Faculty Bibliography

PURPOSE: The aim of this study was to evaluate all aspects of workflow in a large academic MRI department to determine whether process improvement (PI) efforts could improve key performance indicators (KPIs). METHODS: KPI metrics in the investigators' MR imaging department include daily inpatient backlogs, on-time performance for outpatient examinations, examination volumes, appointment backlogs for pediatric anesthesia cases, and scan duration relative to time allotted for an examination. Over a 3-week period in April 2011, key members of the MR imaging department (including technologists, nurses, schedulers, physicians, and administrators) tracked all aspects of patient flow through the department, from scheduling to examination interpretation. Data were analyzed by the group to determine where PI could improve KPIs. Changes to MRI workflow were subsequently implemented, and KPIs were compared before (January 1, 2011, to April 30, 2011) and after (August 1, 2011, to December 31, 2011) using Mann-Whitney and Fisher's exact tests. RESULTS: The data analysis done during this PI led to multiple changes in the daily workflow of the MR department. In addition, a new sense of teamwork and empowerment was established within the MR staff. All of the measured KPIs showed statistically significant changes after the reengineering project. CONCLUSIONS: Intradepartmental PI efforts can significantly affect KPI metrics within an MR imaging department, making the process more patient centered. In addition, the process allowed significant growth without the need for additional equipment or personnel.

OBJECTIVE: To create 3DMR osseous models of the shoulder similar to 3DCT models using a gradient-echo-based two-point/Dixon sequence. MATERIALS AND METHODS: CT and 3TMR examinations of 7 cadaveric shoulders were obtained. Glenoid defects were created in 4 of the cadaveric shoulders. Each MR study included an axial Dixon 3D-dual-echo-time T1W-FLASH (acquisition time of 3 min/30 s). The water-only image data from the Dixon sequence and CT data were post-processed using 3D software. The following measurements were obtained on the shoulders: surface area (SA), height/width of the glenoid and humeral head, and width of the biceps groove. The glenoid defects were measured on imaging and compared with measurements made on en face digital photographs of the glenoid fossae (reference standard). Paired t tests/ANOVA were used to assess the differences between the imaging modalities. RESULTS: The differences between the glenoid and humeral measurements were not statistically significant (cm): glenoid SA 0.12 +/- 0.04 (p = 0.45) and glenoid width 0.13 +/- 0.06 (p = 0.06) with no difference in glenoid height measurement; humeral head SA 0.07 +/- 0.12 (p = 0.42), humeral head height 0.03 +/- 0.06 (p = 0.42), humeral head width 0.07 +/- 0.06(p = 0.18), and biceps groove width 0.02 +/- 0.01 (p = 0.07). The mean/standard deviation difference between the reference standard and 3DMR measurements was 0.25 +/- 0.96 %/0.30 +/- 0.14 mm; 3DCT 0.25 +/- 0.96 /0.75 +/- 0.39 mm. There was no statistical difference between the measurements obtained on 3DMR and 3DCT (percentage, p = 0.45; mm, p = 0.20). CONCLUSION: Accurate 3D osseous models of the shoulder can be produced using a 3D two-point/Dixon sequence and can be added to MR examinations with a minor increase in imaging time, used to quantify glenoid loss, and may eliminate the need for pre-surgical CT examinations.

BACKGROUND: There is still little known regarding the effects of meniscus resection size on tibiofemoral stability. PURPOSE: To determine if partial medial meniscectomy of the posterior horn significantly alters tibiofemoral stability as measured by the anterior-posterior (AP) position and laxity of the medial femoral condyle. STUDY DESIGN: Controlled laboratory study. METHODS: Five cadaveric knees were dissected to the capsule, preserving all ligaments and the quadriceps tendon. Each specimen was first tested on a rig where the AP position and laxity of the medial femoral condyle were measured while a range of forces was applied from full extension to 90 degrees of flexion. Magnetic resonance imaging (MRI) at 3 tesla was then performed for baseline measurements of the meniscus before partial meniscectomy. Arthroscopic partial medial meniscectomy aimed at 30% of the posterior horn was then performed, followed by repeat mechanical testing and MRI. The sequence was then repeated for arthroscopic partial meniscectomy aimed at 60% and 100% of the posterior horn of the medial meniscus. RESULTS: The MRI analysis demonstrated that 22% +/- 9% of the original width of the posterior horn was removed at the first resection, 46% +/- 11% was removed at the second resection, and the third resection was 100% removal of the posterior horn for all specimens. After 22% resection, no significant difference in AP laxity was observed. A statistically significant increase in AP laxity was observed with 46% resection under a 500-N compressive load compared with the intact meniscus. After full resection, significant increases in AP laxity were observed under a 50-N compressive load compared with the intact and 22% and 46% resections. The 22% resection had similar AP positions as the intact knee, whereas the 46% resection and 100% removal of the posterior horn had statistically further posterior AP positions than the intact knee. CONCLUSION: Partial medial meniscectomy with >/=46% resection of the original width of the posterior horn significantly altered the AP position of the medial femoral condyle and also increased laxity. CLINICAL RELEVANCE: These mechanical changes may lead to abnormal cartilage loading and early osteoarthritis.

