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Nudging provider adoption of clinical decision support: study protocol for a stepped-wedge cluster randomized, hybrid type III trial of an electronic health record-agnostic pulmonary embolism risk tool

Khan, Sundas; Thomas, Ynhi; Garg, Nidhi; Genes, Nicholas; Simon, Gregory W; Cleland, Charles M; Mir, Usman; Dauber-Decker, Katherine L; Solomon, Jeffrey N; Shunk, Amelia; Xu, Lynn; Mastrianni, Angela; Cui, Yuhan; Henning, Natalie; Diefenbach, Michael A; McGinn, Thomas; Richardson, Safiya
BACKGROUND:About one-third of the computed tomography (CT) scans ordered yearly to evaluate for pulmonary embolism (PE) in emergency departments (ED) in the U.S. are avoidable. Clinical guidelines recommend the use of validated PE prediction rules which reduce CT scan ordering without an increase in missed PEs, but there is low provider adoption. Clinical decision support (CDS) that incorporates these rules along with nudges (subtle, non-coercive influences on decision-making) may improve provider adoption. In our pilot trial of a PE risk CDS tool with a nudge at order entry, adoption was significantly higher (39.1%) than for the tool without nudges (20.7%). The tool was developed on an EHR-agnostic web-based platform, designed for dissemination to work with any EHR. The objective of this study is to evaluate the tool with a nudge in a multi-site, randomized trial. METHODS:A hybrid type III, stepped-wedge, ED-level, cluster randomized trial will be conducted. Study settings include 12 EDs in three geographically diverse health care systems. The EDs will be randomized over 9 steps over 30 months, ensuring at least 3 months of intervention exposure for all EDs. We will randomize matched pairs of EDs based on patient volume in each stratum to early intervention or late intervention. All providers ordering CTs for the evaluation of PE in adult patients at the site EDs will be included. Our study will be guided by two complementary frameworks: Behavioral Change Wheel Framework and Proctor's Implementation Outcomes Framework. Nudge implementation strategies in the CDS user interface will be a peer comparison of providers' hit rates for CTs ordered for PE and salient messaging. We will use an EHR-agnostic, web-based platform to implement the tool. The primary outcome will be guideline-concordant CT ordering for PE. DISCUSSION/CONCLUSIONS:This trial will advance our understanding of the impact of behavioral strategies on improving provider adoption of CDS. Additionally, the trial will confirm the impact of guideline-concordant CT ordering on CT yield rates across a diverse patient population. The use of an EHR-agnostic platform helps maximize the dissemination potential of the core evidence-based practices it facilitates. TRIAL REGISTRATION/BACKGROUND:NCT07249385; Registered 11/18/2025.
PMCID:13390430
PMID: 42186073
ISSN: 1748-5908
CID: 6070513

Real-time EHR secure messaging to coordinate emergency department disposition for 30-day revisit patients

Solanki, Priyanka; Small, William; Sondhi, Jaya; Jones, Simon; Genes, Nicholas; Mansukhani, Ajay; Prabhu, Dinesha; Turley, Reed; Pineda, Edwin; Johnson, David; Moeller, Benjamin; Bosworth, Brian; Austrian, Jonathan
OBJECTIVES/OBJECTIVE:To evaluate whether real-time electronic health record (EHR)-based secure messaging between emergency department (ED) clinicians and prior discharge teams influences ED disposition decisions for patients re-presenting within 30 days of hospital discharge. MATERIALS AND METHODS/METHODS:This 18-month pre-post study included 27 592 ED revisit encounters across 3 campuses within one academic healthcare system. Robotic process automation generated a real-time EHR secure message connecting the ED attending with the index hospitalization discharge team during the ED disposition window. The primary outcome was the proportion of encounters resulting in ED disposition changes. Secondary outcomes included length of stay and messaging engagement by service, hospital campus, and time of day. RESULTS:Systemwide, inpatient readmissions rates were unchanged (49.4% vs 48.6%, P = .149), and observation status increased (7.0% vs 8.0%, P < .001). At one campus where messaging was paired with proactive care coordination, inpatient admissions decreased (56.9% vs 54.1%, P = .029) and treat-and-release increased (36.8% vs 39.6%, P = .024). Overall, 61.8% of messages received a response, but engagement did not correlate with disposition changes systemwide. DISCUSSION/CONCLUSIONS:Disposition changes occurred only where messaging was integrated with care coordination workflows with the operational capacity to act, indicating that real-time communication alone is insufficient without supporting infrastructure. CONCLUSION/CONCLUSIONS:Real-time EHR messaging may be most effective when paired with structured care coordination models rather than deployed as a standalone alerting tool.
PMID: 42531463
ISSN: 1527-974x
CID: 6070461

