Try a new search

Format these results:

Searched for:

in-biosketch:yes

person:merrij01

Total Results:

352


Electrocardiographic findings in systemic lupus erythematosus: Data from an international inception cohort

Bourre-Tessier, Josiane; Urowitz, Murray B; Clarke, Ann E; Bernatsky, Sasha; Krantz, Mori J; Huynh, Thao; Joseph, Lawrence; Belisle, Patrick; Bae, Sang-Cheol; Hanly, John G; Wallace, Daniel J; Gordon, Caroline; Isenberg, David; Rahman, Anisur; Gladman, Dafna D; Fortin, Paul R; Merrill, Joan T; Romero-Diaz, Juanita; Sanchez-Guerrero, Jorge; Fessler, Barri; Alarcon, Graciela S; Steinsson, Kristjan; Bruce, Ian N; Ginzler, Ellen; Dooley, Mary Anne; Nived, Ola; Sturfelt, Gunnar; Kalunian, Kenneth; Ramos-Casals, Manuel; Petri, Michelle; Zoma, Asad; Pineau, Christian A
Objective: To estimate the early prevalence of various electrocardiographic (ECG) abnormalities in patients with SLE and to evaluate possible associations between repolarization changes (increased corrected QT, QTc, and QT dispersion, QTd) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60KDa). Methods: We studied adult SLE patients from 19 centers participating in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Registry. Demographics, disease activity (SLEDAI-2K), disease damage (SLICC/ACR DI), and laboratory data from the baseline or first follow-up visit were assessed. Multivariate logistic and linear regression models were used to asses for any cross-sectional associations between anti-Ro/SSA and ECG repolarization abnormalities. Results: For the 779 patients included, mean age (SD) was 35.6 years (13.8), 88.4% were women, and mean disease duration was 10.5 months (14.4). Mean SLEDAI-2K was 5.4 (5.6) and mean SLICC/ACR DI was 0.5 (1.0). ECG abnormalities were frequent and included non-specific ST-T changes (30.9%), possible left ventricular hypertrophy (5.4%) and supraventricular arrhythmias (1.3%). A QTc >/= 440ms was found in 15.3%, while QTc >/= 460ms was found in 5.3%. Mean (SD) QTd was 34.2ms (14.7) and QTd >/= 40ms was frequent (38.1%). Neither the specificity, nor the level of anti-Ro/SSA was associated with QTc duration or QTd, although confidence intervals were wide. Total DI was significantly associated with a QTc interval exceeding 440 ms (OR 1.38 95% CI 1.06, 1.79). Conclusion: A substantial proportion of recent-onset SLE patients exhibit repolarization abnormalities although severe abnormalities were rare. (c) 2014 American College of Rheumatology.
PMID: 24838943
ISSN: 2151-464x
CID: 1065332

A highlight from the LUPUS 2014 meeting: eight great ideas

Buyon, Jill P; Cohen, Phillip; Merrill, Joan T; Gilkeson, Gary; Kaplan, Mariana; James, Judith; McCune, W Joseph; Bernatsky, Sasha; Elkon, Keith
This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.
PMCID:4493165
PMID: 26167290
ISSN: 2053-8790
CID: 1668682

A Paper Patient-Based Flare Study in SLE [Meeting Abstract]

Sturgess, Joanna; Allan, Elizabeth; Isenberg, David A; Aranow, Cynthia; Aringer, Martin; Askanase, Anca; Bae, Sang-Cheol; Bernatsky, Sasha R; Bruce, Ian N; Buyon, Jill P; Cervera, Ricard; Clarke, Ann; Dooley, Mary Anne; Fortin, Paul R; Giles, Ian; Ginzler, Ellen M; Gladman, Dafna; Gordon, Caroline; Griffiths, Bridget; Hanly, John G; Inanc, Murat; Jacobsen, Soren; Kamen, Diane L; Khamashta, Munther; Lanyon, Peter; Lim, SSam; Manzi, Susan; Mosca, Marta; Nived, Ola; Peschken, Christine A; Petri, Michelle; Kalunian, Kenneth C; Rahman, Anisur; Ramsey-Goldman, Rosalind; Ruiz-Irastorza, Guillermo; Sanchez-Guerrero, Jorge; Schneider, Matteus; Steinsson, Kristjan; Sturfelt, Gunnar K; Urowitz, Murray; van Vollenhoven, Ronald F; Vasconcelos, Carlos; Wallace, Daniel J; Zoma, Asad; Merrill, Joan T; Morand, Eric; Chambers, Sharon; Costedoat-Chalumeau, Nathalie; Croca, Sara
ISI:000370860202004
ISSN: 2326-5205
CID: 2029802

