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Handboek posttraumatische stressstoornissen
Vermetten, H; Kleber, R; Hart, Onno van der; Haagen, Joris; Sleijpen, Marieke
Utrecht : De Tijdstroom, cop. 2012
Extent: 808 p. ; 25 cm.
ISBN: 9058981215
CID: 1476982
L'impatto del trauma infantile sulla salute e sulla malattia : l'epidemia nascosta = [The impact of early life trauma on health and disease : the hidden epidemic]
Lanius, Ruth A; Vermetten, Eric; Pain, Clare
Roma : Giovanni Fioriti Editore, 2012
Extent: 528 p
ISBN: 8895930533
CID: 1476972
Hypnose en hypnotische technieken
Chapter by: Vermetten, Eric; van der Hart, O
in: Handboek posttraumatische stressstoornissen by Vermetten, H; Kleber, R; Hart, Onno van der; Haagen, Joris; Sleijpen, Marieke [Eds]
Utrecht : De Tijdstroom, 2012
pp. 565-578
ISBN: 9058981215
CID: 1479142
Understanding depression as it occurs in the context of post-traumatic stress disorder
Yehuda, Rachel; Vermetten, Eric; McFarlane, Alexander
PMCID:3407618
PMID: 22852074
ISSN: 2090-1321
CID: 1470002
Neuroendocrine and immune responses to a cognitive stress challenge in veterans with and without PTSD
de Kloet, Carien S; Vermetten, Eric; Rademaker, Arthur R; Geuze, Elbert; Westenberg, Herman G M
BACKGROUND: PTSD has been associated with altered hypothalamus-pituitary-adrenal-axis (HPA-axis), immune and sympathetic nervous system (SNS) regulation. The purpose of this study was to evaluate the effect of cognitive stress on these systems in PTSD patients and controls. METHODS: The subjective units of distress score (SUDS), NK-cell response, plasma levels of noradrenalin and ACTH in response to cognitive stress were assessed in male veterans with PTSD (n=15) and age, region and year of deployment matched veterans without psychopathology (n=15). RESULTS: The challenge induced an increase in SUDS, noradrenalin, ACTH and NK-cell response in both groups. Baseline levels of ACTH were lower in PTSD patients. The test was experienced as more stressful by PTSD patients and resulted in an augmented ACTH response in patients. The noradrenalin and NK-cell responses showed no group differences. The ACTH response correlated with the severity of symptoms in patients, and the noradrenalin response correlated with the ACTH and NK-cell response in controls, but not in patients. DISCUSSION: PTSD patients experience more distress and present with an exaggerated pituitary response to this stressor. In addition, our results suggest an altered interaction between the HPA-axis, SNS and immune system in PTSD.
PMCID:3402140
PMID: 22893842
ISSN: 2000-8066
CID: 1470012
Aanvullende, innovatieve and computerondersteunde
Chapter by: Sleijpen, M; Vermetten, Eric
in: Handboek posttraumatische stressstoornissen by Vermetten, H; Kleber, R; Hart, Onno van der; Haagen, Joris; Sleijpen, Marieke [Eds]
Utrecht : De Tijdstroom, 2012
pp. 579-600
ISBN: 9058981215
CID: 1479132
Biological and clinical framework for posttraumatic stress disorder
Vermetten, Eric; Lanius, Ruth A
PMID: 22608629
ISSN: 0072-9752
CID: 1470022
Where are we going? An update on assessment, treatment, and neurobiological research in dissociative disorders as we move toward the DSM-5
Brand, Bethany L; Lanius, Ruth; Vermetten, Eric; Loewenstein, Richard J; Spiegel, David
This article provides an overview of the process of developing the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) of the American Psychiatric Association with a focus on issues related to the trauma-related disorders, particularly the dissociative disorders (DD). We also discuss the highlights of research within the past 5 years in the assessment, treatment, and neurobiological basis of trauma disorders. Recent research shows that DD are associated with severe symptoms as well as a higher rate of utilization of mental health treatment compared with other psychiatric disorders. As a result, DD, like other complex posttraumatic disorders, exact a high economic as well as personal burden for patients and society. The latest research indicates that DD patients show a suboptimal response to standard exposure-based treatments for posttraumatic stress disorder as well as high levels of attrition from treatment. An emerging body of research on DD treatment, primarily of naturalistic and open trials, indicates that patients who receive specialized treatment that addresses their trauma-based, dissociative symptoms show improved functioning and reduced symptoms. Recent studies of the underlying neurobiological basis for dissociation support a model of excessive limbic inhibition in DD that is consistent with the phenomenology and clinical presentation of these patients. We are optimistic that the forthcoming DSM-5 will stimulate research on dissociation and the DD and suggest areas for future studies.
PMID: 22211439
ISSN: 1529-9732
CID: 1470032
Psychofarmacotherapie
Chapter by: Vermetten, Eric; Den Boer, H; Westenberg, H
in: Handboek posttraumatische stressstoornissen by Vermetten, H; Kleber, R; Hart, Onno van der; Haagen, Joris; Sleijpen, Marieke [Eds]
Utrecht : De Tijdstroom, 2012
pp. 639-660
ISBN: 9058981215
CID: 1479152
Dissociative disorders in DSM-5
Spiegel, David; Loewenstein, Richard J; Lewis-Fernandez, Roberto; Sar, Vedat; Simeon, Daphne; Vermetten, Eric; Cardena, Etzel; Brown, Richard J; Dell, Paul F
BACKGROUND: We present recommendations for revision of the diagnostic criteria for the Dissociative Disorders (DDs) for DSM-5. The periodic revision of the DSM provides an opportunity to revisit the assumptions underlying specific diagnoses and the empirical support, or lack of it, for the defining diagnostic criteria. METHODS: This paper reviews clinical, phenomenological, epidemiological, cultural, and neurobiological data related to the DDs in order to generate an up-to-date, evidence-based set of DD diagnoses and diagnostic criteria for DSM-5. First, we review the definitions of dissociation and the differences between the definitions of dissociation and conceptualization of DDs in the DSM-IV-TR and the ICD-10, respectively. Also, we review more general conceptual issues in defining dissociation and dissociative disorders. Based on this review, we propose a revised definition of dissociation for DSM-5 and discuss the implications of this definition for understanding dissociative symptoms and disorders. RESULTS: We make the following recommendations for DSM-5: 1. Depersonalization Disorder (DPD) should include derealization symptoms as well. 2. Dissociative Fugue should become a subtype of Dissociative Amnesia (DA). 3. The diagnostic criteria for DID should be changed to emphasize the disruptive nature of the dissociation and amnesia for everyday as well as traumatic events. The experience of possession should be included in the definition of identity disruption. 4. Dissociative Trance Disorder should be included in the Unspecified Dissociative Disorder (UDD) category. CONCLUSIONS: There is a growing body of evidence linking the dissociative disorders to a trauma history, and to specific neural mechanisms.
PMID: 22134959
ISSN: 1091-4269
CID: 1470042