Artificial Intelligence Summarization in the Emergency Department-One Size Does Not Fit All

Genes, Nicholas; Landman, Adam B
PMID: 42313388
ISSN: 2574-3805
CID: 6050172

Addressing high-utilizers of virtual urgent care through an EHR clinical decision support nudge

Silberlust, Jared; Roberts, Brian; Leybov, Victoria; Tran, Alexander; Genes, Nicholas
Virtual urgent care (VUC) has become an increasingly utilized resource for acute care delivery. Frequent utilization of VUC may reflect unmet longitudinal care needs and contribute to fragmented care. While high-utilizer patterns are well described in emergency departments, they have not been systematically characterized in telemedicine. We evaluated a clinical decision support (CDS) nudge designed to identify and address high utilizers of VUC at a large academic health system. An electronic health record alert triggered when patients met predefined high-utilizer criteria (>3 visits in 30 days, >12 in six months, or >20 in 12 months) and prompted providers to document a structured follow-up plan using a SmartPhrase. Among 473 eligible patients, 162 (34%) received the SmartPhrase. After adjustment for baseline utilization using negative binomial regression, SmartPhrase use was associated with a 22% relative reduction in VUC visits over the subsequent 30 days (incidence rate ratio 0.78, p = .03). Bootstrapped analyses confirmed a significant reduction in the SmartPhrase group (-1.47 visits; 95% CI [-2.19 to -0.62]), while no significant change occurred in the comparison group. These findings suggest that a low-cost, workflow-integrated CDS nudge may reduce short-term telehealth overutilization by prompting structured follow-up discussions and encouraging longitudinal care planning.
PMID: 42311072
ISSN: 1758-1109
CID: 6050102

Pharmacy Interventions on Medication Orders Increase With Emergency Medicine Clinician Time-on-Shift

Fatuzzo, Stephen; Koziatek, Christian A; Graulty, Christian; Ruggiero, Marissa; Kim, Jung G; Smalley, Samantha; Keeley, Kelsey; Wang, Yelan; Offenbacher, Joseph; Smith, Silas W; Wittman, Ian; Caspers, Christopher; Jamin, Catherine; Genes, Nicholas
STUDY OBJECTIVES/OBJECTIVE:Clinical demands in the emergency department (ED) may contribute to decision and attention fatigue as clinician time-on-shift increases, impacting patient care. Emergency department pharmacists review orders and intervene to correct problems related to safety and appropriateness. This study's objective was to evaluate and characterize the rate of pharmacist interventions on ED medication orders. We hypothesized that pharmacist interventions would increase with clinician time-on-shift. METHODS:We performed a retrospective study of 2 EDs within a single health system between January 2022 and November 2023. Medication and pharmacy intervention details were extracted and linked to clinician schedules, pharmacist schedules, and ED crowding scores. Mixed-effects logistic regression modeling identified factors associated with pharmacist interventions. RESULTS:Pharmacists intervened on 9,054 (1.5%) of 622,171 medication orders placed by 308 clinicians. Pharmacy intervention rate increased with clinician time-on-shift (odds ratio 1.04 for each hour; 95% confidence interval 1.03 to 1.05), with meaningful variation in this effect between individual clinicians. Stratified by clinician type (attendings, residents, or physician assistants) and shift timing (overnight versus daytime shifts), the association between time-on-shift and pharmacy intervention rate remained positive. Stratified by site (A versus B), the association was positive at site A but not at site B. CONCLUSION/CONCLUSIONS:The likelihood of orders requiring pharmacist interventions increased as ED clinicians' time-on-shift increased. This association was consistently observed across differing clinician types and shift timing, but variable across the 2 sites of the study. Clinical staffing models and quality of care could be improved by addressing stressors and fatigue accumulation informed by this analytical model.
PMID: 42287283
ISSN: 1097-6760
CID: 6049192

Factors Associated With Emergency Department Distribution of Fentanyl Test Strips