Development of Lupus Nephritis: Preclinical Evaluation of Patients Who Subsequently Develop Systemic Lupus Erythematosus Demonstrate Elevation of Select Soluble Mediators Prior to and at Disease Classification in Patients with Nephritis [Meeting Abstract]

Munroe, Melissa E; Anderson, Jourdan R; Robertson, Julie M; Niewold, Timothy B; Tsokos, George C; Keith, Michael P; Merrill, Joan T; Buyon, Jill P; Harley, John B; James, Judith A
ISI:000370860203482
ISSN: 2326-5205
CID: 2029592

Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments

Askanase, Anca; Li, Xiaoqing; Pong, Avery; Shum, Katrina; Kamp, Stan; Carthen, Fredonna; Aberle, Teresa; Hanrahan, Leslie; Daly, Paola; Giles, Jon; Merrill, Joan T
OBJECTIVE:Current disease activity measures for systemic lupus erythematosus (SLE) are difficult to score or interpret and problematic for use in clinical practice. Lupus Foundation of America (LFA)-Rapid Evaluation of Activity in Lupus (REAL) is a pilot application composed of anchored visual analogue scores (0-100 mm each) for each organ affected by lupus. This study evaluated the use of LFA-REAL in capturing SLE disease activity. METHODS:In a preliminary test of LFA-REAL, this simplified, organ-based system was compared with the most widely used outcome measures in clinical trials, the British Isles Lupus Assessment Group 2004 Index (BILAG), the SLE Disease Activity Index (SLEDAI) and the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA) SLEDAI Physician's Global Assessment (SS-PGA). The level of agreement was analysed using Spearman rank correlations. RESULTS:91 patients with SLE with mild to severe disease activity were evaluated, their median SLEDAI score was 4.0 (range 0-28) and BILAG score 8.0 (0-32). The median SS-PGA was 38 mm (4-92) versus the total REAL 50 mm (0-268), which expands in range by additive organ scores. Thirty-three patients had moderate to severe disease activity (≥1.5 on SS-PGA landmarks). The median SS-PGA score of this group was 66 mm (50-92) versus median REAL score of 100 mm (59-268), confirming ability to detect a wider distribution of scores at higher disease activity. Total REAL correlated with SLEDAI, BILAG and SS-PGA (correlation coefficient=0.816, 0.933 and 0.903, respectively; p<0.001 for all). Individual LFA-REAL organ scores for musculoskeletal and mucocutaneous also correlated with corresponding BILAG domain scores (correlation coefficient=0.925 and 0.934, p<0.001). CONCLUSIONS:In this preliminary exercise, there were strong correlations between LFA-REAL and validated lupus disease activity indices. Further development may be valuable for consistent scoring in clinical trials, grading optimal assessment of change in disease activity and reliable monitoring of patients in practice.
PMCID:4378376
PMID: 25861457
ISSN: 2053-8790
CID: 4874542

Association of CLEC16A with SLE in a Large Multi-Ancestry Cohort and Implication in B-Cell Receptor Signaling [Meeting Abstract]

Harley, Isaac TW; Vaughn, Samuel; Williams, Adrienne H; Ziegler, Julie T; Comeau, Mary; Marion, Miranda; Glenn, Stuart; Adler, Adam; Kaufman, Kenneth M; Bae, Sang-Cheol; Langefeld, Carl D; Kelly, Jennifer; Gaffney, Patrick M; Scofield, RHal; Petri, Michelle; Edberg, Jeffrey C; Guthridge, Joel M; Boackle, Susan A; Freedman, Barry; Kamen, Diane L; Brown, Elizabeth E; Gilkeson, Gary S; Reveille, John D; Merrill, Joan T; Alarcon-Riquelme, Marta E; Vyse, Timothy; Criswell, Lindsey A; Ramsey-Goldman, Rosalind; Anaya, Juan-Manuel; Tsao, Betty P; James, Judith A; Alarcon, Graciela S; Stevens, Anne M; Sivils, Kathy Moser; Kimberly, Robert P; Vila, Luis M; Jacob, Chaim O; Namjou, Bahram; Kottyan, Leah C; Niewold, Timothy B; Harley, John B; PROFILE
ISI:000370860203275
ISSN: 2326-5205
CID: 2029572

