Faculty Bibliography
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The purpose of this study was to determine whether children with borderline hypothyroidism in the neonatal period had persistent hypothyroidism after 3 years of levothyroxine replacement therapy. Fourteen term infants with slightly abnormal newborn screening results (thyroxine <10th percentile, thyroid stimulating hormone [TSH] <40 mu U/mL) were identified. The subsequent serum confirmatory TSH results of 12 subjects were modestly elevated (5.3 to 18.8 mu U/mL, normal 0.6 to 4.6), whereas 2 subjects who had borderline confirmatory: TSH (4.6 and 4.7 mu U/mL) had abnormal TSH responses to thyrotropin releasing hormone testing. After 3 years of therapy, levothyroxine was discontinued in 13 patients, and repeat thyroid function tests were obtained 1 month later. Levothyroxine was not discontinued in one patient because he had an elevated random TSH (10 mu U/mL) while receiving therapy. At 3 years of age, 13 patients had persistently abnormal thyroid function tests (TSH >4.6 mu U/mL or a thyroid releasing hormone test result consistent with primary hypothyroidism), and levothyroxine was reinitiated. Only one patient had normal thyroid function studies. Although prospective studies are still lacking, we recommend levothyroxine replacement in neu borns with borderline hypothyroidism. (J Pediatr 2000; 136:53-6).
Recent reports indicate that girls with premature adrenarche are at risk of developing functional ovarian hyperandrogenism and polycystic ovarian syndrome (PCOS). As insulin and insulin-like growth factors (IGFs) have been implicated in the pathogenesis of PCOS, we hypothesize that they may also have a role in the hyperandrogenism of premature adrenarche. Thirty-five prepubertal girls (23 Caribbean Hispanics and 12 Black African-Americans) underwent a 60-min ACTH and LH-releasing hormone test. Insulin sensitivity (S-I) was assessed using the frequently sampled iv glucose tolerance test with tolbutamide. Fasting levels of IGF-I, IGF-binding protein-1 (IGFBP-1), IGFBP-3, sex hormone-binding globulin, and free testosterone (T) were also obtained.
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Total Results:
118
Current age of onset of puberty [Letter]
ISI:000089124900051
ISSN: 0031-4005
CID: 3492122
Impaired insulin secretion after moderate caloric restriction throughout puberty [Meeting Abstract]
ISI:000086155300832
ISSN: 0031-3998
CID: 3492082
Value of growth hormone treatment in Turner's syndrome
PMID: 10905378
ISSN: 1355-008x
CID: 3886262
Metabolic consequences of growth hormone treatment in paediatric practice [Meeting Abstract]
No metabolic side-effects of clinical significance have been reported during a 5-year study of growth hormone (GH) therapy in children with GH deficiency, Turner syn drome, idiopathic short stature or chronic renal insufficiency. In particular, insulin levels increase but remain within the normal range, as do glucose and haemoglobin A(1c). A recent study showed that the effects of growth on insulin sensitivity in prepubertal children with idiopathic short stature represent the changes in carbohydrate tolerance observed during normal adolescence. Thus, GH treatment may lead to prolongation of the physiological state of insulin resistance observed in normal puberty. Insulin levels during the fasting state and 2 h after a standard glucose load showed no further rise after the first 3 years of continuous GH therapy. The hyperinsulinaemia observed during GH therapy may, therefore, amplify the anabolic effects of insulin on protein metabolism during puberty.
ISI:000088760100012
ISSN: 0301-0163
CID: 3492102
Three-year follow-up of borderline congenital hypothyroidism [Meeting Abstract]
ISI:000084910000014
ISSN: 0022-3476
CID: 3492072
Commentary - Growth-promoting strategies Turner's syndrome [Editorial]
ISI:000084134100008
ISSN: 0021-972x
CID: 3492062
The roles of insulin sensitivity, insulin-like growth factor I (IGF-I), and IGF-binding protein-1 and -3 in the hyperandrogenism of African-American and Caribbean Hispanic girls with premature adrenarche
ISI:000080674000057
ISSN: 0021-972x
CID: 3492052
The relationship between birth weight (BW), body mass index (BMI) and insulin sensitivity (S-I) in prepubertal Caribbean Hispanic (CH) and black African-American (BAA) girls with premature adrenarche (PA) [Meeting Abstract]
ISI:000079476700517
ISSN: 0031-3998
CID: 3492022
Prolonged growth response to CB (Saizen (R)) in pediatric subjects with GHD who responded poorly to GHRH (Geref (R)) therapy [Meeting Abstract]
ISI:000079476700547
ISSN: 0031-3998
CID: 3492032
Marked increase in the ability of the beta-cells to secrete insulin in response to glucose and FFA occurs post-puberty [Meeting Abstract]
ISI:000079476700577
ISSN: 0031-3998
CID: 3492042