BACKGROUND: The purpose was to determine the relationship between the cartilage volumes in different regions of the femur and tibia, and the lengths of contacts between the meniscus and cartilage. The rationale was that less meniscal contact would make the cartilage more susceptible to loss of volume due to degeneration and wear. METHODS: Fifty MRI scans of osteoarthritic knees at varying degrees of severity were obtained. Computer models of the cartilage layers of the distal femur and proximal tibia were generated, from which cartilage volumes and thicknesses were calculated for different regions. The lengths of meniscal contact and heights were measured in frontal and sagittal views. RESULTS: Cartilage loss progressed initially on the central and inner regions of the distal femur, and on the tibia in the region uncovered by the meniscus. As the cartilage volume decreased further, the wear spread medially, and to a lesser extent anteriorly and posteriorly. There were inverse relations between the loss of volume on both the femur and tibia, and the meniscal contacts and heights. CONCLUSIONS: Cartilage loss initially occurred where there was direct contact between the cartilage of the femur and tibia. The meniscus did not prevent this, nor prevent the spread of the wear medially. This may have been due to the progressive reduction of cartilage-meniscal contact as the meniscus subluxed or lost substance, as the cartilage loss and deformity progressed. This suggested that the meniscus was not able to ameliorate the forces and pressures on the cartilage surfaces to prevent degeneration.

OBJECTIVE: To validate a new method to analyze delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) measurements in the hip for early assessment of cartilage defects in femoroacetabular impingement (FAI). METHODS: We performed a retrospective review of 10 hips in 10 FAI patients, who underwent hip arthroscopy. T(1)-weighted images and dGEMRIC T(1) maps were acquired at 1.5 T on coronal planes, including the anterior-superior, superior, posterior-superior hip cartilage. For all slices, a region of interest (ROI) was defined over the central portion of the femoral cartilage, assumed to be healthy, and T(1) values (x) were transformed to standard scores (z) using z = (x -mu)/sigma, where mu and sigma are the average and standard deviation of T(1) in the femoral ROI. Diagnostic performance of the resulting standardized dGEMRIC maps was evaluated against intraoperative findings and compared with that of a previously proposed dGEMRIC analysis as well as morphologic assessment. RESULTS: Assuming z = -2 or z = -3 as the threshold between normal and degenerated cartilage, sensitivity, specificity and accuracy were 88%, 51% and 62%, and 71%, 63% and 65%, respectively. By using T(1) = 500 ms as single threshold for all dGEMRIC T(1) maps, these values became 47%, 58% and 55%, whereas they were 47%, 79% and 70% for morphologic evaluation. CONCLUSIONS: Standardized dGEMRIC can increase the sensitivity in detecting abnormal cartilage in FAI and has the potential to improve the clinical interpretation of dGEMRIC measurements in FAI, by removing the effect of inter- and intra-patient T(1) variability.

OBJECTIVE: The purpose of this study was to assess the performance of a near-isotropic 3D turbo spin-echo sequence in comparison with a standard 2D protocol and with arthroscopy in direct 1.5-T MR arthrography of the shoulder. SUBJECTS AND METHODS: Dilute gadolinium was injected into three cadaver shoulders, and 3D turbo spin-echo and 2D sequences were evaluated with respect to the signal-to-noise and contrast-to-noise ratios of key tissues. In a prospective study, the 3D intermediate-weighted fat-suppressed sequence (reformatted in three planes) was added to shoulder MR arthrography of 43 consecutively registered patients, 13 of whom later underwent arthroscopy. Two radiologists independently graded the 3D and 2D images in separate sessions to visualize normal anatomic features and to detect pathologic changes in the labrum, cartilage, cuff, and glenohumeral ligaments, assigning confidence levels to their readings. One reader repeated the readings of images of 10 patients. Reports of subsequent arthroscopy were available for 13 patients. RESULTS: The sequences performed comparably with respect to signal-to-noise and contrast-to-noise ratios in the cadavers. The 3D images suffered from mildly increased blurring, but the readers were significantly more confident in assessing the proximal biceps tendon and curved portions of the labrum and in their findings of partial tears of the articular side of the supraspinatus tendon and posterior labral tears on the 3D images. A larger number of partial-thickness cartilage defects were found on 2D images. CONCLUSION: The 3D turbo spin-echo sequence is a promising technique that can be used in shoulder arthrography with image quality and results comparable to those of traditional 2D techniques. Use of the 3D technique may result in greater anatomic detail in evaluating small obliquely oriented structures, including the curved portions of the labrum and the intraarticular portion of the biceps tendon.