Gazzola, Marina Gaeta; Hayman, Chelsea; Wright, Danielle; Kim, Jung G; Genes, Nicholas; Wittman, Ian; Doran, Kelly M; Koziatek, Christian; Wang, Yelan; Smith, Silas W; Boatright, Dowin H
OBJECTIVES/OBJECTIVE:Fentanyl test strips (FTS) have the potential to moderate drug use behavior amidst an unregulated drug supply, yet are underutilized in medical settings. We aimed to describe emergency department (ED) FTS distribution across a large NYC health system and examine characteristics associated with clinicians' ordering FTS compared with the current standard-of-care, take-home naloxone (THN), to identify opportunities to optimize FTS distribution. METHODS:We conducted a retrospective review of THN and FTS provision across a large urban health system in its first year of FTS distribution. We evaluated the demographic and clinical characteristics of visits in which clinicians ordered FTS, compared with THN only. RESULTS:From July 20, 2022 to July 20, 2023, 237 (of 423) clinicians ordered THN for 1279 unique individuals in 1376 eligible visits (436 with FTS, 940 without). In pairwise analysis, FTS receipt was associated with being male, younger, non-White, lacking commercial insurance; substance-related or overdose-related visit chief complaint or diagnosis, attending physician, and patient-directed discharge ( P <0.05 for each). In multivariable regression, higher odds of FTS receipt were associated with male gender (OR=2.4; 95% CI=1.8-3.5), a substance-related chief complaint (OR=2.0; 95% CI=1.2-3.2) or visit diagnosis (OR=5.5; 95% CI=3.8-8.0), and overdose visit diagnosis (OR=1.7; 95% CI=1.1-2.8). Lower odds of FTS receipt were associated with older age (OR=0.98; 95% CI=0.97-0.99), noncommunity hospital sites (OR=0.71; 95% CI=0.60-0.83), and non-attending clinicians (OR=0.83; 95% CI=0.69-0.98). CONCLUSIONS:Integrating FTS into an existing ED THN program was feasible without disrupting clinical workflow. ED encounters where FTS were dispensed differed significantly from THN-only, revealing opportunities to optimize FTS ordering.
PMID: 41566569
ISSN: 1935-3227
CID: 6034392

Leveraging Electronic Health Record Data and Artificial Intelligence to Develop a Crosswalk Tool for Personalized Clinical Experience Profiles of Emergency Medicine Residents

Genes, Nicholas; Graulty, Christian; Kim, Jung G; Chan, Leland; Hayman, Chelsea; Satyamoorthi, Nivedha; Spiegel, Sarah; Offenbacher, Joseph; Finkelstein, Helen; Marin, Marina; Sagalowsky, Selin T
PROBLEM/OBJECTIVE:Graduate medical education requires learners to acquire broad clinical exposures to meet core competencies for unsupervised practice, but variability in clinical learning environments and reliance on resource-intensive assessments hinder precise assessment of trainees' clinical experiences. Electronic health records hold promise for precision medical education, yet manual mapping of International Classification of Diseases, Tenth Revision (ICD-10) codes to specialty-specific clinical practice domains limits scalability. APPROACH/METHODS:The authors leveraged electronic health record data and artificial intelligence (AI) to map residents' encounter diagnoses to the American Board of Emergency Medicine's Model of the Clinical Practice of Emergency Medicine (MCPEM). Resident encounters across 3 sites at a single academic system (January 1 to October 31, 2023) were analyzed with an AI model, mapped to MCPEM categories with ICD-10 descriptors, and quantified with vectors to match to the closest MCPEM category. Faculty raters validated the most common mappings iteratively, which were subsequently integrated into interactive learner dashboards. OUTCOMES/RESULTS:Among 119,320 encounters, 5,960 unique ICD-10 descriptors (1,126 stem codes) were identified. For the 650 most common diagnoses, 507 (78.0%) of emergency department diagnosis text descriptors were determined as valid mappings to an MCPEM subcategory. In mappings where faculty were discordant with the lowest distance mapping, 171 of 305 alternative subcategory mappings (56.0%) achieved agreement, increasing the concordance between reviewers to 515 of 650 (79.2%) overall. Interactive dashboards displayed resident-level case mix mapped to MCPEM categories, with anonymized peer comparisons and program-level aggregates, enabling identification of patterns and gaps by domain. NEXT STEPS/CONCLUSIONS:Planned work includes iterating AI-automated mappings by expanding inputs beyond diagnoses, engaging wider stakeholder review of mapping validations, and assessing generalizability to other specialties' content outlines to produce a scalable and reproducible model to increase the precision of feedback loops to inform graduate medical education, the clinical learning environment, and training design.
PMID: 41883090
ISSN: 1938-808x
CID: 6018372

Industry Electives in Clinical Informatics Fellowship: Early Experiences from a Multi-Institution Survey

