; Ott, German; Radlwimmer, Bernhard; Richter, Julia; Rohde, Marius; Rosenstiel, Philip C; Rosenwald, Andreas; Schilhabel, Markus B; Schreiber, Stefan; Stadler, Peter F; Staib, Peter; Stilgenbauer, Stephan; Sungalee, Stephanie; Szczepanowski, Monika; Toprak, Umut H; TrÃ¼mper, Lorenz H P; Wagener, Rabea; Zenz, Thorsten; Hovestadt, Volker; von Kalle, Christof; Kool, Marcel; Korshunov, Andrey; Landgraf, Pablo; Lehrach, Hans; Northcott, Paul A; Pfister, Stefan M; Reifenberger, Guido; Warnatz, Hans-Jörg; Wolf, Stephan; Yaspo, Marie-Laure; Assenov, Yassen; Gerhauser, Clarissa; Minner, Sarah; Schlomm, Thorsten; Simon, Ronald; Sauter, Guido; SÃ¼ltmann, Holger; Biswas, Nidhan K; Maitra, Arindam; Majumder, Partha P; Sarin, Rajiv; Barbi, Stefano; Bonizzato, Giada; CantÃ¹, Cinzia; Dei Tos, Angelo P; Fassan, Matteo; Grimaldi, Sonia; Luchini, Claudio; Malleo, Giuseppe; Marchegiani, Giovanni; Milella, Michele; Paiella, Salvatore; Pea, Antonio; Pederzoli, Paolo; Ruzzenente, Andrea; Salvia, Roberto; Sperandio, Nicola; Arai, Yasuhito; Hama, Natsuko; Hiraoka, Nobuyoshi; Hosoda, Fumie; Nakamura, Hiromi; Ojima, Hidenori; Okusaka, Takuji; Totoki, Yasushi; Urushidate, Tomoko; Fukayama, Masashi; Ishikawa, Shumpei; Katai, Hitoshi; Katoh, Hiroto; Komura, Daisuke; Rokutan, Hirofumi; Saito-Adachi, Mihoko; Suzuki, Akihiro; Taniguchi, Hirokazu; Tatsuno, Kenji; Ushiku, Tetsuo; Yachida, Shinichi; Yamamoto, Shogo; Aikata, Hiroshi; Arihiro, Koji; Ariizumi, Shun-Ichi; Chayama, Kazuaki; Furuta, Mayuko; Gotoh, Kunihito; Hayami, Shinya; Hirano, Satoshi; Kawakami, Yoshiiku; Maejima, Kazuhiro; Nakamura, Toru; Nakano, Kaoru; Ohdan, Hideki; Sasaki-Oku, Aya; Tanaka, Hiroko; Ueno, Masaki; Yamamoto, Masakazu; Yamaue, Hiroki; Choo, Su Pin; Cutcutache, Ioana; Khuntikeo, Narong; Ong, Choon Kiat; Pairojkul, Chawalit; Popescu, Irinel; Ahn, Keun Soo; Aymerich, Marta; Lopez-Guillermo, Armando; López-OtÃn, Carlos; Puente, Xose S; Campo, Elias; Amary, Fernanda; Baumhoer, Daniel; Behjati, Sam; Bjerkehagen, Bodil; Futreal, P A; Myklebost, Ola; Pillay, Nischalan; Tarpey, Patrick; Tirabosco, Roberto; Zaikova, Olga; Flanagan, Adrienne M; Boultwood, Jacqueline; Bowen, David T; Cazzola, Mario; Green, Anthony R; Hellstrom-Lindberg, Eva; Malcovati, Luca; Nangalia, Jyoti; Papaemmanuil, Elli; Vyas, Paresh; Ang, Yeng; Barr, Hugh; Beardsmore, Duncan; Eldridge, Matthew; Gossage, James; Grehan, Nicola; Hanna, George B; Hayes, Stephen J; Hupp, Ted R; Khoo, David; Lagergren, Jesper; Lovat, Laurence B; MacRae, Shona; O'Donovan, Maria; O'Neill, J Robert; Parsons, Simon L; Preston, Shaun R; Puig, Sonia; Roques, Tom; Sanders, Grant; Sothi, Sharmila; Tavaré, Simon; Tucker, Olga; Turkington, Richard; Underwood, Timothy J; Welch, Ian; Fitzgerald, Rebecca C; Berney, Daniel M; De Bono, Johann S; Cahill, Declan; Camacho, Niedzica; Dennis, Nening M; Dudderidge, Tim; Edwards, Sandra E; Fisher, Cyril; Foster, Christopher S; Ghori, Mohammed; Gill, Pelvender; Gnanapragasam, Vincent J; Gundem, Gunes; Hamdy, Freddie C; Hawkins, Steve; Hazell, Steven; Howat, William; Isaacs, William B; Karaszi, Katalin; Kay, Jonathan D; Khoo, Vincent; Kote-Jarai, Zsofia; Kremeyer, Barbara; Kumar, Pardeep; Lambert, Adam; Leongamornlert, Daniel A; Livni, Naomi; Lu, Yong-Jie; Luxton, Hayley J; Marsden, Luke; Massie, Charlie E; Matthews, Lucy; Mayer, Erik; McDermott, Ultan; Merson, Sue; Neal, David E; Ng, Anthony; Nicol, David; Ogden, Christopher; Rowe, Edward W; Shah, Nimish C; Thomas, Sarah; Thompson, Alan; Verrill, Clare; Visakorpi, Tapio; Warren, Anne Y; Whitaker, Hayley C; Zhang, Hongwei; van As, Nicholas; Eeles, Rosalind A; Abeshouse, Adam; Agrawal, Nishant; Akbani, Rehan; Al-Ahmadie, Hikmat; Albert, Monique; Aldape, Kenneth; Ally, Adrian; Appelbaum, Elizabeth L; Armenia, Joshua; Asa, Sylvia; Auman, J Todd; Balasundaram, Miruna; Balu, Saianand; Barnholtz-Sloan, Jill; Bathe, Oliver F; Baylin, Stephen B; Benz, Christopher; Berchuck, Andrew; Berrios, Mario; Bigner, Darell; Birrer, Michael; Bodenheimer, Tom; Boice, Lori; Bootwalla, Moiz S; Bosenberg, Marcus; Bowlby, Reanne; 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Wong, Winghing; Xi, Liu; Yau, Christina; Zhang, Hailei; Zhang, Hongxin; Zhang, Jiashan

