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Whole brain N-acetylaspartate proton MRS measurements in relapsing-remitting multiple sclerosis: Evidence for different clinical cohorts [Meeting Abstract]

Gonen, O; Li, BS; Babb, JS; He, J; Markowitz, CE; Grossman, RI
ISI:000178825101246
ISSN: 0033-8419
CID: 105102

Proton magnetic resonance spectroscopy evidence for early gray matter involvement in relapsing remitting MS [Meeting Abstract]

Inglese, M; Ge, Y; Filippi, M; Falini, A; Grossman, RI; Gonen, O
ISI:000178825101247
ISSN: 0033-8419
CID: 105103

Metabolite ratios to assumed constant creatine level may confound the quantification of proton brain 1H-MRS [Meeting Abstract]

Gonen, O; Li, BS
ISI:000178825101958
ISSN: 0033-8419
CID: 105104

Multivoxel 1H-MRS to the edge of the human brain: Intrinsic lipids suppression at high magnetic fields [Meeting Abstract]

Gonen, O; Li, BS
ISI:000178825102164
ISSN: 0033-8419
CID: 105105

Proton magnetic resonance spectroscopic characteristics of hypo- and iso-intense T1 lesions versus normal-appearing white matter in relapsing-remitting multiple sclerosis patients [Meeting Abstract]

He, J; Li, BS; Regal, J; Babb, JS; Grossman, RI; Gonen, O
ISI:000178825102169
ISSN: 0033-8419
CID: 105106

Relapsing-remitting multiple sclerosis and whole-brain N-acetylaspartate measurement: evidence for different clinical cohorts initial observations

Gonen, Oded; Moriarty, David M; Li, Belinda S Y; Babb, James S; He, Juan; Listerud, John; Jacobs, Dina; Markowitz, Clyde E; Grossman, Robert I
PURPOSE: To quantify the rate of concentration decline of neuronal marker N-acetylaspartate (NAA) in the entire brain of patients with relapsing-remitting multiple sclerosis (MS) in relation to healthy age-matched control subjects. MATERIALS AND METHODS: Whole-brain NAA (WBNAA) concentration was quantified in 49 patients with relapsing-remitting MS by using magnetic resonance (MR) imaging and proton MR spectroscopy. It was statistically analyzed by using Spearman rank correlation coefficients to test the intragroup relationship between WBNAA and Expanded Disability Status Scale (EDSS) score and Mann-Whitney analyses to test for differences between subgroups' EDSS scores versus previously published WBNAA values for healthy subjects, disease duration, and age. RESULTS: Analyses indicated three subgroups of WBNAA dynamics: Ten patients' conditions were 'stable,' exhibiting an insignificant change of about 0% (0.02/14.37) per year of clinically definite disease duration (P =.54); 27 patients showed 'moderate' decline, -2.8% (-0.34/12.18) per year (P <.01); and 12 patients experienced 'rapid' decline, -27.9% (-3.39/12.14) per year (P <.01). No correlation was found between WBNAA deficit, EDSS score, and age. CONCLUSION: Ascertaining an individual's NAA concentration dynamics might enable early forecast of disease course, reflect disease severity and thus influence treatment decisions, and improve clinical trial efficiency by allowing selection of candidates on the basis of WBNAA dynamics in addition to clinical status
PMID: 12355014
ISSN: 0033-8419
CID: 33784

Evidence for early widespread gray matter involvement in relapsing remitting multiple sclerosis [Meeting Abstract]

Inglese, M; Ge, YL; Filippi, M; Falini, A; Grossman, RI; Gonen, O
ISI:000177900500099
ISSN: 0364-5134
CID: 105107

Whole-brain N-acetylaspartate in relapsing-remitting multiple sclerosis? Evidence for different clinical cohorts [Meeting Abstract]

Gonen, O; Li, BSY; Babb, JS; He, J; Jacobs, D; Markowitz, CE; Grossman, RI
ISI:000177900500105
ISSN: 0364-5134
CID: 105108

Whole brain N-acetylaspartate concentrations are reduced in patients at presentation with clinically isolated syndromes suggestive of MS [Meeting Abstract]

Filippi, M; Bozzali, M; Gambini, A; Rovaris, M; Falini, A; Ghezzi, A; Martinelli, V; Scotti, G; Gonen, O; Grossman, RI; Comi, G
ISI:000174875900386
ISSN: 0028-3878
CID: 105109

Whole-brain N-acetylaspartate concentration: correlation with T2-weighted lesion volume and expanded disability status scale score in cases of relapsing-remitting multiple sclerosis

Bonneville, Fabrice; Moriarty, David M; Li, Belinda S Y; Babb, James S; Grossman, Robert I; Gonen, Oded
BACKGROUND AND PURPOSE: The T2-weighted MR imaging total lesion volume and Expanded Disability Status Scale (EDSS) score are two common measures of relapsing-remitting multiple sclerosis disability and pathologic abnormality. Because the whole-brain N-acetylaspartate concentration is considered to be a new marker of the disease burden, the purpose of this study was to evaluate the relationship among these three measures. METHODS: The whole-brain N-acetylaspartate concentration and T2-weighted lesion volume were quantified by using MR imaging and proton MR spectroscopy in 49 patients with relapsing-remitting multiple sclerosis (36 female and 13 male patients; average age, 39 years; age range, 24-55 years; average EDSS score, 2; range of EDSS scores, 0-6). Correlations among whole-brain N-acetylaspartate concentrations, T2-weighted lesion volumes, and EDSS scores were obtained. RESULTS: No correlation was found between whole-brain N-acetylaspartate levels and either T2-weighted lesion volumes or EDSS scores. A weak correlation was found between the EDSS scores and T2-weighted lesion volumes (P =.043, r(s) = 0.292). CONCLUSION: Despite the lack of correlation between whole-brain N-acetylaspartate concentration and the clinical disability reflected in the EDSS score, only the former evaluates the global neuronal cell disease in the entire brain, including those lesions that are occult to conventional imaging techniques
PMID: 11901002
ISSN: 0195-6108
CID: 27732