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158


FIBRONECTIN IGG INTERACTION CHARACTERIZATION OF THE BINDING SITES IN FIBRONECTIN MOLECULE

ROSTAGNO A; FRANGIONE B; GOLD L I
BIOSIS:PREV198936092828
ISSN: 0021-9525
CID: 101626

SURGICAL TREATMENT OF PRIMARY RETROPERITONEAL TUMORS

TRIDICO F; ZAN S; PANIER SUFFAT P; CONTESSA L; IOZZIA C; MORINO M; ROSTAGNO A; REBECCHI F
BIOSIS:PREV198936003046
ISSN: 0035-6689
CID: 101627

Primary structure of human plasma fibronectin. Characterization of a 38 kDa domain containing the C-terminal heparin-binding site (Hep III site) and a region of molecular heterogeneity

Garcia-Pardo A; Rostagno A; Frangione B
The primary structure of a 38 kDa heparin-binding domain from human plasma fibronectin has been determined. This domain contains 380 residues arranged in three type-III homology regions of approx. 90 residues each, and a 67-amino-acid C-terminal segment. This segment has been shown to be encoded by certain mRNA species only, due to alternative splicing [Kornblihtt, Vibe-Pedersen & Baralle (1984) Nucleic Acids Research 12, 5853-5868], and therefore represents a region of heterogeneity in fibronectin. Our data indicate that at least one of the constituent polypeptide chains contains this region.
PMCID:1147649
PMID: 3593230
ISSN: 0264-6021
CID: 9591

FIBRONECTIN AND COMPLEMENTARY SYSTEMS - THE INTERACTION BETWEEN FIBRONECTIN AND C-4 [Meeting Abstract]

SABALL, E; ROSTAGNO, A
ISI:A1987L057900209
ISSN: 0025-7680
CID: 73964

Fibronectin binds to amyloid P component. Localization of the binding site to the 31,000 dalton C-terminal domain

Rostagno A; Frangione B; Pearlstein E; Garcia-Pardo A
Fibronectin has been shown to play an important role in reticuloendothelial system functioning as well as in neutrophil and fibroblast migration to tissue injury sites. Fibronectin binds several macromolecules including components of the acute phase response. We have studied the interaction of fibronectin with the amyloid P component (AP). This glycoprotein, closely related to C-reactive protein, is deposited together with amyloid fibrils and is also a normal constituent of human fibronectin, its whole tryptic digest, and isolated fragments; fibronectin was retained by immobilized AP in a molar ratio fibronectin:AP of 1:5.8. In this paper we localized the binding site for AP in a tryptic 31 kDa fragment, near the C-terminal end of the fibronectin molecule. A shorter fragment of 22 kDa starting at position 82 of the 31 kDa domain and containing all the disulfide bridges present in the 31 kDa domain did not bind to AP; therefore the active site appears to be located within the 81 N-terminal residues of the 31 kDa fragment. To further support this conclusion, reduction and alkylation of either fibronectin or the 31 kDa fragment had no effect on their binding properties.
PMID: 3778439
ISSN: 0006-291x
CID: 9596

FIBRONECTIN-COMPONENT-P INTERACTION OF AMYLOID TISSUE - CLASSIFICATION OF THE BONDING SITE IN THE FIBRONECTIN MOLECULE [Meeting Abstract]

ROSTAGNO, AA; FRANGIONE, B; PEARLSTEIN, E; GARCIAPARDO, A
ISI:A1986E878600147
ISSN: 0025-7680
CID: 41332

INTERACTION OF CYSTATIN-C WITH THE COMPLEMENT-SYSTEM [Meeting Abstract]

SABALL, E; ROSTAGNO, A; GHISO, J
ISI:A1986E878600149
ISSN: 0025-7680
CID: 73965

BINDING OF FIBRONECTIN TO AMYLOID P COMPONENT CHARACTERIZATION OF FRAGMENTS CONTAINING THE BINDING SITES

ROSTAGNO A; FRANGIONE B; PEARLSTEIN E; GARCIA-PARDO A
BIOSIS:PREV198630041434
ISSN: 0021-9525
CID: 101628