Faculty Bibliography
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117
The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria
This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), with the participation of 210 delegates from 107 national and international societies, from 59 countries. The consensus conference was held on December 6th, 2024. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, defined by a rapid appearance of wheals, angioedema, or both. The lifetime prevalence of acute urticaria is estimated to be approximately 20%. Chronic urticaria, categorized as either chronic spontaneous urticaria or chronic inducible urticaria, is disabling, impairs quality of life, and affects performance at work and school, however, novel therapies are available. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.
PMID: 41649409
ISSN: 1398-9995
CID: 6000592
Diabetes technology & therapeutics. 2023:Conference:(International).DOI: 10.1089/dia.2023.2526.abstracts.index
PATIENT-REPORTED SEVERE HYPOGLYCEMIA AMONG HYBRID CLOSED LOOP SYSTEM (HCLS) USERS: REAL-WORLD EVIDENCE FROM A MULTICENTER STUDY FOR PEOPLE WITH TYPE 1 DIABETES [Meeting Abstract]
Background and Aims: Background: There is growing evidence that Hybrid Closed Loop Systems (HCLS) are associated with a lower risk of severe hypoglycemia (SH) in people with type 1 diabetes. In this study, we use real-world data from the T1D Exchange (T1DX-QI) EMR database to investigate the association between HCLS use and patient-reported SH events using propensity score matching.
Method(s): In this analysis, we examined SH events across propensity score-matched HCLS user and HCLS non-user groups. All available data for the pediatric (6 years and older) and adult population with T1D from March 2018-March 2022 were included in this analysis. Patient-reported SH events are defined as SH events reported by the patient at their most recent clinic visit and were classified as a binary variable (Yes/No), with those reporting one or more SH events being classified under 'Yes' Similarly, HCLS device use was defined as the use of HCLS reported by the patient at their most recent clinic encounter.
Result(s): Propensity scores were estimated using a logit model, including age, gender, race/ethnicity, and insurance status as covariates. Matching was done using 1:1 matching with the nearest neighbor approach and a caliper of 0.1. There were 1537 matched people with T1D in the HCLS user and non-users group. Analysis showed that HCLS users were less likely than HCLS non-users to report >1 SH event (OR [95% CI]: 0.2 [0.1, 0.4] when controlling for covariates.
Conclusion(s): In this population-level real-world data analysis, we found HCLS use among people with T1D associated with lower patient-reported SH events
Method(s): In this analysis, we examined SH events across propensity score-matched HCLS user and HCLS non-user groups. All available data for the pediatric (6 years and older) and adult population with T1D from March 2018-March 2022 were included in this analysis. Patient-reported SH events are defined as SH events reported by the patient at their most recent clinic visit and were classified as a binary variable (Yes/No), with those reporting one or more SH events being classified under 'Yes' Similarly, HCLS device use was defined as the use of HCLS reported by the patient at their most recent clinic encounter.
Result(s): Propensity scores were estimated using a logit model, including age, gender, race/ethnicity, and insurance status as covariates. Matching was done using 1:1 matching with the nearest neighbor approach and a caliper of 0.1. There were 1537 matched people with T1D in the HCLS user and non-users group. Analysis showed that HCLS users were less likely than HCLS non-users to report >1 SH event (OR [95% CI]: 0.2 [0.1, 0.4] when controlling for covariates.
Conclusion(s): In this population-level real-world data analysis, we found HCLS use among people with T1D associated with lower patient-reported SH events
EMBASE:640507056
ISSN: 1557-8593
CID: 5512032
A global metagenomic map of urban microbiomes and antimicrobial resistance
We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.
PMID: 34043940
ISSN: 1097-4172
CID: 4888252
Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. Here, we aimed to assess DNA methylation impact on host genome in natural HIV-1 control. To this end, whole DNA methylome in 70 untreated HIV-1 infected individuals with either high (>50,000 HIV-1-RNA copies/ml, n = 29) or low (<10,000 HIV-1-RNA copies/ml, n = 41) plasma viral load (pVL) levels were compared and identified 2,649 differentially methylated positions (DMPs). Of these, a classification random forest model selected 55 DMPs that correlated with virologic (pVL and proviral levels) and HIV-1 specific adaptive immunity parameters (IFNg-T cell responses and neutralizing antibodies capacity). Then, cluster and functional analyses identified two DMP clusters: cluster 1 contained hypo-methylated genes involved in antiviral and interferon response (e.g. PARP9, MX1, and USP18) in individuals with high viral loads while in cluster 2, genes related to T follicular helper cell (Tfh) commitment (e.g. CXCR5 and TCF7) were hyper-methylated in the same group of individuals with uncontrolled infection. For selected genes, mRNA levels negatively correlated with DNA methylation, confirming an epigenetic regulation of gene expression. Further, these gene expression signatures were also confirmed in early and chronic stages of infection, including untreated, cART treated and elite controllers HIV-1 infected individuals (n = 37). These data provide the first evidence that host genes critically involved in immune control of the virus are under methylation regulation in HIV-1 infection. These insights may offer new opportunities to identify novel mechanisms of in vivo virus control and may prove crucial for the development of future therapeutic interventions aimed at HIV-1 cure.
PMCID:7410168
PMID: 32760119
ISSN: 1553-7374
CID: 5255422
Outcomes of Mechanical Circulatory Support Therapy for Cardiogenic Shock Associated with Late Allograft Failure after Heart Transplantation [Meeting Abstract]
ISI:000522637202046
ISSN: 1053-2498
CID: 5487132
Successful Use of Veno-Arterial Extracorporeal Membrane Oxygenation as a Bridging Strategy in INTERMACS 1 Patients Undergoing HeartMate 3 LVAD Implantation [Meeting Abstract]
ISI:000522637203049
ISSN: 1053-2498
CID: 5487162
The Effect of Anticoagulation on Bleeding and Thrombotic Events during Extracorporeal Membrane Oxygenation Support for Postcardiotomy Shock [Meeting Abstract]
ISI:000522637202340
ISSN: 1053-2498
CID: 5487142
The Role of Palliative Care Consultation in Withdrawal of Veno-Arterial Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock [Meeting Abstract]
ISI:000522637203043
ISSN: 1053-2498
CID: 5487152
Sex Related Differences in Patients with Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation [Meeting Abstract]
ISI:000522637203053
ISSN: 1053-2498
CID: 5487172
Outcomes of Patients Bridged with Acute Mechanical Circulatory Support Devices to HeartMate 3 [Meeting Abstract]
ISI:000522637201135
ISSN: 1053-2498
CID: 5486982