Genes, Nicholas; Solanki, Priyanka; Kannry, Joseph; Khanna, Raman; Mize, Dara; Lingam, Veena; Turer, Robert W; Leu, Michael G
BACKGROUND:Clinical Informatics (CI) fellowship training equips physicians with the skills to design, implement, and evaluate health information systems in support of patient care. While core curricula emphasize academic health system experiences, fellows may have limited exposure to industry settings where much innovation originates. Away electives with vendors, startups, payers, or standards bodies offer unique opportunities to expand perspectives, but little is known about how such rotations are structured, supported, or valued. OBJECTIVES/OBJECTIVE:To characterize the structure, perceived value, and logistical challenges of industry electives among CI fellowship programs, and to synthesize best practices for integrating these experiences into training. METHODS:We surveyed current and former CI fellows and their program directors from two ACGME-accredited programs between September 2024 and March 2025. Fellows were required to complete at least four weeks of an industry elective. Free-text responses were analyzed using inductive thematic analysis, and a consensus-driven process was used to generate practical considerations for program design. RESULTS:Seven fellows reported on industry electives at non-health-center sites such as startups, vendors, and standards bodies. Their responses revealed four themes: (1) enhanced skill development and exposure to technologies and workflows not available in academic settings; (2) logistical barriers, including limited institutional support, short duration, and complex legal agreements; (3) tangible deliverables such as dashboards, analytic tools, abstracts, and grants; and (4) professional networking that often shaped career trajectories, with some fellows receiving job offers. Practical considerations included identifying partner sites, designating supervisors, negotiating agreements early, defining objectives and deliverables, and addressing financial and logistical support. CONCLUSION/CONCLUSIONS:Industry electives provide career-shaping experiences for CI fellows, expanding exposure to innovation and fostering collaboration between academia and industry. With clear objectives, aligned competencies, and institutional support, these rotations can strengthen training and prepare fellows for diverse roles across healthcare and technology.
PMID: 41760130
ISSN: 1869-0327
CID: 6010642

People, process, technology: a framework for clinical informatics fellowship applicants to evaluate programs

Silberlust, Jared; Solanki, Priyanka; Austrian, Jonathan; Testa, Paul; Genes, Nicholas
OBJECTIVES/UNASSIGNED:To propose a structured framework for evaluating and comparing clinical informatics fellowship programs using the People, Process, and Technology (PPT) model. MATERIALS AND METHODS/UNASSIGNED:We adapted Leavitt's organizational theory to create a three-pillar framework operationalized with features relevant to fellowship applicants and directors. We then applied this framework to a random sample of 18 program websites. RESULTS/UNASSIGNED:The PPT framework categorizes key fellowship characteristics into People (eg, mentorship, co-fellows, diversity), Process (eg, clinical duties, research emphasis, education), and Technology (eg, EHR systems, technical training, remote work). A visual grid illustrates variation in operational versus research focus and levels of mentorship. Website analysis revealed inconsistent transparency and detail. DISCUSSION/UNASSIGNED:The PPT framework provides a systematic, accessible approach for applicants to assess fellowship fit and for programs to communicate their strengths. CONCLUSION/UNASSIGNED:Standardizing fellowship descriptions using the PPT model may improve alignment between applicant goals and program offerings, enhancing both the application process and training experience.
PMCID:12831926
PMID: 41589219
ISSN: 2574-2531
CID: 6003142

Health Insurance Portability and Accountability Act Liability in the Age of Generative Artificial Intelligence

Schoolcraft, Dave; Meltzer, Andrew C; Sangal, Rohit; Terry, Aisha T; Robertson, Katherine; Buckland, Daniel; Motalib, Sakib; Genes, Nicholas; Vukmir, Rade; Waseem, Tayab; ,
As artificial intelligence tools become increasingly integrated into emergency department workflows, healthcare providers face a growing risk of legal liability stemming from improper use, particularly with respect to data privacy and Health Insurance Portability and Accountability Act (HIPAA) compliance. This article explores a realistic clinical scenario in which an emergency physician inadvertently violates HIPAA using a publicly available AI tool, such as ChatGPT, Gemini, Llama, and Grok, without a valid Business Associate Agreement in place. We review the legal framework of the HIPAA Privacy, Security, and Breach Notification Rules and delineate the respective liabilities of healthcare institutions and individual clinicians. Key distinctions are made between incidental, accidental, and unauthorized disclosures of protected health information, and we provide clear guidance on post-breach mitigation steps. The article also discusses the statistical likelihood of protected health information reidentification or reproduction by AI models and outlines risks associated with state-level data protection laws. Ultimately, we offer practical recommendations for physicians seeking to leverage AI responsibly in clinical care, including verifying institutional Business Associate Agreements, understanding platform-specific privacy policies, and consulting with privacy officers before entering any patient data. As AI rapidly evolves, clinicians must remain vigilant in safeguarding patient information to avoid legal exposure and uphold ethical standards of care.
PMCID:12859502
PMID: 41625696
ISSN: 2688-1152
CID: 5999492