The Lupus Foundation of America Rapid Evaluation of Activity in Lupus (LFA-REAL) Instrument Correlates Between Trained Clinical Investigators and Clinicians [Meeting Abstract]

Askanase, Anca; Kapoor, Teja; Aranow, Cynthia; Costenbader, Karen H; Grossman, Jennifer; Kamen, Diane L; Lim, SSam; Kim, Mimi; Daly, Paola; Hanrahan, Leslie M; Merrill, Joan T
ISI:000370860202034
ISSN: 2326-5205
CID: 2029532

Complement Activation Predicts Adverse Pregnancy Outcome in Patients with SLE and/or aPL Antibodies [Meeting Abstract]

Salmon, Jane E; Kim, Mimi; Guerra, Marta; Kaplowitz, Elianna; Laskin, Carl; Petri, Michelle; Branch, Ware D; Lockshin, Michael; Sammaritano, Lisa R; Merrill, Joan T; Stephenson, Mary D; Khamashta, Munther; Peaceman, Alan M; Lynch, Anne; Buyon, Jill P
ISI:000370860203402
ISSN: 2326-5205
CID: 2029152

The Prevalence of Anti-DFS70 Antibodies in an International Inception Cohort of Systemic Lupus Erythematosus [Meeting Abstract]

Choi, May; Hanly, John G; Urowitz, Murray; Romero-Diaz, Juanita; Gordon, Caroline; Bae, Sang-Cheol; Bernatsky, Sasha; Wallace, Daniel J; Merrill, Joan T; Isenberg, David A; Rahman, Anisur; Ginzler, Ellen M; Fortin, Paul R; Gladman, Dafna; Sanchez-Guerrero, Jorge; Petri, Michelle; Bruce, Ian N; Dooley, Mary Anne; Ramsey-Goldman, Rosalind; Aranow, Cynthia; Alarcon, Graciela S; Steinsson, Kristjan; Nived, Ola; Sturfelt, Gunnar K; Manzi, Susan; Khamashta, Munther; van Vollenhoven, Ronald F; Zoma, Asad; Ruiz-Irastorza, Guillermo; Lim, SSam; Stoll, Thomas; Inanc, Murat; Kalunian, Kenneth C; Kamen, Diane L; Maddison, Peter; Peschken, Christine A; Jacobsen, Soren; Askanase, Anca; Buyon, Jill P; Chatham, WWinn; Ramos-Casals, Manuel; Pierre, Yvan St; Clarke, Ann E; Fritzler, Marvin J
ISI:000370860202007
ISSN: 2326-5205
CID: 2029032

Economic Evaluation of Lupus Nephritis in an International Inception Cohort: Comparing the Hospitalization, Medication, Dialysis, and Procedure Costs of Those with and without Nephritis [Meeting Abstract]

Barber, Megan; Hanly, John G; O'Keeffe, Aidan; Su, Li; Urowitz, Murray; St Pierre, Yvan; Romero-Diaz, Juanita; Gordon, C; Bae, Sang-Cheol; Bernatsky, Sasha; Wallace, Daniel J; Merrill, Joan T; Isenberg, David A; Rahman, Anisur; Ginzler, Ellen M; Fortin, Paul R; Gladman, Dafna D; Sanchez-Guerrero, Jorge; Petri, Michelle; Bruce, Ian N; Dooley, Mary Anne; Ramsey-Goldman, Rosalind; Aranow, Cynthia; Alarcon, Graciela S; Chatham, WWinn; Steinsson, Kristjan; Nived, Ola; Sturfelt, Gunnar K; Manzi, Susan; Khamashta, Munther; van Vollenhoven, Ronald F; Zoma, Asad; Ramos-Casals, Manel; Ruiz-Irastorza, Guillermo; Lim, SSam; Stoll, Thomas; Inanc, Murat; Kalunian, Kenneth C; Kamen, Diane L; Maddison, Peter; Peschken, Christine A; Jacobsen, Soren; Askanase, Anca; Buyon, Jill P; Theriault, Chris; Thompson, Kara; Farewell, Vernon; Clarke, Ann E
ISI:000370860202253
ISSN: 2326-5205
CID: 2029062