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of 2,658Ã‚ whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5Ã‚ driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10-18.

PMID: 32025007

ISSN: 1476-4687

CID: 5018742

American journal of industrial medicine. 2020:63(2):105-114.DOI: 10.1002/ajim.23062

Workshop summary: Potential usefulness and feasibility of a US national mesothelioma registry

Cummings, Kristin J; Becich, Michael J; Blackley, David J; Deapen, Dennis; Harrison, Robert; Hassan, Raffit; Henley, Sarah Jane; Hesdorffer, Mary; Horton, David Kevin; Mazurek, Jacek M; Pass, Harvey I; Taioli, Emanuela; Wu, Xiao-Cheng; Zauderer, Marjorie G; Weissman, David N

BACKGROUND:The burden and prognosis of malignant mesothelioma in the United States have remained largely unchanged for decades, with approximately 3200 new cases and 2400 deaths reported annually. To address care and research gaps contributing to poor outcomes, in March of 2019 the Mesothelioma Applied Research Foundation convened a workshop on the potential usefulness and feasibility of a national mesothelioma registry. METHODS:The workshop included formal presentations by subject matter experts and a moderated group discussion. RESULTS:Workshop participants identified top priorities for a registry to be: (a) connecting patients with high-quality care and clinical trials soon after diagnosis and (b) making useful data and biospecimens available to researchers in a timely manner. Existing databases that capture mesothelioma cases are limited by factors such as delays in reporting, de-identification, and lack of exposure information critical to understanding as yet unrecognized causes of disease. National disease registries for amyotrophic lateral sclerosis in the United States, and for mesothelioma in other countries, provide examples of how a registry could be structured to meet the needs of patients and the scientific community. CONCLUSIONS:Small-scale pilot initiatives should be undertaken to validate methods for rapid case identification, develop procedures to facilitate patient access to guidelines-based standard care and investigational therapies, and explore approaches to data-sharing with researchers. Ultimately, federal coordination and funding will be critical to the success of a national mesothelioma registry in improving mesothelioma outcomes and preventing future cases of this devastating disease.

PMID: 31743489

ISSN: 1097-0274

CID: 4208842