The rotator cable, an extension of the coracohumeral ligament, is a fibrous band-like structure that courses along the undersurface of the supraspinatus and infraspinatus tendons perpendicular to their tendon fibers. Originally described in the orthopaedic literature, the rotator cable likely plays an important role in the biomechanics of the intact and torn rotator cuff. Published data addressing the performance of MR imaging in the evaluation of the rotator cable is rather limited. The purpose of this exhibit is threefold: 1) to describe the normal gross anatomy, histology, as well as the MR imaging anatomy of the rotator cable, 2) to describe the role of imaging as it pertains to the cable's function in the biomechanics of the intact and torn rotator cuff, 3) to underscore the clinical significance of the cable in terms of classification and treatment of rotator cuff tears. Introduction to the most current knowledge on the origin, distribution, and insertions of the rotator cable using gross anatomy, histology, and MR imaging correlation will be presented. Emphasis will be placed on the MR appearance of the rotator cable in orthogonal imaging planes in both intact and torn rotator cuffs. The role of the rotator cable in the setting of rotator cuff pathology will be underscored using MRI, including its potential contributions to the geometric configuration of cuff tears, altered glenohumeral biomechanics, and fatty degeneration of the rotator cuff musculature. Lastly, a review of the clinical importance of the rotator cable will be provided focused on the effect of the cable's integrity in the management of rotator cuff tears

OBJECTIVES: To evaluate cartilage repair and native tissue using a three-dimensional (3D), radial, ultra-short echo time (UTE) (23)Na MR sequence without and with an inversion recovery (IR) preparation pulse for fluid suppression at 7 Tesla (T). METHODS: This study had institutional review board approval. We recruited 11 consecutive patients (41.5 +/- 11.8 years) from an orthopaedic surgery practice who had undergone a knee cartilage restoration procedure. The subjects were examined postoperatively (median = 26 weeks) with 7-T MRI using: proton-T2 (TR/TE = 3,000 ms/60 ms); sodium UTE (TR/TE = 100 ms/0.4 ms); fluid-suppressed, sodium UTE adiabatic IR. Cartilage sodium concentrations in repair tissue ([Na(+)](R)), adjacent native cartilage ([Na(+)](N)), and native cartilage within the opposite, non-surgical compartment ([Na(+)](N2)) were calculated using external NaCl phantoms. RESULTS: For conventional sodium imaging, mean [Na(+)](R), [Na(+)](N), [Na(+)](N2) were 177.8 +/- 54.1 mM, 170.1 +/- 40.7 mM, 172.2 +/- 30 mM respectively. Differences in [Na(+)](R) versus [Na(+)](N) (P = 0.59) and [Na(+)](N) versus [Na(+)](N2) (P = 0.89) were not significant. For sodium IR imaging, mean [Na(+)](R), [Na(+)](N), [Na(+)](N2) were 108.9 +/- 29.8 mM, 204.6 +/- 34.7 mM, 249.9 +/- 44.6 mM respectively. Decreases in [Na(+)](R) versus [Na(+)](N) (P = 0.0.0000035) and [Na(+)](N) versus [Na(+)](N2) (P = 0.015) were significant. CONCLUSIONS: Sodium IR imaging at 7 T can suppress the signal from free sodium within synovial fluid. This may allow improved assessment of [Na(+)] within cartilage repair and native tissue. KEY POINTS : * NaIR magnetic resonance imaging can suppress signal from sodium within synovial fluid. * NaIR MRI thus allows assessment of sodium concentration within cartilage tissue alone. * This may facilitate more accurate assessment of repair tissue composition and quality.

Improvement in both hardware and software has opened up new opportunities in magnetic resonance (MR) imaging of the shoulder. MR imaging at 3-T has become a reality, with the prospect of 7-T imaging on the horizon. The art of MR arthrography continues to improve, aided by the use of novel imaging positions. New techniques for three-dimensional imaging, the reduction of metal artifact, and biochemical imaging of cartilage hold great promise.

The goal of this study was to demonstrate the feasibility of using 7-Tesla (7T) magnetic resonance imaging (MRI) and micro-finite element analysis (microFEA) to evaluate mechanical and structural properties of whole, cortical, and trabecular bone at the distal femur and proximal tibia in vivo. 14 healthy subjects were recruited (age 40.7 +/- 15.7 years). The right knee was scanned on a 7T MRI scanner using a 28 channel-receive knee coil and a three-dimensional fast low-angle shot sequence (TR/TE 20 ms/5.02 ms, 0.234 mm x 0.234 mm x 1 mm, 80 axial images, 7 min 9 s). Bone was analyzed at the distal femoral metaphysis, femoral condyles, and tibial plateau. Whole, cortical, and trabecular bone stiffness was computed using microFEA. Bone volume fraction (BVF), bone areas, and cortical thickness were measured. Trabecular bone stiffness (933.7 +/- 433.3 MPa) was greater than cortical bone stiffness (216 +/- 152 MPa) at all three locations (P < 0.05). Across locations, there were no differences in bone stiffness (whole, cortical, or trabecular). Whole, cortical, and trabecular bone stiffness correlated with BVF (R >/= 0.69, P < 0.05) and inversely correlated with corresponding whole, cortical, and trabecular areas (R 0.05). Whole, cortical, and trabecular stiffness correlated with body mass index (R >/= 0.62, P < 0.05). In conclusion, at the distal femur and proximal tibia, trabecular bone contributes 66-74% of whole bone stiffness. 7T MRI and microFEA may be used as a method to provide insight into how structural properties of cortical or trabecular bone affect bone mechanical competence in vivo.