Faculty Bibliography

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379

Nature communications. 2013:4.DOI: 10.1038/ncomms3909

Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1alpha pathway

Ouyang, Xinshou; Ghani, Ayaz; Malik, Ahsan; Wilder, Tuere; Colegio, Oscar Rene; Flavell, Richard Anthony; Cronstein, Bruce Neil; Mehal, Wajahat Zafar
Inflammasome pathways are important in chronic diseases; however, it is not known how the signalling is sustained after initiation. Inflammasome activation is dependent on stimuli such as lipopolysaccharide (LPS) and ATP that provide two distinct signals resulting in rapid production of interleukin (IL)-1beta, with the lack of response to repeat stimulation. Here we report that adenosine is a key regulator of inflammasome activity, increasing the duration of the inflammatory response via the A2A receptor. Adenosine does not replace signals provided by stimuli such as LPS or ATP but sustains inflammasome activity via a cAMP/PKA/CREB/HIF-1alpha pathway. In the setting of the lack of IL-1beta responses after previous exposure to LPS, adenosine can supersede this tolerogenic state and drive IL-1beta production. These data reveal that inflammasome activity is sustained, after initial activation, by A2A receptor-mediated signalling.
PMCID:3895487
PMID: 24352507
ISSN: 2041-1723
CID: 759752
Arthritis & rheumatism. 2013:65 10 10(SI):S847-S847.DOI:

Colchicine Use and The Risk Of Myocardial Infarction Among Gout Patients: Results From a Community-Based, Informatics-Driven Retrospective Cohort Study [Meeting Abstract]

Crittenden, Daria B. ; Shah, Binita ; Sedlis, Steven P. ; Swearingen, Christopher J. ; Wagner, Eric S. ; Henry, Yvette M. ; Berger, Peter B. ; Cronstein, Bruce N. ; Pillinger, Michael H.
ISI:000325359204444
ISSN: 0004-3591
CID: 656352
Arthritis & rheumatism. 2013:65 10 10(SI):S784-S785.DOI:

The Use Of Three-Dimensionally Printed beta-Tricalcium Phosphate/Hydroxyapatite To Understand The Regulation Of Adenosine Receptors In Osteoclast Formation and Promotion In Bone Regeneration [Meeting Abstract]

Ishack, Stephanie ; Mediero, Aranzazu ; Wilder, Tuere ; Ricci, John ; Cronstein, Bruce N.
ISI:000325359204297
ISSN: 0004-3591
CID: 656402
Arthritis & rheumatism. 2013:65 10 10(SI):S1165-S1166.DOI:

Netrin1 Is a Critical Autocrine Factor For Osteoclast Differentiation [Meeting Abstract]

Mediero, Aranzazu ; Ramkhelawon, Bhama ; Moore, Kathryn ; Purdue, P. Edward ; Goldring, Steven R. ; Cronstein, Bruce N.
ISI:000325359206159
ISSN: 0004-3591
CID: 657212
Arthritis & rheumatism. 2013:65 10 10(SI):S1096-S1097.DOI:

Tenofovir But Not Adefovir Prevents Liver and Skin Fibrosis In Two Models Of Adenosine-Mediated Injury [Meeting Abstract]

Feig, Jessica L. ; Tivon, Doreen ; Aso, Miguel Perez ; Cardozo, Timothy ; Cronstein, Bruce N.
ISI:000325359206003
ISSN: 0004-3591
CID: 657262
Arthritis & rheumatism. 2013:65 10 10(SI):S790-S790.DOI:

Adenosine 2A Receptor Promotes Collagen Production By Human Fibroblasts Via Smad2/3-Independent Pathways Involving Cyclic AMP and AKT [Meeting Abstract]

Perez-Aso, Miguel ; Fernandez, Patricia ; Mediero, Aranzazu ; Chan, Edwin S. L. ; Cronstein, Bruce N.
ISI:000325359204310
ISSN: 0004-3591
CID: 657292
Arthritis & rheumatism. 2013:65 10 10(SI):S790-S790.DOI:

Adenosine A2A Receptors (A2AR) Promote Scarring By Repressing Mir-29a [Meeting Abstract]

Radusky, Ross C. ; Perez-Aso, Miguel ; Franks, Andrew G., Jr. ; Cronstein, Bruce N. ; Chan, Edwin S. L.
ISI:000325359204311
ISSN: 0004-3591
CID: 657302
Arthritis & rheumatism. 2013:65 10 10(SI):S21-S21.DOI:

Adenosine A(2A) Receptor As a Potential New Therapeutic Target For The Prevention/Treatment Of Osteoarthritis [Meeting Abstract]

Mediero, Aranzazu ; Wilder, Tuere ; Cronstein, Bruce N.
ISI:000325359201052
ISSN: 0004-3591
CID: 657402
Arthritis & rheumatism. 2013:65 10 10(SI):S400-S400.DOI:

Adenosine A2A Receptor Activates The Pro-Fibrotic Wnt / beta-Catenin Signaling In Human Dermal Fibroblasts [Meeting Abstract]

Perez-Aso, Miguel ; Cronstein, Bruce N.
ISI:000325359202440
ISSN: 0004-3591
CID: 657522
Arthritis & rheumatism. 2013:65 10 10(SI):S781-S782.DOI:

Adenosine A(2A) Receptor (A2AR) Diminishes Wear Particle (UHMWPE)-Mediated Osteolysis, Increases Bone Formation and Regulates Expression Of Axonal Guidance Proteins (AGP) By Macrophages, Osteoclasts (OC) and Osteoblasts (OB) [Meeting Abstract]

Mediero, Aranzazu ; Wilder, Tuere ; Perez-Aso, Miguel ; Cronstein, Bruce N.
ISI:000325359204289
ISSN: 0004-3591
CID: 657382