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Trends in kidney transplant outcomes in older adults
McAdams-DeMarco, Mara A; James, Nathan; Salter, Megan L; Walston, Jeremy; Segev, Dorry L
OBJECTIVES/OBJECTIVE:To estimate mortality and death-censored graft loss according to year of kidney transplant (KT) between 1990 and 2011. DESIGN/METHODS:Cohort study. SETTING/METHODS:The Scientific Registry of Transplant Recipients (SRTR). PARTICIPANTS/METHODS:KT recipients aged 65 and older at the time of transplantation (N = 30,207). MEASUREMENTS/METHODS:Mortality and death-censored graft loss ascertained through center report and linkage to Social Security Death Master File and to Medicare. RESULTS:Older adults currently account for 18.4% of KT recipients, up from 3.4% in 1990; similar increases were noted for deceased donor (5.4 times percentage increase) and live donor (9.1 times percentage increase) transplants. Current recipients are not only older, but also more likely to be female and African American, have lengthier pretransplant dialysis, have diabetes mellitus or hypertension, and receive marginal kidneys. Mortality for older deceased donor recipients between 2009 and 2011 was 57% lower (hazard ratio (HR) = 0.43, 95% confidence interval (CI) = 0.33-0.56, P < .001) than between 1990 and 1993; mortality for older live donor recipients was 50% lower (HR = 0.50, 95% CI = 0.36-0.68, P < .001). Death-censored graft loss for older deceased donor recipients between 2009 and 2011 was 65% lower (HR = 0.35, 95% CI = 0.29-0.42, P < .001) than between 1990 and 1993; death-censored graft loss for older live donor recipients was 59% lower (HR = 0.41, 95% CI = 0.24-0.70, P < .001). CONCLUSION/CONCLUSIONS:Despite a major increase in number of older adults transplanted and an expanding window of transplant eligibility, mortality and graft loss have decreased substantially for this recipient population. These trends are important to understand for patient counseling and transplant referral.
PMID: 25439325
ISSN: 1532-5415
CID: 5130512
New Ideas to Policy [Meeting Abstract]
Segev, Dorry L.
ISI:000328999400004
ISSN: 1600-6135
CID: 5130882
Risk of End Stage Renal Disease Attributable to Live Kidney Donation [Meeting Abstract]
Muzaale, Abimereki; Massie, Allan; Wang, Mei-Cheng; Montgomery, Robert; McBride, Maureen; Wainright, Jennifer; Segev, Dorry
ISI:000328999400032
ISSN: 1600-6135
CID: 5130892
Perceived Knowledge of Kidney Transplantation and the Pursuit of a Live Donor [Meeting Abstract]
Gupta, Natasha; Salter, Megan; Garonzik-Wang, Jacqueline; Reese, Pater; Dagher, Nabil; Desai, Niraj; Segev, Dorry
ISI:000328999400061
ISSN: 1600-6135
CID: 5130902
Long-term Outcomes among HIV-infected Kidney Transplant Recipients [Meeting Abstract]
Locke, Jayme; Mehta, Shikha; Aitchison, Samantha; Peck, Arika; Deierhoi, Rhiannon; Segev, Dorry
ISI:000328999400074
ISSN: 1600-6135
CID: 5130912
Trends in Kidney Transplant Outcomes in Older Adults [Meeting Abstract]
McAdams-DeMarco, Mara; James, Nathan; Salter, Megan; Walston, Jeremy; Segev, Dorry
ISI:000328999400079
ISSN: 1600-6135
CID: 5130922
Patterns and Sequelae of Early Hospital Readmission after Kidney Transplantation [Meeting Abstract]
McAdams-DeMarco, Mara; Grams, Morgan; King, Elizabeth; Desai, Niraj; Segev, Dorry
ISI:000328999400080
ISSN: 1600-6135
CID: 5130932
Long-term Outcomes among Hiv-infected Liver Transplant Recipients [Meeting Abstract]
Locke, Jayme; Massie, Allan; Peck, Arika; Aitchison, Samantha; Deierhoi, Rhiannon; Segev, Dorry
ISI:000328999400119
ISSN: 1600-6135
CID: 5130942
Current Allocation Policy Does Not Account for Increased Risk of Death Following Sudden Rise in MELD [Meeting Abstract]
Massie, Allan; Luo, Xun; Poon, Anna; Segev, Dorry
ISI:000328999400120
ISSN: 1600-6135
CID: 5130952
The Effect of Transplant Center Volume on Mortality of Liver Transplant Recipients. [Meeting Abstract]
Pustavoitau, Aliaksei; Massie, Allan; Segev, Dorry
ISI:000339959601027
ISSN: 1527-6465
CID: 5130982